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Home> Hot Product Listed G   > Glycolic acid

Glycolic acid

CAS No.:79-14-1
Molecular Weight:76.05
Molecular Formula:C2H4O3 (Products with the same molecular formula)
MOL File:79-14-1.mol
Names and Identifiers

Hydroxyacetic acid Glycolic acid solutionGlycolic acid Hydroxyethanoic acid glycollic acid

Canonical Smiles
Light yellow to amber liquid
Melting Point
Boiling Point
Refractive Index
n20/D 1.424
Flash Point
128.7 °C
H2O: 0.1 g/mL, clear
Colorless, translucent solid
Solid glycolic acid forms colorless, monoclinic, prismatic crystals.
Orthorhombic needles from water; leaves from diethyl ether
Stable. Incompatible with bases, oxidizing agents and reducing agents.
Spectral properties
IR: 6254 (Coblentz Society Spectral Collection)
1H NMR: 6411 (Sadtler Research Laboratories Spectral Collection)
MASS: 381 (NIST/EPA/MSDC Mass Spectral Database, 1990 Version)
Safety and Handling
Hazard Codes
Risk Statements
Safety Statements

Moderately toxic by ingestion. A severe eye irritant. A skin and mucous membrane irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Glycolic acid (CAS NO.79-14-1):
Hazard Codes: CCorrosive
Risk Statements: 34-22???
R34: Causes burns.?
R22: Harmful if swallowed.
Safety Statements: 26-36/37/39-45-23
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S23: Do not breathe vapour.
RIDADR: UN 3265 8/PG 3
WGK Germany: 1
RTECS: MC5250000
HazardClass: 8
PackingGroup: II

Skin, Eye, and Respiratory Irritations
Skin contact may cause severe skin irritation with discomfort or rash. Higher or prolonged exposure may cause skin burns or ulceration. Eye contact may cause eye corrosion with corneal or conjunctival ulceration. Permanent eye damage can occur. /70% Glycolic acid/
Toxicity results indicate that glycolic acid (70%) causes effects that are typical of a strong acid, such as dermal and eye irritation; however, concentrations of
Mild irritant to skin, mucous membranes.
It produces very severe burns of skin or eye in 70% technical solution.
A mini-cumulative irritation patch assay was performed on a variety of cosmetic formulations containing glycolic acid. Approximately 0.2 mL of the material was applied undiluted to the back under an occlusive patch for 4 consecutive days. The patches were removed approximately 24 hr after each application. Irritation was scored 5 hr after removal of the fourth patch. The sites were not scored daily; however, if a score of 2/4 (moderate erythema) was observed following immediate removal of any patch, no further patching was done and the score was recorded under that patch application and as the final score. The results of the mini-cumulative irritation patch assays using glycolic acid ... /ranged from essentially nonirritating to severely irritating depending on glycolic acid concentration and product pH/.
Cleanup Methods
Sweep up, place in a bag and hold for waste disposal. Ventilate area and wash spill site after material pickup is complete. /99% Glycolic acid/
Neutralize spills with lime or soda ash. /70% Glycolic acid/
UN 3265 8/PG 3
Fire Fighting Procedures
FIREFIGHTING. Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. /99% Glycolic acid/
EXTINGUISHING MEDIA. Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. /99% Glycolic acid/
Available commercially as either a 57% (Hoechst) or a 70% (Du Pont) aqueous solution
CLOROX PATCH: Active Ingredient 1.5% Glycolic acid.
X-MEN: Active Ingredients 3.070% Glycolic acid, 0.180% Alkyl dimethyl benzyl ammonium chloride (50%C14, 40%C12, 10%C16), 0.081% Didecyl dimethyl ammonium chloride, 0.135% Octyl decyl dimethyl ammonium chloride & 0.054% Dioctyl dimethyl ammonium chloride.
SHOW: Active Ingredient 11.185% Glycolic acid.
DUPONT GLYCLEAN AM: Active Ingredient 70% Glycolic acid.
DUPONT BOWL CLEANER: Active Ingredient 9.5% Glycolic acid.
DUPONT KLEANIT: Active Ingredient 5% Glycolic acid.
Exposure Standards and Regulations
Hydroxyacetic acid is an indirect food additive for use as a component of adhesives.
Reactivities and Incompatibilities
Contact with active metals may produce flammable hydrogen gas (solid).
Other Preventative Measures
When chemicals containing glycolic acid are used on a daily basis, protection for the skin and eyes is advised to prevent localized irritation. Child-proof packaging is available to prevent children from ingesting these products. Overall, the evidence indicates there is minimal risk of adverse health effects from glycolic acid during the normal use of commercially available cleaning products.
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. In case of leak or spill, evacuate area. /99% Glycolic acid/
Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure. /99% Glycolic acid/
Avoid breathing mist. Do not get in eyes, on skin, or on clothing. Wash thoroughly after handling. /70% Glycolic acid/
Wash contaminated clothing before reuse. Discard contaminated shoes. Wash thoroughly after handling. /99% Glycolic acid/
If in eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contace lenses, if present, after the first 5 minutes, then continue rinsing. Call a poison control center or doctor for treatment advice. If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor... If inhaled: Move person to fresh air. ... /5% Glycolic acid/
Causes substantial but temporary eye injury. Do not get in eyes or on clothing. WWear protective eyewear (such as goggles). Wash thoroughly with soap and water after handling. Remove contaminated clothing and wash clothing before reuse... Do not use with chlorine bleach or any other chemical product. /5% Glycolic acid/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
Protective Equipment and Clothing
ENGINEERING CONTROLS. Safety shower and eye bath. Use only in a chemical fume hood. /99% Glycolic acid/
PERSONAL PROTECTIVE EQUIPMENT. Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or SIAL - 124737 type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. /99% Glycolic acid/
Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. /99% Glycolic acid/
Engineering Controls: Use sufficient ventilation to keep employee exposure below recommended limits. Personal Protective Equipment: Chemical splash goggles and rubber gloves. Wear a butyl rubber acid suit and NIOSH permissible respiratory protection if there is a reasonable possibility for exposure. /70% Glycolic acid/

