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Home> Hot Product Listed 1   > 1,2-Dibromoethane

1,2-Dibromoethane

CAS No.:106-93-4
EINECS(EC#):203-444-5
Molecular Weight:187.86
Molecular Formula:C2H4Br2 (Products with the same molecular formula)
MOL File:106-93-4.mol
Properties
Appearance
clear liquid
Density
2.173
Melting Point
9-10℃
Boiling Point
131-132℃
Vapour
12mmHg at 25°C
Refractive Index
1.5375-1.5395
Flash Point
Not flamable
Water
4 g/L (20℃)
Solubilities
4 g/L (20 °C) in water
Color/Form
Heavy liquid
Colorless liquid or solid (below 50 degrees F).
Stability
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, magnesium, alkali metals.
HS Code
29337100
Storage temp
0-6°C
Spectral properties
Index of refraction: 1.5379 @ 20 deg C/D
Intense mass spectral peaks: 107 m/z (100%), 109 m/z (94%), 81 m/z (6%), 79 m/z (6%)
IR: 15294 (Sadtler Research Laboratories IR Grating Collection)
1H NMR: 7554 (Sadtler Research Laboratories Spectral Collection)
MASS: 22302 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)
Safety and Handling
Hazard Codes
T
Risk Statements
R23/24/25;R36/37/38;R45;R51/53
Safety Statements
S45;S53;S61
HazardClass
6.1
Safety
Hazard Codes:T,N,F
Risk Statements:45-23/24/25-36/37/38-51/53-34-39/23/24/25-11
45:May cause cancer
23/24/25:Toxic by inhalation, in contact with skin and if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
34:Causes burns
39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
11:Highly Flammable
Safety Statements:53-45-61-36/37/39-26-36/37-16-7
53:Avoid exposure - obtain special instruction before use
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61:Avoid release to the environment. Refer to special instructions safety data sheet
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37:Wear suitable protective clothing and gloves
16:Keep away from sources of ignition - No smoking
7:Keep container tightly closed
RIDADR:UN 1605 6.1/PG 1
WGK Germany:3
HazardClass:6.1
PackingGroup:I
HS Code:29337100
Hazardous Substances Data:106-93-4(Hazardous Substances Data)
PackingGroup
I
Skin, Eye, and Respiratory Irritations
It is an irritant to eyes, skin, & mucous membranes.
A severe skin and eye irritant.
Cleanup Methods
1. VENTILATE AREA OF SPILL OR LEAK. 2. IF IN LIQ FORM, COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR SIMILAR MATERIAL. 3. IF IN SOLID FORM, COLLECT ... IN MOST CONVENIENT & SAFE MANNER FOR RECLAMATION.
Environmental considerations: Land spill: Build a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply universal gelling agent to immobilize the spill.
Environmental considerations: Water spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at the bottom. If dissolved, in region of 10 ppm or greater concn, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
Stop or control the leak, if this can be done without undue risk. Use appropriate foam to blanket release and suppress vapors. Absorb in noncombustible material for proper disposal.
Transport
UN 1605/1647
Fire Fighting Procedures
Use water spray or foam for fighting fires where ethylene dibromide is stored. Use water to keep fire-exposed containers cool.
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty.
Extinguish fire using agent suitable for surrounding fire. Use water to keep fire-exposed containers cool.
Fire Potential
Not flammable
Formulations/Preparations
In oil; mixtures: (ethylene dibromide +) chloropicrin; methyl bromide
Emulsifiable; wt/gal 18.1 lb
Liquid grade
Motor fuel antiknock mixes ca 18% or 2.8 g/l ethylene dibromide and aviation fuel antiknock mixes contain 36% ethylene dibromide.
DOT Emergency Guidelines
If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. Table of Initial Isolation and Protective Action Distances for Ethylene dibromide Small Spills (from a small package or small leak from a large package) -------------------- First ISOLATE in all Directions 30 meters (100 feet) Then PROTECT persons Downwind during DAY: 0.1 kilometers (0.1 miles) Then PROTECT persons Downwind during NIGHT: 0.1 kilometers (0.1 miles) ==================== Large Spills (from a large package or from many small packages) -------------------- First ISOLATE in all Directions 30 meters (100 feet) Then PROTECT persons Downwind during DAY: 0.3 kilometers (0.2 miles) Then PROTECT persons Downwind during NIGHT: 0.6 kilometers (0.4 miles)
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Reactivities and Incompatibilities
Incompatible with calcium, liquid ammonia, zinc, sodium, potassium, and strong oxidizers.
Vinyl bromide is formed slowly on contact with a warm alkaline solution.
If a mixture of liquid ammonia and ethylene bromide is allowed to reach room temperature, an explosion may result with formation of ethylene diamine and higher homologs.
Reaction between magnesium and 1,2-dibromoethane may become violent and release air-sensitive Grignard compounds.
Reacts with hot aluminum.
Reacts with oxidizing materials, alkali metals, ammonia.
Chemically active metals such as sodium, potassium, calcium, hot aluminum & magnesium; liquid ammonia; strong oxidizers.
Other Preventative Measures
DO NOT REUSE /CONTAMINATED/ CLOTHING OR SHOES UNTIL COMPLETELY FREE OF CHEM ODOR.
Good general ventilation is necessary in workrooms in which dibromoethane is used. Vessels containing the liquid should be covered and processes involving its use should be provided with local exhaust ventilation.
Leather foot protection is readily permeated by the liquid form of dibromoethane, so that it should be discarded if it has been exposed to appreciable amounts.
... NIOSH of the USA recommended that (a) worker should not be exposed to dibromoethane during the course of disulfiram therapy ... & (b) no worker should be exposed to both dibromoethane and disulfiram (the latter being also used in industry as an accelerator in rubber prodn, a fungicide and insecticide).
If the use of respirators is necessary, the only respirators permitted are those that have been approved by the Mine Safety and Health Administration (formerly Mining Enforcement and Safety Administration) or by the National Institute for Occupational Safety and Health.
In addition to respirator selection, a complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation.
Skin that becomes contaminated with liquid ethylene dibromide should be immediately washed or showered with soap or mild detergent and water to remove any ethylene dibromide.
Eating and smoking should not be permitted in areas where liquid ethylene dibromide is handled, processed, or stored.
