Related Searches: Benzyl Chloride, benzyl ammonium chloride, dimethyl benzyl ammonium chloride, Benzyl Triethyl Ammonium Chloride, triethyl benzyl ammonium chloride, View all

Benzyl Chloride(CAS No. 100-44-7)

Benzyl Chloride C7H7Cl (cas 100-44-7) Molecular Structure

100-44-7 Structure

Identification and Related Records

Benzyl Chloride
【CAS Registry number】
Tolyl chloride
DBU/benzyl chloride
AKOS BBS-00003953
【Molecular Formula】
C7H7Cl (Products with the same molecular formula)
【Molecular Weight】
【Canonical SMILES】
【MOL File】

Chemical and Physical Properties

colorless liquid
【Melting Point】
【Boiling Point】
1.28mmHg at 25°C
【Refractive Index】
【Flash Point】
0.3 g/L (20℃)
0.3 g/L (20 oC)
Colorless to slightly yellow liquid.
Unstable - inhibitors such as propylene oxide or trimethylamine are usually added to prevent polymerization. Combustible. Incompatible with strong oxidizing agents, water, acids, most common metals, dimethyl sulfoxide. Above flash point vapour-air mixtures are explosive within the limits noted above. Contact with water produces toxic fumes.
【Storage temp】
【Spectral properties】
Index of refraction: 1.5415 @ 15 deg C/D; very refractive
IR: 6 (Sadtler Research Laboratories IR Grating Collection)
UV: 5 (Sadtler Research Laboratories Spectral Collection)
1H-NMR: 3 (Sadtler Research Laboratories Spectral Collection)
MASS: 62385 (NIST/EPA/MSDC Mass Spectral Database, 1990 version); 530 (Atlas of Mass Spectral Data, John Wiley & Sons, NY)
RAMAN: 769 (Sadtler Research Laboratories Spectral Collection)
【Computed Properties】
Molecular Weight:126.58348 [g/mol]
Molecular Formula:C7H7Cl
H-Bond Donor:0
H-Bond Acceptor:0
Rotatable Bond Count:1
Exact Mass:126.023628
MonoIsotopic Mass:126.023628
Topological Polar Surface Area:0
Heavy Atom Count:8
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Ring Count:1
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:2

