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Home> Hot Product Listed N   > Nystatin

Nystatin

Iupac Name:(4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,
6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,
37-octahydroxy-18,20,21-trimethyl-23-oxo-22,
39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,
16-hexaene-38-carboxylic acid
CAS No.:1400-61-9
EINECS(EC#):215-749-0
Molecular Weight:926.1
Molecular Formula:C47H75NO17 (Products with the same molecular formula)
MOL File:1400-61-9.mol
Names and Identifiers
Synonyms

NystanMykostatynaNistatinBiofanalDiastatinNystexMyconystatinCandio-HermalFlagystatinFungicidinStamycinNystavescentO-V StatinNysfunginNystacidMycostatinNystopL-NystatinMycostatinPastillesMoronal (antibiotic)NyotranNystatin

Inchi
InChI=1/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1
Canonical Smiles
CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Isomers Smiles
C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC
(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H](
[C@@H]([C@H](O3)C)O)N)O
Properties
Appearance
yellow suspension
Density
g/cm3
Melting Point
Gradually decomp above 160 deg C without melting by 250 deg C
Boiling Point
476°Cat760mmHg
Vapour
1.6E-07mmHg at 25°C
Refractive Index
1.503
Flash Point
127.3°C
Solubilities
insoluble in water
Color/Form
yellow
Storage temp
?20°C
Spectral properties
Optical rotation at 25 deg C/D: -10 deg (glacial acetic acid); +21 deg (pyridine); +12 deg (dimethylformamide); max absorption (ethanol): 290, 307 and 322 nm; optical rotation at 25 deg C/D: -7 deg (0.1 N HCl in methanol)
Safety and Handling
Hazard Codes
F, C
Risk Statements
R11
Safety Statements
S22;S24/25
Safety
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. An antibiotic. When heated to decomposition it emits toxic fumes of NOx.
Formulations/Preparations
Tablets, dragees, lozenges, suspensions, drops, ointments, powders, gels, creams, ovulas, and vaginal tablets of different concentrations. There are also formulations available in combination with antibiotics and/or steroids such as tetracycline, neomycin, gramicidin, and cortisone. Dosages are often expressed in IE (100 000 IE = 22.73 mg nystatin A1).
Trade Names: Adiclair (Ardeypharm), Biofanal (Pfleger), Candex (Dome), Candio-Hermal (Hermal, Merck), Canstat (Lederle), Diastatin (Pfizer), Fungicidin (Spofa), Fungireduct (Azupharma), Herniocid (Mayrhofer), Korostatin (Holland-Rantos), Lederlind (Lederle), Lystin (Mekim), Mikostatin (Squibb), Moronal (Heyden, Squibb), Multilind (Bristol-Myers Squibb, Fair), Mycostatin (Bristol-Myers Squibb, Heyden, Sanofi Winthrop, Westwood-Squibb), Mykinac (NMC), MycoPosterine N (Kade), Mykundex (Jossa), Nadostine (Pan-Well), Nilstat (Lederle), Nyaderm (Taro), Nysert (Norwich Eaton), Nystacid (Farmos Group), Nystaderm (Dermapharm), Nysta-Dome (Dome), Nystan (Squibb), Nystat-Rx (Pharma-Tek), Nystavescent (Squibb), Nystex (Savage), Oranyst (Taro), O-V Statin (Squibb), Restatin (Remedica), Rivostatin (Rivopharm) Stereomycin (Medica).
Nystatin is commercially available as a cream, ointment, or powder for topical application to the skin; as a powder for oral suspension, oral suspension, or film-coated tablets for oral administration; as oral lozenges for oral topical administration; and as tablets for intravaginal administration.
Oral: For suspension 50 million units Nystatin Powder, Paddock Nystat-Rx, (Pharma-Tek); 150 million units Nystatin Powder, Paddock Nystat-Rx, (Pharma-Tek); 500 million units Nystatin Powder, Paddock Nystat-Rx, (Pharma-Tek); 1 billion units Nystat-Rx, (Pharma-Tek); 2 billion units Nystatin Powder, (Paddock); 5 billion units Nystatin Powder, (Paddock). Oral: Suspension: 100,000 units/mL Mycostatin ( with =1% alcohol parabens and sucrose 50%), (Bristol-Myers Squibb). Oral: Tablets, film-coated 500,000 units Mycostatin Filmlok ( with povidone), (Bristol-Myers Squibb)
Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl nystatin, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: nystatin is included in topical antifungal drug products.
A tolerance of zero is established for residues of nystatin in or on eggs and the uncooked edible tissues of swine and poultry.
New animal drugs for use in animal feeds. Requirement of a medicated feed mill license. Nystatin is included on this list.
New animal drugs for use in animal feeds. Nystatin. ... It is used in chickens and turkeys as follows: ... aid in control of crop mycosis and mycotic diarrhea (Candida albicans) ... treatment of crop mycosis and mycotic diarrhea (Candida albicans).
Ophthalmic and topical dosage form new animal drugs. Nystatin, neomycin, thiostrepton, and triamcinolone acetonide ointment. ... Indications for use. (i) Topically: Use either ointment in dogs and cats for anti-inflammatory, antipruritic, antifungal, and antibacterial treatment of superficial bacterial infections, and for dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly associated with bacterial or candidal (Candida albicans) infections. (ii) Otitis, cysts, and anal gland infections: Use petrolatum base ointment in dogs and cats for the treatment of acute and chronic otitis and interdigital cysts, and in dogs for anal gland infections.
Ophthalmic and topical dosage form new animal drugs. Nystatin, neomycin, thiostrepton, and triamcinolone acetonide ophthalmic ointment. ... The drug is recommended for ophthalmic use as an anti-inflammatory, antipruritic, antifungal (Candida albicans), and antibacterial ointment for local therapy in keratitis and conjunctivitis in cats and dogs and for infectious kerato-conjunctivitis (pink eye) in cattle.
Specification

