Products
  • Products
  • Cas lib
  • Buy offers
  • Encyclopedia
  • Msds lib
  • Synthesis
  • Reach Info
  • Suppliers
Home> Hot Product Listed E   > Ethylenediamine

Ethylenediamine

CAS No.:107-15-3
EINECS(EC#):203-468-6
Molecular Weight:60.1
Molecular Formula:C2H8N2 (Products with the same molecular formula)
MOL File:107-15-3.mol
Names and Identifiers
Properties
Appearance
clear, colorless Liquid
Density
0.898
Melting Point
11℃
Boiling Point
117-118℃
Vapour
15.778mmHg at 25°C
Refractive Index
1.4555-1.4575
Flash Point
34℃
Water
miscible
Solubilities
Miscible with water
Color/Form
Water-white liquid
Colorless, viscous liquid ... [Note: A solid below 47 degrees F].
Stability
Stable under normal temperatures and pressures.
Storage temp
Flammables area
Spectral properties
SADTLER REF NUMBER: 5319 (IR, PRISM)
Index of refraction: 1.4565 @ 20 deg C/D
IR: 5560 (Coblentz Society Spectral Collection)
NMR: 7326 (Sadtler Research Laboratories Spectral Collection)
MASS: 40 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Safety and Handling
Hazard Codes
C
Risk Statements
R10;R21/22;R34;R42/43
Safety Statements
S23;S26;S36/37/39;S45
HazardClass
8
Safety
Hazard Codes:C
Risk Statements:10-21/22-34-42/43
10:Flammable
21/22:Harmful by inhalation, in contact with skin and if swallowed
34:Causes burns
42/43:May cause sensitization by inhalation and skin contact
Safety Statements:23-26-36/37/39-45
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR:UN 1604 8/PG 2
WGK Germany:2
HazardClass:8
PackingGroup:II
Hazardous Substances Data:107-15-3(Hazardous Substances Data)
PackingGroup
II
Sensitive
Air Sensitive
Skin, Eye, and Respiratory Irritations
Irritating to skin, eyes, and respiratory system.
Cleanup Methods
1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.
Overspread /spill with/ sufficient sodium bisulfate and sprinkle water.
Transport
UN 1604
Fire Fighting Procedures
Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.
Do not use water in case of drum or tank fires.
Fire Potential
FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.
Contact with ... chlorinated organic cmpd may cause fires ... .
Formulations/Preparations
USEPA/OPP Pesticide Code 004205; Trade Names: Busan 881, component of (with 039002 and 063301), NCI-C60402.
Grades: Technical; USP, 97%; soln of various strenghts.
Grades or Purity: 99+%
DOT Emergency Guidelines
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible materials. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing is recommended for fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire: Some of these materials may react violently with water. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Do not get water inside containers. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers ... . Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Exposure Standards and Regulations
Ethylenediamine is an indirect food additive for use only as a component of adhesives.
Reactivities and Incompatibilities
Carbon disulfide reacts violently with ... ethylenediamine.
Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgClO4, sulfuric acid, beta-propiolactone, vinyl acetate.
A flask exploded while a chemist was adding ethylenediamine drop-wise to silver perchlorate.
Contact with ... chlorinated organic cmpd may cause ... explosions.
Strong acids & oxidizers, carbon tetrachloride & other chlorinated organic compounds, carbon disulfide [Note: Corrosive to metals].
Mixing acetic anhydride and ethylenediamine in a closed container caused the temp and pressure to incr.
Mixing ethylenediamine and vinyl acetate in a closed container caused the temp and pressure to incr.
Other Preventative Measures
CARE MUST BE TAKEN IN HANDLING BECAUSE OF CAUSTIC NATURE OF ETHYLENEDIAMINE & IRRITATING PROPERTIES OF ITS VAPOR.
Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. ... If employees' clothing has had any possibility of being contaminated with solid ethylenediamine, employees should change into uncontaminated clothing before leaving the work premises. Clothing which has had any possibility of being contaminated with solid or liquid ethylenediamine should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of ethylenediamine from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the ethylenediamine the person performing the operation should be informed of ethylenediamine's hazardous properties. Where there is any possibility of exposure of an employee's body to solid or liquid ethylenediamine, facilities for quick drenching of the body should be provided within the immediate work area for emergency use. Any clothing which becomes wet with liquid ethylenediamine or non-impervious clothing which becomes contaminated with ethylenediamine should be removed immediately and not reworn until the ethylenediamine is removed from the clothing. ... Skin that becomes contaminated with ethylenediamine should be immediately washed or showered to remove any ethylenediamine. Workers subject to skin contact with solid or liquid ethylenediamine should wash any areas of the body which may have contacted ethylenediamine at the end of each work day. Eating and smoking sould not be permitted in areas where solid or liquid ethylenediamine are handled, processed, or stored. Employees who handle solid or liquid ethylenediamine should wash their hands thoroughly before eating, smoking, or using toilet facilities.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
The worker should immediately wash the skin when it becomes contaminated.
The worker should wash daily at the end of each work shift.
Work clothing that becomes wet should be immediately removed due to its flammability hazard.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Protective Equipment and Clothing
Full rubber protective clothing, incl gloves and boots; chem worker's goggles; face shield where contact with face is likely. If necessary to enter closed area for 1/2 hr or less with mist, wear full-faced gas mask with canister approved by Bureau of Standards for use with ammonia.
If the use of respirators is necessary, the only respirators permitted are those that have been approved by the Mine Safety and Health Administration (formerly Mining Enforcement and Safety Administration) or by the National Institute for Occupational Safety and Health. ... Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with solid or liquid ethylenediamine. Employees should be provided with and required to use splash-proof safety goggles where there is any possibility of solid or liquid ethylenediamine or soln containing ethylenediamine contacting the eyes. ... An eye-wash fountain should be provided within the immediate work area for emergency use.
Respiratory protection: 500 ppm or less: A chemical cartridge respirator with a full facepiece and a cartridge(s) which provide protection against ethylenediamine. A gas mask with a chin-style or a front- or back-mounted canister which provides protection against ethylenediamine. Any supplied-air respirator with a full facepiece, helmet, or hood. Any self-contained breathing appratus with a full facepiece; 1000 ppm or less: A type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous-flow mode; Greater than 2000 ppm or entry and escape from unknown concentrations: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode or a combination respirator which includes a type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure or continuous-flow mode and an auxillary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; Escape: any gas mask providing protection against ethylenediamine or any self-contained breathing apparatus.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. />5%/
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.)
Recommendations for respirator selection. Max concn for use: 250 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Eye protection needed. Any powered, air-purifying respirator with cartridge(s) providing protection against the compound of concern. Eye protection needed.
Recommendations for respirator selection. Max concn for use: 500 ppm. Respirator Class(es): Any chemical cartridge respirator with a full facepiece and cartridge(s) providing protection against the compound of concern. Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern. Any powered, air-purifying respirator with a tight-fitting facepiece and cartridge(s) providing protection against the compound of concern. Eye protection needed. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Max concn for use: 1000 ppm. Respirator Class(es): Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern. Any appropriate escape-type, self-contained breathing apparatus.
Specification