Employees who handle liquid ethylene dibromide should wash their hands thoroughly with soap or mild detergent and water before eating, smoking, or using toilet facilities.
Clothing contaminated with liquid ethylene dibromide should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of ethylene dibromide from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the ethylene dibromide, the person performing the operation should be informed of ethylene dibromide's hazardous properties. Non-impervious clothing which becomes contaminated with liquid ethylene dibromide should be removed immediately and not reworn until the ethylene dibromide is removed from the clothing.
Where there is any possibility of exposure of an employee's eyes or body to liquid ethylene dibromide, facilities for quick drenching of the body and an eye-wash fountain should be provided within the immediate work area for emergency use.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers.
PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Principles that apply to chem or biochem lab also apply to microbiological & cell-culture labs ... Special consideration should be given to route of admin. ... Safest method of administering volatile carcinogen is by injection of a soln. Admin by topical application, gavage, or intratracheal instillation should be performed under hood. If chem will be exhaled, animals should be kept under hood during this period. Inhalation exposure requires special equipment. ... Unless specifically required, routes of admin other than in the diet should be used. Mixing of carcinogen in diet should be carried out in sealed mixers under fume hood, from which the exhaust is fitted with an efficient particulate filter. Techniques for cleaning mixer & hood should be devised before expt begun. When mixing diets, special protective clothing &, possibly, respirators may be required. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": When ... admin in diet or applied to skin, animals should be kept in cages with solid bottoms & sides & fitted with a filter top. When volatile carcinogens are given, filter tops should not be used. Cages which have been used to house animals that received carcinogens should be decontaminated. Cage-cleaning facilities should be installed in area in which carcinogens are being used, to avoid moving of ... contaminated /cages/. It is difficult to ensure that cages are decontaminated, & monitoring methods are necessary. Situations may exist in which the use of disposable cages should be recommended, depending on type & amt of carcinogen & efficiency with which it can be removed. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": To eliminate risk that ... contamination in lab could build up during conduct of expt, periodic checks should be carried out on lab atmospheres, surfaces, such as walls, floors & benches, & ... interior of fume hoods & airducts. As well as regular monitoring, check must be carried out after cleaning-up of spillage. Sensitive methods are required when testing lab atmospheres. ... Methods ... should ... where possible, be simple & sensitive. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Rooms in which obvious contamination has occurred, such as spillage, should be decontaminated by lab personnel engaged in expt. Design of expt should ... avoid contamination of permanent equipment. ... Procedures should ensure that maintenance workers are not exposed to carcinogens. ... Particular care should be taken to avoid contamination of drains or ventilation ducts. In cleaning labs, procedures should be used which do not produce aerosols or dispersal of dust, ie, wet mop or vacuum cleaner equipped with high-efficiency particulate filter on exhaust, which are avail commercially, should be used. Sweeping, brushing & use of dry dusters or mops should be prohibited. Grossly contaminated cleaning materials should not be re-used ... If gowns or towels are contaminated, they should not be sent to laundry, but ... decontaminated or burnt, to avoid any hazard to laundry personnel. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Doors leading into areas where carcinogens are used ... should be marked distinctively with appropriate labels. Access ... limited to persons involved in expt. ... A prominently displayed notice should give the name of the Scientific Investigator or other person who can advise in an emergency & who can inform others (such as firemen) on the handling of carcinogenic substances. /Chemical Carcinogens/
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed or replaced.
If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.
Personnel protection: Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
Protective Equipment and Clothing
... ETHYLENE DIBROMIDE WILL PENETRATE THROUGH SEVERAL TYPES OF PROTECTIVE CLOTHING, PARTICULARLY NEOPRENE RUBBER & SEVERAL TYPES OF PLASTIC GLOVES. NYLON ... MOST RESISTANT MATERIAL BUT ... /LACKS/ IN GOOD PHYSICAL CHARACTERISTICS. ... COMBINATION OF NEOPRENE & NYLON /PROPOSED/.
Protective clothing should be worn which includes the following: gloves, bib-type aprons, boots, and overshoes.
At less than or equal to 10 mg/cu m: supplied-air respirator with half-mask facepiece operated in demand (positive pressure) mode; less than or equal to 50 mg/cu m: supplied-air respirator with full facepiece; less than or equal to 2,000 mg/cu m: type C supplied-air respirator with full facepiece operated in continuous-flow mode; greater than 2,000 mg/cu m or entry into an area of unknown concn: self-contained breathing apparatus with full facepiece operated in pressure-demand or other positive pressure mode.
Chlorinated polyethylene as a material for protective clothing has shown break through times of less than one hour, and is therefore not recommended for use with ethylene dibromide.
Employees should be provided with and required to use impervious clothing, gloves, face-shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with ethylene dibromide. Employees should be provided with and required to use splash-proof goggles where there is any possibility of liquid ethylene dibromide contacting the eyes.
PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... Gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Recommendations for respirator selection. Condition: At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration. Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator that has a full face piece and is operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.
Specification

