Products
  • Products
  • Buy offers
  • Encyclopedia
  • Msds lib
  • Synthesis
  • Reach Info
  • Suppliers
Home> Encyclopedia > Hot Product Listed A   > Amoxicillin trihydrate
61336-70-7 structure

Amoxicillin trihydrate

Iupac Name:(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate
CAS No.:61336-70-7
EINECS(EC#): 612-127-4
Molecular Weight:419.449
Molecular Formula:C16H25N3O8S (isomer)
Names and Identifiers
Synonyms

(2s,5r,6r)-6-((r)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid trihydrate (2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate (2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate (2s,5r,6r)-6-{[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2r)-amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate, (2s,5r,6r)- 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2s-(2alpha,5alpha,6beta(s*)))- 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate(2s-(2alpha,5alpha,6beta(s*)))- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-,trihydrate, (2S,5R,6R)- (9CI) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate,[2S-[2a,5a,6b(S*)]]- 61336-70-7 6beta-[(2r)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid trihydrate 804826J2HU AC1L1XZ7 a-gram AK143350 AKOS015896673 alfamox Alfoxil alpha-amino-p-hydroxybenzylpenicillin trihydrate AM 7 amodex amoksicillin amoksicillin forte Amoksina amophar amoran amox amoxicillin (usp) amoxicillin [usan:usp:inn:ban:jan] amoxicillin [usan] amoxicillin hydrate (1:3) amoxicillin hydrate (jp17) amoxicillin pulsys Amoxicillin trihydrate for performance verification, European Pharmacopoeia (EP) Reference Standard Amoxicillin trihydrate, British Pharmacopoeia (BP) Reference Standard amoxicillin trihydrate, european pharmacopoeia (ep) reference standard amoxicillin trihydrate, pharmaceutical secondary standard amoxicillin trihydrate, vetranal(tm), analytical standard amoxicillin, united states pharmacopeia (usp) reference standard Amoxicilline (INN) amoxicillin-ratiopharm amoxicillin-trihydrat amoxicillin-trihydrate amoxidal amoxi-diolan amoxil amoxil (tn) Amoxil trihydrate amoxillat amoxina amoxine amoxipen Amoxipen trihydrate amoxi-wolff Amoxycillin Trihydrate Amoxyl apc-111 api0007243 Atoksilin benzoral BIA0101 brl 2333 brl 2333 trihydrate c16h19n3o5s.3h2o certified reference material CHEBI:51254 ciblor clamoxyl D00229 Demoksil dispermox (tn) DR002561 drg-0075 DTXSID2022599 dura ax eupen flemoxine galenamox gramidil himinomax I06-2211 izoltil KB-276762 kentrocyllin KM0495 KS-5338 Largopen larotid LS-149722 matasedrin metifarma mfcd00072029 Moksilin MOLPORT-006-823-781 moxaline Moxaline trihydrate moxatag MQXQVCLAUDMCEF-CWLIKTDRSA-N neotetranase novabritine pacetocin pamocil paradroxil pasetocin pasetocin (tn) polymox Promoxil Remoxil robamox sawacillin siganopen simplamox sintopen ST24045965 Topramoxin trihydrate trimox unii-804826j2hu uro-clamoxyl utimox velamox wymox zamocillin zamocilline zimox zx-afc000593

Inchi
InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1
InChkey
MQXQVCLAUDMCEF-CWLIKTDRSA-N
Canonical Smiles
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.O.O.O
Isomers Smiles
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C
Properties
Appearance
A White CRYSTALLINE powder
Density
1.54
Melting Point
>200°C (dec.)
Boiling Point
743.2 °C at 760 mmHg Vapour
Refractive Index
302 ° (C=0.1, H2O)
Flash Point
403.3 °C
Solubility
1 G SOL IN ABOUT 370 ML WATER, ABOUT 2000 ML ALC, ABOUT 290 ML PHOSPHATE BUFFER (1%, PH 7), ABOUT 330 ML METHANOL
HS Code
29411000
Storage temp
2-8°C
Spectral properties
SPECIFIC OPTICAL ROTATION: +248 DEG TO +268 DEG
Safety and Handling
Hazard Codes
Xn
Risk Statements
R42/43
Safety Statements
S36
Safety

Hazard Codes of Amoxycillin trihydrate (CAS NO.61336-70-7):?HarmfulXn,IrritantXi
Risk Statements: 42/43
42/43: May cause sensitization by inhalation and skin contact??
Safety Statements: 36-36/37-22
36:Wear suitable protective clothing
36/37: Wear suitable protective clothing and gloves
22: Do not breathe dust???
RTECS: XH8300000

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3590mg/kg (3590mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
mouse LD50 oral > 25gm/kg (25000mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
mouse LD50 subcutaneous > 20gm/kg (20000mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
rabbit LD50 oral > 12500mg/kg (12500mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
rat LD50 intraperitoneal 2870mg/kg (2870mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
rat LD50 oral > 15gm/kg (15000mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg) ? Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973.

Formulations/Preparations
AMOXICILLIN (AMOXIL, LAROTID) IS AVAILABLE FOR ORAL USE IN CAPSULES (250 OR 500 MG), AS ORAL SUSPENSION (125 OR 250 MG/5 ML), & AS PEDIATRIC DROPS (50 MG/ML).
Exposure Standards and Regulations
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Specification

?Amoxycillin trihydrate , its cas register number is 61336-70-7. It also can be called 4-Acetamido-2-ethoxybenzoesaeuremethylester ; and 6-[2-Amino-2-(4-hydroxyphenyl)-acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate .

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin sensitization, Category 1

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Computational chemical data
  • Molecular Weight:419.449g/mol
  • Molecular Formula:C16H25N3O8S
  • Compound Is Canonicalized:True
  • Exact Mass:419.136
  • Monoisotopic Mass:419.136
  • Complexity:590
  • Rotatable Bond Count:4
  • Hydrogen Bond Donor Count:7
  • Hydrogen Bond Acceptor Count:10
  • Topological Polar Surface Area:161A^2
  • Heavy Atom Count:28
  • Defined Atom Stereocenter Count:4
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:4
  • CACTVS Substructure Key Fingerprint: AAADceB7PABAAAAAAAAAAAAAAABYAWAAAAAwAAAABYAAAAABAAAAHgQQCAAADCzF2ASyDoPAAgiI AiHSGACCAABgIBAIiIGODIgKZjqilTOUcABk1hG4mAeY2IGOIAAAAAAAAABAAAAAAAAAAAAAAAAA AA==
Recommended Suppliers
  • Tel:0086-27-59207850
  • Fax:0086-27-59524646
  • Tel:86-571-88938639
  • Fax:86-571-88938652
  • Tel:+86-0592-5567629
  • Fax:+86-0592-5567629
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-21-61124658
  • Fax:86-21-61294103
  • Tel:86-188-74586545
  • Fax:86-27-83214668
  • Tel:+86-025-58535435
  • Fax:
  • Tel:0086-531-58773055
  • Fax:0086-531-58773066
  • Tel:86-21-61723543
  • Fax:86-21-33250189
  • Tel:86-27-59009407
  • Fax:86-27-59707018
 
<