The IUPAC name of?Nystatin is?(4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid. With the?CAS registry number 1400-61-9, it?is also named as?Biofanal.?It is?yellow suspension which is insoluble in water. Additionally,?this chemical should?be sealed in the container and stored at the temperature of -20 °C.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 0.62; (2)# of Rule of 5 Violations: 3; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 18; (8)#H bond donors: 13; (9)#Freely Rotating Bonds: 14 ; (10)Index of Refraction: 1.598; (11)Molar Refractivity: 240.74 cm3; (12)Molar Volume: 705.3 cm3; (13)Polarizability: 95.43×10-24 cm3; (14)Surface Tension: 69.5 dyne/cm; (15)Enthalpy of Vaporization: 188.49 kJ/mol; (16)Vapour Pressure: 0 mmHg at 25°C; (17)Rotatable Bond Count: 3; (18)Tautomer Count: 2; (19)Exact Mass: 925.5035; (20)MonoIsotopic Mass: 925.5035; (21)Topological Polar Surface Area: 320; (22)Heavy Atom Count: 65; (23)Complexity: 1620.

Uses of Nystatin:?It is often used as prophylaxis in patients who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and patients receiving chemotherapy.?It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 μg/mL.?In addition, it is?used as a tool by scientists performing "perforated" patch-clamp electrophysiologic recordings of cells.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns,?so people should keep it away from sources of ignition. When use it, people?do not breathe dust and avoid contact with skin and eyes.?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.?
1. SMILES:O=C2OC(C)C(C)C(O)C(C=CC=CCCC=CC=CC=CC=CC(OC1O[C@@H]([C@@H](O)[C@H](N)[C@@H]1O)C)CC(O)C(C(=O)O)C(O)CC(=O)CC(O)C(O)CCC(O)CC(O)CC(O)C2)C
2. InChI:InChI=1/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-35(65-47-45(60)42(48)44(59)30(4)64-47)26-39(56)41(46(61)62)38(55)24-34(52)23-37(54)36(53)20-19-31(49)21-32(50)22-33(51)25-40(57)63-29(3)28(2)43(27)58/h5-6,8,10-18,27-33,35-39,41-45,47,49-51,53-56,58-60H,7,9,19-26,48H2,1-4H3,(H,61,62)/t27,28,29,30-,31,32,33,35,36?,37,38,39,41,42+,43,44-,45+,47/m1/s1
?

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4400ug/kg (4.4mg/kg) ? Journal of Pharmaceutical Sciences. Vol. 65, Pg. 905, 1976.
mouse LD50 intravenous 3mg/kg (3mg/kg) ? Journal of Antibiotics. Vol. 32, Pg. 1230, 1979.
mouse LD50 oral 8gm/kg (8000mg/kg) ? Progress in Medical Chemistry. Vol. 14, Pg. 105, 1977.
mouse LD50 subcutaneous 120mg/kg (120mg/kg) ? Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 228S, 1957.
rat LD50 intraperitoneal 24305ug/kg (24.305mg/kg) ? Antibiotics Annual. Vol. 3, Pg. 697, 1955/1956.
rat LD50 oral 10gm/kg (10000mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 30, Pg. 81, 1973.

