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Home> Hot Product Listed D   > Dichloromethane
75-09-2 structure

Dichloromethane

Iupac Name:dichloromethane
CAS No.:75-09-2
EINECS(EC#): 200-838-9
Molecular Weight:84.927
Molecular Formula:CH2Cl2 (isomer)
Names and Identifiers
Synonyms

300062X 588X2YUY0A AB1007261 AC1L1MBL AC1O5DP8 AC1Q3UP8 ACMC-1BFR1 aerothene aerothene mm ai3-01773 AMBOTZSOL-002 AN-23837 ANW-42404 bichloride, methylene brn 1730800 C02271 caswell no. 568 ccris 392 ch2cl2 CHEBI:15767 CHEMBL45967 chloride, methylene chlorure de methylene chlorure de methylene [french] cl2ch2 D02330 D0529 D3478 dichioromethane dichloride, methylene dichlormetane dichlormethan dichlormethane dichlor-methane dichloro methane dichloro- methane dichloro -methane dichloromeihane dichlorometan dichlorometane dichloromethan di-chloromethane dichloro-methane dichloromethane- dichloromethane (methylene chloride) dichloromethane (methylenechloride) dichloromethane (peptide grade) dichloromethane [un1593] [poison] dichloromethane reagent grade acs dichloromethane solution, contains 10 % (v/v) methanol dichloromethane, >71% in a non hazardous diluent dichloromethane, 99%, stab. with ca. 50ppm amylene dichloromethane, acs dichloromethane, acs reagent, >=99.5%, contains 40-150 ppm amylene as stabilizer dichloromethane, acs reagent, 99.5% dichloromethane, acs spectrophotometric grade, >=99.5%, contains 50-150 ppm amylene as stabilizer dichloromethane, analytical standard, stabilized dichloromethane, anhydrous dichloromethane, anhydrous, >=99.8%, contains 40-150 ppm amylene as stabilizer dichloromethane, ar, >=99% dichloromethane, biotech. grade, 99.9%, contains 40-150 ppm amylene as stabilizer dichloromethane, environmental grade dichloromethane, for hplc dichloromethane, for hplc, >=99.8% (gc) dichloromethane, for hplc, >=99.9%, contains 40-150 ppm amylene as stabilizer dichloromethane, hplc grade dichloromethane, nf dichloromethane, p.a., acs reagent, reag. iso, reag. ph. eur., 99.8%, contains 40-60 ppm amylene dichloromethane, purification grade dichloromethane, puriss. p.a., acs reagent, reag. iso, >=99.9% (gc) dichloromethane, puriss., meets analytical specification of ph.??eur., nf, >=99% (gc) dichloromethane, saj first grade, >=99.0% dichloromethane, selectophore(tm), >=99.5% dichloromethane, selectophore(tm), >=99.5% (gc), inhibitor-free dichloromethane, special, 99.9%, contains 40-60 ppm amylene dichloromethane, spectrophotometric grade dichloromethane, suitable for 1000 per jis, >=99.5%, for residue analysis dichloromethane, suitable for 300 per jis, for residue analysis dichloromethane, technical grade, 95%, contains 40-60 ppm amylene dichloromethane, uv hplc spectroscopic, 99.9%, contains 40-60 ppm amylene dichlorometliane dichlorornethane dichoromethane di-cle dicliloromethane dicloromethane dideuteromethylenechloride driverit dsstox_cid_868 einecs 200-838-9 epa pesticide chemical code 042004 f 30 f 30 (chlorocarbon) freon 30 FT-0624716 h2ccl2 hcc 30 hsdb 66 I14-19640 J-610006 khladon 30 L023970 LS-1655 m.c M0629 m-clean d MCULE-1114735075 mecl2 mehtylene chloride metaclen methane dichloride methane, dichloro- Methane,dichloro methlene chloride methlyene chloride methlyenechloride methoklone methyene chloride methyienechlorid methyl ene chloride methylen chloride methylenchlorid methylenchloride methylenchoride methylene bichloride methylene chloride methylene chloride (dichloromethane) methylene chloride (nf) methylene chloride (recovered) methylene chloride [usan] methylene chloride acs methylene chloride hplc grade methylene chloride-d2 methylene chloride-methane, dichloro- methylene chlorie methylene choride methylene cloride methylene di chloride methylene dichloride methylene,chloride methylenechlorid methylenechloride