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Home> Hot Product Listed M   > Methyl sulfoxide

Methyl sulfoxide

CAS No.:67-68-5
Molecular Weight:78.12
Molecular Formula:C2H6OS (Products with the same molecular formula)
MOL File:67-68-5.mol
colorless liquid
Melting Point
Boiling Point
Refractive Index
Flash Point
clear colorless
Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials - consult a full data sheet before use. Hygroscopic.
HS Code
Storage temp
Store at RT.
Spectral properties
Index of refraction: 1.4795 at 20 deg C/D; 1.4787 at 21 deg C/D
Index refraction: 1.4770 at 20 deg C/D
IR: 4358 (Coblentz Society Spectral Collection)
UV: 6-5 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
NMR: 535 (Sadtler Research Laboratories Spectral Collection)
13C NMR: 158 (Stothers Carbon13 NMR Spectroscopy Academic Press, NY)
MASS: 19238 (NIST/EPA/MSDC Mass Spectral database, 1990 version)
Raman 28: (Dollish Characteristic Raman Frequencies of Organic Compounds John Wiley and Sons, New York)
Intense mass spectral peaks: 45 m/z, 63 m/z, 78 m/z
Safety and Handling
Hazard Codes
Risk Statements
Safety Statements

Hazard Codes of Dimethyl sulfoxide (CAS NO.67-68-5):?Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-37/39-26-36-23
S24/25:Avoid contact with skin and eyes.?
S37/39:Wear suitable gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S23:Do not breathe vapour.
WGK Germany: 1
RTECS: PV6210000
F: 3
HS Code: 29309070

Skin, Eye, and Respiratory Irritations
... Based on chemical and physical properties alone, /dimethyl sulfoxide/ is ranked 10th/ of the ten most potentially irritating solvents /From table/.
Fire Fighting Procedures
To fight fire use water, foam, carbon dioxide, or dry chemical.
Fire Potential
Combustible when exposed to heat flame or oxidizing materials.
Dimethyl sulfoxide is presently available as Rimso-5, in a 50% aqueous solution.
U.S. - 50% [Rimso-50; GENERIC]; Canada - 50% [Rimso-50].
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl dimethyl sulfoxide, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Dimethyl sulfoxide solution. (a) Specifications. Dimethyl sulfoxide contains 90 percent of dimethyl sulfoxide and 10% of water ... (c) Conditions of use. (1) It is used or intended for use as a topical application to reduce acute swelling due to trauma ... (2) Not for use in horses and dogs intended for breeding purposes nor in horses slaughtered for food. Other topical medications should only be used when the dimethyl sulfoxide treated area is thoroughly dry. Do not administer by any other route (3) For use by or on the order of a licensed veterinarian.
Dimethyl sulfoxide get. (a) Specifications. Dimethyl sulfoxide gel, veterinary contains 90 percent dimethyl sulfoxide in an aqueous gel ... (c) Conditions of use-(1) Indications for use. For use on horses and dogs as a topical application to reduce acute swelling due to trauma. ... (3) Limitations. Do not use in horses and dogs intended for breeding purposes or in horses slaughtered for food. Restricted to topical use on horses and dogs only. Due to rapid penetrating ability of dimethyl sulfoxide, rubber gloves should be worn when applying the drug. No other medications should be present on the skin prior to application of the drug. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Fluocinolone acetonide, dimethyl sulfoxide solution. Fluocinolone acetonide, dimethyl sulfoxide solution. (a) Specifications. Each milliliter of solution contains 0.01 percent fluocinolone acetonide and 20 percent dimethyl sulfoxide with propylene glycol and citric acid. ... (c) Conditions of use. (1) The drug is used in dogs for the relief of impaction commonly present in apparently normal anal sacs, for the reversal of inflammatory changes associated with abnormal anal sacs, and to counteract the offensive odor of anal sac secretions. ... (3) For use only by or on the order of a licensed veterinarian.
Fluocinolone acetonide, dimethyl sulfoxide otic solution. (a) Specifications. Each milliliter of solution contains 0.01 percent of fluocinolone acetonide in 60 percent dimethyl sulfoxide with propylene glycol and citric acid. ... (c) Conditions of use. (1) The drug is used in dogs for the relief of pruritis and inflammation associated with acute and chronic otitis. ... (3) There should be careful initial evaluation and followup of infected ears. Incomplete response or exacerbation of corticosteroid-responsive lesions may be due to the presence of an infection which requires identification or antibiotic sensitivity testing, and the use of the appropriate antimicrobial agent. As with any corticosteroid, animals with a generalized infection should not be treated with this product without proper supportive antimicrobial therapy. Preparations with dimethyl sulfoxide should not be used in pregnant animals. For use by or on the order of a licensed veterinarian.
Reactivities and Incompatibilities
Can react with oxidizing materials.
Violent or explosive reaction with many acyl, aryl, and nonmetal halides (eg acetyl chloride, benzenesulfonyl chloride, bromobenzoyl actanilide, cyanuric chloride, iodine pentafluoride, Mg(ClO4)2, CH3Br, NiO4, oxalyl chloride, P2O3, phosphorus trichloride, phosphoryl chloride, silver fluoride, silver difluoride, sodium hydride, sulfur dichloride, disulfur dichloride, sulfurylchloride, tetrachlorosilane, and thionyl chloride).
Violent or explosive reaction with boron compounds (eg borane, nonahydrononaborate (2-) ion), 4(4'-bromobenzoyl)acetanilide, carbonyl diisothiocyanate, dinitrogen tetraoxide, hexachlorocyclotriphosphazine, copper + trichloroacetic acid, metal alkoxides (eg potassium tert-butoxide, sodium isopropoxide), trifluoroacetic acid anhydride.
Incompatible with magnesium perchlorate, metal oxosalts, perchloric acid, periodic acid, sulfur trioxide.
Forms powerfully explosive mixtures with metal salts of oxoacids (eg aluminum perchlorate, sodium perchlorate, and iron (III) nitrate).
Other Preventative Measures
... DMSO can be harmful. ... Use effective fume removal device.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective Equipment and Clothing
... Based on chemical and physical properties alone, /dimethyl sulfoxide/ is ranked 10th/ of the ten most potentially irritating solvents /From table/.

