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Home> Hot Product Listed M   > Mannitol

Mannitol

CAS No.:87-78-5
EINECS(EC#):201-770-2
Molecular Weight:182.17
Molecular Formula:C6H14O6 (Products with the same molecular formula)
MOL File:87-78-5.mol
Names and Identifiers
Synonyms

hexane-1,2,3,4,5,6-hexolHexahydroxyhexaneMannitolMannidex 16700

Inchi
InChI=1/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
Canonical Smiles
C(C(C(C(C(CO)O)O)O)O)O
Properties
Appearance
White fine powder
Density
1.596 g/cm3
Melting Point
166-168 deg C
Boiling Point
494.9 °C at 760 mmHg
Flash Point
292.5 °C
Solubilities
1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aq soln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc
In water, 2.16X10+5 mg/l @ 25 deg C
Color/Form
Orthorhombic needles from alc
WHITE, CRYSTALLINE POWDER OR FREE FLOWING GRANULES
Spectral properties
Specific optical rotation: -0.49 deg @ 25 deg C/D (water)
IR: 6403 (Coblentz Society Spectral Collection)
NMR: 8046 (Sadtler Research Laboratories Spectral Collection)
Index of refraction: 1.3330
Safety and Handling
Safety

A poison by intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Formulations/Preparations
MANNITOL, USP (OSMITROL), IS AVAIL FOR IV ADMIN AS MANNITOL INJECTION, USP, & MANNITOL & SODIUM CHLORIDE INJECTION, USP, IN CONCN OF 5, 10, 15, 20, OR 25% MANNITOL IN VOL RANGING FROM 50 TO 1000 ML OF WATER OR 0.3 TO 0.45% SODIUM CHLORIDE SOLN.
Grades: Reagent; Commercial; NF; FCC
Resectisol (Amer. McGaw)
Exposure Standards and Regulations
Mannitol used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Reactivities and Incompatibilities
It has been stated that mannitol is incompatible in strongly acidic and alkaline solutions.
Specification

? Mannitol , with CAS number of 87-78-5, can be called Hexahydroxyhexane ; DL-Mannitol ; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol ; hexane-1,2,3,4,5,6-hexol . Mannitol (CAS NO.87-78-5) is analytics reagents, also used for resin and drug synthesis.

Octanol/Water Partition Coefficient
log Kow = -3.10
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Reach Info
Globally, no enterprise has officially registered the substance REACH.
Other official information: ·ECHA Information Page for CAS: 87-78-5 EC: 201-770-2 Mannitol ·ECHA C&L Inventory for CAS: CAS: 87-78-5 EC: 201-770-2 Mannitol
MSDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Mannitol

1.2 Other means of identification

Product number -
Other names MANNITOL USP

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: BULKING_AGENT; HUMECTANT; STABILIZER; SWEETENER; TEXTURIZER; THICKENER
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Mannitol Mannitol 87-78-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound include nausea, vomiting, headache, chills, chest pain and pulmonary edema. It may cause irritation of the skin, eyes and respiratory tract. Other symptoms may include lethargy, confusion, heart failure and death. Exposure has caused an electrolyte and fluid imbalance, hypersensitivity reactions, diarrhea, thirst, fever, tachycardia, hyponatremia, urinary retention, dehydration, blurred vision, convulsions, urticaria, hypotension and hypertension. It has also caused hyperglycemia and glycosuria. Coughing may result from inhalation. Ingestion may cause gastric irritation. Skin contact may cause discoloration of sensitive skin. Eye contact may cause redness and pain. Intravenous use has led to blood pressure elevation and bladder tubule changes. ACUTE/CHRONIC HAZARDS: This compound may cause irritation of the skin, eyes and respiratory tract. When heated to decomposition it emits acrid smoke and toxic fumes of carbon monoxide and carbon dioxide.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

SIX PATIENTS WITH SEVERE MANNITOL INTOXICATION WERE TREATED WITH HEMODIALYSIS & ONE WITH PERITONEAL DIALYSIS. MANNITOL HAD HALF-LIFE OF APPROX 36 HR DURING INTERVALS WITHOUT TREATMENT. IDEAL TREATMENT IS HEMODIALYSIS WHICH RAPIDLY REMOVES MANNITOL (HALF-LIFE, 6 HR) & REPLACES IT WITH SODIUM; PERITONEAL DIALYSIS REMOVED MANNITOL SLOWLY (HALF-LIFE, 21 HR).

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

5.2 Specific hazards arising from the chemical

This chemical is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Mannitol solutions should be stored at room temperature and protected from freezing.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state White fine powder
Colour Orthorhombic needles from alc
Odour Odorless
Melting point/ freezing point 166-168\u00baC
Boiling point or initial boiling point and boiling range 494.9\u00baC at 760 mmHg
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 292.5\u00baC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility greater than or equal to 100 mg/mL at 20\u00b0C
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 1.596 g/cm3
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Mannitol 25% (Invenex) was chemically and physically stable after five autoclavings at 250 deg F for 15 min.

10.3 Possibility of hazardous reactions

A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

It has been stated that mannitol is incompatible in strongly acidic and alkaline solutions.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 13,500 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

D-Mannitol is a simple sugar alcohol and should be readily biodegraded in the environment. (SRC)

12.3 Bioaccumulative potential

An estimated BCF of 1 was calculated for D-mannitol(SRC), using a water solubility of 2.16X10+5 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of D-mannitol is estimated as approximately 5(SRC), using a water solubility of 2.16X10+5 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that D-mannitol is expected to have very high mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: no data available IMDG: no data available IATA: no data available

14.2 UN Proper Shipping Name

ADR/RID: no data available
IMDG: no data available
IATA: no data available

14.3 Transport hazard class(es)

ADR/RID: no data available IMDG: no data available IATA: no data available

14.4 Packing group, if applicable

ADR/RID: no data available IMDG: no data available IATA: no data available

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Mannitol Mannitol 87-78-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 18, 2017
Revision Date Aug 18, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Computational chemical data

Molecular Weight:182.17176 [g/mol]
Molecular Formula:C6H14O6
XLogP3:-3.1
H-Bond Donor:6
H-Bond Acceptor:6
Rotatable Bond Count:5
Exact Mass:182.079038
MonoIsotopic Mass:182.079038
Topological Polar Surface Area:121
Heavy Atom Count:12
Formal Charge:0
Complexity:105
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:4
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:6
Feature 3D Donor Count:6
Effective Rotor Count:5
Conformer Sampling RMSD:0.6
CID Conformer Count:216

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