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Home> Hot Product Listed F   > Fluorescein sodium

Fluorescein sodium

CAS No.:518-47-8
EINECS(EC#):208-253-0
Molecular Weight:376.27
Molecular Formula:C20H12O5?2Na (Products with the same molecular formula)
MOL File:518-47-8.mol
Names and Identifiers
Synonyms

C.I. 45350 disodium salt Fluorescein hidacid uranine 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthene]-3-one, disodium salt 3,6-Dihydroxyxanthene-9-spiro-1'-3'H-isobenzofuran-3'-one disodium salt 9-o-carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt C.I. Acid Yellow 73 disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate 12417 yellow disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate Uranine K Uranine O C.I. 45350 sodium salt 9-(o-Carboxyphenyl)-3,6-dihydroxyxanthylium disodium salt 3,6-Dihydroxyxanthene-9-spiro-1'-3'H-isobenzofuran-3'-one sodium salt of hydroxy-o-carboxy-phenyl-fluorone Uranin 3,6-Dihydroxyxanthene-9-spiro-1'-3'H-isobenzofuran-3'-one dipotassium salt ful-gloAcid Yellow 73~C.I. 45350 Fluorescein, sodium derivative, sodium salt Acid Yellow 73 funduscein fluorescein sodium b.p fluorescein, disodium salt C.I. 45350 certiqual fluoresceine Soap yellow Fluorescein disodium salt hydrate C.I. 766 fluorescein, water soluble Yellow no. 8 d&c yellow no. 8 3',6'-Dihydroxy-spiro[3H-isobenzofuran-1,9'-xanthen]-3-one disodium salt fluor-i-strip a.t. 11824 yellow resorcinol phthalein sodium calcocid uranine b4315 Acid Yellow 73 (C.I.) Soluble fluorescein aizen uranine Dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one disodium salt Uranine Yellow furanium Uranine USP XII Uranine WSS Fluorescein Sodium Salt Uranine A Extra Fluorone Acid Yellow 73 Uranine SS sodium fluoresceinateFluorescein sodium Fluorescein W/S Uranine 9-(o-Carboxyphenyl)-3,6-dihydroxyxanthylium dipotassium salt

Inchi
InChI=1/C20H12O5.2Na/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;;/h1-10,21H,(H,23,24);;/q;2*+1/p-2
Canonical Smiles
C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
Properties
Appearance
orange powder
Density
1.601 g/cm3 (20 C)
Melting Point
320℃
Boiling Point
620.8oC at 760 mmHg
Flash Point
232.6 oC
Water
500 g/L (20℃)
Solubilities
Freely Souluble (600 g/l) SOLVENT
Color/Form
Red, orthorhombic prisms
Yellowish-red to red powder
Orange-red, crystalline powder
Stability
Stable.
HS Code
32041200
Storage temp
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Spectral properties
MAX ABSORPTION (DIOXANE): 225 NM (LOG E= 4.8); 227.5 NM (LOG E= 3.8); 490 NM (LOG E= 2.1)
Absorption max: 493.5, 460 nm
IR: 9792 (Sadtler Research Laboratories Prism Collection)
UV: 20876 (Sadtler Research Laboratories Spectral Collection)
Safety and Handling
Hazard Codes
Xi:Irritant
Risk Statements
R36
Safety Statements
S26;S37/39
Safety

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Human systemic effects by intravenous route: arrhythmias, eye hemorrhage, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
Hazard Codes:?IrritantXi
Risk Statements: 36-36/37/38?
R36: Irritating to eyes
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-37/39-26-36/37/39-27?
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S27: Take off immediately all contaminated clothing
WGK Germany: 1
RTECS: LM5425000
F 3:?Hygroscopic
HS Code: 32041200

Skin, Eye, and Respiratory Irritations
Eye, skin, ... and/or respiratory tract irritation.
Cleanup Methods
Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately-labelled container for disposal. Wash spill site.
Transport
25kgs
Fire Fighting Procedures
Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials. This material is assumed to be combustible. As with all dry powders it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential buildup of static electricity. As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.
Fire Potential
This material is assumed to be combustible.
Slight.
Formulations/Preparations
Fluorescite (fluorescein injection, USP) 10% contains fluorescein sodium (equivalent to fluorescein 10% w/v.
Ak-Fluor (fluorescein injection, USP) 10% is 100 mg/mL in a 5 mL single vial and Ak-Fluor (fluorescein injection, USP) 25% is 250 mg/mL in a 2 mL single dose vial
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl fluorescein sodium, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Fluorescein sodium/
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective Equipment and Clothing
Eye, skin, ... and/or respiratory tract irritation.
Specification

Handling?and?storge of Fluorescein sodium :
Handling: Wash thoroughly after handling. Use with adequate ventilation.Minimize dust generation and accumulation. Avoid ingestion and inhalation.Avoid contact with skin, eyes,and clothing. Keep container tightly closed.????
Storage: Keep container closed when not in use. Store in a cool, dry,well-ventilated area away from incompatible substances. Store protected from moisture.
?Fluorescein sodium (CAS NO.518-47-8) is also called as?9-(O-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one,disodiumsalt ; 9’-(9H)xanthen)-3-one,3’,6’-dihydroxy-spiro(isobenzofuran-1(3hdisodiums) ; 9’-[9H]xanthen]-3-one,3’,6’-dihydroxy-spiro[isobenzofuran-1(3hdisodiumsal ; 9-O-carboxyphenyl-6-hydroxy-3 isoxanthone,disodiumsalt ; Abcoluraninepowders&liquids ; Aizenuranine .

Octanol/Water Partition Coefficient
log Kow = 3.35 (est)
Report

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: Criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 10_100 view >
Registered companies:
Registrant / Supplier details Latest dossier received
Sustainability Support Services (Europe) AB 2017
more >
MSDS

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Uranine

1.2 Other means of identification

Product number -
Other names URANIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Uranine Uranine 518-47-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state orange powder
Colour no data available
Odour no data available
Melting point/ freezing point 173\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 41\u00b0C
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point -28\u00b0C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:500 g/L (20 \u00baC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 1.601 g/cm3 (20\u00baC)
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3295 IMDG: UN3295 IATA: UN3295

14.2 UN Proper Shipping Name

ADR/RID: HYDROCARBONS, LIQUID, N.O.S.
IMDG: HYDROCARBONS, LIQUID, N.O.S.
IATA: HYDROCARBONS, LIQUID, N.O.S.

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Uranine Uranine 518-47-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Computational chemical data

Molecular Weight:332.30628 [g/mol]
Molecular Formula:C20H12O5
XLogP3-AA:3.4
H-Bond Donor:2
H-Bond Acceptor:5
Rotatable Bond Count:0
Tautomer Count:5
Exact Mass:332.068473
MonoIsotopic Mass:332.068473
Topological Polar Surface Area:76
Heavy Atom Count:25
Formal Charge:0
Complexity:522
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:2
Feature 3D Ring Count:5
Effective Rotor Count:0.4
Conformer Sampling RMSD:0.6
CID Conformer Count:1