The 1,2-Ethanediamine?is colorless liquid with an ammonia-like odor. It belongs to the categories of?(1)Pharmaceutical Intermediates ; (2)alpha,omega-Alkanediamines ; (3)alpha,omega-Bifunctional Alkanes ; (4)Biochemistry ; (5)Reagents for Oligosaccharide Synthesis.?With cas registry number of?107-15-3, it also has?other registry numbers including?8030-24-8 and 85404-18-8. Its?IUPAC name and systematic name?are the same which is called ethane-1,2-diamine with SMILES: NCCN.?The superlist name about this chemical are?(1)1,2-Diaminoethane ; (2) 1,2-Ethanediamine ; (3) Ethylenediamine ; (4) Ethylenediamine [UN1604] [Corrosive] ; (5) UN1604 .

Physical properties about this chemical are:?(1) # of Rule of 5 Violations: 0 ; (2) ACD/LogD (pH 5.5): -5.97 ; (3) ACD/LogD (pH 7.4): -4.53 ; (4) ACD/BCF (pH 5.5): 1 ; (5) ACD/BCF (pH 7.4): 1 ; (6) ACD/KOC (pH 5.5): 1 ; (7) ACD/KOC (pH 7.4): 1 ; (8) #H bond acceptors: 2 ; (9) #H bond donors: 4 ; (10) #Freely Rotating Bonds: 3 ; (11) Index of Refraction: 1.446 ; (12) Molar Refractivity: 18.38 cm3 ; (13) Molar Volume: 68.9 cm3 ; (14) Surface Tension: 36.8 dyne/cm ; (15) Density: 0.872 g/cm3 ; (16) Flash Point: 33.9 °C ; (17) Enthalpy of Vaporization: 37.98 kJ/mol; (18) Refractive index: n20/D 1.4565(lit.); (19) Sensitive: Air Sensitive; (20) Boiling Point: 119.7 °C at 760 mmHg ; (21) Vapour Pressure: 15.8 mmHg at 25°C.

Preparation of?1,2-Ethanediamine : this chemical is prepared by the reaction of?ammonia and 1,2-dichloroethane . This reaction can give the mixture of ethylenediamine and the linear polyamines.
ClCH2CH2Cl + 4 NH3 → H2NCH2CH2NH2 + 2 NH4Cl

Uses of?1,2-Ethanediamine : this compound is mainly used?for production of many chemicals. Here is a example.


This reaction will use the solvent water and?AcOK / AcOH buffer, pH = 5. The yield is about 30%.

When you are using this chemical, please be cautious about it as the following:
A human poison by inhalation. Experimental poison by inhalation, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. Corrosive. A severe skin and eye irritant. An allergen and sensitizer. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, CS2, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgClO4, H2SO4, β-propiolactone, or vinyl acetate. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx and NH3.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 100mg/kg (100mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
guinea pig LD50 oral 470mg/kg (470mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human TCLo inhalation 200ppm (200ppm) PERIPHERAL NERVE AND SENSATION: PARESTHESIS AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 223, 1954.
mouse LC50 inhalation 300mg/m3 (300mg/m3) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg) ? Chimica Therapeutica. Vol. 4, Pg. 136, 1969.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: ATAXIA Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rabbit LD50 skin 730uL/kg (0.73mL/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rabbit LDLo subcutaneous 500mg/kg (500mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
rat LCLo inhalation 4000ppm/8H (4000ppm) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat LD50 intraperitoneal 76mg/kg (76mg/kg) ? Toxicology and Applied Pharmacology. Vol. 21, Pg. 454, 1972.
rat LD50 oral 1200mg/kg (1200mg/kg) BEHAVIORAL: ATAXIA Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rat LD50 subcutaneous 300mg/kg (300mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.

Octanol/Water Partition Coefficient
log Kow = -2.04 @ pH 13
Report

The 1,2-Ethanediamine?is colorless liquid with an ammonia-like odor. It belongs to the categories of?(1)Pharmaceutical Intermediates ; (2)alpha,omega-Alkanediamines ; (3)alpha,omega-Bifunctional Alkanes ; (4)Biochemistry ; (5)Reagents for Oligosaccharide Synthesis.?With cas registry number of?107-15-3, it also has?other registry numbers including?8030-24-8 and 85404-18-8. Its?IUPAC name and systematic name?are the same which is called ethane-1,2-diamine with SMILES: NCCN.?The superlist name about this chemical are?(1)1,2-Diaminoethane ; (2) 1,2-Ethanediamine ; (3) Ethylenediamine ; (4) Ethylenediamine [UN1604] [Corrosive] ; (5) UN1604 .

