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Home> Encyclopedia > Hot Product Listed S   > Sodium bicarbonate
144-55-8 structure

Sodium bicarbonate

Iupac Name:sodium carbonate
CAS No.:144-55-8
EINECS(EC#): 205-633-8
Molecular Weight:84.00661
Molecular Formula:CHNaO3 (isomer)
Names and Identifiers

144-55-8 800 Sodium Bicarbonate Powder 8MDF5V39QO AB1009420 AC1LANJA AC1Q1W5G Acidosan ACMC-20ajp0 AKOS015836321 AKOS015951222 B7292 Baking soda Bicarbonate of soda bicarbonate sodium Bicarbonate, 1M buffer solution, pH 8.0 Bicarbonate, 1M buffer solution, pH 8.5 BSS plus C12603 Carbonic acid disodium salt Carbonic acid monosodium salt Carbonic acid sodium salt (1:1) Carbonic acid, disodium salt Carbonic acid, monosodium salt Caswell No. 747 CCRIS 3064 CHEBI:32139 CHEMBL1353 CHNaO3 Co-lav Col-evac Colovage Component of Col-Evac CTK0H5607 D01203 DB01390 DTXSID9021269 E 500 E500 E-500 EC 205-633-8 EINECS 205-633-8 EPA Pesticide Chemical Code 073505 E-Z-EM Prep Lyte FT-0645108 Glycoprep Go-evac Golytely Gripe water Hema BP-38 HSDB 697 hydrogen carbonate sodium Jusonin KS-00000WCP KSC175M0P LS-2380 Meylon Meylon (TN) MFCD00003528 Monosodium carbonate Monosodium hydrogen carbonate monosodium salt NaHCO3 nahcolita Natrii hydrogencarbonas Natrium bicarbonicum Natrium hydrogencarbonicum Natriumbicarbonat, Natriumhydrogencarbonat natriumhydrogencarbonat Natriumhydrogenkarbonat Natron Natrum bicarbonicum Neut Neut (TN) NSC 134031 Nulytely Peg-lyte PubChem23592 RP18407 RTR-005643 S0561 S304 Sandoz sodium bicarbonate SC-27096 see the subdivided heading Sel De vichy Soda (van) Soda Mint SodaSee Sodium acid carbonate Sodium bi carbonate sodium bicabonate sodium bicarbonat sodium bicarbonata sodium bi-carbonate sodium bicarbonate- Sodium bicarbonate (1:1) Sodium bicarbonate (JP17/USP) Sodium bicarbonate [USAN:JAN] Sodium bicarbonate [USP:JAN] Sodium bicarbonate 5% w/v solution in water (+/- 0.3%) Sodium bicarbonate A.C.S. reagent grade Sodium Bicarbonate food grade Sodium bicarbonate in plastic container Sodium bicarbonate liquid concentrate Sodium bicarbonate(1:1) Sodium bicarbonate, 1M buffer solution, pH 10.0 Sodium bicarbonate, 1M buffer solution, pH 8.0 Sodium bicarbonate, 1M buffer solution, pH 9.0 Sodium bicarbonate, 99.5%, for analysis Sodium bicarbonate, 99.5%, for biochemistry Sodium bicarbonate, 99.7+%, ACS reagent Sodium bicarbonate, 99+%, extra pure Sodium bicarbonate, 99+%, for HPLC Sodium bicarbonate, Biochemical Grade Sodium bicarbonate, HPLC, Meets ACS Specifications Sodium bicarbonate, USP SODIUM BICARBONIATE Sodium carbonate (Na(HCO3)) Sodium hydrocarbonate sodium hydrogen cabonate Sodium hydrogen carbonate Sodium hydrogen carbonate, Puratronic(R) sodium hydrogencabonate sodium hydrogencarbonat Sodium hydrogencarbonate sodium hyd-rogencarbonate sodium hydrogen-carbonate sodiumbicarbonate sodiumbi-carbonate sodiumhydrogen carbonate sodium-hydrogen-carbonate Soludal TR-005643 UIIMBOGNXHQVGW-UHFFFAOYSA-M UNII-8MDF5V39QO

Canonical Smiles
Isomers Smiles
White powder or superfime crystal
Melting Point
Boiling Point
2.58E-05mmHg at 25°C
Refractive Index
Flash Point
169.8 °C
Soluble in water:9 g/100 mL (20 oC)
White, monoclinic prisms
White crystalline powder or granules
HS Code
Storage temp
Spectral properties
Safety and Handling
Safety Statements

Safety Statements of Sodium bicarbonate (CAS NO.144-55-8): 24/25?
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: VZ0950000
HS Code: 28363000
Low toxicity by ingestion. An experimental teratogen. A nuisance dust. Human systemic effects: changes in potassium levels, increased urine volume, metabolic acidosis, nausea or vomiting, respiratory changes, sodium level changes. Mutation data reported.


Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 1260mg/kg (1260mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

American Journal of Diseases of Children. Vol. 135, Pg. 965, 1981.
man TDLo oral 20mg/kg/5D-I (20mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING American Journal of Emergency Medicine. Vol. 12, Pg. 57, 1994.
mouse LD50 oral 3360mg/kg (3360mg/kg) ? Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(5), Pg. 30, 1989.
rat LC inhalation > 900mg/m3 (900mg/m3) ? Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(5), Pg. 30, 1989.
rat LD50 oral 4220mg/kg (4220mg/kg) ? Toxicology and Applied Pharmacology. Vol. 6, Pg. 726, 1964.

