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Home> Hot Product Listed T   > Tetraethylthiuram disulfide

Tetraethylthiuram disulfide

CAS No.:97-77-8
EINECS(EC#):202-607-8
Molecular Weight:296.52
Molecular Formula:C10H20N2S4 (Products with the same molecular formula)
MOL File:97-77-8.mol
Properties
Appearance
yellow-white crystals or grey powder
Density
1.27
Melting Point
70-74℃
Boiling Point
117℃
Refractive Index
1.6126 (84 C)
Flash Point
177°C
Water
0.02 g/100 mL
Solubilities
0.02 g/100 mL in water
Color/Form
WHITE TO OFF-WHITE CRYSTALLINE POWDER
Light-gray powder
White, yellowish, or light-gray powder.
Stability
Stable. Incompatible with strong oxidants.
HS Code
29303000
Storage temp
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Spectral properties
SADTLER REFERENCE NUMBER: 1244 (IR, PRISM)
Intense mass spectral peaks: 116 m/z (100%), 88 m/z (49%), 44 m/z (43%), 148 m/z (40%)
Intense mass spectral peaks: 60 m/z, 296 m/z
IR: 15313 (Sadtler Research Laboratories IR Grating Collection)
NMR: 6686 (Sadtler Research Laboratories Spectral Collection)
MASS: NIST 14172 (NIST/EPA/MSDC Mass Spectral Database 1990 version)
1H NMR: SAD 6686 (Sadtler Research Laboratories Spectral Collection)
Safety and Handling
Hazard Codes
Xn:Harmful
Risk Statements
R22;R43;R48/22;R50/53
Safety Statements
S24;S37;S60;S61
HazardClass
9
PackingGroup
III
Skin, Eye, and Respiratory Irritations
Potential symptoms of overexposure are irritation of eyes, skin, respiratory system... .
Cleanup Methods
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)
Transport
UN 2588/3077
Fire Fighting Procedures
Powder, water spray, foam, carbon dioxide.
Fire Potential
Combustible.
Formulations/Preparations
Disulfiram is available in US for rubber processing with following specifications: ... Ash, 0.5% max; moisture, 1.0% max; available sulfur, 10.8%. It is also avail in dispersion containing 25-30% binder and in 50:50 mixt with thiram (methyl tuads).
Disulfiram, USP (antabuse), is available in form of oral tablets that contain 250 or 500 mg of drug.
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl disulfiram, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Tetraethylthiuram disulfide is an indirect food additive for use only as a component of adhesives.
Reactivities and Incompatibilities
The substance decomposes on burning producing toxic and corrosive fumes including nitrogen oxides, sulfur oxides. Reacts violently with strong oxidants. Attacks copper.
... Disulfiram react/s/ with nitrite under mildly acidic conditions to form N-nitroso compounds.
Other Preventative Measures
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention.
Protective Equipment and Clothing
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Specification

The Disulfiram , with cas registry number of 97-77-8,?belongs to the classification codes of?(1) Acaricide ; (2) Agricultural Chemical ; (3) Alcohol deterrents ; (4) Central Nervous System Agents ; (5) Drug / Therapeutic Agent ; (6) Enzyme inhibitors ; (7) Fungicide, bactericide, wood preservative ; (8) Immunomodulator ; (9) Reproductive Effect ; (10) Skin / Eye Irritant. It is also called TETD ; Bis(diethylthiocarbamoyl) disulfide ; Tetraethylthiuram disulfide . Its IUPAC name is diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate . And its systematic name is called 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane . Its trade names include Antabuse and Antabus .?Among all the names, its superlist name include Disulfide, bis(diethylthiocarbamoyl) ; Disulfiram ; Tetraethylthiuram disulfide ; Tetraethylthiuram disulphide ; Thioperoxydicarbonic diamide, tetraethyl- .?Disulfiram?is stable but incompatible with strong oxidants.