Safety and Handling

【Hazard Codes】
【Risk Statements】
【Safety Statements 】
Hazard Codes:T
Risk Statements:45-22-23-37/38-41-48/22
45:May cause cancer
22:Harmful if swallowed
23:Toxic by inhalation
37/38:Irritating to eyes, respiratory system and skin
41:Risk of serious damage to eyes
48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed
Safety Statements:53-45
53:Avoid exposure - obtain special instruction before use
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR:UN 1738 6.1/PG 2
WGK Germany:3
Hazardous Substances Data:100-44-7(Hazardous Substances Data)
【PackingGroup 】
【Skin, Eye, and Respiratory Irritations】
Vapors are intensely irritating to all mucous membranes, particularly to the eye. Unbearable eye irritation ... is produced by 31 ppm in air. ...
Irritant to eyes and respiratory tract in concentrations above the threshold limit. ...
Vapors irritate skin ... .
【Cleanup Methods】
Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.
Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Apply "universal" gelling agent to immobilize spill.
Environmental considerations: Water spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at botttom. Remove trapped material with suction hoses. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spill amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
Stop or control leak, if this can be done without undue risk. Use water spray to cool and protect personnel. Approach release from upwind. Absorb in noncombustible material for proper disposal.
UN 1738
【Fire Fighting Procedures】
Use water spray, dry chemical, foam, or carbon dioxide. Use water to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
If material on fire or involved in fire: Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use "alcohol" foam, dry chemical or carbon dioxide.
【Fire Potential】
Moderate, when exposed to heat or flame.
Grades: Technical: CP; 95%; redistilled. Forms: anhydrous stabilized (with aqueous sodium carbonate solution).
Benzyl chloride is available in USA as technical and refined grades. Small amount of sodium bicarbonate or lime are generally added as a stabilizer when it is shipped in steel drums. Other stabilizers ... Include amines such as triethylamine or dioctylamine, alcohols such as hexyl alcohol and dialkylthioureas.
Benzyl chloride available in the USA has ... a minimum of 98.5% active ingredient. ...
/Available as/ uninhibited & inhibited grades.
May be stabilized with 0.25% propylene oxide.
【DOT Emergency Guidelines】
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Fire: Note: Most foams will react with the material and release corrosive/toxic gases. Small fires: CO2, dry chemical, dry sand, alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. ... Move containers from fire area if you can do it without risk. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. ... DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. Small spills: Cover with DRY earth, DRY sand, or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.
/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
【Reactivities and Incompatibilities】
Will react with water or steam to produce toxic and corrosive fumes /HCl and chlorine gas/; can react vigorously with oxidizing materials.
Unstabilized benzyl chloride readily undergoes a self-condensation reaction in the presence of all common metals (except nickel and lead) with the liberation of heat and hydrogen chloride.
The decomposition can reach explosive violence in presence of metals such as iron.
Oxidizers, acids, copper, aluminum, magnesium, iron, zinc, tin [Note: Can polymerize when in contact with all common metals except nickel and lead. Hydrolyzes in H2O to benzyl alcohol].
Incompatible with dimethyl sulfoxide
The chloride is usually (but not always) stabilised in storage by addition of aqueous alkali or anhydrous amines as acid acceptors. A 270 kg batch which was not stabilized polymerised violently when charged into a reactor. Contact of the chloride (slightly hydrolysed and acidic) with rust led to formation of ferric chloride which catalysed an intermolecular Friedel-Craft reaction to form polybenzyls with evolution of further hydrogen chloride. Contact of unstabilised benzyl chloride with aluminum, iron or rust should be avoided to obviate the risk of polycondensation.
Benzyl acetate was prepared by addition of benzyl chloride (containing 0.6% pyridine as stabiliser) to preformed sodium acetate at 70 deg C, followed by heating at 115 deg C, then finally up to 135 deg C to complete the reaction. On one occasion, gas began to be evolved at the end of the dehydration phase, and the reaction accelerated to a violent explosion, rupturing the 25 mm thick cast iron vessel. This was attributed to presence of insufficient pyridine to maintain basicity, dissolution of iron by the acidic mixture, and catalysis by ferric chloride of a Freidel-Craft type polycondensation reaction to polybenzyls, with evolution of hydrogen chloride, which at 130 deg C would produce an overpressure approaching 100 bar. Previously the chloride had been supplied in steel drums containing 10% sodium carbonate or 3% sodium hydroxzide solutions as stabilisers, but the packing was changed to polythene-lined kegs and the stabiliser omitted. However, higher pyridine concentrations effectively stabilise the chloride in steel drums.
Benzyl cyanide was prepared from the chloride and sodium cyanide in aqueous methanol. Inadequate cooling of the reactor led to a fire.
【Other Preventative Measures】
Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Local exhaust ventilation should be applied wherever there is an incidence of point source emmissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
The manufacturing process should be enclosed as completely as possible. Effective ventilation should be provided together with local exhaust equipment at the main sources of benzyl chloride.
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.
Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed or replaced.
【Protective Equipment and Clothing】
Chemical safety goggles or face shield; self-contained breathing apparatus, positive-pressure hose mask, airline mask, industrial canister-type gas mask, or chemical cartridge respirator; rubber gloves; protective clothing.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Respirator Recommendations: Up to 10 ppm: (Assigned protection factor = 10) Any chemical cartridge respirator with organic vapor and acid gas cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection./(Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor and acid gas canister/(Assigned protection factor = 25) Any powered, air-purifying respirator with organic vapor and acid gas cartridge(s). Substance reported to cause eye irritation or damage; may require eye protection./(Assigned protection factor = 10) Any supplied-air respirator. Substance reported to cause eye irritation or damage; may require eye protection./(Assigned protection factor = 50) Any self-contained breathing apparatus with a full facepiece.
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned protection factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(Assigned protection factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape: (Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor and acid gas canister/Any appropriate escape-type, self-contained breathing apparatus.

