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Home> Hot Product Listed A   > Acetic acid
Acetic acid
CAS No.:64-19-7
EINECS(EC#):200-580-7
Molecular Weight:60.05
Molecular Formula:C2H4O2 (Products with the same molecular formula)
MOL File:64-19-7.mol
Properties
Appearance
clear liquid
Density
1.048
Melting Point
16-16.5℃
Boiling Point
117-118℃
Refractive Index
1.3715
Flash Point
40℃
Water
miscible
Solubilities
Miscible with water
Color/Form
Clear, colorless liquid
Colorless liquid or crystals (Note: Pure compound is a solid below 62 degrees F). Often used in an aqueous solution).
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
HS Code
29152100
Storage temp
Store at RT.
Spectral properties
MAX ABSORPTION (ALCOHOL): 208 NM (LOG E= 1.5)
SADTLER REF NUMBER: 76 (IR, PRISM; V8 (NMR))
Index of refraction: 1.3720 @ deg C/D
IR: 4819 (Coblentz Society Spectral Collection)
UV: 4-3 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
RAMAN: 407 (Sadtler Research Laboratories Spectral Collection)
MASS: 34542 (NIST/EPA/MSDC Mass Spectral Database 1990 version)
1H NMR: 8 (Varian Associates NMR spectra collection)
13C NMR: 7 (Johnson and Jankowski, Carbon-13 NMR Spectra, John Wiley & Sons, New York)
Intense mass spectral peaks: 43 m/z, 60 m/z
Safety and Handling
Hazard Codes
C:Corrosive
Risk Statements
R10;R35
Safety Statements
S23;S26;S45
HazardClass
8
Safety
Hazard Codes:C,Xi
Risk Statements: 34-42-35-10-36/38
R34:Causes burns.
R42:May cause sensitization by inhalation.
R35:Causes severe burns.
R10:Flammable.
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36/37/39-45-23-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 1792 8/PG 2
WGK Germany: 3
RTECS: NN1650000
F: 1-8-10
HazardClass: 8
PackingGroup: II
PackingGroup
II
Skin, Eye, and Respiratory Irritations
Severe burns to eyes and skin may occur. Vapors strongly irritating to eyes and respiratory tract.
The vapor of acetic acid is irritating to the eyes and nose, causing lacrimation and hyperemia.
Irritating concn: 25 mg/cu m.
. Eye irritation has been noted at a concentration below 10 ppm.
Cleanup Methods
Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with caustic soda or soda ash.
Environmental considerations: Water spill: Add dilute caustic soda
Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.
Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert. Wash away remainder with plenty of water (extra personal protection: chemical protection suit including self-contained breathing apparatus).
Remove all ignition sources, ventilate area of spill or leak. If in liquid form, for small quantities, absorb on paper towels large quantities can be collected & atomized in suitable combustion chamber, or diluted neutralized & flushed into a sewer. If in the solid form, collect in the most safe & convenient manner for reclamation or allow to melt & collect as above.
Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Use soda ash to neutralize spills. Control runoff and isolate discharged material for proper. disposal.
Transport
UN 2789
Fire Fighting Procedures
Use water spray, dry chemical, "alcohol" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.
/When fighting fire/ use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.
If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors.
Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. /Corrosive liquid/
Fire Potential
Moderate, when exposed to heat or flame.
Formulations/Preparations
GRADES: USP /United States Pharmacopeia/ (glacial, 99.4 wt % and dilute, 36-37 wt %), cp /chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity/; technical (80; 99.5%); commercial (6, 28, 30, 36, 56, 70, 80 & 99.5%); nf /national formulary/ (diluted; 6.0 g/100 ml).
Reagent grade (glacial)-99.7%, USP grade glacial-99.5%; aq acetic acid-28,36,56,70,80,85 and 90%; lab reagent (aq)-36%
Household vinegar is usually 5% acetic acid.
DOT Emergency Guidelines
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible materials. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing is recommended for fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Evacuation: Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire: Some of these materials may react violently with water. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Do not get water inside containers. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Acetic acid, glacial; Acetic acid, solution, more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Evacuation: Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Acetic acid, solution, more than 10% but not more than 80% acid/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Acetic acid, solution, more than 10% but not more than 80% acid/
Exposure Standards and Regulations
Acetic acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Reactivities and Incompatibilities
Incompatibilities: carbonates, hydroxides, many oxides, and phosphates.
Cooling is necessary to prevent possible explosion from contact of potassium permanganate (or the calcium or sodium salts) with acetic acid
Liquid acetic acid will attack some forms of plastics, rubber, and coatings.
An explosion occurred during initial heating up of a large volume of glacial acetic acid being treated with chromium trioxide. This was attributed to violent interaction of solid chromium trioxide and liquid acetic acid on a hot, exposed steam coil, and subsequent initiation of an explosive mixture of acetic acid vapor and air. The risk has been obviated by using a solution of dichromate in sulfuric acid as oxidant, in place of chromium trioxide. The sulfuric acid is essential, as the solid dichromate moist with acetic acid, obtained by evaporating an acetic acid solution to near-dryness, will explode.
Potassium hydroxide residue in a catalyst pot reacted violently when acetic acid was added.
Mixing acetic acid and 2-aminoethanol in a closed container caused the temperature and pressure to increase.
Mixing glacial acetic acid and chlorosulfonic acid in a closed container caused the temperature and pressure to increase.
During the preparation of beta-hydroxy-beta-methyl glutaric acid using 75 g of diallyl methyl carbinol, the material had been ozonized and allowed to stand overnight. Glacial acetic acid had been added and the mixture was being concentrated under vacuum in a desiccator. After 1 1/2 hours the mixture exploded. Previous preparations using 12.6 g were successful.
Mixing acetic acid and ethylene diamine in a closed container caused the temperature and pressure to increase.
