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Home> Encyclopedia > Hot Product Listed 1   > 1-Adamantanamine hydrochloride
665-66-7 structure

1-Adamantanamine hydrochloride

Iupac Name:adamantan-1-amine;hydrochloride
CAS No.:665-66-7
EINECS(EC#): 211-560-2
Molecular Weight:187.711
Molecular Formula:C10H18ClN (isomer)
Names and Identifiers
Synonyms

(3r,5s,7s)-adamantan-1-amine hydrochloride (3s,5s,7s)-adamantan-1-amine hydrochloride 1-Adamantamine hydrochloride 99% 1-adamantanamin hydrochlorid 1-adamantanamine hcl 1-adamantanamine hydrochloride 1-Adamantanamine hydrochloride, 99+% 1-adamantanamine, hydrochloride 1-adamantanaminehydrochloride 1-adamantylamine hydrochloride 1-aminoada- mantane hydrochloride 1-aminoadamantane hydrochloride 1-aminoadamantene hydrochloride 665-66-7 768-94-5 (parent) A 1260 A0588 a3a501 AB0014024 AB1008533 AC1L20JO AC-8689 ACMC-209nvq adamantamine hydrochloride adamantan-1-amine adamantan-1-amine hydrochloride adamantan-1-aminium chloride adamantanamine hcl adamantanamine hydrochloride adamantanylamine, chloride adamantine hydrochloride adamantyl amine hydrochloride adamantylamine hydrochloride adamin adamine ads-5101 ads-5102 ai3-52211 AK-40714 AKOS015900347 AKOS015951188 amantadine (hydrochloride) amantadine base hydrochloride amantadine hcl amantadine hydrochloride amantadine hydrochloride (jp17/usp) amantadine hydrochloride (symmetrel) amantadine hydrochloride [usan:jan] amantadine hydrochloride [usan:usp:jan] amantadine hydrochloride, european pharmacopoeia (ep) reference standard Amantadine hydrochloride, Pharmaceutical Secondary Standard amantadine hydrochloride, united states pharmacopeia (usp) reference standard Amantadine-hydrochloride(Symmetrel) amantan amantidine hydrochloride amazolon AMBAP665-66-7 aminoadamantane hydrochloride AN-7740 ANW-35220 AOB5792 BB_SC-2097 BC204764 BCP11857 BG00602442 BIA4305 C07939 CA-1982 CCG-38899 cerebramed Certified Reference Material CHEBI:2619 CHEMBL1255870 CHEMBL1569 cpd001370746 CS-2502 CTK2F3028 D00777 EBD2156754 ec 211-560-2 einecs 211-560-2 EU-0100004 exp 105-1 exp-105-1 F3111-1111 FT-0622248 gp 38026 HMS1920A19 hofcomant HY-B0402A hydrochloride I14-0454 influenol J-650095 J-650235 K091 KB-11068 KS-000009I7 KSC353A2R LP00004 LS-14931 lysovir m6q1eo9td0 mantadan Mantadine mantadix MCULE-2948891352 mfcd00074723 MFCD00074723 (98%) midantan midantane MLS000028731 MLS002153257 MLS003899199 MOLPORT-000-692-440 MOLPORT-003-925-531 MOLPORT-038-942-500 mydantane n04bb01 NC00489 NCGC00093531-01 NCGC00093531-02 NCGC00093531-03 NCGC00093531-04 NCGC00260689-01 nsc 83653 nsc755860 nsc-755860 nsc83653 nsc-83653 nurelin OPERA_ID_671 OR14311 pharmakon1600-01500110 PL003185 PUBCHEM6390 Q-200621 RTR-022507 s2451 SAM002554881 SBB003680 SC-06172 SCHEMBL40713 smr000059204 smr001370746 SPECTRUM1500110 sr-01000075353 SR-01000075353-1 ST24032190 ST50508424 STR01017 SW219892-1 SY012930 symmetrel symmetrel (tn) TL8004713 tox21_500004 TR-022507 TRA0093399 tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride (9ci) tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride tricyclo[3.3.1.1 3,7]decan-1-amine hydrochloride tricyclo[3.3.1.13, hydrochloride tricyclo[3.3.1.13,7]decan-1-amine hydrochloride tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride tricyclodecane trivaline unii-m6q1eo9td0 V2452 virasol viregyt virofral virosol wln: l66 b6 a b- c 1b itj bz &gh WOLHOYHSEKDWQH-UHFFFAOYSA-N

