Zinc sulphate

Iupac Name：zinc;sulfate

Molecular Weight：161.45

Modify Date.: 2023-02-13 12:52

Introduction: Zinc sulfate appears as colorless or white rhombic crystals or powder at room temperature. It has convergence property and is easily soluble in water with its aqueous solution being acidic. It is slightly soluble in ethanol and glycerol. Pure zinc sulfate can be stored in the air for a long time without turning yellow. It can lose water to become white powder when placed in dry air. There are various kinds of hydrates: in the range of 0-39 ° C, its stable hydrate balanced with aqueous phase is zinc sulfate heptahydrate; in the range of 39-60 ° C, it is hexahydrate zinc sulfate. At the range of 60-100 °C, it will become zinc sulfate monohydrate. When being heated to 280 °C, various kinds of hydrate will completely lose water with decomposition into zinc sulfate at 680 °C and further decomposition at above 750 ° C and finally decomposition into zinc oxide and sulfur trioxide at about 930 °C. ZnSO4 • 7H2O can form mixed crystal with MSO4 • 7H2O (M = Mg, Fe, Mn, Co, Ni) within a certain range. It is mainly used for the preparation of raw materials of pigment lithopone, zinc barium and other zinc compounds. It also has various kinds of applications such as animal nutrition upon zinc deficiency, animal feed additives, crop zinc fertilizer (trace element fertilizer), important materials of artificial fiber, electrolyte solution upon electrolytic production of zinc metal, mordant in the textile industry, pharmaceutical emetic agents, astringents, fungicides and wood and leather preservatives. It can be derived from the reaction between zinc or zinc oxide and sulfuric acid or from the baking of sphalerite in the baking furnace followed by extraction and refining. View more+

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1. Names and Identifiers

1.1 Name: Zinc sulphate
1.2 Synonyms: ai3-03967 Bonazen Bufopto zinc sulfate Complexonat Medizinc MFCD00011302 Optised Sulfuric acid zinc salt Sulfuric acid zinc salt (1:1) Sulfuric acid, zinc salt (1:1) Sulfuric acid, zinc salt(1:1) White vitriol Zinc - sulfuric acid (1:1) Zinc (II) sulfate Zinc sulfate anhydrous zinc sulfate solution zinc sulfonate zinc(ii) sulfate ZINC(II)SULPHATE zinc,sulfate zink sulfate Zinksulfat

1.3 CAS No.: 7733-02-0

1.4 CID: 24424

1.5 EINECS(EC#): 231-793-3

1.6 Molecular Formula: O4SZn (isomer)

1.7 Inchi: InChI=1S/H2O4S.Zn/c1-5(2,3)4;/h(H2,1,2,3,4);/q;+2/p-2

1.8 InChkey: NWONKYPBYAMBJT-UHFFFAOYSA-L

1.9 Canonical Smiles: [O-]S(=O)(=O)[O-].[Zn+2]

1.10 Isomers Smiles: [O-]S(=O)(=O)[O-].[Zn+2]

2. Properties

2.1 Density: 1.31 g/mL at 20 °C

2.1 Melting point: 100°C

2.1 Boiling point: 105°C (estimate)

2.1 Precise Quality: 161.89700

2.1 PSA: 82.98000

2.1 logP: 0.42550

2.1 Solubility: H2O: soluble

2.2 Appearance: colorless solid

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: used in zinc plating and as a mordant [KIR84]

2.5 Color/Form: Colorless

2.6 Decomposition: When heated to decomposition it emits toxic fumes of /sulfur oxides and zinc oxide/.

2.7 PH: 4.0±0.5

2.8 Water Solubility: H2O: soluble | Soluble

2.9 Stability: Stable.

2.10 StorageTemp: Store at +15°C to +25°C.

3. Use and Manufacturing

3.1 Agricultural Uses: White vitriol is another name for zinc sulphateheptahydrate, and is a commonly used zinc salt. It iswidely used as a fertilizer for overcoming zincdeficiency.

3.2 Definition: zinc sulphate: A white crystalline water-soluble compound made by heating zinc sulphide ore in air and dissolving out and recrystallizing the sulphate. The common form is the heptahydrate, ZnSO4.7H2O; r.d. 1.9. This loses water above 30°C to give the hexahydrate and more water is lost above 70°C to form the monohydrate. The anhydrous salt forms at 280°C and this decomposes above 500°C. The compound, which was formerly called white vitriol, is used as a mordant and as a styptic (to check bleeding).

3.3 General Description: Anhydrous Zinc sulphate is a colorless crystalline solid. Zinc sulphate is also obtained as a hexahydrate, ZnSO4.6H2O, and as a heptahydrate ZnSO4.7H2O. All forms are soluble in water. All are noncombustible. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Zinc sulphate is used in the production of rayon, as a feed supplement, used to obtaine lectrolyte zinc, in printing textiles and to make lithopone, to impregnate wood and hides,as an additive to spinning baths for production of synthetic silks, in electroplating, and in animal feeds.

3.4 Produe Method: Zinc sulfate is produced as an intermediate in recovering zinc from mineral zinc blende, ZnS (see Zinc, Recovery). The mineral is roasted at about 1,000°C to form zinc oxide and sulfur dioxide which, on prolonged heating in excess air, converts to zinc sulfate:2ZnS + 3O2 → 2ZnO + 2SO2992 ZINC SULFATE2ZnO + 2SO2 + O2 → 2ZnSO4In the zinc recovery process, roasted products are leached with sulfuric acid, whereupon zinc oxide is converted to sulfate.ZnO + H2SO4 → ZnSO4 + H2OAlso, zinc sulfate can be prepared by reacting metallic zinc with dilute sulfuric acid followed by evaporation and crystallization:Zn + H2SO4 → ZnSO4 + H2

3.5 Purification Methods: Crystallise it from aqueous EtOH or dilute H2SO4 below 39o when it forms the heptahydrate, and between 39o and 70o it forms the hexahydrate, and above 70o the monohydrate is stable. The anhydrous salt is obtained from the hydrates by heating at 280o or lower temperatures in a current of dry air. It decomposes to ZnO and SO2 at 767o. The solubility of the heptahydrate in H2O is 5.88% at 0o, 61.92% at 30o, 66.61% at 35o and 70.05% at 39o. Zinc sulphate Preparation Products And Raw materials Raw materials

3.6 Usage: Zinc sulfate occurs in nature as the mineral, zinkosite. The heptahydrate, ZnSO4•7H2O is the mineral, goslarite. The salt is used as a mordant in calico-printing, in making rayon, in preserving wood, in animal feeds, in electroplating, and in preparing many zinc compounds.

4. Safety and Handling

4.1 Symbol: GHS07

4.1 Hazard Codes: Xn,N,Xi

4.1 Signal Word: Warning

4.1 Risk Statements: 52/53-50/53-41-22-51/53

4.1 Safety Statements: 61-39-26-60

4.1 Exposure Standards and Regulations: Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc sulfate is included in skin protectant drug products (fever blister and cold sore treatment).

4.2 Packing Group: III

4.2 Other Preventative Measures: If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow if necessary. Keep upwind. Avoid breathing vapors or dust. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Prevention ... /of metal fume fever/ is a matter of keeping exposure of workers below level of concn currently accepted as satisfactory for working with the metal in industry, preferably by employment of proper local exhaust ventilation to collect fumes at their source. Acceptable respirators are avail commercially but should be used only under suitable conditions. /Zinc/
In all cases where zinc is heated to the point where fume is produced, it is most important to ensure that adequate ventilation is provided. Individual protection is best ensured by education of the worker concerning metal-fume fever & the provision of local exhaust ventilation, or, in some situations by wearing of supplied-air hood or mask.

