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Home> Hot Product Listed 1   > 1,2,3-Propanetriol

1,2,3-Propanetriol

CAS No.:56-81-5
EINECS(EC#):200-289-5
Molecular Weight:92.09
Molecular Formula:C3H5(OH)3 (Products with the same molecular formula)
MOL File:56-81-5.mol
Properties
Appearance
Clear, colorless, viscous liquid
Density
1.25
Melting Point
18℃
Boiling Point
290℃
Refractive Index
1.452-1.475
Flash Point
160℃
Water
>500 g/L (20℃)
Solubilities
Miscible
Color/Form
Syrupy, rhombic plates
Cleas, colorless syrupy liquid
Clear, colorless, syrupy liquid or solid (below 64 degrees F)[Note: The solid form melts above 64 degrees F but the liquid form freezes at a much lower temperature].
Stability
Stable. Incompatible with perchloric acid, lead oxide, acetic anhydride, nitrobenzene, chlorine, peroxides, strong acids, strong bases. Combustible.
HS Code
29054500
Storage temp
2-8°C
Spectral properties
Imdex of Refraction: 1.4730 @ 25 DEG C/D
Max Absorption(Undiluted): 270 NM (LOG E= -1.2); SADTLER REF NUMBER: 169 (IR, PRISM)
IR: 10001 (Sadtler Research Laboratories IR Grating Collection)
UV: 3-12 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
NMR: 4979 (Sadtler Research Laboratories Spectral Collection)
MASS: 188 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Safety and Handling
Hazard Codes
F
Risk Statements
R36;R20/21/22;R11
Safety Statements
S24/25;S39;S26
Safety

Hazard Codes: FlammableF,HarmfulXn
Risk Statements: 36-20/21/22-11
36:Irritating to the eyes
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
11: Highly Flammable
Safety Statements: 24/25-39-26
24/25:Avoid contact with skin and eyes
39: Wear eye/face protection
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: UN 1282 3/PG 2
WGK Germany: 1
F: 3: Hygroscopic.
HS Code: 29054500

PackingGroup
Z01
Sensitive
Hygroscopic
Skin, Eye, and Respiratory Irritations
Glycerin dropped on the human eye causes a strong stinging and burning sensation, with tearing and dilation of the conjunctival vessels, but no obvious injury.
Cleanup Methods
Absorb with paper. Evaporate completely all spilt surface. Dispose by burning the paper after complete ventilation of vapor.
Transport
250kgs in
Fire Fighting Procedures
Alcohol foam, carbon dioxide, dry chemical.
Water fog. Water or foam may cause frothing.
Fire Potential
Fire Hazard: Low, when exposed to heat, flame, or powerful oxidizers.
Formulations/Preparations
Glycerin, oral soln, 50% VOL/VOL (0.628 G/ML) osmoglyn (with potassium sorbate; in lime-flavored, alcon.
Glycerin (anhydrous), ophthalmic soln, ophthalgan (with chlorobutanol) wyeth-ayerst.
USP, CP (pharmaceutical & commercial, where highest grade is required); Saponification, soap lye, crude yellow distilled high gravity or dynamite(dehydrated to 99.8-99.9% purity); Natural; synthetic; "Food Chemical Codex".
Several grades of glycerin are available commercially. They differ somewhat in their glycerol content and in other characteristics such as color, odor, and trace impurities.
50% (v/v) (equivalent to 3.1 g/5 ml) (Rx) (Osmoglyn); 75% (v/v) (equivalent to 4.7 g/5 ml) (Rx) (Glyrol).
Grades of Purity: CP: 99.5%; USP: 96%
Exposure Standards and Regulations
Glycerin used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.
Glycerin used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Reactivities and Incompatibilities
Exothermic interaction of granular /sodium/ hydride with undiluted (viscous) glycerol with inadequate stirring caused charring to occur.
Incompatibilities: Strong oxidizers
Can react violently with acetic anhydride, (aniline + nitrobenzene), Ca(OCl)2, chromium trioxide, chromic oxide, (fluoride + lead monoxide), (HClO4 + lead monoxide), potassium permanganate, K2O2, silver perchlorate, sodium peroxide, NaH.
Strong oxidizers (e.g., chromium trioxide, potassium chlorate, potassium permanganate) [Note: Hygroscopic (i.e., absorbs moisture from the air)].
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective Equipment and Clothing
Persons engaged in synth processes should wear suitable personal protective equipment & eye protective equipment. As with plant used for saponification & hydrolysis high standard of maintenance should be observed.
Rubber gloves, goggles.
Specification

Glycerol , its cas register number is 56-81-5. It also can be called Glycerine ; 1,2,3-Propanetriol ; Clyzerin, wasserfrei ; and 1,2,3-Trihydroxypropane ;Glycerin .

