Related Searches: Tetraethyl orthosilicate, tetraethyl, orthosilicate, tetraethyl silicate, ethyl orthosilicate, View all

Tetraethyl orthosilicate(CAS No. 78-10-4)

Tetraethyl orthosilicate C8H20O4Si (cas 78-10-4) Molecular Structure

78-10-4 Structure

Identification and Related Records

Tetraethyl orthosilicate
【CAS Registry number】
Ethylsilicate ((EtO)4Si) (6CI)
Colcoat 6P
Conservare OH
Dynasil A
ES 100
ES 100(silicate)
ES 140
ES 28 (ester)
Ethyl Silicate 45
Ethyl silicate 28
Ethyl silicate 28P
LS 2340
NSC 4790
Remmers 300
SI 42
Silane, tetraethoxy-
Silicon ethoxide
Silicon tetraethoxide
Silicon tetraethoxide(Si(OC2H5)4)
T 0100
T 0100(ester)
TES 28
TSL 8124
TSLB 124
Tetraethyl silicate
Unisilan 74
WD 932
Ethyl silicate
【Molecular Formula】
C8H20O4Si (Products with the same molecular formula)
【Molecular Weight】
【Canonical SMILES】
【MOL File】

Chemical and Physical Properties

colourless liquid with an alcohol-like odour
0.939 g/cm3
【Melting Point】
-77 oC
【Boiling Point】
165.5 oC at 760 mmHg
【Refractive Index】
【Flash Point】
46.7 oC
Colorless liquid
Stable. Flammable. Incompatible with strong oxidizing agents, water, alkalies, mineral acids.
【Storage temp】
Flammables area
【Spectral properties】
Index of refraction: 1.3818 atT 25 deg C/D
Index of refraction: 1.3928 at 20 deg C/D
IR: 6213 (Coblentz Society Spectral Collection)
MASS: 52181 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)
【Computed Properties】
Molecular Weight:208.3275 [g/mol]
Molecular Formula:C8H20O4Si
H-Bond Donor:0
H-Bond Acceptor:4
Rotatable Bond Count:8
Exact Mass:208.113086
MonoIsotopic Mass:208.113086
Topological Polar Surface Area:36.9
Heavy Atom Count:13
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Effective Rotor Count:8
Conformer Sampling RMSD:0.8
CID Conformer Count:36

Safety and Handling

【Hazard Codes】
Xn: Harmful;
【Risk Statements】
【Safety Statements 】

Poison by intravenous route. Moderately toxic by other routes. A skin, mucous membrane, and severe eye irritant. Narcotic in high concentrations. Flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes?:?HarmfulXn
Risk Statements?: 10-20-36/37?
R20:Harmful by inhalation.?
R36/37:Irritating to eyes and respiratory system.
Safety Statements?: 16-36/37/39?
S16:Keep away from sources of ignition.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR:? UN 1292 3/PG 3
WGK Germany?: 1
RTECS? :VV9450000