Physical properties about this chemical are:?(1) # of Rule of 5 Violations: 0 ; (2) ACD/LogD (pH 5.5): -5.97 ; (3) ACD/LogD (pH 7.4): -4.53 ; (4) ACD/BCF (pH 5.5): 1 ; (5) ACD/BCF (pH 7.4): 1 ; (6) ACD/KOC (pH 5.5): 1 ; (7) ACD/KOC (pH 7.4): 1 ; (8) #H bond acceptors: 2 ; (9) #H bond donors: 4 ; (10) #Freely Rotating Bonds: 3 ; (11) Index of Refraction: 1.446 ; (12) Molar Refractivity: 18.38 cm3 ; (13) Molar Volume: 68.9 cm3 ; (14) Surface Tension: 36.8 dyne/cm ; (15) Density: 0.872 g/cm3 ; (16) Flash Point: 33.9 °C ; (17) Enthalpy of Vaporization: 37.98 kJ/mol; (18) Refractive index: n20/D 1.4565(lit.); (19) Sensitive: Air Sensitive; (20) Boiling Point: 119.7 °C at 760 mmHg ; (21) Vapour Pressure: 15.8 mmHg at 25°C.

Preparation of?1,2-Ethanediamine : this chemical is prepared by the reaction of?ammonia and 1,2-dichloroethane . This reaction can give the mixture of ethylenediamine and the linear polyamines.
ClCH2CH2Cl + 4 NH3 → H2NCH2CH2NH2 + 2 NH4Cl

Uses of?1,2-Ethanediamine : this compound is mainly used?for production of many chemicals. Here is a example.


This reaction will use the solvent water and?AcOK / AcOH buffer, pH = 5. The yield is about 30%.

When you are using this chemical, please be cautious about it as the following:
A human poison by inhalation. Experimental poison by inhalation, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. Corrosive. A severe skin and eye irritant. An allergen and sensitizer. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, CS2, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgClO4, H2SO4, β-propiolactone, or vinyl acetate. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx and NH3.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 100mg/kg (100mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
guinea pig LD50 oral 470mg/kg (470mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human TCLo inhalation 200ppm (200ppm) PERIPHERAL NERVE AND SENSATION: PARESTHESIS AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 223, 1954.
mouse LC50 inhalation 300mg/m3 (300mg/m3) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg) ? Chimica Therapeutica. Vol. 4, Pg. 136, 1969.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: ATAXIA Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rabbit LD50 skin 730uL/kg (0.73mL/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rabbit LDLo subcutaneous 500mg/kg (500mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
rat LCLo inhalation 4000ppm/8H (4000ppm) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat LD50 intraperitoneal 76mg/kg (76mg/kg) ? Toxicology and Applied Pharmacology. Vol. 21, Pg. 454, 1972.
rat LD50 oral 1200mg/kg (1200mg/kg) BEHAVIORAL: ATAXIA Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (1), Pg. 38, 1997.
rat LD50 subcutaneous 300mg/kg (300mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.
Catalytic /destruction/ of waste gases from ethylenediamine production is described.
Removal of ethylenediamine from wastewater using ion exchange is described.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
INTERMEDIATE JOINT INTERMEDIATE_USE_ONLY view >
FULL JOINT 10000PLUS view >
Registered companies:
Registrant / Supplier details Latest dossier received
Bayer AG 2013
3M Belgium BVBA/SPRL 2015
Akzo Nobel Functional Chemicals AB 2015
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name ethylenediamine

1.2 Other means of identification

Product number -
Other names 1.2-Diamino-dekan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Agricultural chemicals (non-pesticidal),Corrosion inhibitors and anti-scaling agents,Functional fluids (closed systems),Intermediates,Ion exchange agents,Lubricants and lubricant additives,Paint additives and coating additives not described by other categories
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 4

Skin corrosion, Category 1B

Skin sensitization, Category 1

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H226 Flammable liquid and vapour

H302 Harmful if swallowed

H312 Harmful in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/\u2026

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
ethylenediamine ethylenediamine 107-15-3 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . Do NOT induce vomiting.

4.2 Most important symptoms/effects, acute and delayed

Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to ethylenediamine exposure; therefore, safe threshold limits are difficult to set. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 l/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin bumps with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.

