Products
  • Products
  • Buy offers
  • Encyclopedia
  • Msds lib
  • Synthesis
  • Reach Info
  • Suppliers
Home> Encyclopedia > Hot Product Listed 7   > 7-Ethyl-10-hydroxycamptothecin
86639-52-3 structure

7-Ethyl-10-hydroxycamptothecin

Iupac Name:(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
CAS No.:86639-52-3
Molecular Weight:392.411
Molecular Formula:C22H20N2O5 (isomer)
Names and Identifiers
Synonyms

(+)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0,.0(1),(2)]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione (19s)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione (19s)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione (19s)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)dione, aldrichcpr (S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (s)-4,11-diethyl-4,9-di-oh-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 0H43101T0J 10-hydroxy-7-ethyl camptothecin 10-Hydroxy-7-ethylcamptothecin 10-hydroxy-7-ethyl-camptothecin 110714-48-2 113015-38-6 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,7-diethyl-4,10-dihydroxy- 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,7-diethyl-4,10-dihydroxy- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione,4,11-diethyl-4,9- dihydroxy-,(4S)- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,7-diethyl-4,10-dihydroxy-, (S)- (9CI) 1h-pyrano[3',7]indolizino[1,2-b]quinoline- 3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)- 1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4,10-dihydroxy- 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 439E812 7-Ehthy-10-Hydroxycamptothecin 7-Ethyl-10- Hydroxycamptothecin 7-ethyl-10-hydroxy campthotecin 7-Ethyl-10-Hydroxy Camptothecin 7-Ethyl-10-Hydroxy Camptothecine 7-Ethyl-10-Hydroxy CPT 7-ethyl-10-hydroxy-20(s)-campthothecin 7-Ethyl-10-hydroxy-20(S)-camptothecin 7-Ethyl-10-hydroxy-20-(S)-camptothecine 7-Ethyl-10-hydroxy-20(S)-CPT 7-Ethyl-10-hydroxy-camptothecin 7-ethyl-10-hydroxycamptothecin ((s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione) 7-Ethyl-10-hydroxycamptothecin (SN38) 7-Ethyl-10-Hydroxycamptothecin (SN-38) 7-Ethyl-10-hydroxycamptothecin (TECANS) 7-Ethyl-10-hydroxycamptothecin, >=98% (HPLC), powder 7-Ethyl-10-hydroxycamptothecin, 98% 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% 7-Ethyl-10-hydroxycamptothecine 7-Ethyl-10-hydroxy-camptothecine 7-ethyl-Camptothecin 7-ethyl-Hydroxycamptothecin 7-etyl-10-hydroxycamptothecin 86639-52-3 A12011 AB0013784 AC-1357 AC1L2XLK AJ-48031 AK-36613 AKOS015920433 AMBAP119577-28-5 AN-5834 AOB33769 AS-13533 avachem1025 BC206169 BCP01386 BCP9000200 BDBM50418088 BR-36613 C11173 c22h20n2o5 CAMPTOTHECIN, 10-HYDROXY- CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA Captothecin, 7-ethyl-10-hydroxy- CE-042 CHEBI:8988 CS-1579 D0B6YB D0L5LG DB05482 diethyl(dihydroxy)[?]dione DTXSID4040399 E0748 EHC EX-A989 FJHBVJOVLFPMQE-QFIPXVFZSA-N FT-0630943 FT-0697001 GTPL6925 HCPT HMS3652P12 HMS3677B12 h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (s)- HY-13704 HYDROXYCAMPTOTHECIN HYDROXYCAMPTOTHECIN, 10- I605 irinotecan related compound b, united states pharmacopeia (usp) reference standard J90015 KB-46357 KS-00000NHR LE-SN38 LS00055 LS-127394 MCULE-4181372030 mfcd00871873 N2133 NCGC00167831-01 NCGC00167831-05 NCI60_026056 NK 012 NK012 nk-012 nsc673596 nsc-673596 OZESIOWEPLUEAF-QFIPXVFZSA-N PUBCHEM11040 Q-100871 RL05364 s4908 S-5119 SC-15667 SCHEMBL34018 sn 38 sn 38 lactone sn38 sn-38 SN-38(NK-012) ST2412554 SW219948-1 TL8005626 UNII-0H43101T0J ZINC26891987 ZINC4099013

Inchi
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChkey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
Canonical Smiles
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
Isomers Smiles
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)O
Properties
Density
1.51
Melting Point
217 °C
Boiling Point
810.3 °C at 760 mmHg
Refractive Index
21.5 ° (C=0.2, THF)
Flash Point
443.8 °C
HS Code
2942000000
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:392.411g/mol
  • Molecular Formula:C22H20N2O5
  • Compound Is Canonicalized:True
  • Exact Mass:392.137
  • Monoisotopic Mass:392.137
  • Complexity:820
  • Rotatable Bond Count:2
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:6
  • Topological Polar Surface Area:100A^2
  • Heavy Atom Count:29
  • Defined Atom Stereocenter Count:1
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADceB7OAAAAAAAAAAAAAAAAAAAAWAAAAA8QIEAAAAAAFix8AAAHgAACAAADEzhngYyzvMIFgCo AyXyXAKCgCAhIiAImCF+bNgJZvbC8ZOWcAhm5hHL+QewwPAOgEABAAACAAAAgAIAAAQAAAAAAAAA AA==
Recommended Suppliers
  • Tel:86-571-87670983
  • Fax:86-571-86821328
  • Tel:86-571-88938639
  • Fax:86-571-88938652
  • Tel:+86-311-85355123
  • Fax:+86-311-85355123
  • Tel:86-571-85829152
  • Fax:86-571-85829153
  • Tel:+86-0592-5567629
  • Fax:+86-0592-5567629
  • Tel:86-25-83697070
  • Fax:86-25-83453275
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-21-34226250
  • Fax:86-21-34226250
Recommended Suppliers
  • Tel:86-571-87670983
  • Fax:86-571-86821328
  • Tel:86-571-88938639
  • Fax:86-571-88938652
  • Tel:+86-311-85355123
  • Fax:+86-311-85355123
  • Tel:86-571-85829152
  • Fax:86-571-85829153
  • Tel:+86-0592-5567629
  • Fax:+86-0592-5567629
  • Tel:86-25-83697070
  • Fax:86-25-83453275
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-21-34226250
  • Fax:86-21-34226250
 
<