The Benzyl chloride, with the cas register number 100-44-7, has other names as benzyl chloride; a-chlorotoluene; alpha-chlorotoluene; akos bbs-00003953; (chloromethyl)-benzen; (chloromethyl)benzene; (chloromethyl)-benzene; 1-chloromethylbenzene.

The characteristics of this chemical could be summarized as: (1)ACD/LogP: 2.49; (2)ACD/LogD (pH 5.5): 2.49; (3)ACD/LogD (pH 7.4): 2.49; (4)ACD/BCF (pH 5.5): 45.71; (5)ACD/BCF (pH 7.4): 45.71; (6)ACD/KOC (pH 5.5): 536.87; (7)ACD/KOC (pH 7.4): 536.87; (8)#Freely Rotating Bonds: 1; (9)Index of Refraction: 1.527; (10)Molar Refractivity: 36.01 cm3; (11)Molar Volume: 117.1 cm3; (12)Polarizability: 14.27 ×10-24 cm3; (13)Surface Tension: 33.8 dyne/cm; (14)Density: 1.08 g/cm3; (15)Flash Point: 73.9 °C; (16)Enthalpy of Vaporization: 39.86 kJ/mol; (17)Boiling Point: 179.4 °C at 760 mmHg; (18)Vapour Pressure: 1.28 mmHg at 25°C.

This is a kind of Colorless to yellow liquid with very strong pungent odour and it has tearing property. Besides, it is soluble in diethyl [ethyl] ether, alcohol, chloroform and other organic solvent but insoluble in water. It is unstable and combustible, so inhibitors such as propylene oxide or trimethylamine are usually added to prevent polymerization. Above flash point vapour-air mixtures are explosive within the limits noted above. Contact with water produces toxic fumes. What's more, it is incompatible with strong oxidizing agents, water, acids, most common metals, dimethyl sulfoxide. So while storing it, it should be kept with the storage temp. of 0-6°C, and in a dry, cool, and well-ventilated storeroom, away from other oxygenant and food additives.

Being among the toxic chemicals, it at low levels cause damage to health and it is toxic if by inhalation and in contact with skinmay, then it could even cause cancer. Besides, it is irritating to respiratory system and skin and it has risk of serious damage to eyes. What's more, it has the danger of serious damage to health by prolonged exposure if swallowed. So while dealing with this chemical, we should take the following instructions. Avoid exposure - obtain special instructions before use, and if in case of accident or if you feel unwell seek medical advice immediately (show the label where possible). You could also refer to WGK Germany? 3 to obtain more safety information.

When it comes to its usage, it is usually being the material of making the dye, spice, medicine, synthetic tannin and synthetic resin. Besides, it could also used as an very important organic synthesis intermediate. When in pesticide, it could directly synthesis the organophosphorus fungicide and could be used as the vital material in many other intermediates, such as in synthesis of benzyl cyanide, benzoyl chloride and MPA. As for its product categories, they are various, including pharmaceutical intermediates; organics; biochemistry; reagents for oligosaccharide synthesis.

The Benzyl chloride could be produced with great amount with the following chemical reaction: C6H5CH3 + Cl2 →C6H5CH2Cl + HCl. Additionally, you could convert the following data information into the molecular structure:

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source


National Technical Information Service. Vol. OTS0572390,
guinea pig LDLo skin 10mL/kg (10mL/kg) ? National Technical Information Service. Vol. OTS0572390,
mammal (species unspecified) LC50 inhalation 390mg/m3 (390mg/m3) ? Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 6, 1986.
mammal (species unspecified) LD50 oral 1500mg/kg (1500mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(1), Pg. 92, 1975.
mouse LC50 inhalation 80ppm/2H (80ppm) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 11, Pg. 217, 1976.
mouse LD50 oral 1500mg/kg (1500mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 25, 1982.
mouse LD50 unreported 780mg/kg (780mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(3), Pg. 11, 1979.
rat LC50 inhalation 150ppm/2H (150ppm) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 11, Pg. 217, 1976.
rat LD50 oral 1231mg/kg (1231mg/kg) ? National Technical Information Service. Vol. PB214-270,
rat LD50 subcutaneous 1gm/kg (1000mg/kg) ? Zeitschrift fuer Krebsforschung. Vol. 74, Pg. 241, 1970.
rat LD50 unreported 625mg/kg (625mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(3), Pg. 11, 1979.

