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Home> Hot Product Listed M   > Malathion

Malathion

CAS No.:121-75-5
EINECS(EC#):204-497-7
Molecular Weight:330.358
Molecular Formula:C10H19O6PS2 (Products with the same molecular formula)
MOL File:121-75-5.mol
Names and Identifiers
Synonyms

O,O-Dimethyl S-(1,2-dicarbethoxyethyl) thiothionophosphate Detmol MA Sumitox Karbofos Carbetox Dicarboethoxyethyl O,O-dimethyl phosphorodithioate Maldison Zithiol Diethyl mercaptosuccinic acid, S-ester of O,O-dimethyl phosphorodithioate Ortho Malathion Malaphos Diethyl (dimethoxyphosphinothioylthio) butanedioate O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat Compound 4049 Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester Hilthion 25WDP NA 2783 Prioderm Maltox MLT Fosfotion Diethyl mercaptosuccinate S-ester with O,O-dimethyl phosphorodithioate Chemathion Gammaxine Malmed Hilthion Malathion LV Concentrate Taskil O,O-Dimethyl S-(1,2-dicarbethoxyethyl) phosphorodithioate Kop-thion Derbac-M S-[1,2-Bis(carbethoxy)ethyl] O,O-dimethyl dithiophosphate Forthion EL 4049 Malaphele Malathion ULV Malathion E50 Carbethoxy malathion S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate Diethyl (dimethoxyphosphinothioylthio)succinate Moscarda TM-4049 O,O-Dimethyl-S-(1,2-di(ethoxycarbonyl)ethyl) phosphorodithioate Sadofos Diethyl mercaptosuccinic acid O,O-dimethyl phosphorodithioate Sadofos 30 SF 60 Maltox Insecticide No. 4049 Malatol O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate AC 26691 MLT S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophasphat Mercaptothion Malation S-(1,2-Dicarbethoxyethyl) O,O-dimethyl phosphorodithioate Radotion Diethyl 2-(dimethoxyphosphinothioylthio)succinate Oleophosphothion Malamar NCI-C00215 Carbofos S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl phosphorodithioate O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorothioate Phosphothion Mercaptosuccinic acid diethyl ester Malatox TAK Mercaptotion Kypfos Malacide Emmatos extra Mercaptosuccinic acid diethyl ester, S-ester with O,O-dimethyl phosphorothioate Malathione Carbetovur Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate Cythion Malakill Ovide Organoderm Fyfanon Etiol ENT 17,034 S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato Malasol Malamar 50 1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate Carbophos Fosfotion 550 EthiolacarMalathion Malagran Malathon Malaspray Vegfru malatox OMS 1 Malataf 1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphordithioate Emmatos Cleensheen O,O-Dimethyl dithiophosphate diethylmercaptosuccinate Fosfothion Extermathion Celthion Vetiol Staeubol-PuderButanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester Calmathion O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate Malathiozoo Experimental insecticide 4049 [(Dimethoxyphosphinothioyl)thio]butanedioic acid, diethyl ester American Cyanamid 4,049 Latka 4049 Formal Diethyl [(dimethoxyphosphinothoiyl)thio]butanedioate Siptox I Malphos S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate Sadophos Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) Malafor Cimexan Malathyne Diethyl mercaptosuccinate, O,O-dimethyl thiophosphate O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate Suleo M Four thousand forty-nine Malathyl

Inchi
InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3
InChkey
JXSJBGJIGXNWCI-UHFFFAOYSA-N
Canonical Smiles
CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC
Properties
Appearance
Deep Brown to Yellow Liquid
Density
1.2076
Melting Point
2.85℃
Boiling Point
156℃
Vapour
3.9E-06mmHg at 25°C
Refractive Index
1.508
Flash Point
186.7 °C
Water
0.0145 g/100 mL
Solubilities
0.0145 g/100 mL
Color/Form
Clear colorless liquid when pure
Deep brown to yellow liquid
Deep-brown to yellow liquid ... [Note: A solid below 37 degrees F].
Stability
Stable. Incompatible with oxidizing agents, metals.
Storage temp
APPROX 4°C
Spectral properties
Index of refraction: 1.4985 @ 25 deg C/D
Index of refraction: 1.4960 @ 20 deg C/D
IR: H587 (Sadtler Research Laboratories Prism Collection)
MASS: 239 (Aldermaston, Eight Peak Index of Mass Spectra, UK)
Malathion absorbs light at wavelengths > 290 nm [Gore RC et al; J Assoc Off Anal Chem 54: 1040-82 (1971)] PubMed Abstract
Intense mass spectral peaks: 125 m/z (100%), 173 m/z (98%), 93 m/z (96%), 158 m/z (54%)
Intense mass spectral peaks: 127 m/z, 285 m/z, 330 m/z
Safety and Handling
Hazard Codes
Xn
Risk Statements
R22;R50/53
Safety Statements
S2;S24;S60;S61
HazardClass
6.1(b)
Safety

