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Home> Hot Product Listed E   > Ethyl acetate

Ethyl acetate

Iupac Name:ethyl acetate
CAS No.:141-78-6
EINECS(EC#):205-500-4
Molecular Weight:88.1
Molecular Formula:C4H8O2 (Products with the same molecular formula)
MOL File:141-78-6.mol
Names and Identifiers
Properties
Appearance
Colorless liquid
Density
0.902
Melting Point
-83.5℃
Boiling Point
75-77.5℃
Vapour
112mmHg at 25°C
Refractive Index
1.371-1.374
Flash Point
-4℃
Water
80 g/L (20℃)
Solubilities
80 g/L (20 oC)
Color/Form
CLEAR LIQUID
Colorless liquid.
Spectral properties
Index of Refraction = 1.3719 at 20 deg C/D
MAX ABSORPTION (METHANOL): 209 NM (LOG E= 1.86); SADTLER REFERENCE NUMBER: 4 (IR, PRISM); 3 (IR, GRATING)
IR: 4802 (Coblentz Society Spectral Collection)
UV: 4-21 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
NMR: 79 (Varian Associates NMR Spectra Catalogue)
MASS: 158 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Intense mass spectral peaks: 43 m/z, 61 m/z, 70 m/z, 73 m/z, 88 m/z
Safety and Handling
Hazard Codes
F:Flammable
Risk Statements
R11;R36;R66;R67
Safety Statements
S16;S26;S33
Safety

Hazard Codes:?FlammableF,?IrritantXi,HarmfulXn, ToxicT
Risk Statements:?11-36-66-67-20/21/22-10-39-23/24/25-68
11:?Highly Flammable?
36: Irritating to the eyes?
66:?Repeated exposure may cause skin dryness or cracking?
67:?Vapors may cause drowsiness and dizziness
20/21/22: Harmful by inhalation, in contact with skin and if swallowed?
10:?Flammable??
39: Danger of very serious irreversible effects.
23/24/25:?Toxic by inhalation, in contact with skin and if swallowed??
68: Possible risk of irreversible effects.
Safety Statements:? 16-26-33-36/37-45-7-25
16: Keep away from sources of ignition - No smoking?
26:?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
33:?Take precautionary measures against static discharges?
36/37:?Wear suitable protective clothing and gloves?
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
7: Keep container tightly closed?
25: Avoid contact with eyes
RIDADR:?UN 1173 3/PG 2
WGK Germany: 1
F:?1: Sensitive to air and humidity.
HazardClass:?3
PackingGroup:?II

