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Home> Hot Product Listed 1   > 1,2-Propanediol

1,2-Propanediol

CAS No.:57-55-6
EINECS(EC#):200-338-0
Molecular Weight:76.09
Molecular Formula:C3H8O2 (Products with the same molecular formula)
MOL File:57-55-6.mol
Properties
Appearance
clear viscous liquid
Density
1.036 g/mL at 25℃(lit.)
Melting Point
-60℃
Boiling Point
187℃
Refractive Index
n20/D 1.432(lit.)
Flash Point
99℃
Water
Miscible
Solubilities
Miscible
Color/Form
Colorless viscous liquid
Stability
Stable under normal temperatures and pressures.
HS Code
29053200
Storage temp
Store at RT.
Spectral properties
Index of refraction: 1.4324 at 20 deg C/D
SADTLER REFERENCE NUMBER: 267 (IR, PRISM); 92 (IR, GRATING)
IR: 5974 (Coblentz Society Spectral Collection)
UV: 5-12 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
NMR: 45 (Varian Associates NMR Spectra Catalogue)
MASS: 95 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Safety and Handling
Safety Statements
S24/25
Safety
Slightly toxic by ingestion, skin contact, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, convulsions, changes in surface EEG. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Mutation data reported. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. May react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: TY2000000
HS Code: 29053200
PackingGroup
Z01
Sensitive
Hygroscopic
Skin, Eye, and Respiratory Irritations
Mildly irritating to the eyes.
May cause primary skin irritation in some people, possibly due to dehydration, but the material is not a sensitizer.
May cause transitory stinging, blepharospasm, and lacrimation.
Cleanup Methods
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Collect leaking and spilled liquid in sealable containers as far as possible. Wash away spilled liquid with plenty of water.
Fire Fighting Procedures
Water fog, alcohol foam, carbon dioxide, dry chemical.
In case of fire, keep drums, etc, cool by spraying water.
Fire Potential
Combustible liquid when exposed to heat or flame.
Formulations/Preparations
GRADE: refined, technical, USP, FCC, feed
Both the industrial-grade and USP grade have at least 99.5% purity.
Exposure Standards and Regulations
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Propylene glycol used as an emulsifying agent in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Propylene glycol used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: propylene glycol is included in pediculicide drug products.
Ophthalmic demulcents. The active ingredients of the product consist of any of the following, within the established concentrations for each ingredient: Propylene glyol, 0.2 to 1 percent.
The Food and Drug Administration has determined that propylene glycol in or on cat food is not generally recognized as safe and is a food additive subject to section 409 of the Federal Food, Drug, and Cosmetic Act (the act). The Food and Drug Administration also has determined that this use of propylene glycol is not prior sanctioned.
The Food and Drug Administration has determined that propylene glycol in or on cat food has not been shown by adequate scientific data to be safe for use. Use of propylene glycol in or on cat food causes the feed to be adulterated and in violation of the Federal Food, Drug, and Cosmetic Act (the act), in the absence of a regulation providing for its safe use as a food additive under section 409 of the act, unless it is subject to an effective notice of claimed investigational exemption for a food additive under part 570.17 of this chapter, or unless the substance is intended for use as a new animal drug and is subject to an approved application under section 512 of the act or an effective notice of claimed investigational exemption for a new animal drug under part 511 of this chapter.
Reactivities and Incompatibilities
Reacts with strong oxidants, causing fire hazard.
Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.
No significantly dangerous substances are produced after contact with light, humidity or commonly available chemicals. Propylene glycol may react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate.
A chemical polishing mixture of hydrofluoric acid, propylene glycol, and silver nitrate was put into a closed glass bottle which burst 30 min later, and formation of silver fulminate was suggested. However, in absence of the silver salt such mixtures evolve gas and should not be stored in any event, especially after use for metal polishing, when the dissolved metal(s) tend to further destabilize the mixture.
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
Above 99 deg C use a closed system, ventilation.
Propylene glycol should be handled in a well-ventilated environment; eye protection is recommended.
Protective Equipment and Clothing
Mildly irritating to the eyes.
May cause primary skin irritation in some people, possibly due to dehydration, but the material is not a sensitizer.
May cause transitory stinging, blepharospasm, and lacrimation.
Specification
Propylene Glycol (CAS NO.57-55-6) is also named as (+-)-1,2-Propanediol ; (+-)-Propylene glycol ; (RS)-1,2-Propanediol ; 1,2-Dihydroxypropane ; 1,2-Propylene glycol ; 1,2-Propylenglykol ; 1,2-Propylenglykol [German] ; 2,3-Propanediol ; 2-Hydroxypropanol ; 3-01-00-02142 (Beilstein Handbook Reference) ; AI3-01898 ; BRN 1340498 ; CCRIS 5929 ; Caswell No. 713 ; DL-1,2-Propanediol ; Dowfrost ; EPA Pesticide Chemical Code 068603 ; FEMA No. 2940 ; HSDB 174 ; Isopropylene glycol ; Methylethyl glycol ; Methylethylene glycol ; Monopropylene glycol ; Sirlene ; Solar Winter BAN ; Solargard P ; Trimethyl glycol ; UNII-6DC9Q167V3 ; Ucar 35 ; alpha-Propyleneglycol ; dl-Propylene glycol . Propylene Glycol (CAS NO.57-55-6) is clear viscous liquid. It is mixes with water and dissolves many essential oils. Propylene Glycol is sensitive to excessive heat (tends to oxidize at high temperatures). It can react with oxidizing materials. And it is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents.Liquid may irritate eyes. Propylene Glycol is combustible.
Octanol/Water Partition Coefficient
log Kow = -0.92
Report
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Disposal Methods

