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Home> Hot Product Listed H   > Hydrochlorothiazide

Hydrochlorothiazide

CAS No.:58-93-5
EINECS(EC#):200-403-3
Molecular Weight:297.73912
Molecular Formula:C7H8ClN3O4S2 (Products with the same molecular formula)
MOL File:58-93-5.mol
Properties
Appearance
white crystalline powder
Density
1.693g/cm3
Melting Point
273-275℃
Boiling Point
577°Cat760mmHg
Refractive Index
1.632
Flash Point
302.7°C
Water
negligible
Solubilities
negligible
Color/Form
Crystals
White to off-white crystalline powder
Stability
Stable. Incompatible with strong oxidizing agents.
Storage temp
2-8°C
Spectral properties
UV max (methanol+trace HCl): 317, 271, 226 nm (A1%/1 cm 130, 654, 1280)
Intense mass spectral peaks: 221 m/z, 269 m/z, 297 m/z
MASS: 74591 (NIST/EPA/MSDC Mass Spectral Database, 1990 Version)
IR: 6020 (Coblentz Society spectral collection)
UV: 608 (Absorption Spectra in the UV and Visible Region, Academic Press, New York)
Safety and Handling
Hazard Codes
Xi,T,F
Risk Statements
R22
Safety Statements
S22;S24/25
Hazard Note

Irritant

Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: Sodium level changes, CHLORINE level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A diuretic. When heated to decomposition it emits very toxic fumes of SOx, Cl?, and NOx.
Hazard Codes: Xi??,? T??,F ?
Risk Statements: 22-42/43-36/38-23/25-36/37/38?
R22:Harmful if swallowed.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/38:Irritating to eyes and skin.?
R23/25:Toxic by inhalation and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24-36/37-45-33-16-7-36/37/39-27-26?
S22:Do not breathe dust.?
S24:Avoid contact with skin.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S33:Take precautionary measures against static discharges.?
S16:Keep away from sources of ignition.?
S7:Keep container tightly closed.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S27:Take off immediately all contaminated clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1230 3/PG 2
RTECS: DK9100000
Hazard Note: Irritant