Mixing glacial acetic acid and ethyleneimine in a closed container caused the temperature and pressure to increase.
A mixture of ammonium nitrate and acetic acid ignites when warmed, especially if concentrated.
In reactions between bromine pentafluoride and acetic acid, fire and explosions are likely.
The reaction between chlorine trifluoride and acetic acid is very violent, sometimes explosive.
Acetic anhydride was gradually being titrated into a mixture of chromic anhydride and acetic acid in a 20-gallon, glass-lined tank. After 1 1/2 hours of this procedure, the contents of the reactor exploded.
Mixing glacial acetic acid and oleum in a closed container caused the temperature and pressure to increase.
Explosions involving these materials /perchloric acid and acetic acid/ have occurred in electrolytic polishing baths. The violence in some cases approached that of a true high explosive.
Phosphorus isocyanate and acetic acid react violently.
Several laboratory explosions have occurred using this reaction /phosphorus trichloride and acetic acid/ to form acetyl chloride. Poor heat control probably caused formation of phosphine.
Ignition occurs when potassium t-butoxide reacts with acetic acid.
During the production of terephthalic acid, n-xylene is oxidized in the presence of acetic acid. During these processes, detonating mixtures may be produced. Addition of a small amount of water may largely eliminate the risk of explosion.
Mixing sodium hydroxide and glacial acetic acid in a closed container caused the temperature and pressure to increase.
Mixtures of /acetic acid, acetic anhydride & perchloric acid/ have varying degrees of sensitivity to shock. Vapors above the heated mixtures are flammable.
Erroneous addition of aqueous acetic acid into a tank of acetic anhydride caused a violent exothermic hydrolysis.
Strong oxidizers (especially chromic acid, sodium peroxide & nitric acid), strong caustics [Note: Corrosive to metals].
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Special precautions: Liquid acetic acid will attack some forms of plastics, rubber, and coatings.
Clothing contaminated with acetic acid should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of acetic acid from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the acetic acid, the person performing the operation should be informed of acetic acid's hazardous properties.
Employees who handle solid or liquid acetic acid or solutions containing acetic acid should wash their hands thoroughly before eating, smoking, or using toilet facilities.
Non-impervious clothing which becomes contaminated with solid or liquid acetic acid or solutions containing 50% or more of acetic acid by weight should be removed immediately and not reworn until the acetic acid is removed from the clothing. Non-impervious clothing which becomes contaminated with solutions containing less than 50% but greater than 10% of acetic acid by weight should be removed promptly ad not reworn until the acetic acid is removed from the clothing.
Where there is any possibility of exposure of an employees' body to solid or liquid acetic acid or solutions containing 50% or more of acetic acid by weight, facilities for quick drenching of the body should be provided within the immediate work area for emergency use.
The worker should immediately wash the skin when it becomes contaminated. />10%/
Work clothing that becomes wet should be immediately removed due to its flammability hazard. />10%/
Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.
If material not on fire and not involved in fire: Deep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. Neutralize spilled material with crushed limestone, soda ash, or lime.
Protective Equipment and Clothing
Persons working with pure acid or concentrated solution should wear protective clothing, eye and face, hand and arm protection, and respiratory equipment.
500 ppm: Chemical cartridge respirator with an organic vapor cartridge(s) with a full facepiece or gas mask with an organic vapor canister (chin-style or front- or back-mounted canister) or supplied-air respirator with a full facepiece, helmet, or hood, or self-contained breathing apparatus with a full facepiece. 1000 ppm: Type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous-flow mode. Escape: Gas mask with an organic vapor canister (chin-style or front- or back-mounted canister) self-contained breathing apparatus.
Breakthrough times of greater than one hour were reported by (normally) two or more testers for neoprene, nitrile rubber, polyethylene, polyvinyl chloride, natural rubber and Vitron.
Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with solid or liquid acetic acid or solutions containing 50% or more of acetic acid by weight and to prevent repeated or prolonged skin contact with solutions containing 10% or more but less than 50% of acetic acid by weight.
Employees should be provided with and required to use dust- and splash-proof safety goggles where there is any possibility of solid or liquid acetic acid or solutions containing acetic acid contacting the eyes.
Wear appropriate personal protective clothing to prevent skin contact. />10%/
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. />5%/
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] />50%/
Respirator Recommendations: Up to 50 ppm: (Assigned protection factor = 25) Any supplied-air respirator operated in a continuous-flow mode. Substance causes eye irritation or damage; eye protection needed./(Assigned protection factor = 25) Any powered, air-purifying respirator with organic vapor cartridge(s). Substance causes eye irritation or damage; eye protection needed./(Assigned protection factor = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(Assigned protection factor = 50) Any self-contained breathing apparatus with a full facepiece/(Assigned protection factor = 50) Any supplied-air respirator with a full facepiece.
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned protection factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(Assigned protection factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape: (Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus.
Specification
Acetic acid (CAS NO.64-19-7), its Synonyms are Acetic acid 0.25% in plastic container ; Acetic acid, glacial ; Aci-Jel ; Acide acetique ; Ethanoic acid ; Ethanoic acid monomer ; Ethylic acid.
Octanol/Water Partition Coefficient
log Kow = -0.17
Disposal Methods