A human poison by ingestion and skin contact. Can penetrate intact skin. An experimental poison by ingestion, inhalation, intraperitoneal, intravenous, intraarterial, and subcutaneous routes. Human systemic effects by ingestion: coma, blood pressure depression, and difficulty in breathing. Questionable carcinogen. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Has caused allergic sensitization of the skin. An organic phosphate cholinesterase inhibitor. When heated to decomposition it emits toxic fumes of POx and SOx. See also PHOSPHATESPARATHION
Hazard Codes: Xn;N;F
Risk Statements: 22-50/53-67-65-38-11
22:? Harmful if swallowed?
50/53:? Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment?
67:? Vapors may cause drowsiness and dizziness?
65:? Harmful: May cause lung damage if swallowed?
38:? Irritating to the skin?
11:? Highly Flammable
Safety Statements: 2-24-60-61-62
2:? Keep out of the reach of children?
24:? Avoid contact with skin?
60:? This material and/or its container must be disposed of as hazardous waste?
61:? Avoid release to the environment. Refer to special instructions safety data sheet?
62:? If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
RIDADR:? UN 2783
HazardClass:? 6.1(b)

PackingGroup
III
Skin, Eye, and Respiratory Irritations
Irritating to the eyes.
Cleanup Methods
1. VENTILATE AREA OF SPILL OR LEAK. 2. COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL.
Environmental consideration: Landspill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder.
Environmental consideration: Water spill: If dissolved ... apply activated carbon at ten times the spilled amount /in region of 10 ppm or greater concentration/. Remove trapped material with suction hoses. Use mechanical dredges, or lifts to remove immobilized masses of pollutants and precipitates.
Spills of malathion on floors shall be absorbed with absorbing clay. Sweeping compound may be utilized to facilitate the removal of all visible traces of malathion contaminated clay. Equipment and fixtures contaminated with malathion shall be decontaminated with an alkaline solution (5% sodium hydroxide).
... Alternative treatment process for spent filter cake from malathion mfr requires the following steps: (1) hydrolysis; (2) steam stripping; (3) decantation; (4) composting; & (5) biological treatment.
Ultraviolet radiation in conjunction with ozone is a highly effective degradation technique for malathion ...
Hydrolysis: The overalls polluted with malathion should be shaken and soaked in a soap-and-soda soln for 6-8 hr. Then the overalls must be washed 2-3 times in a hot soap-and-soda soln and rinsed carefully. Containers are decontaminated with 5% caustic or washing soda (300-500 g per 10 l of water). The containers are filled with this soln, kept for 5-12 hr, then washed with ample water. If soda is not at hand, wood ash may be used instead.
Transport
UN 2783
Fire Fighting Procedures
Dry chemicals, carbon dioxide for small fires. Water spray, foam for large fires.
AREA SURROUNDING FIRE SHOULD BE DIKED TO PREVENT WATER RUNOFF.
WEAR SELF CONTAINED BREATHING APPARATUS (OR RESPIRATOR FOR ORGANOPHOSPHATE PESTICIDES) AND RUBBER CLOTHING WHILE FIGHTING FIRES OF MALATHION WITH CHLORINE BLEACH SOLN. ALL CLOTHING CONTAMINATED BY FUMES AND VAPORS MUST BE DECONTAMINATED.
Extinguish fire using agent suitable for type of surrounding fire.
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/
Fire Potential
It is combustible though it may take some effort to ignite.
Commercially available /pharmaceutical/ preparation is flammable.
Formulations/Preparations
WP (25%, 50%), EC (5 LB AND 8 LB PER USA GAL); DUSTS (4%, 5%); AEROSOLS (95%) (9.7 LB/USA GAL) FOR ULTRA LOW VOL USE ...
MALATHION ULTRA LOW VOL CONCN CONTAINS 91% O,O-DIMETHYL S-(1,2-DICARBETHOXYETHYL) PHOSPHORODITHIDATE ...
Flair (Insecticide/Repellant) /contains:/ Pyrethrins: 0.06%; Piperonyl butoxide (technical): 0.48%; Malathion: 0.50%; Carbaryl: 0.50%; Butoxypropylene glycol: 5.0%; 2,3:4,5-Bis(2-butylene) tetrahydro-2-furaldehyde: 0.14%; Petroleum distillate: 17.85%; Inert ingredients: 75.47%.
