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Home> Encyclopedia > Hot Product Listed S   > Salicylamide
65-45-2 structure

Salicylamide

Iupac Name:2-hydroxybenzamide
CAS No.:65-45-2
EINECS(EC#): 200-609-3
Molecular Weight:137.138
Molecular Formula:C7H7NO2 (isomer)
Names and Identifiers
Synonyms

(6z)-6-[amino(hydroxy)methylidene]cyclohexa-2,4-dien-1-one 2-carbamoylphenol 2-carboxamidophenol 2-hydroxybenzamide 2-hydroxy-benzamide 2-hydroxybenzamide (see also:n-hydroxybenzamide (cas 495-18-1)) 2-oxidanylbenzamide 91096-EP2380872A1 A835120 AB00052089_12 AB1004776 AC1L1JPI AC1Q4Z8X acket afko-sal AH-034/32461056 ai3-03454 AJ-08127 AK-81394 AKOS000120983 algamon algiamida allevin amid kyseliny salicylove amid kyseliny salicylove [czech] amidosal amid-sal AN-23746 anamid andasol ANW-35045 BB_SC-0234 BBL016007 bdbm50056900 Benesal benesal (van) benzamide, 2-hydroxy- benzamide, o-hydroxy- Benzamide,2-hydroxy- benzoic acid, 2-hydroxy-, amide benzoic acid,2-hydroxy,amide salicylamide BR-81394 BRD-K81130846-001-02-6 brn 0742439 BSPBIO_001948 CCG-39250 ccris 6045 Cetamide chebi:32114 CHEMBL27577 Cidal CJ-00076 component of tolagesic (salt/mix) D01811 DB08797 DIVK1C_000858 dolomide dropsprin DS-16216 dsstox_cid_1726 dsstox_rid_76295 DTXSID3021726 eggosalil einecs 200-609-3 EM8BM710ZC EU-0000058 flarpirina h.p. 34 HMS1920P14 HMS2092G15 HMS2232E07 HMS502K20 hsdb 227 hydrochlorothiazide related compound hydroxy benzamide I01-5217 IDI1_000858 KB-24513 KBIO1_000858 KBIO2_001426 KBIO2_003994 KBIO2_006562 KBIO3_001448 KBIOGR_001017 KBIOSS_001426 liquiprin LS-1556 M-6078 MCULE-5482995635 mfcd00007978 MLS000069486 MOLPORT-001-641-072 morsarinas NCGC00091414-01 NCGC00091414-02 NCGC00091414-03 NCGC00091414-04 NCGC00091414-05 NCGC00256376-01 NCIOPEN2_001127 NINDS_000858 novecyl nsc 3115 nsc3115 nsc-3115 nsc-757318 ohb o-hydroxybenzamide OPERA_ID_1684 OPREA1_069894 oramid panithal pharmakon1600-01500532 PUBCHEM10992 raspberin RP20335 RTR-022279 S0006 salamid salamide saliamid saliamin salicilamida salicilamida [inn-spanish] salicilamide [dcit] salicilamide [italian] salicim salicylamid salicylamide (jan/usp/inn) salicylamide (tn) salicylamide [inn:ban:jan] salicylamide [usp:inn:ban:jan] Salicylamide(8CI) salicylamide, 99% salicylamide, puriss., >=99.0% (t) salicylamidum salicylamidum [inn-latin] salicylic acid amide salipur salizell salizell (van) salrin salymid samid SC-46863 SCHEMBL21646 serramida SKZKKFZAGNVIMN-UHFFFAOYSA-N smr000046394 SPBIO_001403 SPECTRUM_000946 SPECTRUM1500532 SPECTRUM2_001312 SPECTRUM3_000564 SPECTRUM4_000499 SPECTRUM5_001032 sr 4326 sr-01000721923 SR-01000721923-2 ST2410041 STK301812 tox21_111129 tox21_111129_1 tox21_201944 TR-022279 TRA0035157 urtosal wln: zvr bq ZINC2055