PackingGroup
O52
Skin, Eye, and Respiratory Irritations
Irritating to mucous surfaces, particularly the eyes, gums and respiratory passages ... . On repeated or prolonged exposures, it causes conjunctival irritation and corneal clouding.
Cleanup Methods
1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN A SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE COLLECTED AND ATOMIZED IN A SUITABLE COMBUSTION CHAMBER. ETHYL ACETATE SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE, SUCH AS A SEWER, BECAUSE OF THE POSSIBILITY OF AN EXPLOSION.
Transport
UN 1173
Fire Fighting Procedures
COOL EXPOSED CONTAINERS WITH WATER.
/USE/ CARBON DIOXIDE, DRY CHEM, OR ALCOHOL FOAM.
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Apply water from as far a distance as possible. Cool all affected containers with flooding quantities of water. Use "alcohol" foam, dry chemical or carbon dioxide.
Fire Potential
DANGEROUS WHEN EXPOSED TO HEAT OR FLAME
Formulations/Preparations
GRADES: COMMERCIAL, 85-88%; 95-98%; 99%; NF /NATIONAL FORMULARY GRADE OF CHEMICAL/ (99%); FCC /FOOD CHEMICAL CODEX/.
Nail polish remover typically 40 wt% ethyl acetate.
DOT Emergency Guidelines
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Evacuation: Large spill: Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire: Caution: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane. Large fires: Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Exposure Standards and Regulations
Certification of this color additive when used as a diluent (in inks for marking fruit & vegetables) is not necessary for the protection of the public health and therefore batches thereof are exempt from the requirements of section 706(c) of the Federal Food, Drug, and Cosmetic Act. /Restrictions incl no residue./
Synthetic flavoring substances and adjuvants /for human consumption/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Ethyl acetate is included on this list.
Synthetic flavoring substances and adjuvants /for animal drugs, feeds, and related products/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Ethyl acetate is included on this list.
Reactivities and Incompatibilities
... CAN REACT VIGOROUSLY WITH CHLOROSULFONIC ACID, ... OLEUM, K-TERT-BUTOXIDE ...Explosive reaction with lithium tetrahydroaluminate.
Incompatible with nitrates, strong oxidizers, strong alkalies, strong acids.
Nitrates, strong oxidizers, alkalis & acids.
Other Preventative Measures
USE EFFECTIVE FUME REMOVAL DEVICE /IN LABORATORY/.
Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.
Avoid breathing vapors. Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material not on fire and not involved in fire: Keep sparks, flames and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet should be immediately removed due to its flammability hazard.
An analysis of breakthrough times of low boiling organic solvent vapors in a commercial respirator cartridge under steady state and pulsating flow conditions was performed. A KGC-8 respirator cartridge packed with 22.5 grams of activated charcoal was exposed to 0, 100, 300, or 900 ppm carbon-tetrachloride, ethyl-acetate, methyl-acetate, acetone, or dichloromethane vapor under steady state or pulsed flow conditions in custom built apparatus. The steady state flow condition was achieved by setting the respirator cartridge in its holder and passing each solvent vapor through it at a flow rate of 30 liter per minute (l/min). The pulsating flow condition was achieved placing the respirator cartridge in a Tedler bag, expanding the bag by introducing each test vapor, and 'inhaling' the test vapor through the respirator cartridge using a breathing machine drawing 1.5 liters air per cycle at the rate 20 cycles/min. The total flow rate was adjusted to be similar to the 301/min rate utilized the steady state flow experiments. Solvent vapor concentrations were measured upstream and downstream from the cartridge by gas chromatography. Breakthrough times were determined as the time required for the solvent vapor concentrations downstream from the cartridge to increase to 5 ppm. The data were analyzed by logistic regression techniques. After converting the data to logarithms, the breakthrough times of all five solvents were linearly, inversely proportional to their initial concentrations under both steady state and pulsed flow conditions. The slopes of the lines were smaller for the solvents with the lower boiling points. The ratios of the breakthrough times measured under the pulsating flow to the steady slate flow condition (B/A ratio) varied from 0.77 to 0.71 for dichloromethane. The B/A ratios for the lOO ppm initial concentrations of the other four solvents varied only from 0.95 to 1.01. This indicated that except in the case of dichloromethane, there are no large differences in breakthrough tire under the two different flow conditions at lOO ppm. At the other concentrations, in each experiment as the concentration of the test vapor increased the breakthrough times under the pulsating flow condition became shorter compared to the steady state flow condition. /It was/ concluded that breakthrough of low boiling solvent vapors in respirator cartridges occurs earlier under pulsating flow than under steady state conditions. [Tanaka S et al; Industrial Health 34 (2): 125-31 (1996)] PubMed Abstract
Protective Equipment and Clothing
ORGANIC VAPOR CANISTER OR AIR MASK; GOGGLES OR FACE SHIELD.
Wear appropriate clothing to prevent repeated or prolonged skin contact.
Breakthrough times greater than one hour reported by (normally) two or more testers for butyl rubber (Butyl). Some data usually from immersion tests suggesting breakthrough times greater than one hour are not likely for natural rubber (Nat Rub), polyethylene (PE) and polyvinyl alcohol (PVA). Breakthrough times less (usually significantly less) than one hour reported by (normally) two or more testers for neoprene (Neop), nitrile rubber (nitrile), and polyvinyl chloride (PVC). No data for neoprene /styrene-butadiene rubber (Neop/ SBR), nitrile rubber/polyvinyl chloride (Nitrile/PVC), chlorinated polyethylene (CPE), polyurethane (PU), styrene-butadiene rubber (SBR) and viton.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Recommendations for respirator selection. Max concn for use: 2000 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Eye protection needed. Any powered, air-purifying respirator with organic vapor cartridge(s). Eye protection needed. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s). Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.
Wear positive-pressure SCBA and protective equipment ... . If special chemical protective clothing is required, consult the chemical manufacturer or specific protective clothing compatibility charts. Delay entry until trained personnel and proper protective equipment are available. Remove patient from contaminated area. Quickly remove and isolate patient's clothing, jewelry, and shoes. Gently blot excess liquids with absorbent material. Rinse patient with warm water, 30 deg C/86 deg F, if possible. Wash patient with Tincture of Green Soap or a mild liquid soap and large quantities of water.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Specification