Flea off dip contains: Malathion ... 53.0%; xylene: 15.0%; inert ingredients: 32.0%.
Kill-A-Mite /contains:/ malathion: 15.34%; gamma isomer of benzene hexachloride (lindane): 2.0%; xylene: 12.00%; mineral seal oil: 57.46%; inert ingredients: 13.20%.
Paladin contains: Pyrethrins: 0.06%; Piperonyl butoxide (technical): 0.48%; 2,3:3,5-bis(2-butylene) tetrahydro-2-furaldehyde: 0.24%; malathion: 0.50%; petroleum distillate: 0.97%; inert ingredients: 97.76%.
Mixtures include: Malatox P (Siapa), EC (475 g malathion + 196 g parathion/kg); Saitofos (Siapa), EC (20 g malathion + 270 g methoxychlor + 100 g parathion/kg). Discontinued mixtures include: Combat Vegetable Insecticide (Fisons PLC), (malathion + bioresmethrin).
Dust, emulsifiable concentrate, oil solutions, powder, ULV concentrate, wettable powder
EC; WP; DP; UL. Mixtures (malathion +) fenitrothion; parathion; parathion-methyl; dichlorvos; methoxychlor + parathion; piperonyl butoxide + pyrethrins
DOT Emergency Guidelines
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Fire or Explosion: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Health: Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Fire: Small fires: Dry chemical, CO2, water spray or regular foam. Large fires: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Do not scatter spilled material with high pressure water streams. Dike fire-control water for later disposal. Fire involving tanks: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ Spill or Leak: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. Avoid inhalation of asbestos dust. Small dry spills: With clean shovel place material into clean, dry container and cover loosely; move containers from spill area. Small spills: Take up with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. /Environmentally hazardous substances, liquid, NOS/
/GUIDE 171: SUBSTANCES (LOW TO MODERATE HAZARD)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Environmentally hazardous substances, liquid, NOS/
Reactivities and Incompatibilities
Strong oxidizers, magnesium, alkaline pesticides [Note: Corrosive to metals].
Other Preventative Measures
If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Keep upwind. ... Avoid breathing vapors, or dusts. Wash away any material which may have contacted the body with copious amounts of water, or soap and water.
Nonimpervious clothing which becomes contaminated with malathion should be removed promptly and not reworn until the malathion is removed from the clothing. Employees should be provided with and required to use splash proof safety goggles where liquid malathion may contact the eyes. Where there is any possibility that employees' eyes may be exposed to malathion, an eye wash fountain should be provided within the immediate work area for emergency use. Skin that becomes contaminated with malathion should be promptly washed or showered with soap or mild detergent and water to remove any malathion. ... Eating and smoking should not be permitted in areas where malathion is handled, processed, or stored.
Good industrial hygiene practices recommend that engineering controls be used to reduce environmental concentrations to the permissible exposure level. However, there are some exceptions where respirators may be used to control exposure. Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. ... In addition to respirator selection, a complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation.
Employees shall be required to shower at the end of each shift.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Keep /material/ away from food, drink & animal feeding stuffs.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
In some situations where personnel may become accidently contaminated ... it is necessary to provide shower bath in addition to the usual washing facilities. Special arrangements for cleaning clothing & overalls may be necessary ... /Pesticides/
