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Phosphoric acid(CAS No. 7664-38-2)

Phosphoric acid H3PO4 (cas 7664-38-2) Molecular Structure

7664-38-2 Structure

Identification and Related Records

Phosphoric acid
【CAS Registry number】
Orthophosphoric acid
【Molecular Formula】
H3PO4 (Products with the same molecular formula)
【Molecular Weight】
【Canonical SMILES】
【MOL File】

Chemical and Physical Properties

Clear liquid
1.685 g/mL at 25℃ (lit.)
【Melting Point】
【Boiling Point】
【Refractive Index】
n20/D 1.433
Stable at room temperature in closed containers under normal storage and handling conditions.
【Storage temp】
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Corrosives area. Do not store in metal containers.
【Spectral properties】
Index of refraction: 1.34203 @ 17.5 deg C/D, 10% soln; 1.35032 @ 17.5 deg C/D, 20% soln; 1.35846 @ 17.5 deg C/D, 30% soln
【Computed Properties】
Molecular Weight:97.995181 [g/mol]
Molecular Formula:H3O4P
H-Bond Donor:3
H-Bond Acceptor:4
Rotatable Bond Count:0
Exact Mass:97.976895
MonoIsotopic Mass:97.976895
Topological Polar Surface Area:77.8
Heavy Atom Count:5
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:4
Feature 3D Anion Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1