【PackingGroup 】
Moisture Sensitive
【Skin, Eye, and Respiratory Irritations】
... 3000 ppm is intolerable to human beings; 250 ppm is irritating to eyes and nose ...
Inhalation of vapor causes eye and nose irritation ... Contact with liquid irritates eyes ... .
【Cleanup Methods】
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Remove all ignition sources. Ventilate area of spill or leak. For small quantities, absorb on paper towels. Evaporate in safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper in suitable location away from combustible materials ... Ethyl silicate should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude formation of explosive concn of ethyl silicate vapors are permitted.
Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Note: Reacts with water to form an adhesive mass.
UN 1292
【Fire Fighting Procedures】
Water, foam, dry chemical, carbon dioxide
This chemical is a flammable liquid. Poisonous gases including carbon monoxide and silicon oxide are produced in fire. Use dry chemical, carbon dioxide, or foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ...
【Fire Potential】
Flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials.
/Ethyl silicate/... is marketed in 2 grades, a 29% and 40% silicon dioxide, and in a "condensed" form consisting of 85% ethyl silicate and 15% polyethoxysiloxanes.
Extrema - 99.9999% grade /available/
Pure ethyl silicate >98%. A partially hydrolyzed or polymeric version with a substantial portion having an average of 4-5 silicon atoms and 40 wt% silicon dioxide content is called ethyl silicate 40.
Dynasil A
【DOT Emergency Guidelines】
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Evacuation: Large spill: Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire: Caution: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane. Large fires: Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
【Reactivities and Incompatibilities】
Strong oxidizers, water [Note: Reacts with water to form a silicone adhesive (a milky-white mass)].
Causes swelling and hardening of some plastics.
【Other Preventative Measures】
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
Precautions should be taken in industrial handling to avoid repeated or prolonged contact with higher concn of the vapor and to avoid contact of the vapor or liquid with the eyes.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point
Clothing wet with liquid ethyl silicate should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of ethyl silicate from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the ethyl silicate, the person performing the operation should be informed of ethyl silicate's hazardous properties.
【Protective Equipment and Clothing】
Rubber or polyethylene gloves; safety glasses or other form of eye protection; self-contained breathing apparatus or one that absorbs organic vapors.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Respirator Recommendations: Up to 100 ppm: Assigned Protection Factor (APF) Respirator Recommendation APF = 10 Any supplied-air respirator. Substance reported to cause eye irritation or damage; may require eye protection.
Respirator Recommendations: Up to 250 ppm: Assigned Protection Factor (APF) Respirator Recommendation APF = 25 Any supplied-air respirator operated in a continuous-flow mode. Substance reported to cause eye irritation or damage; may require eye protection.
Respirator Recommendations: Up to 500 ppm: Assigned Protection Factor (APF) Respirator Recommendation APF = 50 Any self-contained breathing apparatus with a full facepiece. APF = 50 Any supplied-air respirator with a full facepiece.
Respirator Recommendations: Up to 700 ppm: Assigned Protection Factor (APF) Respirator Recommendation APF = 2000 Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: Assigned Protection Factor (APF) Respirator Recommendation APF = 10,000 Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. APF = 10,000 Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape conditions: Assigned Protection Factor (APF) Respirator Recommendation APF = 50 Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus.

?Ethyl silicate?(CAS NO.78-10-4), its Synonyms are?Orthosilicic acid, tetraethyl ester ; Silane, tetraethoxy- ; Silicate d'ethyle ; Ethyl orthosilicate ; Ethyl silicate, ((EtO)4Si) ; Etylu krzemian ; Tetraethoxysilane ; Tetraethoxysilicon ; Tetraethyl orthosilicate ; Tetraethyl silicate ; Tetraethyl-O-silicate ; Tetraethylsilikat? . It is?clear colorless liquid with a faint odor .

【Octanol/Water Partition Coefficient】
log Kow = 0.04 (est)

Reported in EPA TSCA Inventory.

【Disposal Methods】
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.
Incineration in admixture with a more flammable solvent. /SRP: Process eqipped with afterburner and effluent gas scrubber./

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

Preparation from absolute alcohol and silicon tetrachloride
U.S. Production

Silicic acid (H4SiO4), tetraethyl ester is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).
Production volumes for non-confidential chemicals reported under the Inventory Update Rule. Year Production Range (pounds) 1986 >1 million - 10 million 1990 >10 million - 50 million 1994 >10 million - 50 million 1998 >10 million - 50 million 2002 10 thousand - 500 thousand
Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Silicic acid (H4SiO4), tetraethyl ester. Aggreated National Production Volume: 500,000 to
Commonly used as a precursor to prepare xerogel1,2

Biomedical Effects and Toxicity

【Pharmacological Action】
Inhalation of vapor causes eye and nose irritation, unsteadiness, tremors, salivation, respiratory difficulty, and unconsciousness. Contact with liquid irritates eyes and may cause dryness, cracking, and inflammation of skin. Ingestion may produce nausea, vomiting, and cramps.
【Therapeutic Uses】
Commonly used as a precursor to prepare xerogel1,2
【Biomedical Effects and Toxicity】
Acute stomach, kidney, and bladder toxicity was evaluated in F344 rats after gastric gavage of tetraethylorthosilicate at daily doses of 0, 0.111, 0.223, and 0.333 g. Five rats of each sex at each dose were sacrificed after 1, 2, and 4 days. In tetraethylorthosilicate treated groups, silicate accumulated in the stomach glands and the muscle layer of the forestomach and glandular stomach.

