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Z-JIB-04 (NSC 693627), 199596-24-2 Purity 98% 100g,500g,1kg,25kg/drum China

Z-JIB-04 (NSC 693627),
CAS: 199596-24-2
FOB Price:1 USD/Gram
Port:shang hai
Minimum Order Quantity:100 Gram
Supply Ability:1000 Gram/Week
Updatetime:Feb 25 2019
Company Profile
Address: Building 87,Lane 669, Dong Jing Road Shanghai,P.R.China
Quick Details
Classification: Others
Cas NO.: 199596-24-2
Name: JIB-04 (NSC 693627) -Z
Molecular Formula: C17H13ClN4
Boiling Point: 472.9±55.0 °C(Predicted)
Purity: 98%
Purity: 98%
Appearance:white solid
Packaging & Delivery
Packaging Detail: 100g,500g,1kg,25kg/drum
Delivery Detail: 2 months
Detailed Description


we are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.


ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38α and SAPK2b/p38β with IC50 of 2 μM, and is selective over 17 other protein kinases including PKA, PKC, AMPK, p42 MAPK, MKK1, SAPK1/JNK, and CDK1 even at the concentration of up to 50 μM. ZM 336372 does not prevent constitutive as well as growth factor or phorbol ester induced activation of MKKl or p42 MAPK/ERK2. Moreover, ZM 336372 dose not reverse the phenotype of Ras- or Raf-transformed cell lines. ZM 336372 treatment induces >100 activation of c-Raf and the B-Raf isoform, but it does not trigger any activation of MKKI or p42 MAPK/ERKP or induce any increase in the GTP-loading of Ras, suggesting that a feedback control loop exists by which Raf isoforms suppress their own activation, such that inhibition is always counterbalanced by reactivation. ZM 336372-induced activation of c-Raf is not prevented by inhibition of the MAPK cascade, protein kinase C or phosphatidylinositide 3-kinase. ZM 336372 (1 μM) abolishes the upregulation of eNOS after treatment with hydrogen peroxide. ZM 336372 treatment in carcinoid tumor cells results in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2, and causes a significant reduction of bioactive hormone levels as well as the transcription factor, human achaete-scute homologue-1. Furthermore, ZM 336372 treatment leads to a marked suppression of cellular proliferation and induction of the cell cycle inhibitors p21 and p18. ZM 336372 inhibits the proliferation of pheochromocytoma cells, and suppresses NE vasoactive peptide production. ZM 336372 treatment in HepG2 induces the suppression of proliferation in a dose-dependent manner, suppression of hormone secretion, and up-regulation of cell cycle inhibitors. ZM 336372 also induces apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β through phosphorylation of GSK-3β at Ser 9.

Molecular Formula:C23H23N3O3
Storage:Dry seal
Keywords:Z-JIB-04 (NSC 693627),,N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;ZM 336372;3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE;Zinc00581684;3-(diMethylaMino)-N-(3-(4-hydroxybe,199596-24-2
Company Information
Trade Category: Lab/Research institutions
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Address: Building 87,Lane 669, Dong Jing Road Shanghai,P.R.China

SHANGHAI SYSTEAM BIOCHEM CO., LTD. is one of the professional suppliers in Chinese pharmaceutical market and is specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research services to our clients and collaboration partners including biotechnology based corporations, pharmaceutical and diagnostic companies, and manufacturers of specialty chemicals as well as to researchers at hospitals, universities and research institutions all over the world. We are committed to provide excellence in researching, manufacturing and drug discovery process, competent technical assistance, highly product quality, timely delivery and plus cost effectively. Our products include a variety of bulk drugs, APIs, new pharmaceutical Intermediates, specialty chemicals, new co.....more>>

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