The IUPAC name of?1,2-Ethylene dibromide is?1,2-dibromoethane. With the?CAS registry number 106-93-4, it is also?named as?Aadibroom;?Celmide.?The product's categories are?organics and bromine chemicals. It is?colorless to light yellow liquid?with a sweetish odor. And it is?slightly soluble in water, and?soluble in most organic solvents and thinners.?In addition, this chemical?slowly decomposes in the presence of light and heat, so it may?turn brown upon exposure to light. It is corrosive to iron and other metals and may decompose upon contact with alkalis. Furthermore, it is incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 2.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.08; (4)ACD/LogD (pH 7.4): 2.08; (5)ACD/BCF (pH 5.5): 22.42; (6)ACD/BCF (pH 7.4): 22.42; (7)ACD/KOC (pH 5.5): 322.43; (8)ACD/KOC (pH 7.4): 322.43; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.521; (13)Molar Refractivity: 26.77 cm3; (14)Molar Volume: 87.9 cm3; (15)Polarizability: 10.61×10-24 cm3; (16)Surface Tension: 36.4 dyne/cm; (17)Enthalpy of Vaporization: 34.77 kJ/mol; (18)Vapour Pressure: 12 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 187.865929; (21)MonoIsotopic Mass: 185.867975; (22)Heavy Atom Count: 4.

