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Flupirtine maleate 75507-68-5 Manufacturer/High quality/Best price 75507-68-5 Purity 99 Hubei Jiutian 25kg,50kg,180kg,200kg,250kg,1000kg,customization China

Flupirtine maleate 75507-68-5 Manufacturer/High quality/Best price
CAS: 75507-68-5
FOB Price:1 USD/Kilogram
Port:Wuhan / Shanghai / Guangzhou/Tianjing
Minimum Order Quantity:10 Gram
Supply Ability:15 Metric Ton/Month
Updatetime:May 17 2022
Company Profile
Contact:Jiu tian
Phone:17354350817
Tel:86-173-54350817
Fax:00-173-54350817
Address: Room 03-6, 5th floor, building 1, international enterprise center phase iii, no. 1, guanggu avenue, east lake new technology development zone, wuhan city
Quick Details
Classification: Pharmaceutical Intermediates
Cas NO.: 75507-68-5
Name: Flupirtine maleate
Molecular Formula: C19H21FN4O6
Melting Point: 186-188°C
Boiling Point: 434.9 °C at 760 mmHg
Flash Point: 216.8 °C
Purity: 99
usage: Pharmaceutical Intermediates
Brand Name: Hubei Jiutian
EINECS: 278-225-0
Aliase: 2-AMINO-6-[[(4-FLUOROPHENYL)METHYL]AMINO]-3-PYRIDINYL]-CARBAMIC ACID, ETHYL ESTER MALEATE;Flupirtinemaleatelupirtine;Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1);Keiton;Ketadolon;Flupirtine Maleate Salt;2-AMino-6-[(p-fluorobenzyl)aMino]-3-pyridinecarbaMic Acid Ethyl Ester Maleate;N-[2-AMino-6-[[(4-fluorophenyl)Methyl]aMino]-3-pyridinyl]carbaMic Acid Ethyl Ester (2Z)-2-Butenedioate
Purity: 99
Appearance:white powder
Brand: Hubei Jiutian
Melting point: 186-188°C
MF: C19H21FN4O6
MW: 420.3916432
Packaging & Delivery
Packaging Detail: 25kg,50kg,180kg,200kg,250kg,1000kg,customization
Delivery Detail: by sea、 by land、 by air
Detailed Description

2-AMINO-6-[[(4-FLUOROPHENYL)METHYL]AMINO]-3-PYRIDINYL]-CARBAMIC ACID, ETHYL ESTER MALEATE;Flupirtinemaleatelupirtine;Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1);Keiton;Ketadolon;Flupirtine Maleate Salt;2-AMino-6-[(p-fluorobenzyl)aMino]-3-pyridinecarbaMic Acid Ethyl Ester Maleate;N-[2-AMino-6-[[(4-fluorophenyl)Methyl]aMino]-3-pyridinyl]carbaMic Acid Ethyl Ester (2Z)-2-Butenedioate

Flupirtine is a selective neuronal potassium channel opener (SNEPCO) that also has N-methyl-D-aspartate (NMDA) receptor antagonist property which has been shown to be effective in the management of body pain. Flupirtine is used as an analgesic for acute pain, in moderate-to-severe cases. Its muscle relaxant properties make it popular for back pain and other orthopedic uses, but it is also used for migraines, in oncology, postoperative care, and gynecology. It is also effective in other painful conditions in which the primary requirement for analgesia is without sedation or anti-inflammatory effects.
It first became available in Europe in 1984 under the brand name Katadolon.
Flupirtine is a derivative of triaminopyridine with a chemical formula of ethyl-N-{2-amino-6-(4-fluorophenylmethylamino) pyridine-3 yl} cabamate. It is available as the maleate salt because flupirtine is itself poorly water soluble. Flupirtine is a base and is weakly lipophilic.

Flupirtine maleate is a centrally-acting, non-addicting analgesic agent somewhat more potent than aspirin, paracetamol and pentazocine. It is reported to be useful in the treatment of postoperative and dental pain.

Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ). It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice. Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine. Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.

Analgesic. Substituted pyridine with central analgesic properties. A potassium channel opener.

Analgesic. Substituted pyridine with central analgesic properties.

Company Information
Name:Hubei Jiutian Bio-medical Technology Co., Ltd √ Verified
Category:
Trade Category: Manufacturer√ Verified
Registered Time: 2018 √ Verified
Registered Capital: US$50 Million - US$100 Million
Legal Representative: Qiaochengyi√ Verified
Employees: 5 - 10 People
Address: Room 03-6, 5th floor, building 1, international enterprise center phase iii, no. 1, guanggu avenue, east lake new technology development zone, wuhan city
Product/Service: electronic chemicals; pharmaceutical intermediates;pesticide intermediates;ultraviolet absorbent; food additives

ubei Jiutian Bio-medical Technology CO.,Ltd, which is professional in research and sale high techology.The company located in Wuhan, We insist on the concept of "technology first, customer first".We always provide excellent products 、technical support and after sales; The company mainly engaged in biomedical products technology research and development,including medical and food additive,business of selling,operating or agent for the import and export of various products and technologies(except those limited or prohibited by the state,for projects subject to examination and approval according to law, business activities can only be carried out after being examined and approved by relevant departments).We have high quality products and outstanding sales team, the main pharmaceut.....more>>

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