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Excess acetic acid and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.
The following wastewater treatment technologies have been investigated for acetic acid: Activated carbon.
The following wastewater treatment technologies have been investigated for acetic acid: Reverse osmosis.

Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000000_10000000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Abbott Diagnostics GmbH 2015
Acetex Intermediates S.A.S. 2010
Akzo Nobel Industrial Chemicals B.V. 2010
more >
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name acetic acid

1.2 Other means of identification

Product number -
Other names Glacial acetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Processing Aids and Additives
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Skin corrosion, Category 1A

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H226 Flammable liquid and vapour

H314 Causes severe skin burns and eye damage

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
acetic acid acetic acid 64-19-7 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. If within a few minutes after ingestion, one small glass of water may be given to drink. Refer immediately for medical attention.

4.2 Most important symptoms/effects, acute and delayed

Breathing of vapors causes coughing, chest pain, and irritation of nose and throat; may cause nausea andvomiting. Contact with skin and eye causes burns. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Garlic contains many sulfhydryl compounds that act as antioxidants. However, the role of nitric oxide (NO) in inflammation is controversial. The aim of the present study is to investigate the possible protective effect of garlic against acetic acid-induced ulcerative colitis in rats, as well as the probable modulatory effect of L-arginine (NO precursor) on garlic activity. Intra-rectal inoculation of rats with 4% acetic acid for 3 consecutive days caused a significant increase in the colon weight and marked decrease in the colon length. In addition, acetic acid induced a significant increase in serum levels of nitrate as well as colonic tissue content of malondialdehyde (MDA). Moreover, colonic tissue contents of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were markedly reduced. On the other hand, pre-treatment of rats with garlic (0.25 g/kgbwt, orally) for 4 consecutive weeks and 3 days during induction of colitis significantly reduced the increase in the colon weight induced by acetic acid and ameliorated alterations in oxidant and antioxidant parameters. Interestingly, oral co-administration of garlic (0.25 g/kgbwt) and L-arginine (625 mg/kgbwt) for the same period of garlic administration mitigated the changes in both colon weight and length induced by acetic acid and increased garlic effect on colon tissue contents of MDA and GSH. In conclusion, L-arginine can augment the protective effect of garlic against ulcerative colitis; an effect that might be mainly attributed to its NO donating property resulting in enhancement of garlic antioxidant effect...

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating vapor generated when heated. (USCG, 1999)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert.

6.3 Methods and materials for containment and cleaning up

Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert. Wash away remainder with plenty of water (extra personal protection: chemical protection suit including self-contained breathing apparatus).

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from food and feedstuffs, strong oxidants, strong acids and strong bases. Store only in original container. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.Store in a dry, well-ventilated place. Separate from oxidizing materials and alkaline substances.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10-hour Time-Weighted Average: 10 ppm (25 mg/cu m).

