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Home> Encyclopedia > Hot Product Listed D   > Donepezil
120014-06-4 structure

Donepezil

Iupac Name:2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
CAS No.:120014-06-4
EINECS(EC#): 601-651-9
Molecular Weight:379.49196
Molecular Formula:C24H29NO3 (isomer)
Names and Identifiers
Synonyms

(2S)-2-[(1-benzylpiperidin-4-yl)Methyl]-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, hydrate(1:1:1) 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one 2-[(1-Benzyl-4-piper 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one AKOS 226-23 Donepezil base Donepezil hydrochloride monohydrate Donezepil n-1-one N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine

Inchi
InChI=1/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
Canonical Smiles
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Properties
Appearance
white or almost white crystal powder
Density
1.141
Melting Point
207℃
Boiling Point
527.9oCat760mmHg
Vapour
3.11E-11mmHg at 25°C
Refractive Index
1.578
Flash Point
273.1oC
Solubility
2.931 mg/L
HS Code
29333990
Safety and Handling
Hazard Codes
Xi
Risk Statements
R36/37/38
Safety Statements
26-36
Safety

Safety Information of?Donepezil (CAS NO.120014-06-4):
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
RIDADR: UN 2811

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

GASTROINTESTINAL: NAUSEA OR VOMITING
Annals of Pharmacotherpy. Vol. 33, Pg. 812, 1999.

Transport
UN 2811
Formulations/Preparations
Formulations: (AHFS, 2009) Donepezil preparations: (AHFS, 2009) Route Dosage Form Strength Brand (Manufacturer) Oral Tablets, film-coated 5 mg Aricept; (Eisai, (also promoted by Pfizer)) Oral Tablets, film-coated 10 mg Aricept; (Eisai, (also promoted by Pfizer)) Oral Tablets, orally disintegrating 5 mg Aricept ODT; (Eisai, (also promoted by Pfizer)) Oral Tablets, orally disintegrating 10 mg Aricept ODT; (Eisai, (also promoted by Pfizer))
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl donepezil hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Donepezil hydrochloride/
Octanol/Water Partition Coefficient
log Kow = 4.86 (est)
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H300 Fatal if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:379.49196g/mol
  • Molecular Formula:C24H29NO3
  • Exact Mass:379.214744
  • Monoisotopic Mass:379.214744
  • Complexity:510
  • Rotatable Bond Count:6
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:4
  • Topological Polar Surface Area:38.8
  • Heavy Atom Count:28
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:1
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
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Recommended Suppliers
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  • Fax:86-311-66561638
  • Tel:+86-311-85355123
  • Fax:+86-311-85355123
  • Tel:86-0-17166540883
  • Fax:86-0-17166540883
  • Tel:86-571-87758773
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  • Tel:+86-0592-5567629
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  • Tel:86-25-83697070
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  • Tel:86-571-87396430
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