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Home> Hot Product Listed L   > L-Alanine

L-Alanine

CAS No.:56-41-7
EINECS(EC#):200-273-8
Molecular Weight:89.09
Molecular Formula:C3H7NO2 (Products with the same molecular formula)
MOL File:56-41-7.mol
Names and Identifiers
Synonyms

L-Alanine AlaL-alanine-12C3 2-Aminopropanoic Acid H-Ala-OH~L-2-Aminopropionic acid 2-Amino-Propionic Acid

Inchi
InChI=1/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
Canonical Smiles
CC(C(=O)O)N
Isomers Smiles
C[C@@H](C(=O)O)N
Properties
Appearance
White crystalline powder
Density
1.161 g/cm3
Melting Point
314-316℃
Boiling Point
212.9 °C at 760 mmHg
Flash Point
82.6 °C
Alpha
14.5 o (C=10,6N HCL,DRY SUB.)
Water
166.5 g/L (25℃)
Solubilities
166.5 g/L (25 oC) in water
Color/Form
Orthorhombic crystals from water
White crystalline powder
Stability
Stable. Incompatible with strong oxidizing agents.
HS Code
29224995
Storage temp
Store at RT.
Spectral properties
Specific optical rotation= +2.42 deg for D-sodium line at 25 deg C (c = 10 in H2O); +13.7 deg for D sodium line at 25 deg C (c = 2.063 in 6N HCl)
SPECIFIC OPTICAL ROTATION: +2.8 DEG @ 25 DEG C/D (WATER, CONCN= 6%); SPECIFIC OPTICAL ROTATION: +9.55 DEG @ 25 DEG C/D (HYDROCHLORIC ACID)
MASS: 30598 (NIST/EPA/MSDC Mass Spectral Database, 1990 Version)
IR: 164 (Sadtler Research Laboratories IR grating collection)
UV: 2-10 (Phillip et al., Organic Electronic Spectral Data, John Wiley and Sons, New York)
Raman: 425 (Sadtler Research Laboratories spectral collection)
H1 NMR: 7553 (Sadtler Research Laboratories spectral collection)
C13 NMR: 36 (Johnson and Jankowski, Carbon-13 NMR Spectra, John Wiley and Sons, New York)
Safety and Handling
Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
S24/25
Safety

Hazard Codes of L-Alanine (CAS NO.56-41-7):?Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26?
S24/25:Avoid contact with skin and eyes.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: AY2990000
F: 10
HazardClass: IRRITANT
HS Code: 29224995

Formulations/Preparations
GRADES: REAGENT; TECHNICAL.
Reagent grade; USP and FCC grades
Exposure Standards and Regulations
L-Alanine is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.
Specification

? L-Alanine ,?its cas register number is 56-41-7. It also can be called? (S)-2-Aminopropanoic acid ; (S)-2-Aminopropionsaeure ; (S)-Alanine ; (S)-alpha-Aminopropionsaeure ; 2-Aminopropanoic acid, L- ; Alanina ; Alanine ;
?Alaninum?; L-(+)-Alanine ; L-2-Aminopropanoic acid ; L-2-Aminopropionic acid ; L-2-Aminopropionsaeure ; L-S-Aminopropionic acid ; L-alpha-Aminopropionic acid ; Propanoic acid, 2-amino-, (S)- ; alpha-Aminopropionic acid .

Octanol/Water Partition Coefficient
log Kow = -2.85
Report

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000_10000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Abbott Diagnostics GmbH 2016
BASF SE 2013
BTC Europe GmbH 2013
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name L-alanine

1.2 Other means of identification

Product number -
Other names H-ALA-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
L-alanine L-alanine 56-41-7 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED. SMALL FIRES: Dry chemical or CO2. LARGE FIRES: Water spray or fog. Move containers from fire area if you can do it without risk. FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from the ends of tanks. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (DOT, 1996)

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state White crystalline powder
Colour Orthorhombic crystals from water
Odour Odorless
Melting point/ freezing point 116\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 294\u00b0C(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 26\u00b0C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:166.5 g/L (25 \u00baC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1.05X10-7 mm Hg at 25\u00b0C (est)
Density and/or relative density 1.161 g/cm3
Relative vapour density 1.45-2.00
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

This compound is incompatible with the following:Strong oxidizers, chlorine dioxide (NIOSH, 1997)

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: An initial alanine concentration of 333 mg/L in an activated sludge inoculum (71.4 mL/L) was reduced by 96% after 23 days as measured by BOD(1). L-Alanine, at an initial concentration of 100 mg/L, reached 40-53% of its theoretical oxygen demand after 3.3-3.75 days in an activated sludge inoculum at 30 mg/L(2). L-Alanine, at an initial concentration of 500 mg/L, reached 96.2-96.6% of its theoretical oxygen demand after 5 days in an activated sludge inoculum at 1,296-1,316 mg/L(3). Alanine at 500 mg/L reached 40% of its theoretical oxidation after 12 hours of aeration in acclimated activated sludge(4). alpha-DL-Alanine, at an initial concentration of 500 mg/L, reached 43% of its theoretical oxygen demand after 24 hours in an activated sludge inoculum at 2,500 mg/L(5). alpha-DL-Alanine at 2-10 mg/L reached approximately 39% of its theoretical oxygen demand after 5 days in tests using a sea water dilution method and a standard dilution method(6). A proposed pathway for the metabolic degradation of alanine in activated sludge is through hydrolysis to lactic acid followed by oxidation through pyruvic acid to formic acid and acetic acid followed by complete oxidation(7).

12.3 Bioaccumulative potential

An estimated BCF of 0.004 in fish was calculated for L-alanine(SRC), using an estimated log Kow of -2.85(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Koc values of 35.7 and 31.7-65 have been measured for alanine in surface sediment(1). According to a classification scheme(2), these Koc values suggest that L-alanine is expected to have very high to high mobility in soil. Measured pKa values of 2.34 (carboxylic acid) and 9.69 (primary amine)(3), indicate that this compound will exist as a zwitterion in the environment.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
L-alanine L-alanine 56-41-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:89.09318 [g/mol]
Molecular Formula:C3H7NO2
XLogP3:-3
H-Bond Donor:2
H-Bond Acceptor:3
Rotatable Bond Count:1
Exact Mass:89.047678
MonoIsotopic Mass:89.047678
Topological Polar Surface Area:63.3
Heavy Atom Count:6
Formal Charge:0
Complexity:61.8
Isotope Atom Count:0
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:1
Feature 3D Anion Count:1
Feature 3D Cation Count:1
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:3

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