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Home> Hot Product Listed 4   > 4,4'-Diaminodiphenylsulfone


Iupac Name:4-(4-aminophenyl)sulfonylaniline
CAS No.:80-08-0
Molecular Weight:248.3
Molecular Formula:C12H12N2O2S (Products with the same molecular formula)
MOL File:80-08-0.mol
white crystalline powder
1.361 g/cm3
Melting Point
Boiling Point
511.7 oC at 760 mmHg
Flash Point
263.2 oC
Stable. Combustible. Incompatible with strong oxidizing agents.
HS Code
Storage temp
-20°C Freezer
Spectral properties
MAX ABSORPTION (ALCOHOL): 261 NM (LOG E= 4.25), 295 NM (LOG E= 4.43)
IR: 6054 (Coblentz Society Spectral Collection)
UV: 864 (Sadtler Research Laboratories Spectral Collection)
NMR: 6921 (Sadtler Research Laboratories Spectral Collection)
IR: 3:1153C (Aldrich Library of Infrared Spectra, Aldrich Chemical Co, Milwaukee, WI)
NMR: 10:24D (Aldrich Library of Mass Spectra, Aldrich Chemical Co, Milwaukee, WI)
Safety and Handling
Hazard Codes
Risk Statements
Safety Statements

Hazard Codes:?HarmfulXn
Risk Statements: 22?
R22:Harmful if swallowed.
Safety Statements: 22?
S22:Do not breathe dust.
RIDADR: 3249
WGK Germany: 1
RTECS: BY8925000
HazardClass: 6.1(b)
PackingGroup of Dapsone (CAS NO.80-08-0): III

Skin, Eye, and Respiratory Irritations
Chronic inhalation can cause irritation of mucous membranes.
UN 3249
Fire Fighting Procedures
To fight fire, use water or special mixtures of dry chemical.
Fire Potential
Combustible when exposed to heat or flame or by chemical reaction with oxidizers.
Exposure Standards and Regulations
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Reactivities and Incompatibilities
Can react violently with halogens, carbides, halogenates, halogenites, zinc, uranium, tin, sodium, lithium, nickel, palladium, phosphorus, potassium, indium, calcium, boron, aluminum, (aluminum + niobium pentoxide), ammonia, ammonium nitrate, ammonium perchlorate, BrF5, BrF3, (Ca + VO + H2O), Ca(OCl)2, Ca3P2, Cs3N, charcoal, (Cu + chlorates), ClO2, ClO, ClF3, CrO3, Cr(OCl)2, hydrocarbons, IF5, IO5, PbO2, Hg(NO3)2, HgO, Hg2O, NO2, P2O3, (KNO3 + As2S3), K3N, KMnO4, AgNO3, Ag2O, NaH, (NaNO3 + charcoal), (Na + SnI), SCl2, Tl2O3, F2. Can react with oxidizing materials.
Protective Equipment and Clothing
Chronic inhalation can cause irritation of mucous membranes.

?Dapsone (CAS NO.80-08-0), its Synonyms are 1,1'-Sulfonylbis(4-aminobenzene) ; 1,1'-Sulphonylbis(4-aminobenzene) ; 4,4'-Dapsone ; 4,4'-Diaminodiphenyl sulfone ; 4,4'-Diaminodiphenyl suphone ; 4,4'-Sulfonylbisaniline ; 4,4'-Sulfonylbisbenzamine ; 4,4'-Sulfonylbisbenzenamine ; 4-Aminophenyl sulfone ; Benzenamine, 4,4'-sulfonylbis- ; Bis(4-aminophenyl) sulfone ; Aniline, 4,4'-sulfonyldi- . It is odorless white or creamy white crystalline powder and slightly bitter taste.

Octanol/Water Partition Coefficient
log Kow = 0.97
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Reach Info
This substance has been officially registered by enterprises.
ECHA (EU chemicals Management Agency) published the completed registration file as follows:
Completed registration file:
Registered as ubmitted Total tonnage band  
FULL JOINT 1000_10000 view >
Registered companies:
Registrant / Supplier details Latest dossier received
3M Belgium BVBA/SPRL 2017
Arcerion GmbH 2013
Atul Europe Limited 2013
more >

Download/Modify | Technical supported by For US version, EU version (23 languages) and more, please refer to


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name dapsone

1.2 Other means of identification

Product number -
Other names 4,4'-Diaminodiphenylsulfone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,Intermediates
Uses advised against no data available

1.4 Supplier's details


1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.