?Ethyl acetate ,?its cas register number is 141-78-6. It also can be called?Acetate d'ethyle ; Acetato de etilo ; Acetic acid, ethyl ester ; Acetic ether ; Acetidin ; Acetoxyethane ; Aethylacetat ; Essigester ; Ethyl acetic ester ; Ethyl ester ; Ethyl ethanoate ;?Ethylacetaat ; Ethylacetate ; Ethylester kyseliny octove ; Etile (acetato di) ; Octan etylu ; Vinegar naphtha .

Octanol/Water Partition Coefficient
SOL IN ALCOHOL, ETHER, ACETONE, AND BENZENE
MISCIBLE WITH CHLOROFORM
MISCIBLE IN FIXED & VOLATILE OILS.
Very soluble in water (64 g/l at 25 deg C)
Miscible with oxygenated and chlorinated solvents.
In water, 8.01X10+4 mg/l at 25 deg C.
Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U112 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Incineration: Burn waste material in an approved waste disposal incinerator.
1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL. 2. BY ATOMIZING IN A SUITABLE COMBUSTION CHAMBER.
Ethyl acetate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.
A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence time of 0.1 to 2 seconds. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Biological treatment.
The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Activated carbon.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 100000_1000000 view >
FULL INDIVIDUAL 0_10 view >
Registered companies:
Registrant / Supplier details Latest dossier received
3M Belgium BVBA/SPRL 2014
Akzo Nobel Chemicals SpA 2013
Avantor Performance Materials Poland S.A. 2016
more >
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl acetate

1.2 Other means of identification

Product number -
Other names Ethyl ethanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour

H319 Causes serious eye irritation

H336 May cause drowsiness or dizziness

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
ethyl acetate ethyl acetate 141-78-6 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Rinse contaminated clothes (fire hazard) with plenty of water. Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

If swallowed

Rinse mouth. Seek medical attention if you feel unwell.

4.2 Most important symptoms/effects, acute and delayed

Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Cool exposed containers with water.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants, strong bases and strong acids.Keep tightly closed in cool place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 400 ppm (1400 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colorless liquid
Colour Clear, volatile
Odour CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE.
Melting point/ freezing point 285\u00b0C(dec.)(lit.)
Boiling point or initial boiling point and boiling range 76.5-77.5\u00b0C(lit.)
Flammability Class IB Flammable Liquid: Fl.P. below 22.78\u00b0C and BP at or above 37.78\u00b0C.Highly flammable.
Lower and upper explosion limit / flammability limit Lower 2.2%; upper 11.5% by volume in air
Flash point -3\u00b0C
Auto-ignition temperature 427.22\u00b0C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.423 mPa.s at 25\u00b0C
Solubility In water:80 g/L (20 \u00baC)
Partition coefficient n-octanol/water (log value) log Kow = 0.73
Vapour pressure 73 mm Hg ( 20 \u00b0C)
Density and/or relative density 0.902g/mLat 25\u00b0C(lit.)
Relative vapour density 3 (20 \u00b0C, vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Slowly decomp by moisture.