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that tetraethyl silicate is expected have very high mobility in soil(SRC). Volatilization of tetraethyl silicate from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 2.0X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Tetraethyl silicate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.88 mm Hg at 25 deg C(4). Biodegradation data were not available(SRC, 2009). Without special precautions, tetraethoxysilane hydrolyzes to a gel in about 10 days(5).
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that tetraethyl silicate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may occur(3) based upon an estimated Henry's Law constant of 2.0X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.9 and 25 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.04(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2009). Without special precautions, tetraethoxysilane hydrolyzes to a gel in about 10 days(8).
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetraethyl silicate, which has a vapor pressure of 1.88 mm Hg at 25 deg C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetraethyl silicate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 deg C(SRC) that was derived using a structure estimation method(3). Tetraethyl silicate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Supplier Location

Top Suppliers

Diamond member zhangjiagang xinya chemical co.,ltd
Business Type:Manufacturer
Diamond member Hubei XinRunde Chemical Co., Ltd
Business Type:Manufacturer
Diamond member Hangzhou Dayangchem Co., Ltd.
Business Type:Manufacturer
Diamond member Hangzhou Utanpharma biology co,.Ltd
Business Type:Trading Company
Diamond member AOPHARM
Business Type:Manufacturer
Hui Chem Company Limited
Business Type:Manufacturer
Finetech Industry limited.
Business Type:Manufacturer
Shanghai Hope Chem Co., Ltd.
Business Type:Manufacturer
Jinan Haohua Industry Co., Ltd.
Business Type:Manufacturer
Huangshan violet Biotechnology Co., Ltd
Business Type:Manufacturer
Raw materials
Preparation Products

Quick Search

Cas    Name

Related products

Tetraethyl orthosilicate

Ethyl silicate; TEOS; Tetraethoxysilanemincolorlessliq; Tetraethoxysilaneredistilledinquartzforlowmetalimpurities; Tetraethoxysilane; Silicon ethoxide...

tetraethyl orthosilicate


Tetramethyl orthosilicate

Tetramethoxysilanecolorlessliq; Methyl silicate; DYNASIL M; Tetramethoxysilane; Silicon tetramethoxide

Tetrasodium orthosilicate

tetrasodium orthosilicate

tetrabutyl orthosilicate

Butylsilicate ((BuO)4Si) (7CI); Butyl orthosilicate; MKC Silicate BTS; NSC 89762;Silane, tetrabutoxy-; Silicon butoxide; Silicon tetrabutoxide;Tetra-n...



tetratridecyl orthosilicate

68909-01-3;tetratridecyl silicate;Silicic acid tetra(C13-C15)alkyl ester;tetratridecyl orthosilicate;AC1L3A2P;Silicic acid, tetra-C13-15-alkyl esters

Lithium orthosilicate

Tetralithium silicate;13453-84-4;Lithium silicate (Li4SiO4);AC1L4YQB;Tetralithium orthosilicate;AC1Q1U4R;tetralithium dioxido(oxo)silane;Lithium ortho...



tetrakis(2-aminoethyl) orthosilicate

tetrakis(2-aminoethyl) orthosilicate;Silicic acid tetrakis(2-aminoethyl) ester;Einecs 230-340-7;Ethanol, 2-amino-, silicate (ester);Ethanol, 2-amino-,...

Tetra(2-butylisopropyl) orthosilicate

Silicic acid tetrakis(1,1-dimethylpentyl) ester

Tetrakis(2-ethoxyethyl) orthosilicate

Ethanol,2-ethoxy-, silicate (6CI);Ethanol, 2-ethoxy-, tetraester with silicic acid(H4SiO4) (8CI);2-Ethoxyethyl silicate;Tetraethoxyethyl orthosilicate...