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Home> Encyclopedia > Hot Product Listed T   > Thiosemicarbazide
79-19-6 structure

Thiosemicarbazide

Iupac Name:aminothiourea
CAS No.:79-19-6
EINECS(EC#): 201-184-7
Molecular Weight:91.132
Molecular Formula:CH5N3S (isomer)
Properties
Appearance
white crystalline solid
Density
1.376
Melting Point
175-183℃
Boiling Point
208.6 °C at 760 mmHg
Refractive Index
1.463 (20 C)
Flash Point
80 °C
Solubility
soluble in water
Color/Form
White crystalline powder
LONG NEEDLES FROM WATER
Other physical and chemical properties
THIOSEMICARBAZIDE; is a white crystalline powder and is odorless. This material is used as a reagent for ketones and certain metals, for photography and as a rodenticide. It is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. It is a chemical intermediate for herbicides and a reagent for detection of metals. (EPA, 1998)
Stability
Stable. Incompatible with strong oxidizing agents.
HS Code
29309070
Storage temp
Poison room
Spectral properties
MAX ABSORPTION (ALCOHOL): 244 NM (LOG E= 4.2); 280 NM (LOG E= 2.4)
IR: 374 (Sadtler Research Laboratories IR Grating Collection)
IR: 21289 (Sadtler Research Laboratories IR Grating Collection)
MASS: 3997 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)
Safety and Handling
Hazard Codes
T+
Risk Statements
R28;R52/53
Safety Statements
S28;S45;S61
HazardClass
6.1
Hazard Note
H300
Safety

Hazard Codes:T+
Risk Statements:28-52/53-26/27/28?
R28:Very toxic if swallowed.?
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements:22-26-36/37-45-61-28A-36/37/39?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR:UN 2811 6.1/PG 2
WGK Germany:3
RTECS:VT4200000
F:8-9-23
HazardClass:6.1
PackingGroup:II
HS Code:29309070
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Toxicity
1. ???

dnd-hmn:hla 20 μmol/L

??? BCPCA6 ?? Biochemical Pharmacology. 25 (1976),821.
2. ???

orl-rat TDLo:1024?mg/kg/78W-C:ETA

??? JJIND8 ?? JNCI, Journal of the National Cancer Institute. 67 (1981),75.
3. ???

orl-rat LD50:9160?μg/kg

??? MarJV# ?? Personal Communication from Josef V. Marhold, VUOS, 539-18, Pardubice, Czechoslovakia, to the Editor of RTECS, Cincinnati, OH, March 29, 1977 29MAR77 .
4. ???

orl-mus LDLo:94?mg/kg

??? AECTCV ?? Archives of Environmental Contamination and Toxicology. 14 (1985),111.
5. ???

ipr-mus LD50:1?mg/kg

??? NTIS** ?? National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
6. ???

scu-mus LD50:16,407?μg/kg ABMGAJ 21,635,68

7. ???

ivn-mus LD50:13?mg/kg

??? JPETAB ?? Journal of Pharmacology and Experimental Therapeutics. 122 (1958),110.
8. ???

orl-dog LD50:10?mg/kg

??? HBTXAC ?? Handbook of Toxicology, Volumes I-V. 5 (1959),155.
9. ???

orl-cat LD50:20?mg/kg

??? PSEBAA ?? Proceedings of the Society for Experimental Biology and Medicine. 70 (1949),688.
10. ???

ipr-gpg LD50:24?mg/kg

??? PSEBAA &
PackingGroup
II
Transport
UN 2811
Formulations/Preparations
Grades: technical and pure
Specification

First Aid Measures of?Thiosemicarbazide (CAS NO.79-19-6):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE. Wash mouth out with water.
Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Report

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P116, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
A potential candidate for rotary kiln incineration at a temperature range of 820 to 1600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H300 Fatal if swallowed

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

Precursor and Product
Computational chemical data
  • Molecular Weight:91.132g/mol
  • Molecular Formula:CH5N3S
  • Compound Is Canonicalized:True
  • Exact Mass:91.02
  • Monoisotopic Mass:91.02
  • Complexity:42.2
  • Rotatable Bond Count:0
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:96.2A^2
  • Heavy Atom Count:5
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
  • CACTVS Substructure Key Fingerprint: AAADcYADAABAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAABAQYAAAAAAAAAAABAABiAAAE AAAAAAAAAAAAAAMEIAAAAAAAAAAAAAAAAAAQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AA==
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