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Home> Hot Product Listed L   > L-Nicotine

L-Nicotine

CAS No.:54-11-5
EINECS(EC#):200-193-3
Molecular Weight:162.23
Molecular Formula:C10H14N2 (Products with the same molecular formula)
MOL File:54-11-5.mol
Names and Identifiers
Synonyms

3-(1-methyl-2-pyrrolidinyl)pyridineL-Nicotine Nicotine(S)-(-)-Nicotine (-)-1-methyl-2-(3-pyridyl)pyrrolidine

Inchi
InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChkey
SNICXCGAKADSCV-SNVBAGLBSA-N
Canonical Smiles
CN1CCCC1C2=CN=CC=C2
Properties
Appearance
Yellow Liquid
Density
1.015
Melting Point
-8℃
Boiling Point
247℃
Refractive Index
1.5255-1.5275
Flash Point
101℃
Alpha
-166 o (C=NEAT)
Water
MISCIBLE
Solubilities
miscible with water
Color/Form
yellow
Storage temp
2-8°C
Spectral properties
Index of refraction: 1.5282 at 20 deg C/D
SADTLER REF NUMBER: 1355 (IR, PRISM); 8148 (IR, GRATING); 401 (UV); V269 (NMR); MAX ABSORPTION (ALC): 262 NM (LOG E= 3.47); SPECIFIC OPTICAL ROTATION: -169 DEG @ 20 DEG C/D
Intense mass spectral peaks: 84 m/z (100%), 133 m/z (31%), 162 m/z (30%), 161 m/z (20%)
IR: 8148 (Sadtler Research Laboratories IR Grating Collection)
MASS: 32257 (NIST/EPA/MSDC Mass Spectral Database, 1990 verion); 980 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Safety and Handling
Hazard Codes
T+:Verytoxic;N:Dangerousfortheenvironment;
Risk Statements
R25;R27;R51/53
Safety Statements
S36/37;S45;S61
HazardClass
6.1
Safety

A deadly human poison by unspecified route. Experimental poison by ingestion, skin contact, intraperitoneal, subcutaneous, intravenous, intramuscular, parenteral, intratracheal, and intraduodenal routes. Human systemic effects by rectal route: hallucinations, distorted perceptions, nausea or vomiting. Human teratogenic effects by ingestion: developmental abnormalities of the cardiovascular system. Human blood pressure effects. Can be absorbed by intact skin. An experimental teratogen. Experimental reproductive effects. “Nicotinism,” poisoning by nicotine, is characterized by stimulation and subsequent depression of the central and autonomic nervous systems. Death can result from respiratory paralysis. Mutation data reported. Used as a pesticide and in veterinary medicine as an external parasiticide. Combustible when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to heat or flame. Can react with oxidizing materials. To fight fire, use alcohol foam, dry chemical, CO2. When heated to decomposition it emits NOx, CO, and other highly toxic fumes. 
Hazard Codes: T+,N,Xn,F,Xi
Risk Statements: 25-27-51/53-36-20/21/22-11-36/37/38 
R25 :Toxic if swallowed. 
R27:Very toxic in contact with skin. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R36:Irritating to eyes. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R11:Highly flammable. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 7-16-36/37-45-61-36-26-37/39
RIDADR: UN 1654 6.1/PG 2
WGK Germany: 3
RTECS: QS5250000

PackingGroup
II
Sensitive
Air Sensitive & Hygroscopic
Cleanup Methods
1. VENTILATE AREA OF SPILL OR LEAK. 2. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK.
Transport
UN 1654
Fire Fighting Procedures
To fight fire, use alcohol foam, dry chemical, carbon dioxide.
If material is on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
Fire Potential
COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAME.
Formulations/Preparations
Preparations: (AHFS, 2009) Nicotine preparations: Route Dosage forms Strengths Brand Names Nasal Solution 0.5 mg/metered spray Nicotrol NS (with parabens); Pfizer Oral Inhalation Inhalant 4 mg/metered spray Nicotrol Inhalaer; Pfizer Topical Transdermal System 15 mg/16 hours (8.3 mg/10 sq cm) Nicotrol Step 1; Pfizer Transdermal System 10 mg/16 hours (16.6 mg/10 sq cm) Nicotrol Step 2; Pfizer Transdermal System 15 mg/16 hours (24.9 mg/30 sq cm) Nicotrol Step 3; Pfizer Transdermal System 7 mg/24 hours Nicotine Transdermal System; Sano, Watson Transdermal System 7 mg/24 hours (36 mg/7 sq cm) Nicoderm CQ Clear Step 3; GlaxoSmithKline Transdermal System 11 mg/24 hours Nicotine Transdermal System; Perrigo Transdermal System 14 mg/24 hours Nicotine Transdermal System; Sano, Watson Transdermal System 14 mg/24 hours (78 mg/15 sq cm) Nicoderm CQ Clear Step 3; GlaxoSmithKline Transdermal System 21 mg/24 hours Nicotine Transdermal System; Sano, Watson Transdermal System 21 mg/24 hours (114 mg/22 sq cm) NicoDerm CQ Step 1; GlaxoSmithKline Buccal (Transmucosal) Lozenges 2 mg (of nicotine) Commit (with aspartame); GlaxoSmithKline Lozenges 4 mg (of nicotine) Commit (with aspartame); GlaxoSmithKline Pieces, chewing gum 2 mg (of nicotine) Nicorette (sugar-free); GlaxoSmithKline Pieces, chewing gum 4 mg (of nicotine) Nicorette DS (sugar-free); GlaxoSmithKline Pieces, chewing gum 4 mg (of nicotine) Nicotine Polacrilex Gum; Perrigo, Watson
Available as the dihydrochloride, salicylate, sulfate, and bitartrate
Available commercially as the (-)-enantiomer sulfate salt
Fumigant; Soluble concentrate
DOT Emergency Guidelines
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at lease 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible..
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Spill or Leak: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Reactivities and Incompatibilities
... Can react with oxidizing materials.
Strong oxidizers, strong acids.
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
In addition to respirator selection, a complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation.
Clothing contaminated with liquid nicotine should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of nicotine from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the nicotine, the person performing the operation should be informed of nicotine's hazardous properties. Non-impervious clothing which becomes contaminated with liquid nicotine should be removed immediately and not reworn until the nicotine is removed from the clothing.
Where there is any possibility of exposure of an employee's body to liquid nicotine, facilities for quick drenching of the body should be provided within the immediate work area for emergency use.
Where there is any possibility that employees' eyes may be exposed to liquid nicotine, an eye-wash fountain should be provided within the immediate work area for emergency use.
Employees who handle liquid nicotine should wash their hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities.
Eating and smoking should not be permitted in areas where liquid nicotine is handled, processed, or stored.
Skin that becomes contaminated with liquid nicotine should be immediately washed or showered with soap or mild detergent and water to remove any nicotine.
If material is not on fire and not involved in a fire: Keep sparks, flames and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
Evacuation: If material is leaking and not on fire, consider evacuation from downwind area based on the amount spilled, location and weather conditions.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Land spill - Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. /Nicotine compounds, n.o.s. or nicotine preparations, n.o.s., liquids/
Water spill - Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses. /Nicotine compounds, n.o.s. or nicotine preparations, n.o.s., liquids/
Air spill - Apply water spray or mist to knock down vapors. Combustion products include corrosive or toxic vapors. /Nicotine compounds, n.o.s. or nicotine preparations, n.o.s., liquids/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.
Protective Equipment and Clothing
GOGGLES OR FACE SHIELD; RUBBER GLOVES; PROTECTIVE CLOTHING.
PERSONAL PROTECTIVE EQUIPMENT SHOULD BE WORN DURING PREPN & APPLICATION OF NICOTINE SOLN. IF ... APPLIED AS SPRAY OR AS VAPOR, RESP PROTECTIVE EQUIPMENT SHOULD BE WORN. ... WASHING FACILITIES ... TO ENSURE IMMEDIATE REMOVAL OF NICOTINE THAT HAS COME IN CONTACT WITH ... SKIN. CONTAMINATED CLOTHING SHOULD BE REMOVED BEFORE NICOTINE PENETRATES TO THE BODIES OF THE WEARERS.
Employees should be provided with and required to use impervious clothing, gloves, face-shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with nicotine. Employees should be provided with and required to use splash-proof goggles where there is any possibility of liquid nicotine contacting the eyes.
Particulate or vapor concn: 5 mg/cu m or less: Any supplied-air respirator or any self-contained breathing apparatus. 25 mg/cu m or less: Any supplied-air respirator with a full facepiece, helmet, or hood, or any self-contained breathing apparatus with a full facepiece. 35 mg/cu m or less: A type C supplied-air respirator operated in pressure-demand or other positive-pressure or continuous-flow mode. Greater than 35 mg/cu m or entry and escape from unknown concentrations: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive-pressure mode, or a combination respirator which includes a type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure or continuous-flow mode and an auxillary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Escape: Any gas mask providing protection against organic vapors and particulates, including pesticide respirators which meet the requirements of this class, or any escape self-contained breathing apparatus.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.)
Respirator Recommendations: Up to 5 mg/cu m Assigned Protection Factor (APF) Respirator Recommendation APF = 10 Any supplied-air respirator. APF = 50 Any self-contained breathing apparatus with a full facepiece.
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: Assigned Protection Factor (APF) Respirator Recommendation APF = 10,000 Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. APF = 10,000 Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape conditions: Assigned Protection Factor (APF) Respirator Recommendation APF = 50 Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus.
Specification

  Nicotine (CAS NO.54-11-5), its Synonyms are (-)-3-(1-Methyl-2-pyrrolidyl)pyridine ; (-)-Nicotine ; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine ; (S)-Nicotine ; 1-Methyl-2-(3-pyridyl)pyrrolidine ; 3-(1-Methyl-2-pyrrolidinyl)pyridine ; 3-(N-Methylpyrrolidino)pyridine ; Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)- ; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)- (9CI) . It is yellow liquid.

Octanol/Water Partition Coefficient
log Kow = 1.17
Report

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P075, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL & DISPOSING IN SECURED SANITARY LANDFILL. 2. BY ATOMIZING IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE.
A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
A) Dissolve in such combustible solvent as alcohols, ... etc. Spray the soln into a furnace with afterburner and scrubber. B) Pour into a mixture of sand and soda ash (9:1). After mixing, put into a paper carton stuffed full with packing paper to serve as fuel. Burn in a furnace. Recommendable method: Incineration.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 10_100 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Contraf-Nicotex-Tobacco GmbH 2015
Nicobrand 2015
more >
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Nicotine

1.2 Other means of identification

Product number -
Other names (-)-Nicotine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Systemic Agent
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H310 Fatal in contact with skin

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P262 Do not get in eyes, on skin, or on clothing.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P310 Immediately call a POISON CENTER/doctor/\u2026

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Nicotine Nicotine 54-11-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nicotine and Related Compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

To fight fire, use alcohol foam, dry chemical, carbon dioxide.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, it emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1. VENTILATE AREA OF SPILL OR LEAK. 2. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Ventilation along the floor.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.5 mg/cu m, skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Yellow Liquid
Colour Colorless to pale yellow, oily liquid
Odour Fish-like odor when warm
Melting point/ freezing point -8\u00baC
Boiling point or initial boiling point and boiling range 247\u00baC
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit LOWER 0.7% BY VOL; UPPER 4.0% BY VOL
Flash point 101\u00baC
Auto-ignition temperature 243.89\u00b0C (USCG, 1999)
Decomposition temperature 247\u00b0C
pH pH = 10.2 (0.05 Molar solution)
Kinematic viscosity Becomes viscous on exposure to air
Solubility In water:MISCIBLE
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1 mm Hg at 61.8\u00b0C (EPA, 1998)
Density and/or relative density 1.015
Relative vapour density 5.61 (EPA, 1998) (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Nicotine is photosensitive and will gradually turn brown when exposed to light or air.

10.3 Possibility of hazardous reactions

COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAME.At 20\u00b0C (20\u00b0C) evaporation of nicotine can quickly cause hazardous air conditions in small enclosed spaces.Nicotine readily absorbs moisture from the air (hygroscopic).Nicotine is light sensitive (photosensitive) and will gradually turn brown on exposure to air or light.Nicotine-An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition it emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... Can react with oxidizing materials.

10.6 Hazardous decomposition products

When heated to decomp it emits /nitrogen oxides, carbon monoxide/ and other highly toxic fumes. ...

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 188 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, age 13-21 days fry); Conditions: freshwater, static, 12\u00b0C; Concentration: 4000 ug/L for 96 hr /> or =95% purity
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age <24 hr neonate); Conditions: freshwater, static, 21\u00b0C, pH 7.6; Concentration: 0.035 mmol/L for 24 hr; Effect: intoxication, immobilization
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

BACTERIAL STRAIN, ISOLATED FROM TOBACCO LEAVES, OXIDIZED NICOTINE TO GAMMA-AMINOBUTYRIC ACID ... ARTHROBACTER OXYDANS, ADAPTED TO L-, D-, DL-NICOTINE, CONVERTED BOTH ... ISOMERS INITIALLY TO 6-HYDROXY NICOTINE. THESE ... THEN METABOLIZED TO ... 6-HYDROXY-N-METHYLMYOSMINE.

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for nicotine(SRC), using a log Kow of 1.17(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of nicotine is estimated as 100(SRC), using a log Kow of 1.17(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that nicotine is expected to have high mobility in soil. The pKb1 of nicotine is 6.16(4), indicating that this compound will partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Adsorption of nicotine, under more acidic conditions, can be represented as a high-affinity type isotherm, indicating that nicotine has a high affinity for humic acids in soil as a result of protonation of the pyrrolidine nitrogen atom of nicotine(6).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1654 IMDG: UN1654 IATA: UN1654

14.2 UN Proper Shipping Name

ADR/RID: NICOTINE
IMDG: NICOTINE
IATA: NICOTINE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Nicotine Nicotine 54-11-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 17, 2017
Revision Date Aug 17, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:162.23156 [g/mol]
Molecular Formula:C10H14N2
XLogP3:1.2
H-Bond Donor:0
H-Bond Acceptor:2
Rotatable Bond Count:1
Exact Mass:162.115698
MonoIsotopic Mass:162.115698
Topological Polar Surface Area:16.1
Heavy Atom Count:12
Formal Charge:0
Complexity:147
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Feature 3D Cation Count:1
Feature 3D Ring Count:2
Effective Rotor Count:2
Conformer Sampling RMSD:0.6
CID Conformer Count:15