Preparation of 1,2-Ethylene dibromide: It can be obtained by ethene petroleum ether and bromine under Geschwindigkeit der Reaktion at -80 - -100°C.

Uses of?1,2-Ethylene dibromide:?It can be used as ethyl reagents and?solvents.In?agriculture, it?is used?as a nematicide and?synthetic plant growth regulator. And it is also used as?intermediate in synthesis of diethyl-bromophenyl acetonitrile, and?fire retardant of vinyl bromide in?medicine. In addition, it is used?in?gasoline to eliminate lead in seismic liquid agent, metal surface treatment agent and fire-fighting agent. It reacts with?2,4,5-tribromo-1H-imidazole to get 2,4,5-tribromo-1-vinylimidazole. This reaction needs reagent?aq. tetrabutylammonium bromide and aq. NaOH by heating. The reaction time is?3 hours. The yield is 90 %.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable,?so it is toxic by inhalation, in contact with skin and if swallowed.?And it is irritating to eyes, respiratory system and skin.?In addition, this chemical may cause cancer and is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?

People can use the following data to convert to the molecule structure.?
1. SMILES: BrCCBr;
2. InChI: InChI=1/C2H4Br2/c3-1-2-4/h1-2H2.

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 79mg/kg (79mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LD50 oral 110mg/kg (110mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
man TDLo oral 43uL/kg (0.043mL/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Human & Experimental Toxicology. Vol. 19, Pg. 152, 2000.
?
mouse LD50 intraperitoneal 220mg/kg (220mg/kg) ? Journal fuer Praktische Chemie. Vol. 320, Pg. 133, 1978.
mouse LD50 unreported 146mg/kg (146mg/kg) ? "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 38, 1971.
mouse LDLo oral 250mg/kg (250mg/kg) ? Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
quail LD50 oral 130mg/kg (130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
British Poultry Science. Vol. 22, Pg. 355, 1981.
?
rabbit LD50 oral 55mg/kg (55mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LDLo rectal 2500mg/kg (2500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Journal of Pharmacology and Experimental Therapeutics. Vol. 34, Pg. 223, 1928.
rat LC50 inhalation 14300mg/m3/30 (14300mg/m3) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 8, Pg. 140, 1973.
rat LD50 oral 108mg/kg (108mg/kg) ? Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 17, 1978.
rat LD50 skin 300mg/kg (300mg/kg) ? "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
women LDLo oral 90mg/kg (90mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 257, 1969.