?Glycolic acid , its CAS NO. is 79-14-1, the synonyms are 2-Hydroxyacetic acid ; Acetic acid, hydroxy- ; EPA Pesticide Chemical Code 000101 ; Glycollic acid ; Hydroxyacetic acid ; Hydroxyethanoic acid ; Kyselina glykolova ; Kyselina hydroxyoctova .

Octanol/Water Partition Coefficient
log Kow = -1.11

Reported in EPA TSCA Inventory.

Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
If Glyclean (TM) AN is spilled and not recovered, or is recovered as a waste for treatment or disposal, the CERCLA Reportable Quantity is 100 lbs. (Release of an unlisted Hazardous Waste Characteristic of Corrosivity). /70% Glycolic acid)
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. /99% Glycolic acid/
Do not contaminate water, food, or feed by ... disposal. ... Do not re-use empty container. Wrap empty bottle and put in trash or recycle. /5% Glycolic acid/
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000_10000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
CABB GmbH 2012
Chemours Netherlands B.V. 2017
Connect Chemicals Italia S.r.l. 2016
more >

Download/Modify | Technical supported by For US version, EU version (23 languages) and more, please refer to


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name glycolic acid

1.2 Other means of identification

Product number -
Other names Glycocide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI,Dyes,Fuels and fuel additives,Intermediates,Oxidizing/reducing agents,Plating agents and surface treating agents,Processing aids, not otherwise listed,Processing aids, specific to petroleum production,Solvents (for cleaning or degreasing)
Uses advised against no data available

1.4 Supplier's details


1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Skin corrosion, Category 1B

Acute toxicity - Inhalation, Category 4

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H314 Causes severe skin burns and eye damage

H332 Harmful if inhaled

Precautionary statement(s)

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.


P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.


P405 Store locked up.


P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
glycolic acid glycolic acid 79-14-1 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Half-upright position. Fresh air, rest. Refer for medical attention.

In case of skin contact

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic acids and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol - resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers.

6.3 Methods and materials for containment and cleaning up

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and clean up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, metals, sulfides, cyanides, strong bases and food and feedstuffs. Dry.Separated from strong oxidants, metals, sulfides, cyanides, strong bases and food and feedstuffs. Dry.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Light yellow to amber liquid
Colour Colorless, translucent solid
Odour Odorless
Melting point/ freezing point 63\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 154\u00b0C(lit.)
Flammability Combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 109\u00b0C(lit.)
Auto-ignition temperature no data available
Decomposition temperature 100\u00b0C
pH pH = 2.5 (0.5%); 2.33 (1.0%); 2.16 (2.0%); 1.91 (5.0%); 1.73 (10.0%)
Kinematic viscosity no data available
Solubility In water:SOLUBLE
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 2.0X10-2 mm Hg at 25\u00b0C (extrapolated)
Density and/or relative density 1.27
Relative vapour density (air = 1): 2.6
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions


10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Materials to avoid Bases, Oxidizing agents, Reducing agents

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 4240 mg/kg bw
  • Inhalation: LC50 Rat inhalation 7.7-14 mg/L for 4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnows); Conditions: static; Concentration: 164 mg/L for 96 hr (nominal)
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea); Conditions: static; Concentration: 141 mg/L for 48 hr
  • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae); Conditions: static; Concentration: 21.6 mg/L for 72 hr; Effect: biomass
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Hydroxyacetic acid achieved 32% theoretical oxidation by acclimated activated sludge after 12 hours of aeration(1). The theoretical BOD for hydroxyacetic acid was reported to be 0.89 after 5 days using acclimated mixed microbial cultures(2). Hydroxyacetic acid, present at 100 mg/L, reached 86% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3). Therefore this compound is expected to biodegrade rapidly in the environment(SRC).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for hydroxyacetic acid (SRC), using a measured log Kow of -1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of hydroxyacetic acid is estimated as 0.14(SRC), using a measured log Kow of -1.11(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that hydroxyacetic acid is expected to have very high mobility in soil. The pKa of hydroxyacetic acid is 3.6(4), indicating that this compound will exist almost entirely in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3261 IMDG: UN3261 IATA: UN3261

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)


14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
glycolic acid glycolic acid 79-14-1 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:76.05136 [g/mol]
Molecular Formula:C2H4O3
H-Bond Donor:2
H-Bond Acceptor:3
Rotatable Bond Count:1
Exact Mass:76.016044
MonoIsotopic Mass:76.016044
Topological Polar Surface Area:57.5
Heavy Atom Count:5
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:3
Feature 3D Donor Count:1
Feature 3D Anion Count:1
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:2