Xipamide(CAS No. 14293-44-8)

Xipamide C15H15ClN2O4S (cas 14293-44-8) Molecular Structure

14293-44-8 Structure

Identification and Related Records

【Name】
Xipamide
【CAS Registry number】
14293-44-8
【Synonyms】
2',6'-Salicyloxylidide,4-chloro-5-sulfamoyl- (8CI)
Aquaphor
Aquaphor (diuretic)
BE 1293
BEI 1293
Chronexan
Diurex (Lacer)
Diurexan
Lumitens
MJF 10938
【EINECS(EC#)】
238-216-4
【Molecular Formula】
C15H15ClN2O4S (Products with the same molecular formula)
【Molecular Weight】
354.81
【Inchi】
InChI=1/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)
【Canonical SMILES】
CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
【MOL File】
14293-44-8.mol

Chemical and Physical Properties

【Density】
1.477 g/cm3
【Melting Point】
255-256℃
【Refractive Index】
1.652
【Computed Properties】
Molecular Weight:354.8086 [g/mol]
Molecular Formula:C15H15ClN2O4S
XLogP3-AA:2.9
H-Bond Donor:3
H-Bond Acceptor:5
Rotatable Bond Count:3
Tautomer Count:7
Exact Mass:354.044105
MonoIsotopic Mass:354.044105
Topological Polar Surface Area:118
Heavy Atom Count:23
Formal Charge:0
Complexity:526
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:3
Feature 3D Donor Count:3
Feature 3D Ring Count:2
Effective Rotor Count:4
Conformer Sampling RMSD:0.6
CID Conformer Count:12

Safety and Handling

【Safety】

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Cl, SOx, and NOx.

【Specification】

  Xipamide , its CAS NO. is 14293-44-8, the synonyms are 4-Chloro-2',6'-dimethyl-5-sulfamoylsalicylanilide ; 4-Chloro-5-sulfamylsalicyloyl-2',6'-dimethylanilide ; 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide ; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide ; Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy- ; 2',6'-Salicyloxylidide, 4-chloro-5-sulfamoyl-  .

Biomedical Effects and Toxicity

【Pharmacological Action】
- Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
- Agents that promote the excretion of urine through their effects on kidney function.

Supplier Location

Top Suppliers

Diamond member Hubei XinRunde Chemical Co., Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-188-74586545
Diamond member Hangzhou Dayangchem Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-88938639
Jinan Haohua Industry Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:0086-531-58773055
Creative Peptides
Country:United StatesUnited States
Business Type:Manufacturer
Telephone:1-631-6197922
HangZhou Peak Chemical Co.,Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:+86-571-88233073
Dishman China
Country:ChinaChina
Business Type:Buying Office
Telephone:86-510-66896010
Dishman Pharmaceuticals & Chemicals Co., Ltd.
Country:ChinaChina
Telephone:+86-510-85840486 13771085865
Lianyungang Zhongyi Fine Chemical Industry Co., Ltd.
Country:
Business Type:Manufacturer
Telephone:86-518-85838167 85838259 85838257 13901906227
Sheetal International
Country:IndiaIndia
Telephone:+91-(2717)-235717
Suzhou Xiangcheng Qingtai Fine Chemicals Co., Ltd.
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