? Dimethyl sulfoxide with a CAS number of 67-68-5. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a distinctive property of penetrating the skin very readily, so that one may taste it soon after it comes into contact with the skin. Its taste has been described as oyster- or garlic-like.
Chemical Stability of Dimethyl sulfoxide (CAS NO. 67-68-5): Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
? Dimethyl sulfoxide is incompatibilities with Other Materials Strong oxidizing agents, perchloric acid.
Hazardous decomposition products of?Dimethyl sulfoxide are carbon monoxide, oxides of sulfur, carbon dioxide, formaldehyde.
Hazardous polymerization of Dimethyl sulfoxide will not occur.

Octanol/Water Partition Coefficient
log Kow = -1.35
Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 10000_100000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Chemservice GmbH - (4R7V) 2012
Envigo Consulting Limited 2015
more >

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According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Dimethyl sulfoxide

1.2 Other means of identification

Product number -
Other names Methane, sulfinylbis-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details


1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)


Precautionary statement(s)








2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Dimethyl sulfoxide Dimethyl sulfoxide 67-68-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Slight eye irritation. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

In case of accidental oral ingestion, specific measures should be taken to induce emesis. Additional measures which may be considered are gastric lavage, activated charcoal and forced diuresis.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Sulfur dioxide, formaldehyde, and methyl mercaptan can form (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Accidental Release Measures. Personal precaustions, protective equipment and emergency procedure: Avoid breathing vapors, mist or gas. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let products enter drains.; Methods and materials for containment adn cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants. Cool. Keep in the dark. Keep in a well-ventilated room.Store away from oxidizing agents, heat, and ignition sources.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state colorless liquid
Colour Colorless liquid
Odour Slightly sulfurous odor
Melting point/ freezing point 8\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 189\u00b0C(lit.)
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit Lower flammable limit: 2.6% by volume; Upper flammable limit: 42% by volume
Flash point 87\u00b0C
Auto-ignition temperature 300.56\u00b0C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 2.47cP at 20\u00b0C
Solubility greater than or equal to 100 mg/mL at 20\u00b0C
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 0.42 mm Hg ( 20 \u00b0C)
Density and/or relative density 1.10g/mL(lit.)
Relative vapour density 2.7 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Combustible when exposed to heat or flame.The vapour is heavier than air and may travel along the ground; distant ignition possible.DIMETHYL SULFOXIDE decomposes violently on contact with many acyl halides and related compounds such as acetyl chloride, benzenesulfonyl chloride, benzoyl chloride, cyanuric chloride, phosphorus trichloride, phosphorus oxychloride, and thionyl chloride [Chem. Eng. News 35(9):87 (1957)].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... can react with oxidizing materials.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /sulfur oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 17.9 mL/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow); Conditions: static; Concentration: 34 g/L for 96 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Concentration: 7000 mg/L for 24 hr; Effect: inhibition of mobility /Conditions of bioassay not specified in source examined
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Dimethyl sulfoxide, present at 100 mg/L, reached 3.1% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Little degradation of dimethyl sulfoxide (<20%) was noted in a screening test using an activated sludge inoculum(2). Using the OECD 301E method, 99% degradation was observed(3). Using the OECD 303A method (domestic sewage simulation), 90% degradation of dimethyl sulfoxide was observed at a concentration of 65 mg/L over a 32-day incubation period(3,4). One ready biodegradation test performed following the norm AFNOR NFT 90-312 concluded that dimethyl sulfoxide is readily biodegradable(4). Dimethyl sulfoxide, at a 500 mg/L concentration, was entirely biodegraded within about 37 hours with aerobic settling sludge obtained from the activated sludge process at an opto-electronic plant, under optimized pH/temperature conditions(4). The available biodegradation screening tests have conflicting results(3), but based on available data and weight-of-evidence approach, dimethyl sulfoxide is expected to be inherently biodegradable(4).

12.3 Bioaccumulative potential

A BCF of <4 was measured in fish for dimethyl sulfoxide using carp (Cyprinus carpio) which were exposed over a 6-week period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dimethyl sulfoxide can be estimated to be 2(SRC). According to a classification scheme(2), this estimated Koc value suggests that dimethyl sulfoxide is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1993 IMDG: UN1993 IATA: UN1993

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Dimethyl sulfoxide Dimethyl sulfoxide 67-68-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:78.13344 [g/mol]
Molecular Formula:C2H6OS
H-Bond Donor:0
H-Bond Acceptor:2
Rotatable Bond Count:0
Exact Mass:78.013936
MonoIsotopic Mass:78.013936
Topological Polar Surface Area:36.3
Heavy Atom Count:4
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1