【Octanol/Water Partition Coefficient】
log Kow = 2.30
【Disposal Methods】
[40 CFR 240-280, 300-306, 702-799 (7/1/2002)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P028, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Incineration at 1500 deg F for 0.5 sec minimum for primary combustion and 2200 deg F for 1.0 sec for secondary combustion. Elemental chlorine formation may be alleviated by injection of steam or methane into the combustion process.
A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence time of 0.1 to 2 seconds. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

... Chlorination of toluene
By passing chlorine over boiling toluene until it has increased 38% in wt. Product is washed with water and separated by fractional distillation.
Benzyl chloride is manufactured by the thermal or photochemical chlorination of toluene at 65-100 deg C.
U.S. Imports

(1978) 1.09X10+7 G (PRINCPL CUSTMS DISTS)
(1982) 4.64X10+8 G (PRINCPL CUSTMS DISTS)
(1985) 7.69X10+8 g
(1986) 1306664 lb
U.S. Production

(1977) 4.30X10+10 G (EST)
(1982) 3.30X10+10 G (EST)
4.99X10+10 g (estimate)
(1989) Plant capacities for production of benzyl chloride in the western world totaled 144,200 metric ton/year
Consumption Patterns

Butyl benzyl phthalate, 60%; benzyl alcohol, 12.5%; quaternary ammonium compounds, 11%; benzyl cyanide, 3%; other, including benzyl acetate, benzyl salicylate and benzyl cinnamate, 13.5% (1985)
CHEMICAL PROFILE: Benzyl Chloride. Butyl benzyl phthalate, 65%; benzyl quaternary ammonium compounds, 15%; benzyl alcohol, 10%; miscellaneous, including benzyl acetate, salicylate, propionate and cinnamante, 10%.
CHEMICAL PROFILE: Benzyl chloride. Demand: 1986: 65 million lb; 1987: 67 million lb; 1991 /projected/: 72 million lb (In addition, 1.3 million lb were imported in 1986; exports are minimal).

Biomedical Effects and Toxicity

【Pharmacological Action】
Intensely irritating to skin, eyes, and mucous membranes. Highly toxic; may cause death or permanent injury after very short exposure to small quantities. Has been listed as a direct-acting or primary carcinogen. Large doses cause central nervous system depression.
【Biomedical Effects and Toxicity】
In rats receiving (14)Cbenzyl chloride in corn oil by gavage, the peak plasma level was reached after 30 min. The distribution half-life was 1.3 hr, while the elimination half-life was 58.5 hr. After 48 hr, the higher concentrations were found in the stomach, gastric contents, ileum and duodenum, followed by liver, adrenal, bone marrow and blood. After 72 hr, approximately 76% was excreted in urine and, in expired air, 7% as (14)CO2 and less than 1.3% as benzyl chloride or its metabolites.
Benzyl chloride is absorbed through lung and gastrointestinal tract.
The tissue distribution and excretion of (14)C-labeled benzyl chloride was investigated in adult male and female rats after admin of a single oral dose at 25 mg/kg. Radioactivity was detected in all tissues selected for exam. Elimination of the isotope occurred predominantly in the urine. Female rats excreted the isotope at a faster rate than the males and also maintained slightly lower tissue concentration (with the exception of blood and kidneys). Isotope recovery was achieved at 90% in the urine and feces of female rats at 24 hr, compared with an 80% recovery in the males. [Bunner BL, Creasia DA; J Toxicol Environ Health 10 (4-5): 837-46 (1982)] PubMed Abstract