Special aircraft should preferably be used for spraying or dusting toxic organophosphorus pesticides. ... Aerial spraying or dusting gives rise to clouds which spread over larger surfaces than clouds produced by ground application. Aerial spraying should therefore be carried out on windless days only. Residential areas, water supply sources, etc must be avoided. ... When aircraft approaches, signalmen /guiding the aircraft/ should leave the windward side. ... The local population should be informed about the site & time of aerial pesticide treatment. Access of unauthorized persons & especially children to the area to be treated must be ... forbidden. Warning signs should be placed at the limits of the area. Ground spraying must be carried out with compressed-air spraying equipment towed by tractors with closed cabs. /Organophosphorus pesticides/
Small packages of pesticides are preferable for individual application in order to limit the quantities to be weighed & metered. A special vessel with long stirring rod for dilution & suspension of the poison must be available in order to reduce manual handling to a minimum. The strict observance of hygiene rules--no smoking & no food intake during work. Thorough washing with soap after work, changing protective clothing before going home--is of utmost importance. /Organophosphorus pesticides/
Containers ... should be cleaned with a suspension of bleaching powder in water or with other alkaline soln after soaking for 24 hr and then be rinsed with hot water. /Organophosphorus pesticides/
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. /Organophosphorus pesticides, liquid, NOS/
Personnel protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Organophosphorus pesticides, liquid, NOS/
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. /Organophosphorus pesticides, solid, NOS/
Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. If contact with the material anticipated, wear appropriate protective clothing. /Organophosphorus pesticides, solid, NOS/
Parathion and possibly other organophosphate insecticide residues may persist in clothing, despite repeated laundering. /Organophosphates and related compounds/
Do not drink alcoholic beverages before or during spraying since alcohol promotes absorption of organic phosphates. /Organic phosphates/
Protective Equipment and Clothing
Employees should be provided with and required to use ... face shields (eight inch minimum), and other appropriate protective clothing necessary to prevent repeated, or prolonged skin contact with malathion.
Any employee whose work involves likely exposure of the skin to malathion or malathion formulations, eg, mixing or formulating, shall wear full body coveralls, or the equivalent, impervious gloves, and footwear. When there is danger of malathion coming in contact with the eyes, safety goggles shall be provided and worn.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Recommendations for respirator selection. Max concn for use: 100 mg/cu m. Respirator Class(es): Any chemical cartridge respirator with organic vapor cartridge(s) in combination with a dust, mist, and fume filter. Any supplied-air respirator.
Recommendations for respirator selection. Max concn for use: 250 mg/cu m. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s) in combination with a high-efficiency particulate filter. Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter. Any powered, air-purifying respirator with organic vapor cartridge(s) in combination with a dust, mist, and fume filter. May require eye protection. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.
Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/
WORKERS HANDLING AND APPLYING ORGANOPHOSPHATE PESTICIDES (OPP) MUST ... BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES, AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. THE SIGNALMEN FOR AERIAL DUSTING OPERATIONS SHOULD BE EQUIPPED WITH A HAT AND CAPE MADE OF POLYVINYL CHLORIDE OR A FABRIC IMPREGNATED WITH A WATER REPELLENT. /PESTICIDES, ORGANOPHOSPHORUS/
Specification

