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Topiramate(CAS No. 97240-79-4)

Topiramate C12H21NO8S (cas 97240-79-4) Molecular Structure

97240-79-4 Structure

Identification and Related Records

【Name】
Topiramate
【CAS Registry number】
97240-79-4
【Synonyms】
McN-4853
Epitomax
2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranos sulfamate
a-D-Fructopyranose,2,3:4,5-bis-O-(1-methylethylidene)-,sulfamate
Tipiramato [Spanish]
Topamax
Topiramate [USAN:BAN:INN]
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
Topiramate
Topamax
RWJ-17021-000
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
Topiramate (JAN/USAN)
Tipiramate [French]
Topamax (TN)
【Molecular Formula】
C12H21NO8S (Products with the same molecular formula)
【Molecular Weight】
339.36
【MOL File】
97240-79-4.mol

Chemical and Physical Properties

【Appearance】
white to off-white crystalline powder
【Density】
1.336 g/cm3
【Melting Point】
125℃
【Boiling Point】
438.7 °C at 760 mmHg
【Refractive Index】
1.497
【Flash Point】
219.1 °C
【Water】
DMSO Solubility : ~44 mg/mL
【Solubilities】
DMSO Solubility : ~44 mg/mL
【Color/Form】
white
【Stability】
Stable if stored as directed.
【Storage temp】
2-8°C

Safety and Handling

【Hazard Codes】
Xn: Harmful;
【Risk Statements】
R36/37/38
【Safety Statements 】
26-36
【Safety】

Safety Information of Topiramate (CAS NO. 97240-79-4):
Hazard Codes: Xi?Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
WGK Germany: 3
RTECS: LS7083000

【Specification】

? Topiramate?with cas registry number of 97240-79-4 is?white to off-white crystalline powder, also called?2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate ; 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate ; Epitomax ; HSDB 7531 ; McN-4853 ; RWJ-17021-000 ; Tipiramate ; Tipiramate [French] ; Tipiramato ; Tipiramato [Spanish] ; Topamax ; Topamax Sprinkle?; Topiramato ; Topiramato [INN-Spanish] ; Topiramatum ; Topiramatum [INN-Latin] ; Topiramatum [Latin] ; UNII-0H73WJJ391 ; beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate .?It is?used as an anticonvulsant and an antidepressant. It?is also used to treat Post Traumatic Stress Disorder.

Use and Manufacturing

【Usage】

Used as an anticonvulsant

Biomedical Effects and Toxicity

【Biological Activity】
Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

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