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 420(SRC), determined from a log Kow of 2.30(2) and a regression-derived equation(3), indicates that benzyl chloride is expected to have moderate mobility in soil(SRC). However, mobility in soil will be mitigated by hydrolysis (SRC). Volatilization of benzyl chloride from moist soil surfaces is not expected to be important based on a hydrolysis half-life of 14 hrs at 25 deg C(4-6). Benzyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.23 mm Hg(7).
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 420(SRC), determined from a log Kow of 2.30(2) and a regression-derived equation(3), indicates that benzyl chloride is expected to adsorb slightly to suspended solids and sediment(SRC). However, adsorption to suspended solids and sediment will be mitigated by hydrolysis (SRC). Benzyl chloride is expected to undergo chemical hydrolysis with a half-life of 14 hrs at 25 deg C(4-6). Due to the reactivity of benzyl chloride in water, volatilization from water surfaces, bioaccumulation in aquatic organisms, and adsorption to suspended solids and sediments in water are not expected to be important fate processes(SRC).
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyl chloride, which has a vapor pressure of 1.23 mm Hg at 25 deg C(2) is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase benzyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.5 days (SRC), calculated from its rate constant of 2.9X10-12 cu cm/molecule-sec at 25 deg C(3).

Supplier Location

Top Suppliers

Diamond member Wuhan Fortuna Chemical Co., Ltd.
Business Type:Manufacturer
Diamond member shijiazhuang guizheng trade co.,ltd
Business Type:Trading Company
Diamond member AOPHARM
Business Type:Manufacturer
Finetech Industry limited.
Business Type:Manufacturer
Shenzhen Simeiquan Biotechnology Co.Ltd
Business Type:Manufacturer
Business Type:Manufacturer
Wuhan Welink Imp. & Exp. Co.
Business Type:Manufacturer
Wuhan Dachu Hexing Technology Co., Ltd.
Business Type:Trading Company
Zhejiang Kaili Industrial Co., Ltd.
Business Type:Manufacturer
Zouping Mingxing Chemical Co.,Ltd.
Business Type:Manufacturer

Quick Search

Cas    Name

Related products

Benzyl Triethyl Ammonium Chloride

TEBA; TEBAC; Benzyl triethylammonium chloride; Triethyl benzyl ammonium chloride; BENZYLTRIETYLAMMONIUM CHLORIDE; BENZYL TRIMETHYL AMMONIUM CHLORIDE (...

4-Methyl benzyl chloride

p-Xylyl chloride; alpha-Chloro-p-xylene; Benzene, 1-(chloromethyl)-4-methyl-; 4-Methylbenzyl Chloride; p-chloromethyltoluene

2-Methyl benzyl chloride

1-(Chloromethyl)-2-methylbenzene; o-Xylyl chloride; alpha-Chloro-o-xylene; 2-Methylbenzyl Chloride; o-methylbenzyl chloride

4-(Phenylthio)benzyl chloride

Sulfide, a-chloro-p-tolyl phenyl (7CI,8CI);1-(Chloromethyl)-4-(phenylthio)benzene;NSC 43056;Benzene,1-(chloromethyl)-4-(phenylthio)-;

Benzyl Tripropyl Ammonium Chloride


t-Butyl-benzyl-phosphinyl chloride

t-Butyl-benzyl-phosphinyl chloride

4-(methoxymethyl)benzyl chloride

4-(methoxymethyl)benzyl chloride


Pyrimido[1,2-.alpha.]azepinium,2,3,4,6,7,8,9,10-octahydro-1-(phenylmethyl)-,chloride;1-BENZYL-1,8-DIAZA-BICYCLO[5.4.0]UNDEC-7-ENIUM CHLORIDE;BENZYL-DB...

Benzyl-d7 chloride

Benzene-d5,(chloromethyl-d2)- (9CI);Benzyl chloride-d7;Perdeuteriobenzyl chloride;

2-(Benzyloxy)benzyl chloride

1-Chloromethyl-2-benzyloxybenzene;2-(Benzyloxy)benzyl chloride;Benzyl(α-chloro-o-tolyl) ether


ALPHA-CHLOROTOLUENE-ALPHA-13C;BENZYL-ALPHA-13C CHLORIDE;BENZYL-ALPHA-13C CHLORIDE, 99 ATOM % 13C;benzyl chloride-α-13c;α-chlorotoluene-α-13c;Chloro...


BENZYL-2,3,4,5,6-D5 CHLORIDE;BENZYL-2,3,4,5,6-D5 CHLORIDE, 98 ATOM % D;Benzene-d5, (chloromethyl)-;α-chlorotoluene-2,3,4,5,6-d5