Inchi
InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)
InChkey
SKZKKFZAGNVIMN-UHFFFAOYSA-N
Canonical Smiles
C1=CC=C(C(=C1)C(=O)N)O
Properties
Appearance
white to pink crystalline powder
Density
1,175
Melting Point
139-142℃
Boiling Point
284° F (NTP, 1992)
Refractive Index
1.562 (20 C)
Flash Point
181°C/14mm
Solubility
Soluble in hot water
Color/Form
WHITE OR SLIGHTLY PINK CRYSTALLINE POWDER
YELLOW LEAFLETS FROM DILUTE ALCOHOL
Other physical and chemical properties
PHYSICAL DESCRIPTION: Odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82°F) about 5. Sublimation begins at the melting point. (NTP, 1992)
Stability
Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
HS Code
2924299090
Storage temp
Store at 2 - 8 C. Keep container tightly closed.
Spectral properties
INDEX OF REFRACTION: 1.595 (ALPHA); 1.637 (BETA); 1.727 (GAMMA) (MONOCLINIC SYSTEM)
SADTLER REFERENCE NUMBER: 3253 (IR, PRISM); 373 (IR, GRATING); MAX ABSORPTION (ALCOHOL): 302 NM (LOG E= 3.62)
MAX ABSORPTION (ALCOHOL): 548 NM (A= 548, 1%, 1 CM); 302 NM (A= 302, 1%, 1 CM)
IR: 1696 (Coblentz Society Spectral Collection)
UV: 973 (Sadtler Research Laboratories Spectral Collection)
NMR: 6740 (Sadtler Research Laboratories Spectral Collection)
MASS: 86 (Aldermaston, Eight Peak Index of Mass Spectra, UK)
Intense mass spectral peaks: 65 m/z, 92 m/z, 120 m/z, 137 m/z
Safety and Handling
Hazard Codes
Xn
Risk Statements
R22
Safety Statements
26-36
HazardClass
6.1(b)
Hazard Note
H302; H315; H319; H335
Safety

Hazard Codes:?Xn
Risk Statements: 22-36/37/38-20/21/22?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: VN6475000
HazardClass: 6.1(b)
PackingGroup of Salicylamide (CAS NO.65-45-2): III

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
cat LDLo oral 150mg/kg (150mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
dog LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
guinea pig LD50 oral 1730mg/kg (1730mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
guinea pig LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse LD50 intraperitoneal 180mg/kg (180mg/kg) ? Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
mouse LD50 intravenous 313mg/kg (313mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse LD50 oral 300mg/kg (300mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse LD50 subcutaneous 300mg/kg (300mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
rabbit LD50 oral 3200mg/kg (3200mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
rabbit LDLo intraperitoneal 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
rat LD50 intraperitoneal 600mg/kg (600mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953.
rat LD50 oral 980mg/kg (980mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

PackingGroup
III
Transport
3249
Formulations/Preparations
SALICYLAMIDE, NF CAPSULES, 200 MG, WITH METHAPYRILENE HYDROCHLORIDE 50 MG & SCOPOLAMINE AMINOXIDE HYDROBROMIDE 500 UG (SOMINEX); CAPSULES, 324 MG, WITH METHAPYRILENE HYDROCHLORIDE 12 MG & SCOPOLAMINE AMINOXIDE HYDROBROMIDE 150 MG (DEVAREX).
TABLETS, NF, 230 MG (AMID-SAL) & 600 MG (SALRIN); TABLETS, 200 MG WITH METHAPYRILENE HYDROCHLORIDE 25 MG (NYTOL); WITH SCOPOLAMINE AMINOXIDE HYDROBROMIDE 250 UG (SOMINEX); TABLETS, 250 MG WITH METHAPYRILENE HYDROCHLORIDE 25 MG & SCOPOLAMINE HYDROBROMIDE 200 UG (SURE-SLEEP).
LIQUIPRIN...ORAL: SOLN 60 MG/ML; SALAMIDE...SALICIM...ORAL: TABLETS 300 MG; SALRIN...ORAL: TABLETS 300 & 600 MG.
GRADES: TECHNICAL; NF.
Specification

? Salicylamide (CAS NO.65-45-2), its Synonyms are 2-Hydroxybenzamide ; Benzamide, 2-hydroxy- ; 2-Carbamoylphenol ; 2-Carboxamidophenol ; Acket ; Afko-Sal ; Algamon ; Algiamida ; Allevin ; Amid kyseliny salicylove ; o-Hydroxybenzamide . It is odorless white or slightly pink crystals and bitter taste, leaves a sensation of warmth on the tongue.

Octanol/Water Partition Coefficient
Log Kow = 1.28
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P391 Collect spillage.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:137.138g/mol
  • Molecular Formula:C7H7NO2
  • Compound Is Canonicalized:True
  • XLogP3-AA:1.3
  • Exact Mass:137.048
  • Monoisotopic Mass:137.048
  • Complexity:136
  • Rotatable Bond Count:1
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:63.3A^2
  • Heavy Atom Count:10
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADcYBiMAAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAHgAQCAAADASBmAAwBoBAAgCI AiFSEACCAAAkIAAIiAEGDMgIJjaClROAcUBm4BEImYeYyCCOAAAAAAAIAAAAAAAAABAAAAAAAAAA AA==
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