4.3 Hazard Class: 9

4.3 Hazard Declaration: H319-H412

4.3 Cleanup Methods: Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.
Environmental considerations: Water spill: Neutralize with agricultural lime, crushed limestone or sodium bicarbonate. Add soda ash. Adjust pH to neutral (pH= 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

4.4 DisposalMethods: SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Chemical Treatability of Zinc; Concentration Process: Ultrafiltration; Chemical Classification: Metals; Scale of Study: Continuous flow, pilot scale; Type of Wastewater Used: Industrial wastewater; Results of Study: 0.38 ppm effluent concentration. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Miscellaneous sorbents; Chemical Classification: Metals; Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: Final concentration reduced to 0.1 ppb; SiO2 + CaO slags used. /Zinc/
The proprietary Sulfex process (Permutit Co) has been applied to zinc wastes. The process involves addition of ferrous sulfide, which gradually releases sulfide to precipitate the zinc ... . /Zinc/
In the case where zinc removal is the only consideration and recovery is not warranted, removal by precipitation can be accomplished by standard pH adjustment through lime addition, precipitation and flocculation, and sedimentation, employing standard waste treatment equipment, operating data for existing chemical precipitation units indicate that levels of 1 mg/l or less of zinc are readily obtainable with lime precipitation, although assurance of consistent removal of precipitated zinc to lower levels from the effluent stream may require filtration. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Chemical precipitation; Chemical Classification: Metals; Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: 10.6% reduction by sedimentation. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Biological Treatment; Chemical Classification: Metals; 1) Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: 89% reduction; Activated sludge process. 2) Scale of Study: full scale; Type of Wastewater Used: domestic wastewater; Results of Study: 20-91% reduction achieved; Survey of municipal wastewater treatment plants. 3) Scale of Study: Continuous flow and pilot scale; Type of Wastewater Used: domestic wastewater; Results of Study: 13-14% reduction in primary treatment. 4) Scale of Study: Laboratory scale; Type of Wastewater Used: Synthetic wastewater; Results of Study: Biological growth inhibited; Study of nitrosomas bacteria. 5) Scale of Study: Continuous flow and full scale; Type of Wastewater Used: Domestic wastewater; Results of Study: 60% reduction; Activated sludge process. 6) Scale of Study: Laboratory scale; Type of Wastewater Used: Synthetic wastewater; Results of Study: Oxygen uptake inhibited. 7) Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: 57% reduction; Activated sludge process. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Chemical precipitation; Chemical Classification: Metals; 1) Scale of Study: Pilot scale; Type of Wastewater Used: Synthetic wastewater; Results of Study: 1% reduction with alum; 3 coagulants used: 220 ppm of alum at pH= 6.4. 40 ppm of ferric chloride at pH= 6.2; 415 ppm of lime at pH= 11.5; chemical coagulation was followed by dual media filtration. 2) Scale of Study: Laboratory scale, continuous flow; Type of Wastewater Used: Synthetic wastewater; Results of Study: 100% reduction with lime; Lime dose of 50 ppm added. 3) Scale of Study: Pilot scale; Type of Wastewater Used: Domestic wastewater and pure compound (one solute in a solvent) Results of Study: Iron system - 63% reduction, low lime system - 85% reduction; High lime system - 76% reduction; 3 coagulant systems were used: Iron system used 45 ppm as Fe of Fe2(SO4)3 at pH= 6.0. Low lime system used 20 ppm as Fe of Fe2 (SO4)3 and 260 ppm of CaO at pH= 10.0. High lime system used 600 ppm of CaO at pH= 11.5. Chemical coagulation was followed by multimedia filtration. 4) Scale of Study: Full scale, continuous flow; Type of Wastewater Used: Domestic wastewater; Results of Study: 90% reduction with lime (full scale); 37% reduction with lime (continuous flow); Lime dose of 350-400 ppm as calcium oxide at pH= 11.3. 5) Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: 10.6% reduction by sedimentation. 6) Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: 91.4% reduction with lime; Lime dose of 400 ppm added. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Reverse osmosis; Chemical Classification: Metals; Scale of Study: Batch flow; Type of Wastewater Used: Pure compound (one solute in a solvent); Results of Study: 1) 96.6% reduction with C/PEI membrane at pH= 8.0 100% reduction with C/PEI membrane at pH= 11.0; CA membrane operated at 400 psig and 16-22 deg C. 2) Results of Study: 96.9%-99.5% reduction with CA membrane; CA membrane operated at 400 psig and 16-22% deg C. /Zinc/
Chemical Treatability of Zinc; Concentration Process: Activated carbon; Chemical Classification: Metals; Scale of Study: Full scale continuous flow; Type of Wastewater Used: (not stated); 1) Results of Study: 81% reduction; 124 ppb effluent concentration; Carbon used as advanced treatment of biologically and chemically treated wastewater. Plant capacity 0.66 cu m/sec. Data presented for two time periods. 2) Results of Study: 61% reduction; 162 ppb effluent concentration; Carbon used as advanced treatment of biologically and chemically treated wastewater. Plant capacity 0.66 cu m/sec. Data presented for two time periods. /Zinc/
Disposal procedures for spills include ferric hydroxide precipitation and cement-based fixation processes; the latter method is very effective in rendering zinc contaminants insoluble (Dawson and Mercer 1986). Unsalvageable zinc waste may be buried in an approved landfill while salvageable zinc is typically recycled.