5.2 Specific hazards arising from the chemical

Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Dry.Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 10 ppm (25 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear, colorless Liquid
Colour Water-white liquid
Odour Ammonia-like
Melting point/ freezing point 11\u00baC
Boiling point or initial boiling point and boiling range 118\u00b0C(lit.)
Flammability Class IC Flammable Liquid: Fl.P. at or above 22.78\u00b0C and below 37.78\u00b0C.Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit LOWER 2.5%; UPPER 12% @ 100 DEG C /ANHYDROUS 76%/
Flash point 38\u00b0C
Auto-ignition temperature 380\u00b0C
Decomposition temperature no data available
pH 11.9 @ 25\u00b0C (25% soln)
Kinematic viscosity 0.0154 cP @ 25\u00b0C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) log Kow = -2.04 @ pH 13
Vapour pressure 10 mm Hg ( 20 \u00b0C)
Density and/or relative density 0.899g/mLat 25\u00b0C(lit.)
Relative vapour density 2.07 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.A base. Highly reactive with many compounds. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, hydrogen chloride, mesityl oxide, nitric acid, oleum, AgClO4, sulfuric acid, beta-propiolactone and vinyl acetate. Incompatible with strong acids, strong oxidizers (perchlorate salts), and chlorinated organic compounds. It is also incompatible with halogenated organic compounds and metal halides. May react with nitromethane and diisopropyl peroxydicarbonate. May ignite on contact with cellulose nitrate. Readily absorbs carbon dioxide from the air to give crusty solid deposits. . Ethylenediamine reacts violently with ethylene chlorohydrin. (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1554.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Carbon disulfide reacts violently with ... ethylenediamine.

10.6 Hazardous decomposition products

When heated to decomp it emits toxic fumes of /nitrogen oxides and ammonia/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 500 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 115.7 mg/l/96 hr @ 22\u00b0C (95% confidence limit 98.6-131.6 mg/l) /Static bioassay
  • Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 0.88 mg/l /Conditions of bioassay not specified
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

In one standard dilution test using non-acclimated sewage seed, 24 and 47% of the theoretical BOD was removed after 5 and 20 days, respectively, in fresh water, and 2 and 16%, respectively, in salt water(1). In a second standard dilution test using non-acclimated sewage seed, 0.6 and 17% BOD was removed in 5 days using fresh and salt water, respectively(2). The concentration of the ethylenediamine was 7 to 10 ppm in both studies(1,2). Using acclimated activated sludge, 97.5% COD was removed at a rate of 9.8 mg COD/g/hr (3), 67% of the theoretical BOD was removed in 5 days in a second study(4) and 36 and 70% of the theoretical BOD was removed in 5 and 20 days, respectively, in a third study(1). Ethylenediamine, at a concentration of 100 mg/l, showed a 93 to 95% theoretical BOD loss over a 28 day period in the Japanese MITI test using an activated sludge inoculum(5).

12.3 Bioaccumulative potential

An estimated BCF of less than 1 was calculated for ethylenediamine(SRC), using a log Kow of -2.04(1)and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

12.4 Mobility in soil

Ethylenediamine has two primary amine groups and at the pH range found in most soils it is expected to be partially protonated given a pKa1 of 10.7 and a pKa2 of 7.6(1). An average Koc of 4766 (range=2071 to 6160) was measured for ethylenediamine in six different soils; five were from the vadose zone and one from an aquifer (saturated zone)(2). pH values ranged from 6.0 to 9.6 and the fraction of organic carbon from 0.0024 to 0.0391 for this group of soils. Soils with increased cation exchange capacity and organic content had greater affinity for ethylenediamine(2).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1604 IMDG: UN1604 IATA: UN1604

14.2 UN Proper Shipping Name

ADR/RID: ETHYLENEDIAMINE
IMDG: ETHYLENEDIAMINE
IATA: ETHYLENEDIAMINE

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
ethylenediamine ethylenediamine 107-15-3 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:60.09832 [g/mol]
Molecular Formula:C2H8N2
XLogP3:-2
H-Bond Donor:2
H-Bond Acceptor:2
Rotatable Bond Count:1
Exact Mass:60.068748
MonoIsotopic Mass:60.068748
Topological Polar Surface Area:52
Heavy Atom Count:4
Formal Charge:0
Complexity:6
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Donor Count:2
Feature 3D Cation Count:2
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:3