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Ranolazine HCl(CAS No. 95635-56-6)

Ranolazine HCl C24H33N3O4?2(HCl) (cas 95635-56-6) Molecular Structure

95635-56-6 Structure

Identification and Related Records

【Name】
Ranolazine HCl
【CAS Registry number】
95635-56-6
【Synonyms】
(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE
n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride
(+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE
Ranolazine DiHCI
Ranolazine and salt
(±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide
RANOLAZINE DI HCL
Ranolazine2Hcl
Ranolazine Dihydrochloride
【Molecular Formula】
C24H33N3O4?2(HCl) (Products with the same molecular formula)
【Molecular Weight】
500.46
【Inchi】
InChI=1/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
【Canonical SMILES】
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O.Cl.Cl
【MOL File】
95635-56-6.mol

Chemical and Physical Properties

【Appearance】
White Crystalline Powder
【Density】
g/cm3
【Melting Point】
222-229.5 °C(lit.)
【Boiling Point】
624.1 °C at 760 mmHg
【Flash Point】
331.2 °C
【Solubilities】
soluble in water
【Color/Form】
off-white
【Computed Properties】
Molecular Weight:500.4584 [g/mol]
Molecular Formula:C24H35Cl2N3O4
H-Bond Donor:4
H-Bond Acceptor:6
Rotatable Bond Count:9
Tautomer Count:3
Exact Mass:499.200462
MonoIsotopic Mass:499.200462
Topological Polar Surface Area:74.3
Heavy Atom Count:33
Formal Charge:0
Complexity:531
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:3

Safety and Handling

【Safety Statements 】
S22;S24/25
【Safety】

Safety Statements: 22-24/25
S22:  Do not breathe dust  
S24/25:Avoid contact with skin and eyes.  

【Specification】

 Ranolazine dihydrochloride , its cas register number is 95635-56-6. It also can be called N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride ; Ranexa ; and Renolazine .

Use and Manufacturing

【Usage】

 Ranolazine dihydrochloride (CAS NO.95635-56-6) is an anti-ischemic agent which modulates myocardial metabolism, and is used for Antianginal.

Biomedical Effects and Toxicity

【Biological Activity】
Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.
【Pharmacological Action】
- Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Supplier Location

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