Octanol/Water Partition Coefficient
log Kow = 1.96
Report

The IUPAC name of?1,2-Ethylene dibromide is?1,2-dibromoethane. With the?CAS registry number 106-93-4, it is also?named as?Aadibroom;?Celmide.?The product's categories are?organics and bromine chemicals. It is?colorless to light yellow liquid?with a sweetish odor. And it is?slightly soluble in water, and?soluble in most organic solvents and thinners.?In addition, this chemical?slowly decomposes in the presence of light and heat, so it may?turn brown upon exposure to light. It is corrosive to iron and other metals and may decompose upon contact with alkalis. Furthermore, it is incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 2.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.08; (4)ACD/LogD (pH 7.4): 2.08; (5)ACD/BCF (pH 5.5): 22.42; (6)ACD/BCF (pH 7.4): 22.42; (7)ACD/KOC (pH 5.5): 322.43; (8)ACD/KOC (pH 7.4): 322.43; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.521; (13)Molar Refractivity: 26.77 cm3; (14)Molar Volume: 87.9 cm3; (15)Polarizability: 10.61×10-24 cm3; (16)Surface Tension: 36.4 dyne/cm; (17)Enthalpy of Vaporization: 34.77 kJ/mol; (18)Vapour Pressure: 12 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 187.865929; (21)MonoIsotopic Mass: 185.867975; (22)Heavy Atom Count: 4.

Preparation of 1,2-Ethylene dibromide: It can be obtained by ethene petroleum ether and bromine under Geschwindigkeit der Reaktion at -80 - -100°C.

Uses of?1,2-Ethylene dibromide:?It can be used as ethyl reagents and?solvents.In?agriculture, it?is used?as a nematicide and?synthetic plant growth regulator. And it is also used as?intermediate in synthesis of diethyl-bromophenyl acetonitrile, and?fire retardant of vinyl bromide in?medicine. In addition, it is used?in?gasoline to eliminate lead in seismic liquid agent, metal surface treatment agent and fire-fighting agent. It reacts with?2,4,5-tribromo-1H-imidazole to get 2,4,5-tribromo-1-vinylimidazole. This reaction needs reagent?aq. tetrabutylammonium bromide and aq. NaOH by heating. The reaction time is?3 hours. The yield is 90 %.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable,?so it is toxic by inhalation, in contact with skin and if swallowed.?And it is irritating to eyes, respiratory system and skin.?In addition, this chemical may cause cancer and is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?

People can use the following data to convert to the molecule structure.?
1. SMILES: BrCCBr;
2. InChI: InChI=1/C2H4Br2/c3-1-2-4/h1-2H2.

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 79mg/kg (79mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LCLo inhalation 400ppm/3H (400ppm) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
guinea pig LD50 oral 110mg/kg (110mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
man TDLo oral 43uL/kg (0.043mL/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Human & Experimental Toxicology. Vol. 19, Pg. 152, 2000.
?
mouse LD50 intraperitoneal 220mg/kg (220mg/kg) ? Journal fuer Praktische Chemie. Vol. 320, Pg. 133, 1978.
mouse LD50 unreported 146mg/kg (146mg/kg) ? "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 38, 1971.
mouse LDLo oral 250mg/kg (250mg/kg) ? Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
quail LD50 oral 130mg/kg (130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
British Poultry Science. Vol. 22, Pg. 355, 1981.
?
rabbit LD50 oral 55mg/kg (55mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LD50 skin 300mg/kg (300mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 6, Pg. 158, 1952.
rabbit LDLo rectal 2500mg/kg (2500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Journal of Pharmacology and Experimental Therapeutics. Vol. 34, Pg. 223, 1928.
rat LC50 inhalation 14300mg/m3/30 (14300mg/m3) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 8, Pg. 140, 1973.
rat LD50 oral 108mg/kg (108mg/kg) ? Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 17, 1978.
rat LD50 skin 300mg/kg (300mg/kg) ? "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
women LDLo oral 90mg/kg (90mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 257, 1969.

Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U067, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Ethylene dibromide is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Controlled incineration with adequate scrubbing and ash disposal facilities.
A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/
Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/
1,2-Dibromoethane has a very low solubility in water and can be removed from effluents by gravity separators or settling ponds. Small remainders may be removed by aerating the water, whereby the harmful material evaporates. The gases which form during this process have to be burnt in special waste incinerators, because during decomposition of 1,2-dibromoethane; hydrogen bromide is liberated. However, this action will only be necessary if the emission of hydrogen bromide rises above the permitted level. Recommendable methods: Incineration & evaporation. Not recommendable method: Discharge to sewer. Peer-review: Bromine cmpd should be more diluted with hydrocarbons than the equivalent chlorine cmpd. Large amt burned may lead to the emission of bromine. Small amt: evaporate. (Peer-review conclusions of an IRPTC expert consultation (May 1985))
Incineration: The Manufacturing Chemists Association suggests the following disposal procedures for EDB /1,2-dibromoethane/ and other bromine-containing cmpd: Pour onto vermiculite, sodium bicarbonate or a sand-soda ash mixture (90-10). Mix and shovel into paper boxes. Place in an open incinerator. Cover with scrap wood and paper. Ignite with an excelsior train or dump into a closed incinerator with afterburner. Dissolve in a flammable solvent. Spray into the fire box of an incinerator equipped with afterburner and scrubber (alkali).
PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Small quantities of ... some carcinogens can be destroyed using chem reactions ... but no general rules can be given. ... As a general technique ... treatment with sodium dichromate in strong sulfuric acid can be used. The time necessary for destruction ... is seldom known ... but 1-2 days is generally considered sufficient when freshly prepd reagent is used. ... Carcinogens that are easily oxidizable can be destroyed with milder oxidative agents, such as saturated soln of potassium permanganate in acetone, which appears to be a suitable agent for destruction of hydrazines or of compounds containing isolated carbon-carbon double bonds. Concn or 50% aqueous sodium hypochlorite can also be used as an oxidizing agent. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Carcinogens that are alkylating, arylating or acylating agents per se can be destroyed by reaction with appropriate nucleophiles, such as water, hydroxyl ions, ammonia, thiols & thiosulfate. The reactivity of various alkylating agents varies greatly ... & is also influenced by sol of agent in the reaction medium. To facilitate the complete reaction, it is suggested that the agents be dissolved in ethanol or similar solvents. ... No method should be applied ... until it has been thoroughly tested for its effectiveness & safety on material to be inactivated. For example, in case of destruction of alkylating agents, it is possible to detect residual compounds by reaction with 4(4-nitrobenzyl)-pyridine. /Chemical Carcinogens/
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000_10000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
ICL Europe Coöperatief U.A. (OR1) 2010
Innospec Limited 2015
LANXESS SOLUTIONS UK LTD 2011
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-dibromoethane

1.2 Other means of identification

Product number -
Other names Ethane, 1,2-dibromo-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Volatile organic compounds
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Inhalation, Category 3

Specific target organ toxicity \u2013 single exposure, Category 3

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H331 Toxic if inhaled

H335 May cause respiratory irritation

H350 May cause cancer

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/\u2026

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
1,2-dibromoethane 1,2-dibromoethane 106-93-4 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Local inflammation, blisters and ulcers on skin; irritation in lungs and organic injury to liver and kidneys; may be absorbed through skin. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Rinse eyes with water. Wash polluted portions with soap and water.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray or foam for fighting fires where ethylene dibromide is stored. Use water to keep fire-exposed containers cool.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Decomposition gases are toxic and irritating. Behavior in Fire: Decomposes into toxic irritating gases. Reacts with hot metals such as aluminum and magnesium. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1. VENTILATE AREA OF SPILL OR LEAK. 2. IF IN LIQ FORM, COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR SIMILAR MATERIAL. 3. IF IN SOLID FORM, COLLECT ... IN MOST CONVENIENT & SAFE MANNER FOR RECLAMATION.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, strong bases, powdered metals and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Store in an area without drain or sewer access.Store in a cool, dry, dark, well-ventilated location. Separate from oxidizing materials, alkali metal, ammonia.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted avg: 0.O45 ppm

Recommended Exposure Limit: 15 min Ceiling value: 0.13 ppm.