Recommended Exposure Limit: 15-minute Short-Term Exposure Limit: 15 ppm (37 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear liquid
Colour Clear, colorless liquid
Odour Pungent
Melting point/ freezing point 17\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 117-118\u00b0C(lit.)
Flammability Class II Combustible Liquid: Fl.P. at or above 37.78\u00b0C and below 60\u00b0C.Flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 4.0% by volume; Upper flammable limit: 19.9% by volume
Flash point 40\u00b0C
Auto-ignition temperature 426.67\u00b0C
Decomposition temperature no data available
pH Aqueous solution 1.0 molar = 2.4; 0.1 molar = 2.9; 0.01 molar = 3.4
Kinematic viscosity 1.056 mPa-s at 25\u00b0C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 11.4 mm Hg ( 20 \u00b0C)
Density and/or relative density 1.049g/mLat 25\u00b0C(lit.)
Relative vapour density 2.07 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under normal laboratory storage conditions.

10.3 Possibility of hazardous reactions

Moderate fire risk.Mixing acetic acid in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: 2-Aminoethanol, chlorosulfonic acid, ethylene diamine, ethyleneimine [NFPA 1991]. Acetic acid or acetic anhydride can explode with nitric acid if not kept cold. Potassium hydroxide residue in a catalyst pot reacted violently when acetic acid was added [MCA Case History 920. 1963]. During the production of terephthalic acid, n-xylene is oxidized in the presence of acetic acid. During these processes, detonating mixtures may be produced. Addition of a small amount of water may largely eliminate the risk of explosion [NFPA 491M.1991.p. 7]. Acetaldehyde was put in drums previously pickled with acetic acid. The acid caused the acetaldehyde to polymerize and the drums got hot and vented [MCA Case History 1764. 1971]. A mixture of ammonium nitrate and acetic acid ignites when warmed, especially if concentrated [Von Schwartz 1918. p. 322 ]. Several laboratory explosions have been reported using acetic acid and phosphorus trichloride to form acetyl chloride. Poor heat control probably caused the formation of phosphine [J. Am. Chem. Soc. 60:488. 1938]. Acetic acid forms explosive mixtures with p-xylene and air (Shraer, B.I. 1970. Khim. Prom. 46(10):747-750.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatibilities: carbonates, hydroxides, many oxides, and phosphates.

10.6 Hazardous decomposition products

When heated to decomposition it emits irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 3.53 g/kg
  • Inhalation: LC50 Rat inhalation 11.4 mg/L /4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow); Conditions: static bioassay in Lake Superior water at 18-22\u00b0C; Concentration: >315 mg/L for 1 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: static bioassay, neutralized to pH 8.0 and 20\u00b0C; Concentration: 6,000 mg/L for 24 hr; Effect: immobilization
  • Toxicity to algae: EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 156000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

Biological oxygen demand after 10 days at 20\u00b0C is: 82% biological oxidation in fresh water and 88% biological oxidation in sea water

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for acetic acid(SRC), using a log Kow of -0.17(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

A log Koc of 0.00 (Koc = 1), which was derived from experimental measurements, has been reported for acetic acid(1,2). According to a classification scheme(3), this Koc value suggests that acetic acid is expected to have very high mobility in soil. No detectable sorption was measured for acetic acid using the OECD Guideline 106 method employing an acidic forest soil, pH 2.8, an agricultural soil, pH 6.7, and a lake sediment, pH 7.1(4). Adsorption of acetic acid to 3 nearshore marine sediments collected from three different locations resulted in Kd values of 0.65 (Koc = 228), 0.085 (Koc = 6.5) and 0.046 (Koc = 27) using clastic mud (3.5% organic carbon, pH 7.0), muddy sand (1.3% organic carbon, pH 7.7), and carbonate sand (0.17% organic carbon, pH 8.1), respectively(5). The pKa of acetic acid is 4.76(6), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(7).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2789 IMDG: UN2789 IATA: UN2789

14.2 UN Proper Shipping Name

ADR/RID: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more\nthan 80% acid, by mass
IMDG: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more\nthan 80% acid, by mass
IATA: ACETIC ACID, GLACIAL or ACETIC ACID SOLUTION, more\nthan 80% acid, by mass

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
acetic acid acetic acid 64-19-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:60.05196 [g/mol]
Molecular Formula:C2H4O2
XLogP3-AA:-0.2
H-Bond Donor:1
H-Bond Acceptor:2
Rotatable Bond Count:0
Exact Mass:60.021129
MonoIsotopic Mass:60.021129
Topological Polar Surface Area:37.3
Heavy Atom Count:4
Formal Charge:0
Complexity:31
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Anion Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1