methylene-chloride methylenedichloride methylenum chloratum metylenchloride metylene chloride metylenu chlorek metylenu chlorek [polish] mfcd00000881 MOLPORT-001-757-423 n,n-methylenechloride narkotil NCGC00091504-01 NCGC00260075-01 nci-c50102 NCIMECH_000221 nevolin nsc 406122 nsc406122 nsc-406122 plastisolve QMABHXAIH@ r 30 r30 (refrigerant) rcra waste no. u080 rcra waste number u080 refrigerant 30 residual solvent class 2 - methylene chloride, united states pharmacopeia (usp) reference standard RL04864 RTR-037666 salesthin SC-26935 solaesthin soleana vda solmethine STL264204 tox21_202526 TRA0007256 un 1593 un 1593, mdc un1593 unii-588x2yuy0a wln: g1g YMWUJEATGCHHMB-UHFFFAOYSA-N

Inchi
InChI=1S/CH2Cl2/c2-1-3/h1H2
InChkey
YMWUJEATGCHHMB-UHFFFAOYSA-N
Canonical Smiles
C(Cl)Cl
Properties
Appearance
A colorless liquid with a sweet, penetrating, ether-like odor
Density
1.325
Melting Point
-97℃
Boiling Point
-142.1° F (NTP, 1992)
Refractive Index
1.4242
Flash Point
39-40℃
Solubility
Water solubility: 20 g/L (20 °C)
Color/Form
Colorless liquid [Note: A gas above 104 degrees F].
Other physical and chemical properties
DICHLOROMETHANE; is a colorless liquid with a sweet, penetrating, ether-like odor. Noncombustible by if exposed to high temperatures may emit toxic chloride; fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover.
Stability
In the absence of moisture at ordinary temp, dichloromethane; is relatively stable when compared with its congeners, chloroform; and carbon tetrachloride;.
HS Code
2903120001
Storage temp
Store at RT.
Spectral properties
Index of refraction: 1.4244 @ 20 deg C/D
IR: 4354 (Coblentz Society Spectral Collection)
NMR: 6401 (Sadtler Research Laboratories Spectral Collection)
MASS: 117 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
IR PRISM: 6620 (gas), 1011, IR GRATING: 28523
Intense mass spectral peaks: 49 m/z, 84 m/z
Safety and Handling
Hazard Codes
Xn
Risk Statements
R40
Safety Statements
S23;S24/25;S36/37
HazardClass
6.1
Safety
Hazard Codes of Dichloromethane (CAS NO.75-09-2):?Xn,T,F
Risk Statements: 40-39-23/24/25-11
R40:Limited evidence of a carcinogenic effect.
R39:Danger of very serious irreversible effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R11:Highly flammable.
Safety Statements: 23-24/25-36/37-45-16-7
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
RIDADR: UN 1593 6.1/PG 3
WGK Germany: 2
RTECS: PA8050000
F: 3-10
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 43400mg/m3/4. (43400mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ATAXIA
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
dog LCLo inhalation 14108ppm/7H (14108ppm) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.
dog LD50 intraperitoneal 1274mg/kg (1274mg/kg) Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
dog LDLo intravenous 200mg/kg (200mg/kg) Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
dog LDLo oral 3gm/kg (3000mg/kg) Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
guinea pig LCLo inhalation 5000ppm/2H (5000ppm) Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.
human LDLo oral 357mg/kg (357mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969.
human TCLo inhalation 500ppm/1Y-I (500ppm) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: CHANGE IN RATE
Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968.
human TCLo inhalation 500ppm/8H (500ppm) BEHAVIORAL: EUPHORIA Science. Vol. 176, Pg. 295, 1972.
man TDLo oral 1429uL/kg (1.429mL/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: NORMOCYTIC ANEMIA
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994.
mouse LC50 inhalation 14400ppm/7H (14400ppm) National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.
mouse LD50 intraperitoneal 437mg/kg (437mg/kg) Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960.
