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Home> Encyclopedia > Hot Product Listed E   > Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-
58-73-1 structure

Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-

Iupac Name:2-benzhydryloxy-N,N-dimethylethanamine
CAS No.:58-73-1
EINECS(EC#): 200-396-7
Molecular Weight:291.81568
Molecular Formula:C17H22ClNO (isomer)
Names and Identifiers
Synonyms

2-(Diphenylmethoxy)-N,N-dimethylethylamine a-(2-Dimethylaminoethoxy)diphenylmethane b-Dimethylaminoethylbenzhydrylether Benzhydramine Dimedrol base Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl- Ethylamine,2-(diphenylmethoxy)-N,N-dimethyl- (7CI,8CI) FAR 90X2 N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine O-Benzhydryldimethylaminoethanol Probedryl

Inchi
InChI=1/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
Canonical Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Properties
Appearance
clear light yellow liquid
Density
1.024
Melting Point
167-172℃
Boiling Point
343.7 oC at 760 mmHg
Flash Point
101.5 oC
HS Code
2922199090
Spectral properties
Intense mass spectral peaks: 58 m/z, 73 m/z, 152 m/z, 165 m/z, 255 m/z
Safety and Handling
Safety

Deadly human poison by an unspecified route. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human systemic effects by ingestion: somnolence, alteration of operant conditioning, changes in psychophysiological tests. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 75mg/kg (75mg/kg) ? Therapie. Vol. 28, Pg. 767, 1973.
guinea pig LD50 subcutaneous 56mg/kg (56mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 189, 1954.
human TDLo oral 714ug/kg (0.714mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Drug Development Research. Vol. 27, Pg. 33, 1992.
man LDLo unreported 7353ug/kg (7.353mg/kg) ? "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 56mg/kg (56mg/kg) ? Yakkyoku. Pharmacy. Vol. 34, Pg. 27, 1983.
mouse LD50 intravenous 29mg/kg (29mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
mouse LD50 oral 160mg/kg (160mg/kg) ? Chimica Therapeutica. Vol. 7, Pg. 224, 1972.
mouse LD50 subcutaneous 50mg/kg (50mg/kg) ? Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
rat LD50 intraperitoneal 280mg/kg (280mg/kg) ? Indian Journal of Medical Research. Vol. 59, Pg. 614, 1971.
rat LD50 intravenous 42mg/kg (42mg/kg) ? Drugs in Japan Vol. -, Pg. 476, 1990.
rat LD50 oral 390mg/kg (390mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
rat LD50 subcutaneous 474mg/kg (474mg/kg) ? Drugs in Japan Vol. -, Pg. 476, 1990.
women TDLo multiple routes 793ug/kg/1H-I (0.793mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Pharmacotherapy Vol. 14, Pg. 492, 1994.
women TDLo oral 30mg/kg (30mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Deutsche Medizinische Wochenschrift. Vol. 120, Pg. 1695, 1995.
women TDLo oral 82mg/kg (82mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Toxicology Letters. Vol. 109(Suppl,
women TDLo oral 178mg/kg (178mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Annals of Emergency Medicine. Vol. 33, Pg. 104, 1999.

Formulations/Preparations
HYDROCHLORIDE...BAX, BENADRYL, BENOCTEN, BENZEHIST, DABYLEN, DOLESTAN, FELBEN, FENYLHIST, HALBMOND, ROHYDRA, SEDOPRETTEN, VALDRENE, WEHYDRYL. /HYDROCHLORIDE/
CAPSULES, 25 & 50 MG; INJECTION (SYRINGES & AMPULS); ELIXIR, 50 MG (SINGLE ADULT DOSES). /HYDROCHLORIDE, FROM TABLE/
Exposure Standards and Regulations
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Specification

?Diphenhydramine (CAS NO.58-73-1), its Synonyms are 2-(Benzhydryloxy)-N,N-dimethylethylamine ; 2-(Diphenylmethoxy)-N,N-dimethylethylamine ; Alledryl ; Allergical ; Amidryl ; Antistominum ; Benzantine ; Benzhydramine ; beta-Dimethylaminoethanol diphenylmethyl ether ; beta-Dimethylaminoethylbenzhydrylether ; Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl- ; Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl- .

Report

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin irritation, Category 2

Eye irritation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H315 Causes skin irritation

H319 Causes serious eye irritation

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
product :
3922-74-5
3922-74-5
Computational chemical data
  • Molecular Weight:291.81568g/mol
  • Molecular Formula:C17H22ClNO
  • Exact Mass:291.138992
  • Monoisotopic Mass:291.138992
  • Complexity:211
  • Rotatable Bond Count:6
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:12.5
  • Heavy Atom Count:20
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:2
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Recommended Suppliers
  • Tel:0086-27-59207850
  • Fax:0086-27-59524646
  • Tel:86-571-88938639
  • Fax:86-571-88938652
  • Tel:86-0-17166540883
  • Fax:86-0-17166540883
  • Tel:86-571-85829152
  • Fax:86-571-85829153
  • Tel:+86-0592-5567629
  • Fax:+86-0592-5567629
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-571-86960370
  • Fax:86-571-86940780
  • Tel:86-371-86658258
  • Fax:86-371-86658258
  • Tel:86-27-83214668
  • Fax:86-27-83214668
  • Tel:+86-025-58535435
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