4.5 RIDADR: UN 3082 9/PG 3

4.5 Fire Fighting Procedures: If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty.

4.6 FirePotential: Non-combustible

4.7 Safety Profile: Poison by ingestion,intraperitoneal, subcutaneous, andintravenous routes. Human systemic effectsby ingestion: acute pulmonary edema,agranulocytosis, blood pressure decrease,diarrhea and other gastrointestinal changes,hypermotility, increased pulse rate withoutblood pressure decrease, level changes formetals other than Na/K/Fe/Ca/P/Cl,microcytosis with or without anemia,normocytic anemia. Experimentalteratogenic and reproductive effects.Questionable carcinogen with experimentaltumorigenic data. Human mutation datareported. An eye irritant. When heated todecomposition it emits toxic fumes of SOxand ZnO. See also SULFATES and ZINCCOMPOUNDS.

4.8 Caution Statement: P273-P280-P305 + P351 + P338-P337 + P313

4.8 Formulations/Preparations: Grades: Technical; USP; reagent. /Heptahydrate/
Fertilizer solutions are sold on the basis of 10-12% elemental zinc content
Neozin (American optical): solution (sterile) 0.25% with phenylephrine hydrochloride 0.125% and benzalkonium chloride 0.004% in 15 mL containers (nonprescription).
Optised (Professional Pharmacal): solution (sterile) 0.25% with phenylephrine hydrochloride 0.125% and benzalkonium chloride 1:10000 in 15 mL containers (nonprescription).
Prefrin-Z (Allergan): solution (sterile) 0.25% with phenylephrine hydrochloride 0.12%, polyvinyl alcohol 1.4%, sodium bisulfite, sodium citrate, sodium chloride, sodium hydroxide and thimerosal 0.005% in 15 mL containers.
Visine-AC (Leeming): solution (sterile, isotonic) 0.25% with tetrahydrozoline hydrochloride 0.05%, boric acid, sodium citrate, sodium chloride, edetate disodium 0.1% and benzalkonium chloride 0.01% in 15 mL and 30 mL containers (nonprescription).
Zincfrin (Alcon/BP): solution (sterile) 0.25% with phenylephrine hydrochloride 0.12% and benzalkonium chloride 0.01% in 15 mL containers (nonprescription).
Op-Thal-Zin (Alcon). Solution (sterile) 0.25% with benzalkonium chloride 0.01% in 15 ml containers (nonprescription).
Zinc sulfate, basic: monohydrate ... zinc content 20%
Zinc sulfate ophthalmic solution: 0.217% Eye-Sed ... Zinc sulfate combination ophthalmic solutions: 0.25% with naphazoline hydrochloride 0.02%: VasoClear A ... 0.25% with Phenylephrine hydrochloride 0.12%: Phenylzin ... 0.25% with tetrahydrozoline hydrochloride 0.05%: Collyrium 2 Eye Drops ... .
Zinc sulfate preparations: Baths: zinc sulfate Bath ... Eye Lotions: Collyrium Zinc Luteum ... Collyrium Zinc Sulfuric ...
Zinc sulfate preparations: Eye-drops: ... Zinc Sulfate & Adrenaline Eye-drops ... Irrigations: Zinc Sulfate Irrigation ... Lotions: Zinc sulfate Lotions ... Zinc Sulfate Lotion ... Mouth-washes: Zinc Sulfate and Zinc Chloride Mouth-wash ...
Copper and Zinc Sulfate Lotion ...
Trade Names: Bonazen, Medizinc, Bufopto Zinc Sulfate, Caswell-No-927, Op-thal-zin, Optraex, Solvenzinc, Verazinc, Zincate, Zincomed, Zincosite, A13-03967, Orazinc, Zinc-200, Zinclet, Neozin, Optised, Prefrin-Z, Visine-AC, Zincfrin, Zinc-Gro: Zincosite
ZnSO4 is available as the mono-, hexa-, and heptahydrates with zinc contents of 36, 24, and 22%, respectively. The principal commercial preparation of zinc sulfate is the monohydrate granular (36% of zinc) ...
Ophthalmic: Solution: 0.25% with Naphazoline Hydrochloride 0.012%, Clear Eyes ACR ( with benzalkonium chloride and glycerin; viscous), (Prestige); 0.25% with Tetrahydrozoline Hydrochloride 0.05% Visine A.C. ( with benzalkonium chloride and edetate disodium), (Pfizer).