mouse LD50 oral 873mg/kg (873mg/kg) EHP, Environmental Health Perspectives. Vol. 106(Suppl,
mouse LD50 subcutaneous 6460mg/kg (6460mg/kg) Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962.
mouse LD50 unreported 4770mg/kg (4770mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982.
rabbit LCLo inhalation 10000ppm/7H (10000ppm) Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944.
rabbit LD50 unreported 1225mg/kg (1225mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.
rabbit LDLo oral 1900mg/kg (1900mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955.
rabbit LDLo subcutaneous 2700mg/kg (2700mg/kg) Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
rat LC50 inhalation 52gm/m3 (52000mg/m3) Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979.
rat LD50 intraperitoneal 916mg/kg (916mg/kg) Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 oral 1600mg/kg (1600mg/kg) BEHAVIORAL: ATAXIA FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970.
rat LD50 unreported 5350mg/kg (5350mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.
rat LDLo intratracheal 350mg/kg (350mg/kg) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
National Technical Information Service. Vol. OTS0520615,

PackingGroup
III
Skin, Eye, and Respiratory Irritations
Irritation of eyes and respiratory tract.
Cleanup Methods
Environmental considerations - Air spill: Apply water spray or mist to knock down vapors.
Environmental considerations: Water spill: Use natural deep water pockets, excavated lagoon, or sand bag barriers to trap material at bottom. remove trapped material with suction hoses.
Environmental considerations - Land spill: Dig a pit, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.
Stop or control the leak, if this can be done without undue risk. Control runoff and isolate discharged material for proper disposal.
Transport
UN 1593/1912
Fire Fighting Procedures
Use dry chemical, carbon dioxide, foam, or water spray. Use water spray to keep fire-exposed containers cool.
Extinguishant: Dry chemical, carbon dioxide, foam.
If material involved in fire: Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Keep run-off water out of sewers and water sources.
Fire Potential
It is flammable in the range of 12-19% in air but ignition is difficult.
Formulations/Preparations
Dichloromethane is available as commercial/technical grade & grades intended specifically for vapor degreasing, aerosol use, food extraction, reagent use & spectrophotometry. Purity, when reported, ranges from 99-99.9% (reagent/high performance liq chromatography grade). Acidity (as hydrochloric acid) may be up to 5-10 mg/kg. The max concn of water in commercial grade dichloromethane is generally 100-200 mg/kg, but anhydrous dichloromethane (less than 50 mg/kg water) is also available.
Small amt of stabilizers are often added to dichloromethane at the time of manufacture. Cyclohexane (50 mg/kg) & propylene oxide have been added to commercial aerosols & reagent grades of dichloromethane for this purpose. Other reported stabilizers include 2-methyl-2-butene @ 50 mg/kg, ethanol or methanol at approx 0.2%, & small quantities (1 mg/kg) of phenol.
Additives may include 0.0001-1% of stabilizers such as: amines, 4-cresol, hydroquinone, methanol, 2-methylbut-2-ene, 1-naphthol, nitromethane + 1,4-dioxane, phenol, resorcinol, and thymol.
In the USA, a standard grade dichloromethane has the following typical specifications: a clear, water white liquid, free of suspended matter acidity, 5 mg/kg max; non volatile residue 10 mg/kg max; free halogen none; & a 100% distillation range of 39.5-40.5 deg C.
Grades available from Mallinkrodt Speciaty Chemicals include AR, ChomAR, NANOGRADE, SpectrAR, UltimAR, ACS Reagent, USP, HPLC, and GC grades.
DOT Emergency Guidelines
/GUIDE 160: HALOGENATED SOLVENTS/ Health: Toxic by ingestion. Vapors may cause dizziness or suffocation. Exposure in an enclosed area may be very harmful. Contact may irritate or burn skin and eyes. Fire may produce irritating and/or toxic gases. Runoff from fire control or dilution water may cause pollution.
/GUIDE 160: HALOGENATED SOLVENTS/ Fire or Explosion: Some of these materials may burn, but none ignite readily. Most vapors are heavier than air. Air/vapor mixtures may explode when ignited. Container may explode in heat of fire.
/GUIDE 160: HALOGENATED SOLVENTS/ Public Safety: CALL Emergency Response Telephone Number. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 160: HALOGENATED SOLVENTS/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. Structural firefighters' protective clothing will only provide limited protection.
/GUIDE 160: HALOGENATED SOLVENTS/ Evacuation: Large spill: Consider initial downwind evacuation for at least 100 meters (330 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 160: HALOGENATED SOLVENTS/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire.
/GUIDE 160: HALOGENATED SOLVENTS/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Stop leak if you can do it without risk. Small liquid spills: Take up with sand, earth or other non-combustible absorbent material. Large spills: Dike far ahead of liquid spill for later disposal. Prevent entry into waterways, sewers, basements or confined areas.
/GUIDE 160: HALOGENATED SOLVENTS/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Wash skin with soap and water. Keep victim warm and quiet. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Exposure Standards and Regulations
Certification of this color additive when used as an ink for marking fruit and vegetables is not necessary for the protection of the public health, and therefore batches thereof are exempt from the certification pursuant to section 721(c) of the act. Restriction: No residues.
Dichloromethane is an indirect food additive for use only as a component of adhesives.
Reactivities and Incompatibilities
Mixtures of /dinitrogen/ tetraoxide with dichloromethane are explosive when subjected to shock of 25 g TNT equiv or less.
Mixtures of lithium shavings with several halocarbon derivatives are impact sensitive and will explode, sometimes violently. Such materials include: dichloromethane
Dichloromethane dissolves endothermically in concentrated nitric acid to give a detonable soln.
Contact of 1.5 g portions of the solid potassium tert-butoxide with drops of dichloromethane caused ignition after 2 min.
PROLONGED HEATING WITH WATER @ 180 DEG C RESULTS IN FORMATION OF FORMIC ACID, METHYL CHLORIDE, METHANOL, HYDROCHLORIC ACID & SOME CARBON MONOXIDE.
will form explosive mixtures with an atmosphere having a high oxygen content, in liq oxygen, nitrogen tetroxide, potassium, sodium, sodium-potassium alloy.
Contact with strong oxidizers, strong caustics and chemically active metals such as aluminum or magnesium powder, sodium and potassium may cause fires and explosions.
Dichloromethane, previously considered to be nonflammable except in oxygen, becomes flammable in air at 102 deg C/1 bar, @ 27 deg C/1.7 bar or @ 27 deg C/1 bar in presence of less than 0.5 vol% of methanol.
Strong oxidizers; caustics; chemically-active metals such as aluminum, magnesium powders, potassium & sodium; concentrated nitric acid.
Mixtures in air with methanol vapor are flammable. Reacts violently with (potassium hydroxide + N-methyl-N-nitrosourea).
Other Preventative Measures
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock down vapors.
Good industrial hygiene practices recommend that engineering controls be used to reduce environmental concentrations to the permissible level. However, there are some exceptions where respirators may be used to control exposure. Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. In addition to respirator selection, a complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation.
Persons not wearing protective equipment and clothing should be restricted from areas of spills or leaks until cleanup has been completed.
Promptly remove nonimpervious clothing that becomes wet.
A major concern in the painting studio is solvents, including dichloromethane. Precautions include use of dilution and local exhaust ventilation, control of storage areas, disposal of solvent soaked rags in covered containers, minimizing skin exposure and the use of respirators and other personal protective equipment. The control of fire hazards is also important, since many of the solvents are highly flammable.
Personnel protection: Avoid breathing vapors. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
Areas in which it is produced or used should be provided with adequate exhaust ventilation, sufficient to keep the atmospheric concn below the exposure limits. Special caution should be exercised when entering tanks which may have contained dichloromethane the workers involved should be equipped with oxygen masks or respirators, eye protection, safety belts and life lines, and be under the constant control of a supervisor.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should wash hands, preferably using dispensers of liq detergent, & rinse thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one piece & close fitting at ankles & wrists), gloves, hair covering & overshoes. Clothing should be changed daily but discarded immediately if obvious contamination occurs also, workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn. However, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Operations connected with synth & purification should be carried out under well ventilated hood. Analytical procedures should be carried out with care & vapors evolved during procedures should be removed. Expert advice should be obtained before existing fume cupboards are used & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Vertical laminar flow biological safety cabinets may be used for containment of in vitro procedures provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak tight. Horizontal laminar flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used. Each cabinet or fume cupboard to be used should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Principles that apply to chem or biochem lab also apply to microbiological & cell culture labs Special consideration should be given to route of admin. Safest method of administering volatile carcinogen is by injection of a soln. Admin by topical application, gavage, or intratracheal instillation should be performed under hood. If chem will be exhaled, animals should be kept under hood during this period. Inhalation exposure requires special equipment. Unless specifically required, routes of admin other than in the diet should be used. Mixing of carcinogen in diet should be carried out in sealed mixers under fume hood, from which the exhaust is fitted with an efficient particulate filter. Techniques for cleaning mixer & hood should be devised before expt begun. When mixing diets, special protective clothing &, possibly, respirators may be required. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": When admin in diet or applied to skin, animals should be kept in cages with solid bottoms & sides & fitted with a filter top. When volatile carcinogens are given, filter tops should not be used. Cages which have been used to house animals that received carcinogens should be decontaminated. Cage-cleaning facilities should be installed in area in which carcinogens are being used, to avoid moving of contaminated cages. It is difficult to ensure that cages are decontaminated, & monitoring methods are necessary. Situations may exist in which the use of disposable cages should be recommended, depending on type & amt of carcinogen & efficiency with which it can be removed. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": To eliminate risk that contamination in lab could build up during conduct of expt, periodic checks should be carried out on lab atmospheres, surfaces, such as walls, floors & benches, & interior of fume hoods & airducts. As well as regular monitoring, check must be carried out after cleaning up of spillage. Sensitive methods are required when testing lab atmospheres. Methods should where possible, be simple & sensitive. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Rooms in which obvious contamination has occurred, such as spillage, should be decontaminated by lab personnel engaged in expt. Design of expt should avoid contamination of permanent equipment. Procedures should ensure that maintenance workers are not exposed to carcinogens. Particular care should be taken to avoid contamination of drains or ventilation ducts. In cleaning labs, procedures should be used which do not produce aerosols or dispersal of dust, ie, wet mop or vacuum cleaner equipped with high efficiency particulate filter on exhaust, which are avail commercially, should be used. Sweeping, brushing & use of dry dusters or mops should be prohibited. Grossly contaminated cleaning materials should not be reused. If gowns or towels are contaminated, they should not be sent to laundry, but decontaminated or burnt, to avoid any hazard to laundry personnel. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Doors leading into areas where carcinogens are used should be marked distinctively with appropriate labels. Access limited to persons involved in expt. A prominently displayed notice should give the name of the Scientific Investigator or other person who can advise in an emergency & who can inform others (such as firemen) on the handling of carcinogenic substances. /Chemical Carcinogens/
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed or replaced.
Protective Equipment and Clothing
Wear appropriate chemical protective boots.
Employees should be provided with & required to use impervious clothing, gloves, face shields (eight-in minimum), & other appropriate protective clothing necessary to prevent repeated or prolonged skin contact with liq methylene chloride. Employees should be provided with & required to use splash-proof safety goggles where liq methylene chloride may contact the eye.
Polyvinyl chloride (PVC) and natural rubber should not be used for protective clothing. Use neoprene for protective clothing. Do not use closed circuit rebreathing system employing soda lime or other carbon dioxide absorber because of formation of toxic compounds capable of producing cranial nerve paralysis. Equipment should not be iron or metal, susceptible to hydrogen chloride.
The permeation of methylene chloride through seven protective clothing materials was studied to determine the permeation parameters, and to investigate the effect of solubility (polymer weight gain) and material thickness on the permeation parameters. The materials tested were two different nitrile rubbers, neoprene, combination (a blend of natural rubber, neoprene and nitrile), two different polyvinyl chlorides, and polyvinyl alcohol. Methylene chloride permeated through all materials, except polyvinyl alcohol, with breakthrough times in the range of 2 to 8 min, and permeation rates in the range of 1250-5800 ug/sq cm min. It was shown that for /methylene chloride/, there is a correlation between the solubility (weight gain) and the ratio of permeation rate to breakthrough time (PR/BT). For all material chemical pairs, an increase in solubility, increased (PR/BT). The change in material thickness had an effect on breakthrough time and permeation rate, but no effect on normalized breakthrough time. An increase in thickness reduced permeation rate and increased breakthrough time. [Vahdat N; Am Ind Hyg Assoc J 48 (7): 646-51 (1987)] PubMed Abstract
PRECAUTIONS FOR "CARCINOGENS": Dispensers of liq detergent /should be available. Safety pipettes should be used for all pipetting. In animal laboratory, personnel should wear protective suits (preferably disposable, one piece & close fitting at ankles & wrists), gloves, hair covering & overshoes. In chemical laboratory, gloves & gowns should always be worn. However, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. Gowns should be of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/
For methylene chloride breakthrough times less (usually significantly less) than one hour reported by (normally) two or more testers for natural rubber, neoprene/sytrene-butadiene rubber, neoprene/natural rubber, nitrile, polyethylene, and polyvinyl chloride.
For methylene chloride some data suggesting breakthrough times of approximately an hour or more for polyvinyl alcohol and viton.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Recommendations for respirator selection. Condition: At concentrations above the NIOSH REL, or where there is no REL at any detectable cocentration. Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.
Compatible protective equipment construction material include: Polyurethane, polyvinyl alcohol, viton.
Specification
Dichloromethane (CAS NO.75-09-2) is a colorless liquid with a sweet, penetrating-like ether. If exposed to high temperatures , it may emit toxic chloride fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover. It is somewhat soluble in water, subjected to slow hydrolysis which is accelerated by light. It has some kinds of uses. Solvent is the most important use of methylene chloride. Dichloromethane with the dissolving ability, low boiling point and relatively low toxicity, so it has be made as the highest frequency use in organic synthesis. It can be used as extraction solvent, mainly as?the extraction of caffeine in coffee beans, besides it can be used as hops, spices oil-resin extraction solvents, pigment thinner, organic synthesis. As a solvent for resins and plastics industry is widely used in pharmaceutical, plastics and film industries.
Octanol/Water Partition Coefficient
log Kow= 1.25
Disposal Methods

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U080, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number F002, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Potential candidate for liquid injection incineration, with a temperature range of 650 to 1600 deg C and a residence time of 0.1 to 2 seconds; for rotary kiln incineration with a temperature range of 820 to 1600 deg C and residence times of seconds for liquids and gases, hours for solids; and for fluidized bed incineration, with a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, longer for solids.
Dichloromethane is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.
Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced. Recommendable method: Incineration.
PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas fired type, in which a first stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": HEPA (high efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... small quantities of ... some carcinogens can be destroyed using chem reactions ... but no general rules can be given. ... As a general technique ... treatment with sodium dichromate in strong sulfuric acid can be used. The time necessary for destruction ... is seldom known ... but 1-2 days is generally considered sufficient when freshly prepd reagent is used. ... Carcinogens that are easily oxidizable can be destroyed with milder oxidative agents, such as saturated soln of potassium permanganate in acetone, which appears to be a suitable agent for destruction of hydrazines or of compounds containing isolated carbon-carbon double bonds. Concn or 50% aqueous sodium hypochlorite can also be used as an oxidizing agent. /Chemical Carcinogens/
The following wastewater treatment technology has been investigated for dichloromethane. Concentration Process: Stripping.

Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 100000_1000000 view >
FULL INDIVIDUAL 0_10 view >
Registered companies:
Registrant / Supplier details Latest dossier received
3M Belgium BVBA/SPRL 2016
Akzo Nobel Industrial Chemicals GmbH 2014
Avantor Performance Materials Poland S.A. 2016
more >
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Carcinogenicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H351 Suspected of causing cancer

Precautionary statement(s)
Prevention

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:84.927g/mol
  • Molecular Formula:CH2Cl2
  • Compound Is Canonicalized:True
  • Exact Mass:83.953
  • Monoisotopic Mass:83.953
  • Complexity:2.8
  • Rotatable Bond Count:0
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:0
  • Topological Polar Surface Area:0A^2
  • Heavy Atom Count:3
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADcQAAAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEAIAAAAAAAAAAMAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AA==
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