Safety and Handling

【Hazard Codes】
【Risk Statements】
【Safety Statements 】
Safety Information
Hazard Codes:CorrosiveCHarmfulXnToxicTFlammableF
Risk Statements: 34-35-22-39/23/24/25-36/38-11
R11: Highly flammable.
R22: Harmful if swallowed.
R34: Causes burns.
R35: Causes severe burns.
R36/38: Irritating to eyes and skin.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements: 7-16-26-45-36/37/39-1/2-24/25
S7: Keep container tightly closed.
S16: Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S1/2: Keep locked up and out of the reach of children.
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3453 8/PG 3
WGK Germany: 3
RTECS: TB6300000
F: 3-10
HazardClass: 8
PackingGroup: III
Human poison by ingestion. Moderately toxic by skin contact. A corrosive irritant to eyes, skin, and mucous membranes, and a systemic irritant by inhalation. A common air contaminant. A strong acid. Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas. Potentially violent reaction with sodium tetrahydroborate. Dangerous; when heated to decomposition it emits toxic fumes of POx.
【PackingGroup 】
【Skin, Eye, and Respiratory Irritations】
Causes severe eye and skin irritation.
Phosphoric acid mist is an irritant to the eyes, upper respiratory tract, and skin. The solid is especially irritating to the skin in the presence of moisture. A dilute solution buffered to pH 2.5 caused a moderate, brief stinging sensation but no injury when dropped in the human eye. A 75% solution will cause severe skin burns.
【Cleanup Methods】
1. Ventilate area of spill or leak. 2. If in the solid form, collect spilled material in the most convenient and safe manner for reclamation or for disposal in a secured sanitary landfill. 3. If in the liquid form, collect for reclamation or absorb in vermiculite, dry sand, earth, or a similar material.
Cellosized absorbent material may be used for vapor suppression and containment of spills.
Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.
Water spill: Neutralize with agricultural lime (slaked lime), crushed limestone, or sodium bicarbonate. Adjust pH to neutral (pH-7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime, crushed limestone, or sodium bicarbonate.
UN 3453 8/PG 3
【Fire Fighting Procedures】
Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.
If material /is/ on fire or involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all containers with flooding quantities of water. Apply water from as far a distance as possible.
【Fire Potential】
Not combustible.
Commercial phosphoric acid, containing 68.8% or less of phosphoric anhydride, is composed only of monomeric phosphoric acid, h3po4. Commercial compositions containing more than 68.8% phosphoric anhydride contain increasing quantities of polymers of phosphoric acid.
Pure solid phosphoric acid contains 72.44% phosphoric anhydride. Max concn of liq phosphoric acid is 88% phosphoric acid, or 63.75% phosphoric anhydride.
Polyphosphoric acid (mixture of orthophosphoric acid with pyrophosphoric, triphosphoric, and higher acids and is sold on the basis of its calculated hspo4 content, e.g.; 115% phosphoric acid. super phosphoric acid is a similar mixtur solid at 105% hspo4.
Wet-process acid, merchant grade, has min assay of 53.1%; purified wet-process acid, tech grade, has min assay of 54%; thermal acid, tech grade, has min assay of 54.32%
Wet acid (merchant grade) is 53-54% phosphoric anhydride and superacid grade is 68-70% phosphoric anhydride.
Reagent grade concentrated phosphoric acid is 85-87% (wt/wt) phosphoric acid (equivalent to about 17 m).
【DOT Emergency Guidelines】
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Evacuation: Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
【Exposure Standards and Regulations】
Phosphoric acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
【Reactivities and Incompatibilities】
Reacts with metals to liberate flammable hydrogen gas.
With sodium tetrahydroborate: Interaction of sodium and other tetrahydroborates with anhydrous acids (phosphoric acid) to generate diborane is very exothermic, and may be dangerously violent with rapid mixing.
Heat generated with: Alcohols and glycols; Aldehydes; Amides; Amines; Azo-compounds; Carbamates; Caustics; Esters; Ketones; Phenols and cresols; Organophosphates; Epoxides; Combustible materials; Explosives; Unsaturated halides; And organic peroxides.
Formation of flammable gases with: Aldehydes; Cyanides; Mercaptans; and sulfides. Formation of toxic fumes with: Cyanides; Fluorides; Halogenated organics; Sulfides; And organic peroxides.
With chlorides and stainless steel: Presence of traces of chloride ion in technical 75% phosphoric acid in a closed stainless storage tank caused corrosive liberation of hydrogen which later exploded at a sparking contact.
Hot, dilute phosphoric acid reacts with nickel carbonate to form trinickel orthophosphate.
Reacts with strong alkalies and most metals.
Strong caustics, most metals [Note: Readily reacts with metals to form flammable hydrogen gas. DO NOT MIX WITH SOLUTIONS CONTAINING BLEACH OR AMMONIA].
Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas.
【Other Preventative Measures】
Ventilation control: acid cleaning: nature & extent of ventilation control required depends on rate of acid mist escape; where exposure mild addn of inhibitor may make process or slot ventilation unnecessary. inhibitors should never be added to automatically timed conveyorized job without adjustment.
Phosphoric acid soln in water is used alone or with a mixture of alcohols and ethers, including butyl cellosolve, to remove light rust on steel. If mists, fogs, or elevated temperatures are involved, ventilation control is necessary.
In presence of impurities in metals, nascent hydrogen may be generated which could lead to formation of phosphine gas. It is necessary to avoid inhalation of vapors coming from phosphoric acid metal cleaning tanks. Slotted local exhaust ventilation @ upper edges of tanks recommended.
Clothing contaminated with phosphoric acid should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of phosphoric acid from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the phosphoric acid, the person performing the operation should be informed of phosphoric acid's hazardous properties.
Non-impervious clothing which becomes contaminated with phosphoric acid should be removed immediately and not reworn until the phosphoric acid is removed from the clothing.
Avoid breathing vapors. keep upwind. Avoid bodily contact with the material. do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
SRP: the scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. in those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
【Protective Equipment and Clothing】
Goggles or face shield
Wear rubber gloves, and overalls prepared with a total seal.
Wear special protective clothing and positive pressure self-contained breathing apparatus.
Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to liquids containing > 1.6% of contaminant; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure with liquids containing > 1.6% of contaminant. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Recommendations for respirator selection. Max concn for use: 25 mg/cu m. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection.
Recommendations for respirator selection. Max concn for use: 50 mg/cu m. Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Max concn for use: 1000 mg/cu m. Respirator Class(es): Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Substance is noncombustible.
Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
【Disposal Methods】