Cleanup Methods
Should a spill occur while you are handling this chemical, you should dampen the solid spill material with acetone, then transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor tight plastic bag for eventual disposal. solvent wash all contaminated surfaces with acetone followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the safety officer (or other responsible person) has verified that the area has been properly cleaned
Transport
UN 1230 3/PG 2
Formulations/Preparations
Capsules: 12.5 mg: Hydrochlorothiazide Capsules, Mylan; Microzide, Watson. Oral Solution: 50 mg/5 ml: Hydrochlorothiazide Solution, Roxane. Tablets: 25 mg: Aquazide-25, Western Research; HydroDIURIL (scored), Merck; Oretic, Abbott; 50 mg: Aquazide-H, Western Research; Ezide, EconoMed; HydroDIURIL (scored), Merck; 100 mg: Hydrochlorothiazide Tablets, Ivax.
Oral Tablets, film-coated, 250 mg Methylodopa and Hydrochlorothiazide 15 mg: Aldoril (with propylene glycol), Merck; Methyldopa and Hydrochlorothiazide Tablets, Endo, Major, Mylan. 250 mg Methyldopa and Hydrochlorothiazide 25 mg, Aldoril (with propylene glycol), Merck; Methyldopa and Hydrochlorothiazide Tablets, Endo, Major, Mylan; 500 mg Methyldopa and Hydrochlorothiazide 30 mg, Aldoril D (with propylene glycol), Merck. /Methyldopa and hydrochlorothiazide/
Oral Capsules, extended-release: 80 mg Propranolol Hydrochloride and Hydrochlorothiazide 50 mg: Inderide LA, Wyeth-Ayerst; 120 mg Propranolol Hyrochloride Hydrochlorothiazide 50 mg: Inderide LA, Wyeth-Ayerst; 160 mg Propranolol Hydrochloride and Hydrochlorothiazide 50 mg: Inderide LA, Wyeth-Ayerst. Tablets: 40 mg Propranolol Hydrochloride and Hydrochlorothiazide 25 mg, Inderide (scored), Wyeth-Ayerst; Propranolol Hydrochloride and Hydrochlorothiazide Tablets, Barr, Mylan, Purepac, Sidmak; 80 mg Propranolol Hydrochloride and Hydrochlorothazide 25 mg: Inderide (scored), Wyeth-Ayerst; Propranolol Hydrochloride and Hydrochlorothiazide Tablets, Barr, Mylan, Purepac, Sidmak. /Propranolol hydrochloride and hydrochlorothiazide/
Oral Capsules: 37.5 mg Triamterene and Hydrochlorothiazide 25 mg: Dyazide (with benzyl alcohol and povidone), GlaxoSmithKline; 50 mg Triamterene and Hydrochlorothiazide 25 mg: Triameterene and Hydrochlorothiazide Capsules, Geneva, Ivax, Major, Martex; Oral Tablets: 37.5 mg Triamterene and Hydrochlorothiazide 25 mg: Maxzide (scored), Bertek; 75 mg Triamterene and Hydrochlorothiazide 50 mg, Maxzide (scored), Bertek. /Triamterene and Hydrochlorothiazide (Co-triamterzide)/
Oral Capsules: 25 mg with Hydralazine Hydrochloride 25 mg: Hydralazine Hydrochloride with Hydrochlorothiazide Capsules, Major, United Research; Hydra-Zide, Par; 50 mg with Hydralazine Hydrochloride 50 mg: Hydra-Zide, Par; 50 mg with Hydralazine Hydrochloride 100 mg: Hydra-Zide, Par. Tablets: 6.25 mg with Benazepril 5 mg: Lotensin HCT (scored), Novartis; 12.5 mg with Benazepril 10 mg: Lotensin HCT (scored), Novartis; 12.5 mg with Benazepril 20 mg: Lotensin HCT (scored), Novartis; 12.5 mg with Irbesartan 150 mg, Avalide, Bristol-Myers Squibb (also promoted by Sanofi-Synthelabo); 12.5 mg with Irbesartan 300 mg, Avalide, Briston-Meyers Squibb (also promoted by Sanofi-Synthelabo); 12.5 mg with Lisinopril 10 mg: Prinzide, Merck; Zestoretic, AstraZeneca; 12.5 mg with Lisinopril 20 mg: Prinzide, Merck; Zestoretic, AstraZeneca; 12.5 mg with Valsartan 80 mg: Diovan HCT, Novartis; 12.5 mg with Valsartan 160 mg: Diovan HCT, Novartis; 15 mg with Hydralazine Hydrochloride 25 mg and Reserpine 0.1 mg; 25 mg with Benazepril 20 mg: Lotensin HCT (scored), Novartis; 25 mg with Lisinopril 20 mg: Prinzide, Merck; Zestoretic, AstraZeneca. Tablets, film-coated: 6.25 mg with Bisoprolol Fumarate 2.5 mg: Ziac, Lederle; 6.25 mg with Bisoprolol Fumarate 5 mg: Ziac, Lederle; 6.25 mg with Bisoprolol Fumarate 10 mg: Ziac, Lederle; 12.5 mg with Losartan Potassium 50 mg: Hyzaar, Merck; 12.5 mg with Moexipril Hydrochloride 7.5 mg: Uniretic (scored), Schwarz; 12.5 mg with Quinapril Hydrochloride 10 mg (of quinapril): Accuretic (with povidone; scored), Parke-Davis; 12.5 mg with Quinapril Hydrochloride 20 mg (of quinapril): Accuretic (with povidone; scored), Parke-Davis; 25 mg with Losartan Potassium 100 mg: Hyzaar, Merck; 25 mg with Moexipril Hydrochloride 15 mg: Uniretic (scored), Schwarz; 25 mg with Quinapril Hydrochloride 20 mg (of quinapril): Accuretic (with povidone; scored), Parke-Davis. /Hydrochlorothiazide combinations/
Oral Tablets: 25 mg Captopril and Hydrochlorothiazide 15 mg: Capozide (scored), Bristol-Myers Squibb; 25 mg Captopril and Hydrochlorothiazide 25 mg: Capozide (scored), Bristol-Mayers Squibb; Captopril and Hydrochlorothiazide Tablets, Endo, Geneva, Ivax, Mylan, Teva; 50 mg Captopril and Hydrochlorothiazide 15 mg: Capozide (scored), Bristol-Meyers Squibb; Captopril and Hydrochlorothiazide Tablets, Endo, Geneva, Ivax, Mylan, Teva; 50 mg Captopril and Hydrochlorothiazide 25 mg: Capozide (scored), Briston-Meyers Squibb; Captopril and Hydrochlorothiazide Tablets, Endo, Geneva, Ivax, Mylan, Teva. /Captopril and Hydrochlorothiazide/
Oral Tablets: 50 mg Metoprolol Tartrate and Hydrochlorothiazide 25 mg: Lopressor HCT (with povidone; scored), Novartis; 100 mg Metoprolol Tartrate and Hydrochlorothiazide 25 mg: Lopressor HCT (with povidone; scored), Novartis; 100 mg Metoprolol Tartrate and Hydrochlorothiazide 50 mg: Loperssor HCT (with povidone; scored), Novartis. /Metoprolol Tartrate and Hydrochlorothiazide/
Tablets, 25, 50, and 100 mg. Oral solution, 50 mg/5 ml. Concentrated oral solution, 100 mg/ml.
Oral Tablets: 5 mg of Anhydrous Amiloride Hydrochloride and Hydrochlorothiazide 50 mg, Moduretic (scored), Merck. /Amiloride hydrochloride and hydrochlorothiazide/
Oral Tablets: 10 mg Timolol Maleate and Hydrochlorothiazide 25 mg: Timolide (with povidone; scored), Merck. /Timolol Maleate and Hydrochlorothiazide/
Oral tablets: 25 mg Spironolacton adn Hydrochlorothiazide 25 mg. Tablets, film-coated: 25 mg Spironolactone and Hydrochlorothiazide 25 mg: Aldactazide (with povidone), Pharmacia; Spironolactone and Hydrochlorothiazide Tablers, Major, Mutual, Mylan, UDL, URL; 50 mg Spironolactone and Hydrochlorothiazide 50 mg: Aldactazide (with povidone; scored), Pharmacia. /Spironolactone and Hydrochlorothiazide/
Oral Tablets: 5 mg Enalapril Maleate and Hydrochlorothiazide 12.5 mg: Vaseretic, Merck; 10 mg Enalapril Maleate and Hydrochlorothiazide 25 mg: Vaseretic, Merck. /Enalapril Maleate and Hydrochlorothiazide/
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl hydrochlorothiazide, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Hydrochlorothiazide injectable. Implantation or injectable dosage form new animal drugs not subject to certification. Specifications and conditions of use are provided.
Specification