Physical properties of?Disulfiram are:?(1) ACD/LogP: 3.88 ; (2) # of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 3.88 ; (4) ACD/LogD (pH 7.4): 3.88 ; (5) ACD/BCF (pH 5.5): 523.35 ; (6) ACD/BCF (pH 7.4): 523.36 ; (7) ACD/KOC (pH 5.5): 3074.04 ; (8) ACD/KOC (pH 7.4): 3074.11 ; (9) #H bond acceptors: 2 ; (10) #H bond donors: 0 ; (11) #Freely Rotating Bonds: 7 ; (12) Index of Refraction: 1.619 ; (13) Molar Refractivity: 86.39 cm3 ; (14) Molar Volume: 246 cm3 ; (15) Surface Tension: 56.9 dyne/cm ; (16) Density: 1.205 g/cm3 ; (17) Flash Point: 177 °C ; (18) Enthalpy of Vaporization: 61.57 kJ/mol ; (19) Boiling Point: 369 °C at 760 mmHg ; (20) Vapour Pressure: 1.22E-05 mmHg at 25°C.

Preparation of?Disulfiram :?This chemical?could be prepared from oxidation of sodium diethyldithiocarbamate with iodine :
2 NaS2CNEt2 + I2 → Et2NC(S)S-SC(S)NEt2 + 2 NaI (Et = C2H5)

Uses of?Disulfiram :?This product has been used as?a drug to cure chronic alcoholism. It is first discovered in 1948. At present, it has been found that?it may be?used?in cancer therapy and?cocaine dependence.

When you are using this chemical, please be cautious about it as the following:
The Disulfiram is harmful if swallowed and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. So, remember wear suitable gloves and avoid contact with skin. After use it,keep it in the container and avoid release to the environment. Its?container must be disposed of as hazardous waste.

You can still convert the following datas into molecular structure:
(1) SMILES:S=C(SSC(=S)N(CC)CC)N(CC)CC ;
(2) InChI:InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3;
(3) InChIKey:AUZONCFQVSMFAP-UHFFFAOYAF

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 230, 1969.
dog LDLo oral 3500mg/kg (3500mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
human LDLo oral 160mg/kg (160mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
British Medical Journal. Vol. 2, Pg. 94, 1977.
man LDLo oral 150mg/kg/6W-I (150mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Archives of Internal Medicine. Vol. 143, Pg. 1271, 1983.
man TDLo oral 150mg/kg/6W-I (150mg/kg) MUSCULOSKELETAL: JOINTS Arthritis and Rheumatism. Vol. 25, Pg. 1494, 1982.
man TDLo oral 450mg/kg/6W-I (450mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Gastroenterology. Vol. 93, Pg. 830, 1998.
mouse LD50 intraperitoneal 75mg/kg (75mg/kg) ? National Technical Information Service. Vol. AD691-490,
mouse LD50 oral 1980mg/kg (1980mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 36, 1957.
mouse LD50 subcutaneous 2600mg/kg (2600mg/kg) ? Drugs in Japan Vol. -, Pg. 523, 1995.
rabbit LD50 oral 1800mg/kg (1800mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
rat LD subcutaneous > 4gm/kg (4000mg/kg) ? Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
rat LD50 intraperitoneal 248mg/kg (248mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal de Pharmacologie. Vol. 9, Pg. 35, 1978.
rat LD50 oral 500mg/kg (500mg/kg) ? Archiv fuer Toxikologie. Vol. 22, Pg. 12, 1966.
women LDLo oral 90mg/kg/18D-I (90mg/kg) BEHAVIORAL: COMA

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Deutsche Medizinische Wochenschrift. Vol. 118, Pg. 1355, 1993.
women TDLo oral 90mg/kg/18D-I (90mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" Journal of Clinical Psychiatry. Vol. 46, Pg. 67, 1985.
women TDLo oral 140mg/kg/2W (140mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Southern Medical Journal. Vol. 80, Pg. 1577, 1987.

Octanol/Water Partition Coefficient
log Kow= 3.88
Report

The Disulfiram , with cas registry number of 97-77-8,?belongs to the classification codes of?(1) Acaricide ; (2) Agricultural Chemical ; (3) Alcohol deterrents ; (4) Central Nervous System Agents ; (5) Drug / Therapeutic Agent ; (6) Enzyme inhibitors ; (7) Fungicide, bactericide, wood preservative ; (8) Immunomodulator ; (9) Reproductive Effect ; (10) Skin / Eye Irritant. It is also called TETD ; Bis(diethylthiocarbamoyl) disulfide ; Tetraethylthiuram disulfide . Its IUPAC name is diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate . And its systematic name is called 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane . Its trade names include Antabuse and Antabus .?Among all the names, its superlist name include Disulfide, bis(diethylthiocarbamoyl) ; Disulfiram ; Tetraethylthiuram disulfide ; Tetraethylthiuram disulphide ; Thioperoxydicarbonic diamide, tetraethyl- .?Disulfiram?is stable but incompatible with strong oxidants.