?Malathion ,?its cas register number is 121-75-5. It also can be called? ((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester ; American cyanamid 4,049 ; Butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, diethyl ester ; Camathion ;
?Carbethoxy malathion ; Dicarboethoxyethyl O,O-dimethyl phosphorodithioate ; Dorthion ; Ethiolacar ; Forthion ; Hilthion ;
Karbofos?; Malacide ; Mercaptosuccinic acid diethyl ester ; O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) dithiophosphate ;
?Oleophosphothion ; Paladin ; Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate ; S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate ; Sadophos ; Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate ; Sumitox . Malathion (CAS NO.121-75-5) is a deep brown to yellow liquid

Octanol/Water Partition Coefficient
log Kow= 2.36
Report

IARC Cancer Review: Group 3 IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal No Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 30 ,1983,p. 103.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* ?? National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-24 ,1978. ; No Evidence: rat NCITR* ?? National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-192 ,1979. . EPA Genetic Toxicology Program.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MALATHION MAY BE DISPOSED OF BY ABSORBING IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL ... & /DISPOSING OF SO AS TO MEET LOCAL, STATE, & FEDERAL REGULATIONS/.
Incineration together with flammable solvent in furnace equipped with afterburner and scrubber is recommended.
The following wastewater treatment technologies have been investigated for Malathion: Biological treatment and reverse osmosis.
Malathion is reported to be "hydrolyzed almost instantly" at pH 12; 50% hydrolysis at pH 9 requires 12 hr. Alkaline hydrolysis under controlled conditions (0.5 N NAOH in ethanol) /0.5 N sodium hydroxide in alcohol/ gives quantitative yields of (CH30)2P(S)SNA, whereas hydrolysis in acidic media yields (CH30)2P(S)OH. On prolonged contact with iron or iron-containing material, it is reported to break down and completely lose insecticidal activity. Incineration together with a flammable solvent in a furnace equipped with afterburner and scrubber is recommended. Recommendable methods: Incineration & landfill. Peer review: Only small amt may be landfilled. (Peer-review conclusions of an IRPTC expert consultation (May 1985))
Molten salt combustion: The melts contained either sodium carbonate or potassium carbonate. The use of potassium carbonate is of interest because the combustion product, potassium chloride can be used as a fertilizer. Destruction of the pesticide was greater than 99.9%. No pesticides were detected in the melt; however, traces of pesticides were detected in the off-gas. The conc of pesticides in the off-gas were generally well below the TLV.
All organic pesticides, whether of botanical or synthetic origin, can be destroyed by incineration. /Organic pesticides/
Manufacturers or formulators of very large amounts of pesticides may find it advantageous to build incinerators adequate to destroy all organic pesticides and equipped with scrubbers to remove acid wastes. /Organic pesticides/
Reach Info
Globally, no enterprise has officially registered the substance REACH.
Other official information: ·ECHA Information Page for CAS: 121-75-5 EC: 204-497-7 Malathion ·ECHA C&L Inventory for CAS: CAS: 121-75-5 EC: 204-497-7 Malathion
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name malathion

1.2 Other means of identification

Product number -
Other names mercaptothion

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Organophosphates and carbamates
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin sensitization, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H317 May cause an allergic skin reaction

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P391 Collect spillage.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
malathion malathion 121-75-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Exposure to fumes from a fire or to liquid causes headache, blurred vision, constricted pupils of the eyes, weakness, nausea, cramps, diarrhea, and tightness in the chest. Muscles twitch and convulsions may follow. The symptoms may develop over a period of 8 hours. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Vapors and fumes from fires are hazardous. They include sulfur dioxide and phosphoric acid. Behavior in Fire: Gives off hazardous fumes. Area surrounding fire should be diked to prevent water runoff. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. See Chemical Dangers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in an area without drain or sewer access. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature 2 - 8\u00b0C

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 10 mg/cu m. Skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Deep Brown to Yellow Liquid
Colour Colorless or slightly yellow
Odour Skunk-like odor
Melting point/ freezing point 2.85\u00baC
Boiling point or initial boiling point and boiling range 156\u00baC
Flammability Class IIIB Combustible Liquid: Fl.P. at or above 93.33\u00b0C., but may be difficult to ignite.Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 186.7\u00baC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:0.0145 g/100 mL
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 3.9E-06mmHg at 25\u00b0C
Density and/or relative density 1.2076
Relative vapour density (air = 1): 11.4
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Malathion is combustible but ignites with difficulty.MALATHION is a yellow to brown liquid that solidifies at 2.9\u00b0 C, moderately toxic. Organic phosphate insecticide, acts as an inhibitor of cholinesterase. When heated to decomposition it emits toxic fumes of oxides of sulfur and phosphorus [Lewis, 3rd ed., 1993, p. 789].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible materials: Strong oxidizing agents. Corrodes metal.

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions - Carbon oxides, sulfur oxides, oxides of phosphorus