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 100000PLUS view >
Registered companies:
Registrant / Supplier details Latest dossier received
3M Belgium BVBA/SPRL 2014
3M Deutschland GmbH 2016
Active Tools Europe GmbH 2017
more >
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name propane-1,2-diol

1.2 Other means of identification

Product number -
Other names 1,2-Propanediol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Enzymes and Enzyme Stabilizers;Solvents
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
propane-1,2-diol propane-1,2-diol 57-55-6 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

If swallowed

Rinse mouth. Seek medical attention if you feel unwell.

4.2 Most important symptoms/effects, acute and delayed

Liquid may irritate eyes. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Check the anion gap, arterial pH, renal function, and glucose level. Serum propylene glycol levels up to 1,000 mg/dL do not correlate well with clinical status. Patients have been conscious with serum levels of 760 mg/dL.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water fog, alcohol foam, carbon dioxide, dry chemical.

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and alkalis. Dry. Well closed. Ventilation along the floor.Propylene glycol is hygroscopic and should be stored in a well-closed container, protected from light, in a cool, dry place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear viscous liquid
Colour Colorless viscous liquid
Odour Practically odorless
Melting point/ freezing point -59\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 187\u00b0C(lit.)
Flammability Combustible.
Lower and upper explosion limit / flammability limit Lower flammable limit: 2.6% by volume; Upper flammable limit: 12.5% by volume
Flash point 103\u00b0C
Auto-ignition temperature 415\u00b0C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.581 cP at 20\u00b0C
Solubility greater than or equal to 100 mg/mL at 21.11\u00b0C
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 0.08 mm Hg at 20\u00b0C ; 0.13 mm Hg at 25\u00b0C
Density and/or relative density 1.036g/mLat 25\u00b0C(lit.)
Relative vapour density 2.62 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.

10.3 Possibility of hazardous reactions

Combustible liquid when exposed to heat or flame ...PROPYLENE GLYCOL is hygroscopic. It is sensitive to excessive heat (tends to oxidize at high temperatures). This compound can react with oxidizing materials. It is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents. It dissolves many essential oils. A mixture of this compound with hydrofluoric acid and silver nitrate was put in a glass bottle which burst 30 minutes later.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Reacts with strong oxidants, causing fire hazard.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 21000 - 33700 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill sunfish); Conditions: static; Concentration: > 10,000 ppm for 96 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age 6-24 hr); Conditions: freshwater, static, 20\u00b0C, pH > or =7.0; Concentration: >10000000 ug/L for 24, 48 hr; Effect: intoxication, immobilization /formulation
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Propylene glycol achieved 64% of its theoretical BOD using a sewage inoculum and a 5 day incubation period(1). A Warburg respirometer study employing a sewage seed showed that propylene glycol reached 78% of its theoretical BOD during a 40 day incubation period(2). Propylene glycol achieved 2.2, 56.7 and 80% of its theoretical BOD using a sewage inoculum and 5, 10, and 50 day incubation periods, respectively(3). Using raw wastewater and synthetic seawater as inoculum, propylene glycol achieved 55 and 83% of its theoretical BOD during 5 and 20 day incubation periods, respectively(4). Using wastewater from pretreated domestic sewage, propylene glycol reached 74.5% of its theoretical BOD in 5 days(5). Propylene glycol underwent 73-78% mineralization within 51 days when incubated with various agricultural soils from Clemson University, SC under laboratory conditions at 22\u00b0C and 1,000 ppm propylene glycol in the soil; 40-79% mineralization was observed for propylene glycol incubated in the same soils for 64 days at 7\u00b0C(6).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for propylene glycol(SRC), using a log Kow of -0.92(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of propylene glycol is estimated as 1(SRC), using a log Kow of -0.92(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylene glycol is expected to have very high mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
propane-1,2-diol propane-1,2-diol 57-55-6 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:76.09442 [g/mol]
Molecular Formula:C3H8O2
XLogP3:-0.9
H-Bond Donor:2
H-Bond Acceptor:2
Rotatable Bond Count:1
Exact Mass:76.05243
MonoIsotopic Mass:76.05243
Topological Polar Surface Area:40.5
Heavy Atom Count:5
Formal Charge:0
Complexity:20.9
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:2
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:6