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Home> Encyclopedia > Hot Product Listed 2   > 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylpropyl)-, sodium salt (1:1)
59110-35-9 structure

2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylpropyl)-, sodium salt (1:1)

Iupac Name:methyl
N-[2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethyl]carbamate
CAS No.:59110-35-9
Molecular Weight:718.85576
Molecular Formula:C9H9NOS (isomer)
Properties
Density
0.93
Boiling Point
390°C at 760 mmHg
Refractive Index
1.518
Flash Point
°C
Solubility
In water, 294 mg/L at 25 deg C (est)
Color/Form
Fine, white, microcrystalline powder
Spectral properties
Intense mass spectral peaks: 141 m/z, 156 m/z, 183 m/z
Safety and Handling
Safety
An experimental poison by ingestion, intraperitoneal, and intravenous routes. Human central nervous system and psychotropic effects by ingestion. When heated to decomposition it emits toxic fumes of NOx and Na2O. See also BARBITURATES.
Toxicity

1.    

ratLD50:78mg/kg

    Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944
2.    

ratLD50:70mg/kg

    Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
3.    

rabbitLD50:194mg/kg

    Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
4.    

mouseLD50:247mg/kg

    Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.

Skin, Eye, and Respiratory Irritations
May cause irritation. Remove to fresh air. Flush with copious quantities of water.
Cleanup Methods
Wipe up spillage or collect spillage using a high- efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.
Fire Fighting Procedures
Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials.
As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.
Formulations/Preparations
Butabarbital sodium preparations: (AHFS, 2009) Butabarbital sodium preparations: (AHFS, 2009) Route Dosage Form Strength Brand (Manufacturer) Oral Elixir 30 mg/5 mL Butisol Sodium (MedPointe) Oral Tablets 30 mg Butisol Sodium (MedPointe) Oral Tablets 50 mg Butisol Sodium (MedPointe)
Exposure Standards and Regulations
Schedule III shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. ... Depressants: Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system: Any substance which contains any quantity of a derivative of barbituric acid or any salt thereof. DEA Code Number: 2100. /Derivatives of barbituric acid or any salt thereof/
Reactivities and Incompatibilities
Solutions of butabarbital sodium should not be added to acidic solutions because precipitation of butabarbital may occur.
Other Preventative Measures
This material is assumed to be combustible. As with all dry powders, it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential buildup of static electricity.
As a general rule, when handling USP Reference Standards avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Wash thoroughly after handling.
/Use/ safety goggles and protect exposed skin.
Protective Equipment and Clothing
Engineering controls such as exhaust ventilation are recommended.
Use a NIOSH-approved respirator, if it is determined to be necessary by an industrial hygiene survey involving air monitoring. In the event that a respirator is not required, an approved dust mask should be used.
Specification

 The extinguishing agent of  Butisol Sodium (CAS NO.143-81-7) are dry powder, foam, sand, carbon dioxide, water mist.

Octanol/Water Partition Coefficient
log Kow = 1.65 [Wongo O, McKeown RH; J Pharm Sci 77: 926 (1988)] PubMed Abstract
Disposal Methods
SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
SRP: At the time of review, regulatory criteria for small quantity disposal are subject to significant revision, however, household quantities of waste pharmaceuticals may be managed as follows: Mix with wet cat litter or coffee grounds, double bag in plastic, discard in trash.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

Computational chemical data
  • Molecular Weight:718.85576g/mol
  • Molecular Formula:C9H9NOS
  • Exact Mass:718.345894
  • Monoisotopic Mass:718.345894
  • Complexity:386
  • Rotatable Bond Count:20
  • Hydrogen Bond Donor Count:8
  • Hydrogen Bond Acceptor Count:14
  • Topological Polar Surface Area:243
  • Heavy Atom Count:49
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:2
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:3
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