? Hydrochlorothiazide (CAS NO.58-93-5), its Synonyms are 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide ; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide ; 3,4-Dihydrochlorothiazide ; 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ; 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide ; 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide ; Acesistem ; Acuilix ; Acuretic ; Aldactazide 25/25 ; Aldazida ; Aldectazide 50/50 ; Aldoril D30 ; Aldoril D50 ; Apo-Hydro ; Apresazide ; Aquarills ; Aquarius ; Aquazide H ; Aquazide-H ; Bremil ; Briazide ; CCRIS 2082 ; Carozide ; Catiazida ; Chlorizide ; Chlorosulthiadil ; Chlorsulfonamidodihydrobenzothiadiazine dioxide ; Chlorzide ; Chlothia . It is white powder.

Report

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
You should dispose of all waste and contaminated materials associated with this chemical as specified by existing local, state and federal regulations concerning hazardous waste disposal. It is suggested that your contaminated materials should be destroyed by incineration in a special, high temperature (>2000 degrees F) chemical incinerator facility.
Reach Info
Globally, no enterprise has officially registered the substance REACH.
Other official information: ·ECHA Information Page for CAS: 58-93-5 EC: 200-403-3 Hydrochlorothiazide ·ECHA C&L Inventory for CAS: CAS: 58-93-5 EC: 200-403-3 Hydrochlorothiazide
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name hydrochlorothiazide

1.2 Other means of identification

Product number -
Other names 6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin sensitization, Category 1

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
hydrochlorothiazide hydrochlorothiazide 58-93-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Acute symptoms may include dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. May also cause hypersensitivity reactions, skin and mucous membrane irritation. Long term effects may include adverse hematologic reactions including aplastic anemia. ACUTE/CHRONIC HAZARDS: This compound may cause skin and mucous membrane irritation.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher.

5.2 Specific hazards arising from the chemical

Flash point data for this chemical are not available but it is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Should a spill occur while you are handling this chemical, you should dampen the solid spill material with acetone, then transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor tight plastic bag for eventual disposal. solvent wash all contaminated surfaces with acetone followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the safety officer (or other responsible person) has verified that the area has been properly cleaned

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Hydrochlorothiazide tablets and oral solution should be stored in well closed containers at a temperature less than 40\u00b0C, preferably at 15 to 30\u00b0C. Freezing of the oral solution should be avoided.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white crystalline powder
Colour Crystals
Odour Practically odorless
Melting point/ freezing point 273-275\u00baC
Boiling point or initial boiling point and boiling range 577\u00baC at 760mmHg
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 302.7\u00baC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility >44.7 [ug/mL]
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 1.693g/cm3
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Commercially available hydrochlorothiazide tablets have an expiration date of 3 or 5 years following the date of manufacture depending on the packaging.

10.3 Possibility of hazardous reactions

Strong reducing agents will produce toxic gases ammonia and hydrogen sulfide.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

When heated to decomposition it emits very toxic fumes of /sulfur oxides, hydrogen chloride, and nitrogen oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 3,080 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence for the carcinogenicity of hydrochlorothiazide in humans. There is inadequate evidence for the carcinogenicity of hydrochlorothiazide in experimental animals. Overall evaluation: Hydrochlorothiazide is not classifiable as to its carcinogenicity in humans (Group 3).

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1230 IMDG: UN1230 IATA: UN1230

14.2 UN Proper Shipping Name

ADR/RID: METHANOL
IMDG: METHANOL
IATA: METHANOL

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
hydrochlorothiazide hydrochlorothiazide 58-93-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.

16.Other information

Information on revision

Creation Date Aug 18, 2017
Revision Date Aug 18, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Computational chemical data

Molecular Weight:297.73912 [g/mol]
Molecular Formula:C7H8ClN3O4S2
XLogP3:-0.1
H-Bond Donor:3
H-Bond Acceptor:7
Rotatable Bond Count:1
Exact Mass:296.964475
MonoIsotopic Mass:296.964475
Topological Polar Surface Area:135
Heavy Atom Count:17
Formal Charge:0
Complexity:494
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:4
Feature 3D Donor Count:3
Feature 3D Cation Count:1
Feature 3D Ring Count:2
Effective Rotor Count:1.6
Conformer Sampling RMSD:0.6
CID Conformer Count:2

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