Skin, Eye, and Respiratory Irritations
The substance is mildly irritating to the eyes.
Cleanup Methods
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
Fire Fighting Procedures
In case of fire in the surroundings: use appropriate extinguishing media.
Fire Potential
Not combustible.
Baking powders in commercial use normally contain sufficient soda and the /leavening/ acid to neutralize it in order to yield not less than 12% of their weight as carbon dioxide when used.
The bicarbonate of commerce is about 99.8% pure.
High purity commercial grades /for veterinary use/ comtain about 27.3% sodium.
Commercial grades include U.S.P. and food grade; animal feed and industrial grade
Sodium bicarbonate /present in/: Arm & Hammer Carpet Deodorizer and Arm & Hammer Cat Litter Deodorizer.
ACS reagent, hemodialysis food grades 1, 2, 4, 3, 3DF, S, and, ITFF; USP and FCC grades
Parenteral: Solution, sterile, to adjust pH of injections: 4% (0.48 mEq/mL) (2.4 mEq) Neut ( with edetate disodium), (Hospira); 4.2% (0.5 mEq/mL) (2.5 mEq) Sodium Bicarbonate Additive Solution, (American Pharmaceutical Partners).
Parenteral: Injection, for preparation of IV admixtures: 7.5% (0.892 mEq/mL) (178.4 mEq) pharmacy bulk package Sodium Bicarbonate Injection MaxiVial, (American Pharmaceutical Partners).
Parenteral: Injection: 4.2% (0.5 mEq/mL) (2.5 or 5 mEq) Sodium Bicarbonate Injection,( American Pharmaceutical, Hospira); 5% (0.595 mEq/mL) (297.5 mEq) Sodium Bicarbonate Injection, (Baxter, Hospira); 7.5% (0.892 mEq/mL) (8.92 or 44.6 mEq) Sodium Bicarbonate Injection, (American Pharmaceutical Partners, American Regent, Hospira); 8.4% (1 mEq/mL) (10 or 50 mEq) Sodium Bicarbonate Injection, (American Pharmaceutical Partners, American Regent, Hospira).
Oral: Powder: Arm & Hammer Baking Soda, (Church & Dwight); Tablets: 325 mg Soda Mint ( with peppermint oil), (CMC), Sodium Bicarbonate Tablets,( CMC), Sodium Bicarbonate Tablets, (Rugby); 650 mg (available by nonproprietary name).
Exposure Standards and Regulations
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: sodium bicarbonate is included in digestive aid drug products.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: sodium bicarbonate is included in weight control drug products.
Sodium bicarbonate used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl sodium bicarbonate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Reactivities and Incompatibilities
A mixture /of sodium hydrogen carbonate, carbon and water/ was being stirred and steam heated when power failure interrupted stirring, and heating was turned off for a hour before power was restored. When stirring was restarted, the hot contents of the pan erupted immediately. Carbon dioxide is evolved from warm aqueous solutions of the base, and absence of stirring and presence of the carbon adsorbent would lead to non-equilibrium retention of the gas, which would be released instantaneously on stirring.
Several cases of spontaneous ignition after exposure to air of fine coke particles removed from filter strainers on a petroleum refinery furfural extraction unit have been noted. This has been associated with the use of sodium hydrogen carbonate (bicarbonate) injected into the plant for pH control, which produced a pH of 10.5 locally. This would tend to resinify the aldehyde, but there is also the possibility of a Cannizzaro reaction causing conversion of the aldehyde to furfuryl alcohol and furoic acid. The latter, together with other acidic products of autoxidation of the aldehyde, would tend to resinify the furfuryl alcohol. Pyrolysis gas-liquid chromatography (GLC) showed the presence of a significant proportion of furfuryl alcohol-derived resins in the coke. The latter is now discarded into drums of water, immediately after discharge from the strainers, to prevent further incidents. /2-Furaldehyde (Furfural): sodium hydrogen carbonate/
A self-propagating reaction can occur when ... sodium bicarbonate- ... based dry chemical extinguishing agent is mixed with monoammonium phosphate dry chemical extinguishing agent. Moisture will accelerate reaction. Products are water, ammonia, carbon dioxide and various solid substances. In a fire extinguisher the pressure developed will blow out the valve.
Sodium-potassium alloy undergoes a violent reaction with certain extinguishing agents: water, sodium bicarbonate, carbon tetrachloride. /Sodium-potassium alloy: water/
Protective Equipment and Clothing
The substance is mildly irritating to the eyes.

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)


Precautionary statement(s)








2.3 Other hazards which do not result in classification


Synthesis Route
144-55-8Total: 6 Synthesis Route
Precursor and Product
Computational chemical data
  • Molecular Weight:84.00661g/mol
  • Molecular Formula:CHNaO3
  • Exact Mass:83.982339
  • Monoisotopic Mass:83.982339
  • Complexity:33.9
  • Rotatable Bond Count:0
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Topological Polar Surface Area:60.4
  • Heavy Atom Count:5
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:2
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