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Home> Hot Product Listed R   > Reserpine
50-55-5 structure

Reserpine

CAS No.:50-55-5
EINECS(EC#): 200-047-9
Molecular Weight:608.6787
Molecular Formula:C33H40N2O9 (isomer)
Names and Identifiers
Synonyms

3,4,5-Trimethoxybenzoyl methyl reserpate Reserpine base reserpine crystalline Reserpine,98% Resperine

Inchi
InChI=1/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChkey
QEVHRUUCFGRFIF-UHFFFAOYSA-N
Canonical Smiles
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Isomers Smiles
CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC
(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Properties
Appearance
light yellow powder
Density
1.32
Melting Point
265℃ (dec.)
Boiling Point
700.1°Cat760mmHg
Refractive Index
177 ° (C=1, DMF)
Flash Point
377.2°C
Solubility
Insoluble
Color/Form
White or pale buff to slightly yellowish powder
Long prisms from dil acetone
Stability
Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents.
Storage temp
2-8°C
Spectral properties
Specific optical rotation: -118 deg @ 23 deg C/D (c= 1 in chloroform), -168 deg @ 26 deg C/D (c= 0.624 in dimethylformamide), -164 deg @ 26 deg C/D (c= 0.96 in pyridine); max absorption (chloroform): 216 nm, 267 nm, 295 nm (log e= 61,700; 17,000; 10,200)
UV: 6-1224 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
MASS: 283 (Aldermaston, Eight Peak Index of Mass Spectra, UK)
Intense mass spectral peaks: 195 m/z, 365 m/z, 397 m/z, 608 m/z
Safety and Handling
Hazard Codes
Xi
Risk Statements
R10;R36;R67
Safety Statements
S26
Hazard Note
H302
Safety
Hazard Codes:Xn,Xi
Risk Statements:22-67-36-10
22:Harmful if swallowed
67:Vapors may cause drowsiness and dizziness
36:Irritating to the eyes
10:Flammable
Safety Statements:22-36/37/39-26
22:Do not breathe dust
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR:3077
WGK Germany:3
PackingGroup:II
Hazardous Substances Data:50-55-5(Hazardous Substances Data)
PackingGroup
II
Transport
UN 1219
Formulations/Preparations
Reserpine (Sandril, Serpasil, others) is available in tablets that contain 0.1, 0.25 or 1.0 mg or in capsules that contain 0.5 mg
Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg/4 ml; Injection: 5 mg/2 ml, and 25 mg/10 ml; Tablets; 0.1, 0.25, 0.5, and 1 mg
Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil, Apresoline, Hydrochloride #1 (with tartrazine) (Ciba); 0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay), HHR (Geneva Generics, Schein, Towne), Hydroserpine Plus (Zenith), Rezide (Edward), Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba), Serathide (Interstate), Serpazide (Major), Tri-Hydroserpine (Rugby), Unipres (Reid-Rowell).
Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil, Esidrix (with tartazine) (Ciba); 0.1 mg with hydrochlorothiazide 50 mg: Serpasil, Esidrix #2 (with tartazine) (Ciba), 0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace); 0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow); 0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals), Metatensin #4 (Merrell Dow), Naquival (with tatazine) (Schering), Trichlormethanizide with resperpine tablets (Bolar, Moore); Trichlortensin (Rugby); 0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics), Chloroserpine-250 (Rugby, Schein), Diupres 250.
Reserpine combinations: Oral tablets: 0.125 mg with chlorothiazide 500 mg: Chloroserp-500 (Quality Generics), Chloroserpine-500 (Rugby, Schein), Diupres 500 (MSD); 0.125 mg with chlorthalidone 25 mg: Demi-Regroton (USV); 0.125 mg with hydrochlorothiazide 25 mg: Hydropres 25 (MSD), Hydro-Reserpine-25 (Interstate), Hydroserp (Bioline, Quality Generics), Hydroserpine #1 (Goldline, Rugby, Schein, Zenith), Hydrosine 25 mg (Major), Mallopress (Mallard); 0.125 mg with hydrochlorothiazide 50 mg: Hydropres 50 (MSD), Hydro-Reserpine-50 (Interstate), Hydroserp (Bioline, Quality Generics), Hydroserpalan (Lannett), Hydroserpine #2 (Goldline, Rugby, Schein, Zenith), Hydrosine 50 mg (Major), Hydrotensin-50 (Mayrand).
Reserpine combinations: Oral tablets: 0.125 mg with hydroflumethiazide 25 mg: Hydro-Fluserpine #1 (Schein), Hydropine (Rugby), Salazide-Demi (major), Salutensin-Demi (Bristol); 0.125 mg with quinethazone 50 mg: Hydromox-R (Lederle); 0.2 mg with hydralazine hydrochloride 50 mg: Serpasil-Apresoline Hydrochloride #2 (with tartrazine) (Ciba); 0.25 mg with chlorthalidone 50 mg: Regroton (USV); 0.25 mg with polythiazide 2 mg: Renese-R (Pfizer).
Oral tablets: Serpalan (Lilly) 0.1 and 0.25 mg; Serpasil (Lannett) 0.1 and 0.25 mg; Serpate (Vale) 0.1 and 0.25 mg; 1 mg Reserpine tablets (Towne)
Reserpine Elixir: An Elixir containing reserpine and alcohol 11 to 13%.
Reserpine Injection: A sterile solution of resperine in water for injections, prepared with the aid of a suitable acid.
Seominal: Tablets each containing reserpine 200 ug, phenobarbitone 10 mg, and theobromine 325 mg.
Exposure Standards and Regulations
Drug products withdrawn or removed from the market for reasons of safety or effectiveness. Reserpine: All oral dosage form drug products containing more than 1 milligram of reserpine.
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Specification

off-white crystalline powder
usageEng:An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.
Safety Statements:22-36/37/39-26
22:Do not breathe dust
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids. /From table/
Reach Info
Globally, no enterprise has officially registered the substance REACH.
Other official information: ·ECHA Information Page for CAS: 50-55-5 EC: 200-047-9 Reserpine ·ECHA C&L Inventory for CAS: CAS: 50-55-5 EC: 200-047-9 Reserpine
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Computational chemical data
  • Molecular Weight:608.6787g/mol
  • Molecular Formula:C33H40N2O9
  • Exact Mass:608.273381
  • Monoisotopic Mass:608.273381
  • Complexity:1000
  • Rotatable Bond Count:10
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:10
  • Topological Polar Surface Area:118
  • Heavy Atom Count:44
  • Defined Atom Stereocenter Count:6
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
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  • Fax:0086-27-59524646
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  • Fax:86-22-58951207
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