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Home> Encyclopedia > Hot Product Listed R   > Ribonuclease A
9001-99-4 structure

Ribonuclease A

CAS No.:9001-99-4
EINECS(EC#): 232-646-6
Molecular Weight:393.3496
Molecular Formula:C20H15N3O6 (isomer)
Names and Identifiers
Synonyms

RIBONUCLEASE RIBONUCLEASE I RIBONUCLEASE I, E COLI

Inchi
InChI=1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
Canonical Smiles
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC=C(C5=C4)[N+](=O)[O-])O
Isomers Smiles
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC=C(C5=C4)[N+](=O)[O-])O
Properties
Appearance
White to white with a yellow cast powder
Melting Point
243 °C (dec.)
Color/Form
white
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Storage temp
2-8°C
Safety and Handling
Safety Statements
S28;S37;S45
Safety

Safety Statements:
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: RF0760000
F 10: Keep under argon.
F 21: Sensitive to humidity.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 355mg/kg (355mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
mouse LD50 subcutaneous 230mg/kg (230mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 intramuscular 310mg/kg (310mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 intraperitoneal 392mg/kg (392mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.
rat LD50 subcutaneous 290mg/kg (290mg/kg)   "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie. Nucleases: Biological Function and Practical Applications," Berdyshev, G.D., et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985Vol. -, Pg. 56, 1985.

Specification

 Ribonuclease A , its cas register number is 9001-99-4. It also can be called Alkaline ribonuclease ; Amphinase ; Pancreatic ribonuclease ; RNase; Ribonuclease ; S-RNase ; and Ribonucleic phosphatase .

MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Computational chemical data
  • Molecular Weight:393.3496g/mol
  • Molecular Formula:C20H15N3O6
  • Exact Mass:393.096085
  • Monoisotopic Mass:393.096085
  • Complexity:861
  • Rotatable Bond Count:1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:7
  • Topological Polar Surface Area:126
  • Heavy Atom Count:29
  • Defined Atom Stereocenter Count:1
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
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Recommended Suppliers
  • Tel:0086-27-59207850
  • Fax:0086-27-59524646
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  • Fax:86-571-88938652
  • Tel:+86-0592-5567629
  • Fax:+86-0592-5567629
  • Tel:+86-025-58535435
  • Fax:
  • Tel:86-27-87465837
  • Fax:86-27-87772287
  • Tel:86-311-66600578
  • Fax:86-311-66600576
  • Tel:86-571-85232161
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  • Tel:86-512-87666785
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