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Following cleanup, separate solids then precipitate with lime pH 11.0. ... An anionic polymer may be added to assist in settling of the solids. ... If necessary, the water, after treatment with lime, can pass through dual media filtration to remove the solids and then neutralize with hydrochloric acid. ... Following neutralization either at the spill site or at a waste management facility, the resultant sludge can be disposed of in a secure landfill.
Technology appropriate for incineration: Rotary kiln.
Technology appropriate for incineration: Venturi scrubber.
Neutralization & landfill: Neutralize with soda ash or soda ash-slaked lime mixture (1:1) and bury in an approved landfill.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing
two new processes for the production of phosphoric acid have been developed; The besa-2 process, developed by bohna engineering & research, san francisco, and occidental research corp's kpa process. In the besa-2 process, phosphate rock and sulfuric acid react in two steps. The first is the conventional means of producing single super-phosphate, gypsum, and monocalcium phosphate. In the second step, there is digestion of the single superphosphate in methanol with sulfuric acid. The second new method, the kpa process, reduces phosphate ore to phosphorus in a high-temperature rotary kiln. It utilizes the heats of combustion of phosphorus and carbon monoxide in the kiln to provide most of the energy required for reduction and replaces the electric power used in the furnace process with fossil fuel as the energy source.
Wet-process acid is manufactured by the digestion of phosphate rock (calcium phosphate) with sulfuric acid. Other acids such as hydrochloric acid may be used, but the sulfuric acid-based processes are by far the most prevalent. Phosphoric acid is separated from the resultant calcium sulfate slurry by filtration.
Thermal (furnace) process: White (yellow) phosphorus is burned in excess air and the resulting phosphorus pentoxide is hydrated, heats of combustion and hydration are removed, and the phosphoric acid mist collected.

U.S. Exports
(1972) 2.0X10+10 GRAMS
(1974) 8.63X10+10 GRAMS

U.S. Imports
(1972) 5.44X10+10 GRAMS
(1974) 3.63X10+10 GRAMS

U.S. Production
(1972) 5.99X10+12 GRAMS
(1975) 6.97X10+12 GRAMS
(1984) 1.03X10+13 g
Production by wet process was 10.947 tons and by the furnace process 0.611 million short tons in 1989.
(1990) 24.07 billion lb
(1991) 24.11 billion lb
(1991) 1.3058X10+7 metric tons
(1992) 25.58 billion lb
(1993) 23.04 billion lb
Annual production capacity estimate as of 4/1/97 (P2O5 content basis): 11,080 thousand metric tons.
Industrial-grade (thousands of tons/yr): 1991: 636; 1992: 555; 1993: 570.
Wet-process agricultural (thousands of tons/yr): 1991: 9,300; 1992: 10,179; 1993: 8,532.
Phosphoric acid. Demand: 1988-1989 (fertilizer year): 11.0 million tons; 1989-1990: 11.2 million tons; 1993-1994 /projected/: 12.0 million tons. (Includes exports, but not imports, which are negligible.)
Phosphoric acid. Demand: 1985: 10.1 million short tons; 1986: 9.4 million short tons; 1990 /projected/: 10.9 million short tons.

