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Home> Products> Pharmaceuticals and Biochemicals > Pharmaceutical > Best Sell MMAF powder for antitubulin agent 1415246-68-2

Best Sell MMAF powder for antitubulin agent 1415246-68-2

CAS:
FOB Price:10 USD/Gram
Port:shanghai
Minimum Order Quantity:10/Gram
Supply Ability:100 Kilogram/Year
Payment Terms:T/T,Western Union,MoneyGram,
Updatetime:Sep 18 2017
Company Profile
Contact:celia zhang
Tel:86-27-50458986
Address: Unit1 4Building, Su haobei Distict, Wucang District, Wuhan city, Hubei Province
Website: http://www.demechem.com/
Aliase: Monomethylauristatin F
Purity: 98
Appearance:powder
Brand: Demeikai
MW:: 768.42
MF:: C39H66CIN5O8
DMSO:: ≤ 27 mg/mL
Usage: tubulin; ADCs cytotoxin
Packaging & Delivery
Packaging Detail: foil bag
Delivery Detail: send by Fedex,DHL,TNT
Detailed Description

 MMAF Basic Info.

CAS:1415246-68-2

MW:768.42

MF:C39H66CIN5O8

DMSO: ≤ 27 mg/mL

Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.

IC50 value:

Target: tubulin; ADCs cytotoxin

Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.

 

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself.  MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

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Company Information
Name:Wuhan Deme chem Biotechnology Co., Ltd √ Verified
Category:Corporation/Limited Liability Company
Trade Category: Trading Company√ Verified
Registered Time: 2016 √ Verified
Registered Capital: US$101 Thousand - US$500 Thousand
Legal Representative: xianghong xu√ Verified
Employees: 11 - 50 People
Address: Unit1 4Building, Su haobei Distict, Wucang District, Wuhan city, Hubei Province
Website: http://www.demechem.com/
Product/Service: Steroid, Active ingredient and Pharmaceutical .

Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .