Products
  • Products
  • Buy offers
  • Encyclopedia
  • Msds lib
  • Synthesis
  • Reach Info
  • Suppliers
Home> Encyclopedia > Hot Product Listed 4   > 4-Aminophenol
123-30-8 structure

4-Aminophenol

Iupac Name:4-aminophenol
CAS No.:123-30-8
EINECS(EC#): 204-616-2
Molecular Weight:109.128
Molecular Formula:C6H7NO (isomer)
Names and Identifiers
Synonyms

135807-EP2371803A1 135807-EP2377843A1 1-amino-4-hydroxybenzene 1-amino-4-hydroxybenzene 4-Amino phenol 4-amino phenol 4-amino-1-hydroxybenzene 4-aminobenzenol 4-amino-phenol 4-aminophenol, >=98% 4-aminophenol, >=99% (hplc) 4-aminophenol, pestanal(r), analytical standard 4-aminophenol, united states pharmacopeia (usp) reference standard 4-aminophenol? 4-hydroxyaniline 4-hydroxy-aniline 4-hydroxyphenylamine 4nl 9225-EP2275420A1 9225-EP2280008A2 9225-EP2308872A1 9225-EP2316829A1 A0384 AB1009438 AC1L195P AC1Q523T AC1Q523U acetaminophen impurity k ai3-14872 AJ-333/25022099 AJ-51764 AKOS000119829 AKOS016371265 AM86423 aminophenol, p- AN-22912 AN-24398 azol basf ursol p base BB_SC-6973 BBL011574 BC227837 bdbm26195 benzofur p BMSE000462 c.i. 76550 c.i. oxidation base 6 c.i. oxidation base 6a C02372 ccris 4146 certinal CHEBI:17602 CHEMBL1142 ci 76550 citol CJ-12175 D07MTM dsstox_cid_4499 DTXSID3024499 durafur brown r (salt/mix) durafur brown rb einecs 204-616-2 EPITOPE ID:117708 F2190-0438 fouramine p fourrine 84 fourrine p base FT-0617593 furro p (salt/mix) furro p base futramine p (salt/mix) hsdb 2640 I01-0483 J-514454 kodelon L-1224 LS-676 mfcd00007869 MLS001066356 MOLPORT-001-641-054 nako brown r NCGC00090816-01 NCGC00090816-02 NCGC00090816-03 NCGC00090816-04 NCGC00090816-05 NCGC00258583-01 nsc 1545 nsc1545 nsc-1545 P-Amino phenol p-aminobenzenol p-aminofenol p-aminofenol [czech] p-aminophenol p-amino-phenol p-aminophenol [un2512] [poison] p-aminophenol [un2512] [poison] PAP para amino phenol para aminophenol paraaminophenol para-aminophenol para-amino-phenol para-hydroxyaniline paramidophenol paranol pelagol cp (salt/mix) pelagol grey cp (salt/mix) pelagol grey p base pelagol p base peltol p (salt/mix) phenol derivative, 9 phenol, 4-amino- phenol, p-amino- p-hydroxyaniline p-hydroxyphenylamine PLIKAWJENQZMHA-UHFFFAOYSA-N R7P8FRP05V renal ac rodinal RP18925 SC-19013 SCHEMBL3424 SGCUT00256 smr000471841 ST088538 ST2405553 STK286017 takatol tertral p base TO_000006 tox21_113242 TR-003672 TRA0083709 un 2512 unal UNII-LST7140D72 COMPONENT PLIKAWJENQZMHA-UHFFFAOYSA-N ursol p ursol p base wln: zr dq Z57127517 ZINC4623758 zoba brown p base

Inchi
InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
InChkey
PLIKAWJENQZMHA-UHFFFAOYSA-N
Canonical Smiles
C1=CC(=CC=C1N)O
Properties
Appearance
Off white granular powder
Density
1.21
Melting Point
188℃
Boiling Point
367 to 369° F (NTP, 1992)
Vapour
0.00202mmHg at 25°C
Refractive Index
1.5764 (20 C)
Flash Point
189℃
Solubility
Water solubility: 1.5 g/100 mL (20 °C)
Color/Form
Orthorhombic plates from water
White plates from water
Colorless crystals
White or reddish yellow crystals
Other physical and chemical properties
PHYSICAL DESCRIPTION: White or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992)
Stability
Stable, though may discolour in air. Incompatible with acids, chloroformates, strong oxidizing agents.
HS Code
28402090
Storage temp
Refrigerator
Spectral properties
MAX ABSORPTION (WATER): 229 NM (LOG E= 3.78); 294 NM (LOG E= 3.30)
SADTLER REFERENCE NUMBER: 158 (IR, GRATING)
IR: 712 (Sadtler Research Laboratories Prism Collection)
UV: 236 (Sadtler Research Laboratories Spectral Collection)
NMR: 717 (Sadtler Research Laboratories Spectral Collection)
MASS: 46 (Aldermaston, Eight Peak Index of Mass Spectra, UK)
Intense mass spectral peaks: 52 m/z, 80 m/z, 109 m/z
Safety and Handling
Hazard Codes
Xn
Risk Statements
R20/22;R50/53;R68
Safety Statements
S28;S36/37;S60;S61
HazardClass
6.1
Safety

