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Home> Encyclopedia > Hot Product Listed S   > Sulfaquinoxaline
59-40-5 structure

Sulfaquinoxaline

Iupac Name:4-amino-N-quinoxalin-2-ylbenzenesulfonamide
CAS No.:59-40-5
EINECS(EC#): 200-423-2
Molecular Weight:300.34
Molecular Formula:C14H12N4O2S (isomer)
Names and Identifiers
Synonyms

N-(2-QUINOXALINYL)SULFANILAMIDE N'-2-QUINOXALYL SULFANILAMINE SULFABENZPYRAZINE SULFACHINOXALIN SULFACHINOXALINE sulfa-q 20 SULFAQUINOXALIN

Inchi
InChI=1S/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18)
InChkey
NHZLNPMOSADWGC-UHFFFAOYSA-N
Canonical Smiles
C1=CC=C2C(=C1)N=CC(=N2)NS(=O)(=O)C3=CC=C(C=C3)N
Properties
Appearance
Crystalline Solid
Density
1.3196 (rough estimate)
Melting Point
247-2480C
Boiling Point
551.1 °C at 760 mmHg
Refractive Index
1.6440 (estimate)
Flash Point
287.1 °C
Solubility
50 mg/ml
Color/Form
Minute crystals
Stability
Stable at normal temperatures and pressures.
HS Code
2935009090
Storage temp
Keep tightly closed.
Spectral properties
UV max: (pH 6.6 in water): 252, 360 nm (E at 1% and 1cm = 1110, 275)
IR: 3685 (Sadtler Research Laboratories IR prism collection)
UV: 1-563 (Phillip et al., Organic Electronic Spectral Data, John Wiley and Sons, New York)
Safety and Handling
Hazard Codes
Xn
Risk Statements
22-42/43
Safety Statements
22-36/37-45
Safety

Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and SOx.
 

Hazard Codes: Xn
Risk Statements:
22:  Harmful if swallowed 
42:  May cause sensitization by inhalation
43:  May cause sensitization by skin contact
Safety Statements:
22:  Do not breathe dust
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 15gm/kg (15000mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A370, Pg. 1983,
rat LD50 oral 1370mg/kg (1370mg/kg)   Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982Vol. 16NOV1982,
Formulations/Preparations
Veterinary-labeled product(s): 200 mg per mL (OTC) (Sulfa -Q 20%; GENERIC). 319.2 mg per mL (OTC) (Optimed; 31.92% Sul-Q-Nox).
Sulquin 6-50; Liquid Sul-Q-Nox; Sulfa-Nox Liquid; Sulfa-Nox Concentrate
Exposure Standards and Regulations
Oral dosage form new animal drugs. Sulfamerazine, sulfamethazine, and sulfaquinoxaline powder. ... Conditions of use: (1) Chickens ...(A) As an aid in the control of coccidiosis caused by Eimeria tenella and E. necatrix susceptible to sulfamerazine, sulfamethazine, and sulfaquinoxaline ... (B) As an aid in the control of acute fowl cholera caused by Pasteurella multocida susceptible to sulfamerazine, sulfamethazine, and sulfaquinoxaline ... (2) Turkeys ... (A) As an aid in the control of coccidiosis caused by Eimeria meleagrimitis and E. adenoeides susceptible to sulfamerazine, sulfamethazine, and sulfaquinoxaline ... (B) As an aid in the control of acute fowl cholera caused by Pasteurella multocida susceptible to sulfamerazine, sulfamethazine, and sulfaquinoxaline ... .
Oral dosage new animal drugs. Sulfaquinoxaline drinking water. ... Conditions of use. It is used in drinking water as follows: (1) Chickens. (i) As an aid in the control of outbreaks of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti. ... (2) Turkeys. (i) As an aid in the control of outbreaks of coccidiosis caused by Eimeria meleagrimitis and E. adenoeides. ... 3) Chickens and turkeys. (i) As an aid in the control of acute fowl cholera caused by Pasteurella multocida susceptible to sulfaquinoxaline and fowl typhoid caused by Salmonella gallinarum susceptible to sulfaquinoxaline. ... (4) Cattle and calves. (i) For the control and treatment of outbreaks of coccidiosis caused by Eimeria bovis or E. zurnii.
Oral dosage new animal drugs. Sulfaquinoxaline drench. ... Conditions of uses: ... For the control and treatment of outbreaks of coccidiosis in cattle and calves caused by Eimeria bovis or E. zurnii.
A tolerance of 0.1 part per million is established for negligible residues of sulfaquinoxaline in the uncooked edible tissues of chickens, turkeys, calves, and cattle.
New animal drugs for use in animal feeds. Requirement of a medicated feed mill license. Sulfaquinoxaline is included on this list.
New animal drugs for use in animal feeds. Sulfaquinoxaline. ... Conditions of use: (1) Chickens ... As an aid in preventing outbreaks of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti under average conditions of exposure. ... As an aid in preventing outbreaks of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti where excessive exposure to coccidia is increased due to overcrowding or other management factors. ... As an aid in controlling outbreaks of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti. ... (2) Turkeys ... As an aid in preventing outbreaks of coccidiosis caused by Eimeria meleagrimitis and E. adenoeides. ... As an aid in controlling outbreaks of coccidiosis caused by Eimeria meleagrimitis, and E. adenoeides. ... (3) Chickens and turkeys ... As an aid in the control of acute fowl cholera caused by Pasteurella multocida susceptible to sulfaquinoxaline and fowl typhoid caused by Salmonella gallinarum susceptible to sulfaquinoxaline. ... (4) Rabbits ... As an aid in preventing coccidiosis caused by Eimeria stiedae. ... As an aid in controlling outbreaks of coccidiosis caused by Eimeria stiedae.
The Generic Animal Drug and Patent Restoration act requires that each sponsor of an approved animal drug must submit to the FDA certain information regarding patents held for the animal drug or its method of use. The Act requires that this information, as well as a list of all animal drug products approved for safety and effectiveness, be made available to the public. Sulfaquinoxaline is included on this list.
Other Preventative Measures
People who handle this medication should avoid contact with eyes, skin, or clothing to prevent eye and skin burns. In case of contact, the areas affected should be flushed for at least fifteen minutes; medical attention should be sought for eye exposure. Keep out of the reach of children.
Specification

 Sulfaquinoxaline (59-40-5) also can be called Sulfabenzpyrazine ; N,N-Di(.beta.-hydroxyethyl)aniline ; 4-Amino-N-(2-quinoxalinyl)benzenesulfonamide ; N1-(2-Quinoxalyl)sulfanilamide ; Compd 3-120 .

Octanol/Water Partition Coefficient
log Kow = 1.68
Report

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin sensitization, Category 1

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Computational chemical data
  • Molecular Weight:300.34g/mol
  • Molecular Formula:C14H12N4O2S
  • Compound Is Canonicalized:True
  • XLogP3-AA:1.7
  • Exact Mass:300.068
  • Monoisotopic Mass:300.068
  • Complexity:442
  • Rotatable Bond Count:3
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:6
  • Topological Polar Surface Area:106A^2
  • Heavy Atom Count:21
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADccBzsABAAAAAAAAAAAAAAAAAAAAAAAA8YIAAAAAAAACx9AAAHAQQQAAACAjBVgQ98bJIEAKg ATZnZHDCgD0xEiAI2Dg4dJiIYOLAkZGUIAhgkALIyCcQAAAAAAQAAAAAACAACAAAAAAAQAAAAAAA AA==
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