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Home> Hot Product Listed P   > Polyinosinic acid-polycytidylic acid
210108-88-6 structure

Polyinosinic acid-polycytidylic acid

Iupac Name:[(6Z)-2,4,9,13-tetraacetyloxy-3a,10-dihydroxy-2,5,8,8-tetramethyl-12-methylidene-11-(2-methylpropanoyloxy)-3,4,5,9,10,11,13,13a-octahydro-1H-cyclopenta[12]annulen-1-yl] benzoate
CAS No.:210108-88-6
EINECS(EC#): 618-469-0
Molecular Weight:744.831
Molecular Formula:C15H10N2O2.H.(C3H6O)N.OH (isomer)
Names and Identifiers
Synonyms

[3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic acid [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid 5-Inosinic acid homopolymer-5-cytidylic acid homopolymer complex (1:1) 5-Inosinic acid, homopolymer, complex with 5-cytidylic acid homopolymer (1:1) 5-Inosinic acid, homopolymer, complex with 5-cytidylic acid homopolymer (1:1) (9CI) 5-Inosinic acid, polymers, complex with 5-cytidylic acid polymers (1:1) 5-Inosinic acid, polymers, complex with 5-cytidylic acid polymers (1:1) (8CI) NSC-120949 PI:C Poly (cytidylic acid)-poly(inosinic acid) Poly (I).poly(C) Poly (I:C) Poly (rI).(rC) Poly (rI).poly(rC) Poly (rI)-poly(rC) Poly (rI:rC) Poly 1-poly-c Poly C poly I POLY I:C Poly I:poly C Poly IC POLY I-C Poly rI:poly rC Poly(cytidylic acid)-poly(inosinic acid) Poly(I).poly(C) Poly(I).poly(C) complex Poly(I:C) (VAN) Poly(I+C) Poly(rI).(rC) Poly(rI).poly(rC) PolyC polycytidylic acid Polycytidylic-polyinosinic acid Polycytidysic acid Polyinosinate:polycytidylate Polyinosinate-polycytidylate complex Polyinosinic acid Polycytidylic acid Polyinosinic acid.polycytidylic acid Polyinosinic acid:polycytidylic acid Polyinosinic acid:polycytidylic acid complex Polyinosinic:polycytidylic acid Polyinosinic:polycytidylic acid copolymer Polyinosinic-polycyticylic acid complex Polyinosinic-polycytidylic acid Polyinosinic-polycytidylic acid complex Polyribocytidylic acid-polyriboinosinic acid complex Polyriboinosinic acid:polyribocyticylic acid Polyriboinosinic acid:polyribocytidylic acid Polyriboinosinic acid-polyribocytidylic acid complex Polyriboinosinic: polyribocytidylic acid Polyriboinosinic-polyribocytidylic acid Polyriboinosinic-polyribocytidylic acid complex

Inchi
InChI=1S/C39H52O14/c1-20(2)35(45)51-31-22(4)30(48-23(5)40)28-33(52-36(46)27-15-13-12-14-16-27)38(11,53-26(8)43)19-39(28,47)32(49-24(6)41)21(3)17-18-37(9,10)34(29(31)44)50-25(7)42/h12-18,20-21,28-34,44,47H,4,19H2,1-3,5-11H3/b18-17-
InChkey
WITHKWWZWFNDND-ZCXUNETKSA-N
Canonical Smiles
CC1C=CC(C(C(C(C(=C)C(C2C(C(CC2(C1OC(=O)C)O)(C)OC(=O)C)OC(=O)C3=CC=CC=C3)OC(=O)C)OC(=O)C(C)C)O)OC(=O)C)(C)C
Properties
Density
1.24
Boiling Point
°Cat760mmHg
Flash Point
141.7°C
Storage temp
−20°C
Safety and Handling
Safety

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Human mutation data reported. An eye irritant. When Polyinosinic:polycytidylic acid copolymer (CAS NO.24939-03-5) is heated to decomposition ,it emits acrid smoke and irritating fumes.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 15mg/kg (15mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 intraperitoneal 35mg/kg (35mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 intravenous 9500ug/kg (9.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 parenteral 20mg/kg (20mg/kg) BEHAVIORAL: EXCITEMENT Nature. Vol. 223, Pg. 715, 1969.
rabbit LD50 intravenous 220ug/kg (0.22mg/kg) VASCULAR: OTHER CHANGES

BLOOD: HEMORRHAGE
Voprosy Virusologii. Problems of Virology. Vol. 23(2), Pg. 201, 1978.
rat LD50 intraperitoneal 365mg/kg (365mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.
rat LD50 intravenous 185mg/kg (185mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.

MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

Computational chemical data
  • Molecular Weight:744.831g/mol
  • Molecular Formula:C15H10N2O2.H.(C3H6O)N.OH
  • Compound Is Canonicalized:True
  • Exact Mass:744.336
  • Monoisotopic Mass:744.336
  • Complexity:1440
  • Rotatable Bond Count:14
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:14
  • Topological Polar Surface Area:198A^2
  • Heavy Atom Count:53
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:10
  • Defined Bond Stereocenter Count:1
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADcfB8PAAAAAAAAAAAAAAAAAAAAYAAAAAwAAAAAAAAAAABAAAAGgAACAAAD1SgmAIyCIAABgCI AiDSCAACAAAkAAAIiAEACMgJNjKANRiCcQAlwAELqYfI6PyPgAAAAAAAAAAAAAAAAAAAAYQADCAA AA==
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