4.9 WGK Germany: 3

4.9 RTECS: ZH5260000

4.9 Protective Equipment and Clothing: ... Recommended appropriate protective equipment including protective eyewear, long-sleeved shirts and long-legged pants, rubber gloves, and boots. /zinc salts/
/NIOSH approved respirator/; goggles or face shield; protective gloves.

4.10 Skin, Eye, and Respiratory Irritations: Zinc salts of strong mineral acids are astringent, corrosive to skin ... /Zinc salts/
Inhalation of dust causes irritation of nose and throat. ... Contact with eyes or skin causes irritation.

4.11 Safety: Safety Information of Zinc sulfate (CAS NO.7733-02-0):
Hazard Codes:Xn,Xi ,N
Risk Statements:52/53-50/53-41-22-51/53
52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
41:Risk of serious damage to eyes
22:Harmful if swallowed
51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements:61-39-26-60
61:Avoid release to the environment. Refer to special instructions safety data sheet
39:Wear eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
60:This material and/or its container must be disposed of as hazardous waste
RIDADR:UN 3082 9/PG 3
WGK Germany:3
RTECS:ZH5260000

4.12 Specification: First Aid Measures of Zinc sulfate (CAS NO.7733-02-0):
Ingestion:Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation:If fumes or combustion products are inhaled, remove to fresh air. Lay victim down and keep warm and rested. If breathing is shallow, or has stopped, ensure clear airway and apply resuscitation. Transport to a hospital or doctor immediately.
Skin:If this product comes into contact with skin, wash skin with soap and water. Remove contaminated clothing and footwear. Ensure contaminated clothing is thoroughly washed before using again. Transport to hospital or doctor if symptoms develop.
Eyes:If this product comes into contact with eyes, hold eyes open and wash continuously for 15 minutes with running water. Ensure irrigation under eyelids by occasionally lifting eyelids. Do not attempt to remove contact lenses unless trained. Transport to a hospital or doctor immediately.
Storage of Zinc sulfate (CAS NO.7733-02-0): Keep well closed.