P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
dapsone dapsone 80-08-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound include somnolence, retinal changes, cyanosis, jaundice, changes in tubules and other kidney changes, hemolysis with or without anemia, joint effects, hepatitis, dermatitis and peripheral neuritis. Other symptoms include peripheral motor neuropathy, retinal damage, optic atrophy and, in large doses, intravascular hemolysis, methemoglobinemia, renal failure, hemorrhages and exudates in fundi, localized capillary non-perfusion by angiography, and permanent poor vision. Prolonged skin exposure may lead to irritation. Severe eye irritation, irritation of the nose and throat and sneezing also occur. Exposure may cause restlessness, coma, hematuria, gastrointestinal irritation, maculopapular, erythematous skin eruptions, fever, mental disturbances, visual disturbances, oliguria or anuria with azotemia, agranulocytosis, thrombocytopenia, purpura, conjunctival injection, bullous lesions of the skin, petechiae, increased erythema, injury from sunlight, renal damage and death. It may also cause sore throat, pallor, aplastic anemia, other blood dyscrasias, exfoliative dermatitis, erythema multiforme, toxic epidermal necrolysis, morbilliform and scarlatiniform reactions, urticaria, erythema nodosum, muscle weakness, nausea, vomiting, abdominal pain, vertigo, blurred vision, tinnitus, insomnia, headache, psychosis, phototoxicity, tachycardia, albuminuria, the nephrotic syndrome, hypoalbuminemia without proteinuria, renal papillary necrosis, male infertility, drug-induced lupus erythematosus, an infectious mononucleosis-like syndrome, severe anoxia, hyperexcitability, methemoglobin induced depression and convulsions. Other symptoms may include anorexia, dizziness, nervousness, lymphadenitis, fixed drug eruptions, and eosinophilia. This compound can cause Heinz-body formation, paresthesia, pruritus, exacerbation of lepromatous leprosy in malnourished persons, malaise, hepatic necrosis and lymphadenopathy. It can also cause leukopenia, pseudo-leukemia and abnormalities in liver function tests. ACUTE/CHRONIC HAZARDS: This compound is harmful if swallowed, inhaled or absorbed through the skin. It may cause irritation. When heated to decomposition it emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and sulfur oxides.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Methylene blue is the first-choice treatment of methemoglobinemia, but it is not readily available in most Korean emergency departments because of an import suspension. An 84-year-old woman with dapsone-induced massive methemoglobinemia visited our emergency department for unclear mentality and cyanosis. Because methylene blue was not available, we intravenously administrated vitamin C (VC) for symptomatic methemoglobinemia, although VC is not a universally accepted treatment. Vitamin C (10 g intravenously) administered 6 hourly successfully treated the dapsone-induced methemoglobinemia and did not adversely affect renal functions. Thus, we recommend that if methylene blue is unavailable, 6 hourly intravenous administrations of 10 g of VC should be considered for dapsone-induced methemoglobinemia.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

This chemical is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust; Environmental precautions: Do not let product enter drains; Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white crystalline powder
Colour Crystals from 95% ethanol
Odour Odorless
Melting point/ freezing point 161\u00b0C(lit.)
Boiling point or initial boiling point and boiling range 132\u00b0C
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 24\u00b0C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility >37.2 [ug/mL]
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 2.68X10-8 mm Hg at 25\u00b0C (est)
Density and/or relative density 1.361 g/cm3
Relative vapour density 8.3 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

4,4'-SULFONYLDIANILINE can neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Incompatible with strong oxidizing agents. Also incompatible with epoxy resins under uncontrolled conditions .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible materials: Strong oxidizing agents

10.6 Hazardous decomposition products

When heated to decomposition it emits very toxic fumes of /nitrogen and sulfur oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 1000 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


Inadequate evidence of carcinogenicity in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for dapsone(SRC), using a log Kow of 0.97(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dapsone can be estimated to be 260(SRC). According to a classification scheme(2), this estimated Koc value suggests that dapsone is expected to have moderate mobility in soil. Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
dapsone dapsone 80-08-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Precursor and Product
Computational chemical data

Molecular Weight:248.30088 [g/mol]
Molecular Formula:C12H12N2O2S
H-Bond Donor:2
H-Bond Acceptor:4
Rotatable Bond Count:2
Exact Mass:248.061948
MonoIsotopic Mass:248.061948
Topological Polar Surface Area:94.6
Heavy Atom Count:17
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:2
Feature 3D Cation Count:2
Feature 3D Ring Count:2
Effective Rotor Count:2
Conformer Sampling RMSD:0.6
CID Conformer Count:1