Inchi
InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
InChkey
WOLHOYHSEKDWQH-UHFFFAOYSA-N
Canonical Smiles
C1C2CC3CC1CC(C2)(C3)N.Cl
Isomers Smiles
C1C2CC3CC1CC(C2)(C3)N.Cl
Properties
Appearance
Crystalline Solid
Density
1.067
Melting Point
300℃
Boiling Point
225.7 °C at 760 mmHg
Vapour
0.13 mm Hg at 25 deg C (est)
Refractive Index
1.558
Flash Point
96 °C
Solubility
50 mg/mL in water
Color/Form
HEXAKISTETRAHEDRAL CRYSTALS BY SUBLIMATION
Stability
No data.
HS Code
29213099
Storage temp
Store in a cool, dry place. Store in a tightly closed container.
Spectral properties
IR: 7570 (Coblentz Society Infrared Spectral Database)
NMR: 15203 (Sadtler Research Laboratories Spectral Collection)
MASS: 90068 (NIST/EPA/MSDC Mass Spectral Database, 1990 version
Safety and Handling
Hazard Codes
Xn
Risk Statements
R22
Safety Statements
22-36/37-36
Safety

Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: XnHarmful
Risk Statements: 22-40-20/21/22
20:?Harmful by inhalation?
21:?Harmful in contact with skin?
22:?Harmful if swallowed?
40:?Limited evidence of a carcinogenic effect?
Safety Statements: 22-36/37-36
22:?Do not breathe dust?
36:?Wear suitable protective clothing??
37:?Wear suitable gloves?

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 37mg/kg (37mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
guinea pig LD50 oral 360mg/kg (360mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
man LDLo oral 28571ug/kg (28.571mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: HEMORRHAGE
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man LDLo oral 286mg/kg (286mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TOXIC PSYCHOSIS
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man TDLo oral 13mg/kg/5D-I (13mg/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985.
man TDLo oral 24mg/kg/1D-I (24mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT
Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990.
mouse LD50 intraperitoneal 198mg/kg (198mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 intravenous 95mg/kg (95mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
mouse LD50 subcutaneous 290mg/kg (290mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
rat LD50 intravenous 90mg/kg (90mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 oral 800mg/kg (800mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 subcutaneous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971.
women LDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: PULSE RATE
American Journal of Medicine. Vol. 77, Pg. 388, 1984.

Sensitive
Hygroscopic
Formulations/Preparations
Oral: Capsules, liquid-filled Tablets: 100 mg (available by nonpropriety name), 100 mg, Symmetrel, (Endo); Solution: 50 mg/5 mL, Symmetrel Syrup ( with parabens), (Endo).
Trade Names.Hydrochloride: Amazolon (Sawai), Mantadine (Du Pont), Mantadix (Du Pont, Rh?ne-Poulenc), Symmetrel (Ciba-Geigy), Virofral (Ferrosan). Sulfate: Contenton (SKD), PK-Merz (Merz).
administered PO, intranasal, SC, IP, or aerosol routes.
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl amantadine hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Amantadine hydrochloride/
Specification

?The chemical synonyms of?Amantadine hydrochloride (CAS NO.665-66-7): 1-Adamantanamine hydrochloride ; AI3-52211 ; Adamantanamine hydrochloride ; Adamantine hydrochloride ; Amantadine HCl ; Amantan ; Amazolon ; Aminoadamantane hydrochloride ; EXP 105-1 ; GP 38026 ; Influenol ; Mydantane ; NSC 83653 ; Symmetrel ; Trivaline ; UNII-M6Q1EO9TD0 ; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride (9CI) ; Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride .

Octanol/Water Partition Coefficient
log Kow = 2.44
Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin corrosion, Category 1B

Serious eye damage, Category 1

Reproductive toxicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H314 Causes severe skin burns and eye damage

H361 Suspected of damaging fertility or the unborn child

H402 Harmful to aquatic life

H412 Harmful to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:187.711g/mol
  • Molecular Formula:C10H18ClN
  • Compound Is Canonicalized:True
  • Exact Mass:187.113
  • Monoisotopic Mass:187.113
  • Complexity:144
  • Rotatable Bond Count:0
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:1
  • Topological Polar Surface Area:26A^2
  • Heavy Atom Count:12
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:2
  • CACTVS Substructure Key Fingerprint: AAADceByAAAEAAAAAAAAAAAAAAAAAAAAAAAwYMGAAAAAAAAAAAAAHAAQAAAADYiBAAAAAABAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAIAgAAAAAAAEAAAAAEQgMAOAAAAAAAAAAAAAASAAAAAAAAAAAAA AA==
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