Physical properties of?Disulfiram are:?(1) ACD/LogP: 3.88 ; (2) # of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 3.88 ; (4) ACD/LogD (pH 7.4): 3.88 ; (5) ACD/BCF (pH 5.5): 523.35 ; (6) ACD/BCF (pH 7.4): 523.36 ; (7) ACD/KOC (pH 5.5): 3074.04 ; (8) ACD/KOC (pH 7.4): 3074.11 ; (9) #H bond acceptors: 2 ; (10) #H bond donors: 0 ; (11) #Freely Rotating Bonds: 7 ; (12) Index of Refraction: 1.619 ; (13) Molar Refractivity: 86.39 cm3 ; (14) Molar Volume: 246 cm3 ; (15) Surface Tension: 56.9 dyne/cm ; (16) Density: 1.205 g/cm3 ; (17) Flash Point: 177 °C ; (18) Enthalpy of Vaporization: 61.57 kJ/mol ; (19) Boiling Point: 369 °C at 760 mmHg ; (20) Vapour Pressure: 1.22E-05 mmHg at 25°C.

Preparation of?Disulfiram :?This chemical?could be prepared from oxidation of sodium diethyldithiocarbamate with iodine :
2 NaS2CNEt2 + I2 → Et2NC(S)S-SC(S)NEt2 + 2 NaI (Et = C2H5)

Uses of?Disulfiram :?This product has been used as?a drug to cure chronic alcoholism. It is first discovered in 1948. At present, it has been found that?it may be?used?in cancer therapy and?cocaine dependence.

When you are using this chemical, please be cautious about it as the following:
The Disulfiram is harmful if swallowed and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. So, remember wear suitable gloves and avoid contact with skin. After use it,keep it in the container and avoid release to the environment. Its?container must be disposed of as hazardous waste.

You can still convert the following datas into molecular structure:
(1) SMILES:S=C(SSC(=S)N(CC)CC)N(CC)CC ;
(2) InChI:InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3;
(3) InChIKey:AUZONCFQVSMFAP-UHFFFAOYAF

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 230, 1969.
dog LDLo oral 3500mg/kg (3500mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
human LDLo oral 160mg/kg (160mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
British Medical Journal. Vol. 2, Pg. 94, 1977.
man LDLo oral 150mg/kg/6W-I (150mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Archives of Internal Medicine. Vol. 143, Pg. 1271, 1983.
man TDLo oral 150mg/kg/6W-I (150mg/kg) MUSCULOSKELETAL: JOINTS Arthritis and Rheumatism. Vol. 25, Pg. 1494, 1982.
man TDLo oral 450mg/kg/6W-I (450mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Gastroenterology. Vol. 93, Pg. 830, 1998.
mouse LD50 intraperitoneal 75mg/kg (75mg/kg) ? National Technical Information Service. Vol. AD691-490,
mouse LD50 oral 1980mg/kg (1980mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 36, 1957.
mouse LD50 subcutaneous 2600mg/kg (2600mg/kg) ? Drugs in Japan Vol. -, Pg. 523, 1995.
rabbit LD50 oral 1800mg/kg (1800mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
rat LD subcutaneous > 4gm/kg (4000mg/kg) ? Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 305, 1952.
rat LD50 intraperitoneal 248mg/kg (248mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal de Pharmacologie. Vol. 9, Pg. 35, 1978.
rat LD50 oral 500mg/kg (500mg/kg) ? Archiv fuer Toxikologie. Vol. 22, Pg. 12, 1966.
women LDLo oral 90mg/kg/18D-I (90mg/kg) BEHAVIORAL: COMA

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Deutsche Medizinische Wochenschrift. Vol. 118, Pg. 1355, 1993.
women TDLo oral 90mg/kg/18D-I (90mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" Journal of Clinical Psychiatry. Vol. 46, Pg. 67, 1985.
women TDLo oral 140mg/kg/2W (140mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Southern Medical Journal. Vol. 80, Pg. 1577, 1987.

Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 100_1000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Taminco BVBA 2013
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name disulfiram

1.2 Other means of identification

Product number -
Other names Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin sensitization, Category 1

Specific target organ toxicity \u2013 repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H317 May cause an allergic skin reaction

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P314 Get medical advice/attention if you feel unwell.

P391 Collect spillage.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
disulfiram disulfiram 97-77-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; sensitization dermatitis; lassitude (weakness, exhaustion), tremor, restlessness, headache, dizziness; metallic taste; peripheral neuropathy; liver damage Target Organs: Eyes, skin, respiratory system, central nervous system, peripheral nervous system, liver (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/For acute disulfiram overdose/; Maintain an open airway and assist ventilation if necessary. Treat coma and seizures if they occur. /For disulfiram-ethanol interaction/; maintain an open airway and assist ventilations if necessary. Treat hypotension with supine position and intravenous fluids (e.g., saline), and treat vomiting with metoclopramide. If a pressor agent is needed, a direct-acting agent such as norepinephrine is preferred over indirect-acting drugs such as dopamine. Administer benzodiazepine anxiolytics (e.g., diazepam or lorazepam) and reassurance as needed. There is no specific antidote.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Powder, water spray, foam, carbon dioxide.

5.2 Specific hazards arising from the chemical

Flash point data for this chemical are not available; however, it is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

6.3 Methods and materials for containment and cleaning up

Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.Commercially available disulfiram tablets should be protected from light and stored in tight, light-resistant containers at a temperature less than 40\u00b0C preferably between 15-30\u00b0C. Oral suspensions of disulfiram have been prepared extemporaneously from commercially available tablets of the drug. A suspension of 1% disulfiram, 1/4% methylcellulose, and 10% Tang /breakfast drink/ in distilled water has been reported to be stable for up to 6 months if refrigerated at 2-8\u00b0C and protected from light.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 2 mg/cu m. Precautions should be taken to avoid concurrent exposure to ethylene dibromide.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state yellow-white crystals or grey powder
Colour WHITE TO OFF-WHITE CRYSTALLINE POWDER
Odour Slight odor.
Melting point/ freezing point 6\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 124\u00b0C/10mmHg(lit.)
Flammability Noncombustible SolidCombustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 56\u00b0C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:0.02 g/100 mL
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 0 mm Hg at 20\u00b0C approximately
Density and/or relative density 1.27
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Combustible.Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.TETRAETHYLTHIURAM DISULFIDE is sensitive to light. This compound is incompatible with strong acids, strong oxidizers and nitrosating agents (e.g. N-Nitrosodiphenylamine). .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

The substance decomposes on burning producing toxic and corrosive fumes including nitrogen oxides, sulfur oxides. Reacts violently with strong oxidants. Attacks copper.

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 500 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Oncorhynchus mykiss (Rainbow trout, donaldson trout; early life stage (fertilized egg to fry)) 9.0 ug/L/60 days (95% confidence interval: 8.0-10.0 ug/L); renewal /formulated product
  • Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 0.12 mg/L/48 hr /Conditions of bioassay not specified in source examined
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

An estimated BCF of 280 was calculated for disulfiram(SRC), using a log Kow of 3.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

12.4 Mobility in soil

The Koc of disulfiram is estimated as 3,100(SRC), using a log Kow of 3.88(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that disulfiram is expected to have slight mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3077 IMDG: UN3077 IATA: UN3077

14.2 UN Proper Shipping Name

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

14.3 Transport hazard class(es)

ADR/RID: 9 IMDG: 9 IATA: 9

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
disulfiram disulfiram 97-77-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:296.5392 [g/mol]
Molecular Formula:C10H20N2S4
XLogP3:3.9
H-Bond Donor:0
H-Bond Acceptor:4
Rotatable Bond Count:7
Exact Mass:296.050931
MonoIsotopic Mass:296.050931
Topological Polar Surface Area:121
Heavy Atom Count:16
Formal Charge:0
Complexity:201
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Effective Rotor Count:9
Conformer Sampling RMSD:0.8
CID Conformer Count:186