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Home> Hot Product Listed H   > Hydroxypropyl methyl cellulose

Hydroxypropyl methyl cellulose

CAS No.:9004-65-3
Molecular Weight:318.233
Molecular Formula:C3H8O2?xCH4O?x (Products with the same molecular formula)
MOL File:9004-65-3.mol
Names and Identifiers

Hydroxymethyl propyl celluloseCellulose, 2-hydroxypropyl methyl etherHydroxypropyl methyl cellulose (HPMC)Marpolose 65MP40039363-71-8Walocel MW 60GAMethocel 240SMethocel 4FM-PRGWalocel MK 3.000PFTears NaturaleHydroxypropylmethylcellulose125053-98-762683-26-5Pharmacoat 645MetoloseHPMC 20000PVHYDROXYPROPYLMETHYL CELLULOSE(HPMC) (CH3)2CH)11106-33-5Cellulose hydroxypropyl methyl etherCellulose,ethers,2-hydroxypropyl methyl ether2-Hydroxypropyl cellulose methyl etherMethofas PMCellulose ether for PVC -HydroxypropylmethylcelluloseNoigel 0215HCulminal 20000PFRMethyl hydroxypropyl celluloseMethocel 20-333Marpolose 60MP5Cesca HPC 50Methocel 228Marpolose 90MP15000Methocel 2272-Hydroxypropyl methyl cellulose(HYDROXYPROPYL)METHYL CELLULOSEUltra TearsHipromelosa [INN-Spanish]Benecel MP 943WEM 1100 (cellulose derivative)Methocel E, F, J, KHpmcd71373-07-42-HydroxyPropylMethylEther(Cellulos)68073-10-9Methocel E,F,KMethocel 311Methyl cellulose, propylene glycol etherViscontran MHPC 50HypromelloseCarbohydrate gum8063-82-9hydroxypropyl methyl cellulose(HPMC)137397-91-2Marpolose EMP-HHydroxypropylmethylcellulosumHydroxypropyl Methyl Cellulose(HPMC or MHPC)TC 5 (cellulose derivative)MOPTsHYDROXY PROPYL METHYL CELLULOSE??? (HPMC)DP 1208DP 1209Hydroxy propyl methyl celluloseBenecel MP 363CCourlose HPMIsopto TearsHypromellosum [Latin]SynchronHipromelosa [Spanish]MC 400Isopto FrinCelacol HPM 5000Pharmacoat 603Isopto plainHydroxypropyl Methyl CelluloseCelacol HPM 15000DSPharmacoat 606Benecel MP 943Estivin IICelacol HPM 45065607-39-8Methocel KMethocel JHydroxypropyl methyl celluloseMarpolose 90MP4000137397-90-1Hypromellosum [INN-Latin]Methocel 40-202HPMC (Hydroxypropyl Methyl cellulose)Synchron-OralTC 5RMethocel MK 4HPMC-Industrial grade12673-53-9Hydroxypropyl methylcellulose171544-38-0Methocel FTC 5ETearisolHPMCMethocel EHydroxypropyl methylcellulose 182859029-31-1Marpolose MP 400037341-76-7137397-89-8Culminal MHPCMethyl Hydroxy Propyl CelluloseMarpolose 65MP4000Pharmacoat HPMC 615Methocel 856NMetolose SHMethocel HGAccel R 100HYDROXYPROPYL METHYLCELLULOSEHPM 100DSHydroxy?Propyl?Methyl?CelluloseCELLULOSE, 2-HYDROXYPROPYL METHYL ETHER (R=CH3Methocel 20-231MethylhydroxypropylcellulosumIsopto alkalineHPMC(Hydroxypropyl methyl cellulose)Goniosol

Canonical Smiles
white to off-white powder
Melting Point
Boiling Point
1101.5°C at 760 mmHg
Flash Point
Stable. Solid is combustible, incompatible with strong oxidizing agents.
Storage temp
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Safety and Handling
Safety Statements
Reach Info

Download/Modify | Technical supported by For US version, EU version (23 languages) and more, please refer to


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name Hypromellose

1.2 Other means of identification

Product number -
Other names HPMC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)


Precautionary statement(s)








2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Hypromellose Hypromellose 9004-65-3 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state no data available
Colour no data available
Odour no data available
Melting point/ freezing point no data available
Boiling point or initial boiling point and boiling range no data available
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point no data available
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility no data available
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density no data available
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Hypromellose Hypromellose 9004-65-3 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Not Listed.
EC Inventory Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 17, 2017
Revision Date Aug 17, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Computational chemical data

Molecular Weight:748.8074 [g/mol]
Molecular Formula:C32H60O19
H-Bond Donor:6
H-Bond Acceptor:19
Rotatable Bond Count:21
Exact Mass:748.37288
MonoIsotopic Mass:748.37288
Topological Polar Surface Area:241
Heavy Atom Count:51
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:18
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1

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