4.13 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	66mg/kg (66mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
dog	LDLo	subcutaneous	78mg/kg (78mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
human	TDLo	oral	45mg/kg/7D-C (45mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP GASTROINTESTINAL: OTHER CHANGES BLOOD: NORMOCYTIC ANEMIA	British Medical Journal. Vol. 1, Pg. 754, 1978.
human	TDLo	oral	106mg/kg (106mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	British Medical Journal. Vol. 1, Pg. 1390, 1977.
man	TDLo	oral	180mg/kg/6W-I (180mg/kg)	BLOOD: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1443, 1984.
mouse	LD50	intraperitoneal	29060ug/kg (29.06mg/kg)		Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 256, Pg. 1043, 1963.
mouse	LD50	intravenous	23300ug/kg (23.3mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
mouse	LD50	oral	245mg/kg (245mg/kg)		Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 230, 1987.
mouse	LD50	subcutaneous	781mg/kg (781mg/kg)	GASTROINTESTINAL: CHANGES IN PANCREATIC WEIGHT BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Japanese Journal of Toxicology and Environmental Health. Vol. 44, Pg. 305, 1998.
rabbit	LD50	oral	2gm/kg (2000mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rabbit	LDLo	intravenous	23mg/kg (23mg/kg)		Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
rabbit	LDLo	subcutaneous	300mg/kg (300mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat	LD50	intraperitoneal	196mg/kg (196mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LD50	intravenous	69900ug/kg (69.9mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LD50	oral	1710mg/kg (1710mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LDLo	subcutaneous	330mg/kg (330mg/kg)		Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
women	TDLo	oral	3120mg/kg/43W (3120mg/kg)	BLOOD: MICROCYTOSIS WITH OR WITHOUT ANEMIA BLOOD: AGRANULOCYTOSIS	Gastroenterology. Vol. 94, Pg. 508, 1988.

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Serious eye damage, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H318 Causes serious eye damage H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/\u2026 P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. Synthesis Route

7733-02-0Total: 9 Synthesis Route

7440-66-6

7733-02-0 681 Suppliers

Literatures:
Zn: SVol., 296, page 936 - 938 US1814062 , ; C. II, , p. 2927
Yield: null

84177-23-1

7733-02-0 681 Suppliers

Literatures:
Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, , vol. 12, p. 659 - 670
Yield: null

100685-55-0

7733-02-0 681 Suppliers

Literatures:
Annalen der Physik (Weinheim, Germany), , vol. 38, p. 132 - 132
Yield: null

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7. Precursor and Product

precursor:

75-91-2

15092-81-6

74895-05-9

7758-99-8

100685-55-0

84177-23-1

product :

54010-75-2

7646-85-7

7757-82-6

20654-08-4

14324-55-1

557-42-6

81784-23-8

7214-08-6

547-68-2

557-05-1

557-41-5

14024-63-6

136-23-2

7446-11-9

14128-73-5

1315-09-9

13978-85-3

10028-15-6

72022-68-5

553-72-0

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8. Other Information

8.0 Merck: 14,10159

8.1 Description: Zinc sulfate appears as colorless or white rhombic crystals or powder at room temperature. It has convergence property and is easily soluble in water with its aqueous solution being acidic. It is slightly soluble in ethanol and glycerol. Pure zinc sulfate can be stored in the air for a long time without turning yellow. It can lose water to become white powder when placed in dry air. There are various kinds of hydrates: in the range of 0-39 ° C, its stable hydrate balanced with aqueous phase is zinc sulfate heptahydrate; in the range of 39-60 ° C, it is hexahydrate zinc sulfate. At the range of 60-100 °C, it will become zinc sulfate monohydrate. When being heated to 280 °C, various kinds of hydrate will completely lose water with decomposition into zinc sulfate at 680 °C and further decomposition at above 750 ° C and finally decomposition into zinc oxide and sulfur trioxide at about 930 °C. ZnSO4 ? 7H2O can form mixed crystal with MSO4 ? 7H2O (M = Mg, Fe, Mn, Co, Ni) within a certain range. It is mainly used for the preparation of raw materials of pigment lithopone, zinc barium and other zinc compounds. It also has various kinds of applications such as animal nutrition upon zinc deficiency, animal feed additives, crop zinc fertilizer (trace element fertilizer), important materials of artificial fiber, electrolyte solution upon electrolytic production of zinc metal, mordant in the textile industry, pharmaceutical emetic agents, astringents, fungicides and wood and leather preservatives. It can be derived from the reaction between zinc or zinc oxide and sulfuric acid or from the baking of sphalerite in the baking furnace followed by extraction and refining.

8.2 Uses: Zinc sulfate occurs in nature as the mineral, zinkosite. The heptahydrate, ZnSO4?7H2O is the mineral, goslarite. The salt is used as a mordant in calico-printing, in making rayon, in preserving wood, in animal feeds, in electroplating, and in preparing many zinc compounds.