Consumption Patterns
75% in manufacture of fertilizers; 8% for manufacture of agricultural feeds; 11% for builders and water treatment (Used in detergents, pre-soaks and cleansers); 2.5% in production of foods, beverages, pet foods, and dentifrices; 1% in direct acid treatment of metal surfaces; 2.5% for manufacture of fire control agents, antifreeze, catalysts, drilling muds, and phosphors, and for refractories, textiles and other misc uses (1973)
end use pattern-derivative: fertilizers, 89%; animal feeds, 4%; detergents & water treatment, 3%; food & beverages, 2%; metal treatments, 1%; misc, 1% (1983)
Phosphoric acid. Diammonium phosphate, 20%; merchant shipments (for feed, industrial and blending applications), 10%; superphosphoric acid (SPA), 7%; monoammonium phosphate (MAP), 5.5%; triple-superphosphate (TSP), 4%; dry fertilizer exports, 41% (including 75% diammonium phosphate, 20% TSP, 5% MAP); SPA exports, 7.5%; phosphoric acid exports, 4%; miscellaneous, 1%.
Phosphoric acid. Diammonium phosphate 49%; superphosphoric acid, 15%; monoammonium phosphate, 10%; triple superphosphate, 8%; merchant shipments (including industrial and blending applications), 6%; phosphoric acid export, 5%; animal feed, 4%; miscellaneous, 3%.
Builders and water treatment, 15%; foods, 13%; metals, 17%; others, 55%. /Industrial-grade phosphoric acid/
Phosphorous acid is used for reaction with inorganic and organic products, for water treatment, industrial and agricultural uses. It is also used to bleach industrial and cleaning supplies.
【Sampling Procedures】
Determination in air: Collection on a cellulose membrane filter for colorimetric determination.
NIOSH Method 7903. Analyte: Orthophosphoric acid. Matrix: Air. Sampler: Solid sorbent tube (washed silica gel, 400 mg/200 mg with glass fiber filter plug). Flow Rate: 0.2 to 0.5 l/min: Sample Size: 50 liters. Shipment: Routine. Sample Stability: Stable.
NIOSH Method S333. Analyte: Phosphoric acid. Matrix: Air. Procedure: Filter collection, water leach, complex formation. Flow Rate: 1.5 l/min. Sample Size: 90 liters.
NIOSH Method 216. Analyte: Phosphoric acid. Matrix: Air. Procedure: Collection on a membrane filter. Flow Rate: 1.5 l/min. Sample Size: 50 liter.
NIOSH Method 7300. Analyte: Phosphorus. Matrix: Air. Sampler: Filter (0.8 um, cellulose ester membrane). Flow Rate: 1 to 4 l/min. Sample Size: 500 liters. Shipment: Routine. Sample Stability: Stable. /Phosphorus/

Biomedical Effects and Toxicity

【Pharmacological Action】
Materials used in the production of dental bases, restorations, impressions, prostheses, etc.
【Therapeutic Uses】
Diluted phosphoric acid national formulary: it has been employed in lead poisoning and in other conditions in which it is desired to administer large amt of phosphate and @ same time produce mild acidosis. It has been given in dose of 60 ml daily (5 ml/hr) under carefully controlled conditions.
Phosphoric acid is used to control the pH of the urinary tract in many animals, particularly in mink and cats, to prevent stone formation.
Pharmaceutic aid (solvent).
MEDICATION (VET): has been used to treat lead poisoning.
【Biomedical Effects and Toxicity】
The hygroscopic growth of phosphoric acid aerosol (diameter change > 0.5 micrometers) within the human tracheobronchial tree is modeled to investigate changes in deposition characteristics when compared to nonhygroscopic aerosols of identical preinspired size. Phosphoric acid particles are assumed to grow in a stepwise fashion to 99% relative humidity within conducting airways of the lung, having initially reached equilibrium at 90% relative humidity (T= 37 degrees) in the trachea. Deposition efficiencies for growth and no growth are calculated from theoretical equations for inertial impaction, sedimentation, and diffusion. The results show that neglecting the growth of an inhaled phosphoric acid aerosol may result in underestimation of the total deliverable dose by a factor of as much as 600-700%. Significant differences in regional deposition sites for hygroscopic or nonhygroscopic aerosols are predicted. Increased deposition efficiencies imply that measured physical properties (respirable fraction, aerodynamic diameter) of aerosols alone are not sufficient to assess deposition characteristics within the lung; hygroscopic growth must also be considered. [Martonen TB, Clark ML; Fundam Appl Toxicol 3 (1): 10-5 (1983)] PubMed Abstract
/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
Aquatic Fate: While acidity may be reduced readily by natural water hardness minerals, the phosphate may persist indefinitely.

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