NIOSH recommends that ethylene dibromide be regulated as a potential human carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concn.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear liquid
Colour Heavy liquid
Odour Chloroform odor
Melting point/ freezing point 317\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 132\u00b0C
Flammability Noncombustible LiquidNot combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 103\u00b0C(lit.)
Auto-ignition temperature Not flammable (USCG, 1999)
Decomposition temperature no data available
pH no data available
Kinematic viscosity 1.727 cP @ 20\u00b0C
Solubility In water:4 g/L (20 \u00baC)
Partition coefficient n-octanol/water (log value) log Kow = 1.96
Vapour pressure 11.7 mm Hg ( 25 \u00b0C)
Density and/or relative density 2.173
Relative vapour density ~6.5 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

/1,2-Dibromomethane/ is stable and nonflammable.

10.3 Possibility of hazardous reactions

Not flammableETHYLENE DIBROMIDE slowly decomposes in the presence of light and heat. Turns brown upon exposure to light. Corrosive to iron and other metals. May decompose upon contact with alkalis. Incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia. May attack some plastics, rubber and coatings. May poison platinum catalysts [Hawley]. Reacts as an alkylating agent .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible with calcium, liquid ammonia, zinc, sodium, potassium, and strong oxidizers.

10.6 Hazardous decomposition products

At 240-270\u00b0C in a glass vessel, ethylene bromide decomposes into vinyl bromide & hydrogen bromide.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 108 mg/kg
  • Inhalation: LC50 Rat inhalation 14,300 mg/cu m/30 min
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

NTP: Reasonably anticipated to be a human carcinogen, EPA: Probable human carcinogen, IARC: Probably carcinogenic to humans

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Lepomis macrochirus 18 mg/l/48 hr /Conditions of bioassay not specified
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

Ethylene dibromide degraded readily in primary sewage sludge suspensions under both aerobic and anaerobic conditions(1); under aerobic conditions, degradation occurred within days, while under anaerobic conditions, degradation took 5-6 weeks(1). In three day die-away tests using Japanese river and seawater, ethylene dibromide was observed to have moderate degradation (21-35% degradation)(2). Low concs of ethylene dibromide (<100 ug/l) were biotransformed completely within 2 weeks by a reductive dehalogenation under methanogenic conditions in a continuous-flow column(3); sterile controls showed that some abiotic degradation was also occurring, but microbial degradation was dominant(3). In a microcosm study simulating methanogenic conditions found in aquifer material, ethylene dibromide was found to biodegrade relatively rapidly(4); after 16 weeks of incubation, greater than 99% of initial ethylene dibromide was transformed(4); in sterile controls, only 20% was transformed after 40 weeks(4).

12.3 Bioaccumulative potential

A BCF for ethylene dibromide has been measured to be < 1(1). Orange red killifish exposed to an aqueous solution containing ethylene dibromide at 15 and 150 ug/l had a BCF ranging from <3.5-14.9 and 1.6-3.2, respectively(2). According to a classification scheme(3), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Ethylene dibromide exhibits slow to moderate adsorption to soil with measured Koc values ranging from 14 to 160(1). According to a classification scheme(2), these Koc values suggest that ethylene dibromide is expected to have high to very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1605 IMDG: UN1605 IATA: UN1605

14.2 UN Proper Shipping Name

ADR/RID: ETHYLENE DIBROMIDE
IMDG: ETHYLENE DIBROMIDE
IATA: ETHYLENE DIBROMIDE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
1,2-dibromoethane 1,2-dibromoethane 106-93-4 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:187.86116 [g/mol]
Molecular Formula:C2H4Br2
XLogP3:2
H-Bond Donor:0
H-Bond Acceptor:0
Rotatable Bond Count:1
Exact Mass:187.865929
MonoIsotopic Mass:185.867975
Topological Polar Surface Area:0
Heavy Atom Count:4
Formal Charge:0
Complexity:6
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Hydrophobe Count:2
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:3