Octanol/Water Partition Coefficient
log Kow = -1.76
Disposal Methods

Mixture with a more flammable solvent followed by incineration.

Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000_10000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Blue Cube Germany Assets GmbH & Co. KG 2013
Estee Lauder N.V. 2013
Huntsman Textile Effects (Germany) GmbH 2012
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name glycerol

1.2 Other means of identification

Product number -
Other names Glycerin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Solvents
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
glycerol glycerol 56-81-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Rinse skin with plenty of water or shower. Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Rinse mouth.

4.2 Most important symptoms/effects, acute and delayed

No hazard (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

The clinician should attend to the management of dehydration, electrolyte imbalance (hypokalemia and hyponatremia), hyperglycemia, and acidosis or alkalosis. ... /Osmotic diuretics/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water or foam may cause frothing.

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing vapor. Place spillage in appropriately labelled container for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.Glycerol should preferably be stored at 40 - 60\u00b0C under nitrogen blanketing. It is not corrosive and presents little risk of ignition because of its high flash point. Highly concentrated glycerol does not corrode steel, but storage tanks of carbon steel must be protected by surface coating to prevent rusting by residual moisture. Glycerol is therefore usually stored in tanks of stainless steel or aluminum.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH concluded that the documentation cited by OSHA was inadequate to support the proposed PEL (as an 8 hour TWA) of 10 mg/cu m for glycerine (mist).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear, colorless, viscous liquid
Colour Syrupy, rhombic plates
Odour MILD ODOR
Melting point/ freezing point -55\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 182\u00b0C/20mmHg(lit.)
Flammability Class IIIB Combustible Liquid: Fl.P. at or above 93.33\u00b0C.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 160\u00b0C
Auto-ignition temperature 370\u00b0C
Decomposition temperature no data available
pH Neutral to litmus
Kinematic viscosity 954 CENTIPOISES AT 25 DEG C; 17 CENTIPOISES AT 25 DEG C (70% SOLN)
Solubility In water:>500 g/L (20 \u00baC)
Partition coefficient n-octanol/water (log value) log Kow = -1.76
Vapour pressure <1 mm Hg ( 20 \u00b0C)
Density and/or relative density 1.25g/mL(lit.)
Relative vapour density 3.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Mixtures of glycerin with water, ethanol (95%), and propylene glycol are chemically stable. Glycerin may crystallize if stored at low temperatures; the crystals do not melt until warmed to 20\u00b0C.

10.3 Possibility of hazardous reactions

GLYCERINE is incompatible with strong oxidizers. It is also incompatible with hydrogen peroxide, potassium permanganate, nitric acid + sulfuric acid, perchloric acid + lead oxide, acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, F2 + PbO, KMnO4, K2O2, AgClO4 and NaH. A mixture with chlorine explodes if heated to 158-80\u00b0C. It reacts with acetic acid, potassium peroxide, sodium peroxide, hydrochloric acid, (HClO4 + PbO) and Na2O2. Contact with potassium chlorate may be explosive. It also reacts with ethylene oxide, perchloric acid, nitric acid + hydrofluoric acid and phosphorus triiodide.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Exothermic interaction of granular /sodium/ hydride with undiluted (viscous) glycerol with inadequate stirring caused charring to occur.

10.6 Hazardous decomposition products

Pure gycerin is not prone to oxidation by the atmosphere under ordinary conditions, but is decomposes on heating with the evolution of toxic acrolein.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 12.6 g/kg
  • Inhalation: LC50 Rat inhalation > 570 mg/cu m/1 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, age < or = 24 hr); Conditions: freshwater, static, 20-22\u00b0C; Concentration: >10000 mg/L for 24 hr /formulated product
  • Toxicity to algae: Toxicity threshold (cell multiplication inhibition test) Algae (Microcystis aeruginosa) 2900 mg/l
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Glycerin, present at 100 mg/L, reached 63% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Biodegradation rate constants of 0.258/day and 0.200/day in respirometric test systems employing activated sludge have also been reported, corresponding to 68% and 78% degradation, respectively(2).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for glycerin(SRC), using a log Kow of -1.76(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of glycerin can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that glycerin is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
glycerol glycerol 56-81-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:92.09382 [g/mol]
Molecular Formula:C3H8O3
XLogP3:-1.8
H-Bond Donor:3
H-Bond Acceptor:3
Rotatable Bond Count:2
Exact Mass:92.047344
MonoIsotopic Mass:92.047344
Topological Polar Surface Area:60.7
Heavy Atom Count:6
Formal Charge:0
Complexity:25.2
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:3
Feature 3D Donor Count:3
Effective Rotor Count:2
Conformer Sampling RMSD:0.4
CID Conformer Count:9

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