Hazard Codes:?? Xn,?? N
The Risk Statements information of??4-aminophenol :
40:? Limited evidence of a carcinogenic effect?
68:? Possible risk of irreversible effects?
20/22:? Harmful by inhalation and if swallowed?
50/53:? Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment?
The Safety Statements information of? 4-aminophenol:
28:? After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)?
60:? This material and/or its container must be disposed of as hazardous waste?
61:? Avoid release to the environment. Refer to special instructions safety data sheet?
36/37:? Wear suitable protective clothing and gloves?
RIDADR:UN 2512 6.1/PG 3
WGK Germany:3

Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 56200ug/kg (56.2mg/kg) ? Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LDLo subcutaneous 37mg/kg (37mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913.
guinea pig LDLo subcutaneous 1500mg/kg (1500mg/kg) ? Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 401, 1895.
mammal (species unspecified) LD50 oral 1530mg/kg (1530mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 skin 6400mg/kg (6400mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 unreported 563mg/kg (563mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 19, 1983.
mouse LD50 unreported 750mg/kg (750mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985.
mouse LDLo intraperitoneal 100mg/kg (100mg/kg) ? Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.
mouse LDLo subcutaneous 470mg/kg (470mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 188, Pg. 130, 1938.
rabbit LD50 oral 10gm/kg (10000mg/kg) ? Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956.
rabbit LD50 skin > 10gm/kg (10000mg/kg) ? BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LC50 inhalation > 5mg/m3/1H (5mg/m3) ? BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LD50 intraperitoneal 465mg/kg (465mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 31, 1944.
rat LD50 oral 375mg/kg (375mg/kg) BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 29-4/1973,
rat LD50 unreported 675mg/kg (675mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985.
PackingGroup
III
Skin, Eye, and Respiratory Irritations
An allergen and skin and eye irritant.
Transport
UN 2512
Fire Fighting Procedures
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. /Aminophenols/
Formulations/Preparations
Grades: technical; photographic
DOT Emergency Guidelines
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading . Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Aminophenols/
/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Aminophenols/
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. /Aminophenols/
Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. /Aminophenols/
Protective Equipment and Clothing
An allergen and skin and eye irritant.
Specification

?4-Aminophenol , its cas register number is 123-30-8. It also can be called 4-Amino-1-hydroxybenzene ; 4-Hydroxyaniline ; and 1-Amino-4-hydroxybenzene . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin:?Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Or in the eyes:?Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product:?Get medical aid. Wash mouth out with water. Notes to physician: Treat supportively and symptomatically.
In addition, 4-Aminophenol (CAS NO.123-30-8)?may discolor on exposure to air and light.. It is not compatible with strong oxidizing agents, acids, bases, acid chlorides, acid anhydrides, chloroformates, and you must not take it with incompatible materials, light, exposure to a. And also prevent it to broken down into hazardous decomposition products:?Nitrogen oxides, carbon monoxide, carbon dioxide.

Octanol/Water Partition Coefficient
log Kow= 0.04 @ pH 7.4
Report

Related aminophenols? 2-Aminophenol 3-Aminophenol
Related compounds???? Aniline Phenol

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Acute toxicity - Inhalation, Category 4

Germ cell mutagenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H332 Harmful if inhaled

H341 Suspected of causing genetic defects

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:109.128g/mol
  • Molecular Formula:C6H7NO
  • Compound Is Canonicalized:True
  • XLogP3-AA:0
  • Exact Mass:109.053
  • Monoisotopic Mass:109.053
  • Complexity:66.9
  • Rotatable Bond Count:0
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:46.2A^2
  • Heavy Atom Count:8
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADcYBiIAAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAHgAQCAAACAyBkAAwxoBAAgCA ACRCQACCAAAgIgAIiAAGbIgIJiKCkZOAcABk0BEI2AewQAAAAEAAAAAAAAAAgAAAAAAAAAAAAAAA AA==
Recommended Suppliers
  • Tel:0086-27-59207850
  • Fax:0086-27-59524646
  • Tel:+86-311-85355123
  • Fax:+86-311-85355123
  • Tel:86-571-87758773
  • Fax:86-571-86821328
  • Tel:86-571-85829152
  • Fax:86-571-85829153
  • Tel:86-27-111111111111
  • Fax:86-27-11111111111111
  • Tel:86-25-83697070
  • Fax:86-25-83453275
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-531-88110457
  • Fax:86-531-88113608
  • Tel:86-21-61124658
  • Fax:86-21-61294103
  • Tel:86-371-86658258
  • Fax:86-371-86658258
Recommended Suppliers
  • Tel:0086-27-59207850
  • Fax:0086-27-59524646
  • Tel:+86-311-85355123
  • Fax:+86-311-85355123
  • Tel:86-571-87758773
  • Fax:86-571-86821328
  • Tel:86-571-85829152
  • Fax:86-571-85829153
  • Tel:86-27-111111111111
  • Fax:86-27-11111111111111
  • Tel:86-25-83697070
  • Fax:86-25-83453275
  • Tel:86-571-87396430
  • Fax:86-571-87396431
  • Tel:86-531-88110457
  • Fax:86-531-88113608
  • Tel:86-21-61124658
  • Fax:86-21-61294103
  • Tel:86-371-86658258
  • Fax:86-371-86658258
 
<