8.3 Indications

Convergence preservatives: as eye drops, can be used for the treatment of conjunctivitis, trachoma, nasal blepharitis and so on.
Oral stimulation of gastric mucosa can cause reflex vomiting. It can be used as emetic drug, now less used.
It can be used for the treatment of zinc deficiency: zinc is the ingredient of many important enzymes in vivo such as carbonic anhydrase and alkaline phosphatase, being an indispensable trace element in the human body. Supplementation of zinc can be used for treating zinc deficiency such as dwarfism, acral dermatitis and zinc deficiency caused by long-term vein nutritional deficiency and so on.
It can be used for the treatment of zinc deficiency related diseases: such as acne vulgaris, skin ulcers (venous, arterial, leprosy), psoriasis, seborrheic dermatitis, chronic eczema, oral ulcers, hair loss and smell taste disorders.
It can be used as mordant for printing and dyeing, wood preservative, bleaching agent for papermaking, also used in medicine, artificial fiber, electrolysis, electroplating, and pesticide as well as zinc salt production.

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8.4 Production Methods: Zinc sulfate is produced as an intermediate in recovering zinc from mineral zinc blende, ZnS (see Zinc, Recovery). The mineral is roasted at about 1,000°C to form zinc oxide and sulfur dioxide which, on prolonged heating in excess air, converts to zinc sulfate:
2ZnS + 3O2 → 2ZnO + 2SO2
992 ZINC SULFATE2ZnO + 2SO2 + O2 → 2ZnSO4
In the zinc recovery process, roasted products are leached with sulfuric acid, whereupon zinc oxide is converted to sulfate.
ZnO + H2SO4 → ZnSO4 + H2O
Also, zinc sulfate can be prepared by reacting metallic zinc with dilute sulfuric acid followed by evaporation and crystallization:
Zn + H2SO4 → ZnSO4 + H2

8.5 Chemical Properties: used in zinc plating and as a mordant [KIR84]

8.6 Physical properties: The anhydrous sulfate is a colorless rhombohedral crystalline solid; refractive index 1.658; density 3.54 g/cm³; decomposes at 600°C; soluble in water, methanol, and glycerol.
The heptahydrate, ZnSO₄?7H₂O, is a colorless crystalline solid; metallic taste; rhombohedral crystals; effloresces; refractive index 1.457; density 1.957 g/cm³ at 25°C; melts at 100°C; loses all its water molecules at 280°C; decomposes above 500°C; very soluble in water, 96.5 g/100mL at 20°C; soluble in glycerol, 40 g/100 mL; insoluble in alcohol
The hexahydrate, ZnSO₄?6H₂O constitutes colorless monoclinic or tetragonal crystals; density 2.072 g/cm³at 15°C; loses five water molecules at 70°C; soluble in water.

8.7 Uses: Zinc sulfate solution has been used as a component in media for in vitro hyphal growth assays. It has also been used as a supplement in the media along with isopropyl β-D-1-thiogalactopyranoside (IPTG), while expressing zinc containing proteins.

9. Computational chemical data

Molecular Weight: 161.45g/mol
Molecular Formula: O₄SZn
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 159.880871
Monoisotopic Mass: 159.880871
Complexity: 62.2
Rotatable Bond Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Topological Polar Surface Area: 88.6
Heavy Atom Count: 6
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADcQAAOABAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10. Question & Answer

What is the use of zinc sulphate tablets? Mar 12 2022
Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues. Zinc sulfate is used to treat and to prevent zinc deficiency
Which carbon electrode gets plated with Zinc on a beaker with zinc sulphate solution? Sep 04 2021
In a beaker containing zinc sulpate and two carbon electrodes connected to a battery, which electrode gets electro plated with Zinc? Why?
Why should all the acid be used up when making zinc sulphate crystals? Aug 15 2021
So to make zinc sulphate crystals you add granulated zinc to heated sulphuric acid. However, you have to make sure all the acid is used up and you know so when the zinc stops reacting and producing bubbles "hydrogen". You then filter out the solution and set it on a water bath to crystallise it. Th...

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