Octanol/Water Partition Coefficient
log Kow = 7.08 (est)
Report

The IUPAC name of?Nystatin is?(4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid. With the?CAS registry number 1400-61-9, it?is also named as?Biofanal.?It is?yellow suspension which is insoluble in water. Additionally,?this chemical should?be sealed in the container and stored at the temperature of -20 °C.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 0.62; (2)# of Rule of 5 Violations: 3; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 18; (8)#H bond donors: 13; (9)#Freely Rotating Bonds: 14 ; (10)Index of Refraction: 1.598; (11)Molar Refractivity: 240.74 cm3; (12)Molar Volume: 705.3 cm3; (13)Polarizability: 95.43×10-24 cm3; (14)Surface Tension: 69.5 dyne/cm; (15)Enthalpy of Vaporization: 188.49 kJ/mol; (16)Vapour Pressure: 0 mmHg at 25°C; (17)Rotatable Bond Count: 3; (18)Tautomer Count: 2; (19)Exact Mass: 925.5035; (20)MonoIsotopic Mass: 925.5035; (21)Topological Polar Surface Area: 320; (22)Heavy Atom Count: 65; (23)Complexity: 1620.

Uses of Nystatin:?It is often used as prophylaxis in patients who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and patients receiving chemotherapy.?It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 μg/mL.?In addition, it is?used as a tool by scientists performing "perforated" patch-clamp electrophysiologic recordings of cells.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns,?so people should keep it away from sources of ignition. When use it, people?do not breathe dust and avoid contact with skin and eyes.?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.?
1. SMILES:O=C2OC(C)C(C)C(O)C(C=CC=CCCC=CC=CC=CC=CC(OC1O[C@@H]([C@@H](O)[C@H](N)[C@@H]1O)C)CC(O)C(C(=O)O)C(O)CC(=O)CC(O)C(O)CCC(O)CC(O)CC(O)C2)C
2. InChI:InChI=1/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-35(65-47-45(60)42(48)44(59)30(4)64-47)26-39(56)41(46(61)62)38(55)24-34(52)23-37(54)36(53)20-19-31(49)21-32(50)22-33(51)25-40(57)63-29(3)28(2)43(27)58/h5-6,8,10-18,27-33,35-39,41-45,47,49-51,53-56,58-60H,7,9,19-26,48H2,1-4H3,(H,61,62)/t27,28,29,30-,31,32,33,35,36?,37,38,39,41,42+,43,44-,45+,47/m1/s1
?

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4400ug/kg (4.4mg/kg) ? Journal of Pharmaceutical Sciences. Vol. 65, Pg. 905, 1976.
mouse LD50 intravenous 3mg/kg (3mg/kg) ? Journal of Antibiotics. Vol. 32, Pg. 1230, 1979.
mouse LD50 oral 8gm/kg (8000mg/kg) ? Progress in Medical Chemistry. Vol. 14, Pg. 105, 1977.
mouse LD50 subcutaneous 120mg/kg (120mg/kg) ? Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 228S, 1957.
rat LD50 intraperitoneal 24305ug/kg (24.305mg/kg) ? Antibiotics Annual. Vol. 3, Pg. 697, 1955/1956.
rat LD50 oral 10gm/kg (10000mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 30, Pg. 81, 1973.

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Reach Info
Globally, no enterprise has officially registered the substance REACH.
Other official information: ·ECHA Information Page for CAS: 1400-61-9 EC: 215-749-0 Nystatin ·ECHA C&L Inventory for CAS: CAS: 1400-61-9 EC: 215-749-0 Nystatin
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Nystatin

1.2 Other means of identification

Product number -
Other names Fungicidin Mycostatin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company WWW.GuideChem.COM
Address 8F, Block C, No.3 Building, Zijin Plaza, No.701, Gudun Road, Hangzhou, Zhejiang 310030, China
Telephone +86-571-89739798
Fax 86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-571-89739798
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Nystatin Nystatin 1400-61-9 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state yellow suspension
Colour no data available
Odour no data available
Melting point/ freezing point no data available
Boiling point or initial boiling point and boiling range 476\u00baC at 760mmHg
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 127.3\u00baC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility no data available
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1.6E-07mmHg at 25\u00b0C
Density and/or relative density no data available
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: no data available IMDG: no data available IATA: no data available

14.2 UN Proper Shipping Name

ADR/RID: no data available
IMDG: no data available
IATA: no data available

14.3 Transport hazard class(es)

ADR/RID: no data available IMDG: no data available IATA: no data available

14.4 Packing group, if applicable

ADR/RID: no data available IMDG: no data available IATA: no data available

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Nystatin Nystatin 1400-61-9 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.

16.Other information

Information on revision

Creation Date Aug 13, 2017
Revision Date Aug 13, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

NMR Spectrum
Computational chemical data

Molecular Weight:926.0949 [g/mol]
Molecular Formula:C47H75NO17
XLogP3-AA:-0.2
H-Bond Donor:12
H-Bond Acceptor:18
Rotatable Bond Count:3
Tautomer Count:2
Exact Mass:925.5035
MonoIsotopic Mass:925.5035
Topological Polar Surface Area:320
Heavy Atom Count:65
Formal Charge:0
Complexity:1620
Isotope Atom Count:0
Defined Atom Stereocenter Count:10
Undefined Atom Stereocenter Count:9
Defined Bond Stereocenter Count:6
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1

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