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 1025 mg/kg
  • Inhalation: LC50 Rat inhalation 43,790 ug/cu m/4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Salmo trutta (Brown trout) weight 1.1 g; Conditions: static bioassay, 12\u00b0C; Concentration: 101 ug/L for 96 hr (95% confidence limit: 84-115 ug/L) /Technical, 95%
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) neonate; Conditions: freshwater, static; Concentration: 16.81 ug/L for 24 hr />95% purity
  • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae) initial cell density was 15,000; Conditions: freshwater, static, 24\u00b0C, pH 7.5, dissolved oxygen 1 to 3 mg/L; Concentration: 2320 ug/L for 48 hr; Effect: growth, cell density
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Malathion, present at 100 mg/L, reached 22% of its Theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Malathion is rapidly degraded in soils with reported degradation in 10 days in various non sterile (sterile) loam soils: 92% (8%), 94% (5%), and 81% (19%)(2). Biochemical reactions utilized include desulfuration, oxidation, hydrolysis, transfer of alkyl or aryl groups, alkylation, dealkylation, reduction and conjugation(2). The rate of degradation increased with increasing soil organic matter and was related to soil pH(3). C14-Malathion was biodegraded 50% and 10% after 17 days in clay loam (45.3% sand, 19.7% silt, 35% clay, 5.74% organic matter) and sandy soil (74.74% sand, 24.76% silt, 0.5% clay, 1.9% organic matter), respectively(4). In activated sludge, malathion had a first-order degradation rate of 0.161/hr(8). In raw river water (pH 7.3-8.0), malathion was degraded 90% within 2 weeks, no change was observed in distilled water over 3 weeks suggesting that degradation was biological(5). Degradation of malathion was complete in 3 days in non-sterile estuarine sediments, and 57% in 11 days in sterilized sediment(6). Malathion has a first-order degradation rate of 0.902/day and a half-life of 0.8 days under aerobic conditions, under anaerobic conditions a first-order degradation rate of 0.302/day and a half-life of 2.3 days were reported in sediment from San Diego Creek, CA(7). Products of degradation include alpha and beta monocarboxylic acids (major metabolite in soil), and dicarboxylic acid(9).

12.3 Bioaccumulative potential

Malathion did not bioconcentrate in the freshwater fish topmouth gudgeon (Pseudorasbora parva)(1). No detectable concentration of malathion was observed in pinfish (Lagodon sp) after exposure to 20-75 ug/L(2). Malathion undergoes biotransformation in fish with some of the metabolites being malaoxon, malathion monoacid, malathion diacid, O,O-dimethyl phosphorodithioate, O,O-dimethyl phosphorodithiolate, O,O-dimethyl phosphorodithionate and O,O-dimethylphosphate(2). Based on the rapid metabolism, bioconcentration of malathion in aquatic organisms is expected to be low(SRC). The BCF for egg masses of the Triaenodes tardus (caddisfly) was found to be 10(3). Malathion had BCFs of 3.0, 23 and 1.2 in axenically cultured parrot feather (Myriophyllum aquaticum), duckweed (Spirodela oligorrhiza L) and elodea (Elodea canadensis), respectively(4).

12.4 Mobility in soil

The Koc of malathion was determined 26 times in a field study conducted with five applications at a 10 day interval in a lychee orchard in northern Thailand; Koc values were reported as 927-17,620(1). Other reported Koc values of malathion in soil are 1175(2), 1200(3) and 1800(4). According to a classification scheme(5), these Koc values suggest that malathion is expected to have low to no mobility in soil(SRC). An experiment conducted to see how much malathion leaches at depths of 50 cm in soil found that most of the malathion is degraded in the higher layers of soil (within the polar carboxylic acid groups) and only small degradation products, that are usually biodegradable, move to the groundwater(6).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2783 IMDG: UN2783 IATA: UN2783

14.2 UN Proper Shipping Name

ADR/RID: ORGANOPHOSPHORUS PESTICIDE, SOLID, TOXIC
IMDG: ORGANOPHOSPHORUS PESTICIDE, SOLID, TOXIC
IATA: ORGANOPHOSPHORUS PESTICIDE, SOLID, TOXIC

14.3 Transport hazard class(es)

ADR/RID: 6.1(b) IMDG: 6.1(b) IATA: 6.1(b)

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
malathion malathion 121-75-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 19, 2017
Revision Date Aug 19, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:330.358021 [g/mol]
Molecular Formula:C10H19O6PS2
XLogP3:2.4
H-Bond Donor:0
H-Bond Acceptor:8
Rotatable Bond Count:11
Exact Mass:330.036066
MonoIsotopic Mass:330.036066
Topological Polar Surface Area:128
Heavy Atom Count:19
Formal Charge:0
Complexity:341
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Effective Rotor Count:11
Conformer Sampling RMSD:1
CID Conformer Count:168