10.3 Possibility of hazardous reactions

A very dangerous fire hazard when exposed to heat or flame.The vapour is heavier than air and may travel along the ground; distant ignition possible.ETHYL ACETATE is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with lithium aluminum hydride. It may also ignite with potassium tert-butoxide. It is incompatible with nitrates, strong alkalis and strong acids. It will attack some forms of plastics, rubber and coatings. It is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... can react vigorously with oxidizing materials ... Potentially explosive reaction with lithium tetrahydroaluminate. Ignites on contact with potassium teri-butoxide. Violent reaction with chlorosulfonic acid, (LiAIH2 + 2-chloromethyl furan), oleum.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 11.3 mL/kg
  • Inhalation: LC50 Mouse inhalation 1500 ppm/4hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow) age 29-30 days, length 18.2 mm, weight 0.106 g; Conditions: freshwater, flow through, 24.3\u00b0C, pH 7.4, hardness 45.0 mg/L CaCO3, alkalinity 37.0 mg/L CaCO3, dissolved oxygen 6.7 mg/L; Concentration: 230000 ug/L for 96 hr (95% confidence interval: 220000-250000 ug/L) /99+% purity
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, renewal, 25\u00b0C, pH >7; Concentration: 2306000 ug/L for 24 hr; Effect: behvior equilibrium /formulation
  • Toxicity to algae: EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 4300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Ethyl acetate, present at 100 mg/L, reached 95% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A review concluded that ethyl acetate is easily removed by biological treatment(2). Reported 5 day BOD values using a sewage inoculum range from 36-68% of theoretical(3-6) with the value being somewhat reduced in salt water(3). One investigator reported that ethyl acetate was completely degraded in 20 hr using activated sludge(7). In a bench-scale continuous-flow activated sludge reactor with an 8 hour retention time, 99.9% removal including 17% volatilization loss) was obtained, with 80% of the theoretical BOD(8). Ethyl acetate was 90% biooxidized in a 20-day BOD test using a filtered raw sewage seed; it was biooxidized 77% in a 28-day OECD closed-bottle test(9). A screening procedure that was systematically applied to a large number of organic chemicals ranked ethyl acetate as being completely biodegraded in a short time by general microorganisms(10). After a 5 hr lag, 43 to 53% of theoretical BOD was obtained in 50 to 70 hr(10). In screening tests, ethyl acetate, present at a concentration of 5 ppm, reached 26.6 and 57.1% of its theoretical BOD in 5 days using the standard dilution method and seawater dilution method, respectively(11). 99.9% removal of ethyl acetate was observed in a complete mix continuous-flow activated sludge system; 93% of this removal was attributed to biodegradation(12).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for ethyl acetate(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of ethyl acetate is estimated as 18(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethyl acetate is expected to have very high mobility in soil(SRC). A log Ki (snow surface/air (cu m/sq m)) of -3.69 has been reported for sorption to snow(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1173 IMDG: UN1173 IATA: UN1173

14.2 UN Proper Shipping Name

ADR/RID: ETHYL ACETATE
IMDG: ETHYL ACETATE
IATA: ETHYL ACETATE

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
ethyl acetate ethyl acetate 141-78-6 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:88.10512 [g/mol]
Molecular Formula:C4H8O2
XLogP3:0.7
H-Bond Donor:0
H-Bond Acceptor:2
Rotatable Bond Count:2
Exact Mass:88.05243
MonoIsotopic Mass:88.05243
Topological Polar Surface Area:26.3
Heavy Atom Count:6
Formal Charge:0
Complexity:49.5
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Effective Rotor Count:2
Conformer Sampling RMSD:0.4
CID Conformer Count:9