Amphetamine Polarity

Is C₉H₁₃N (Amphetamine) Polar or Nonpolar? Molecular Polarity & Structure Analysis

Figure 1: 2D Lewis Structure (C ₉H ₁₃N; trigonal pyramidal nitrogen centre)

Polarity Parameters of C₉H₁₃N

CAS Registry Number	300-62-9
Molecular Formula	C9H13N
Molecular Weight	135.21 g/mol
Valence Electrons	54
Lewis Structure Guide	View C9H13N Lewis Structure Guide
Dipole Moment (μ)	≈ 1.07 D (calculated: GFN2-xTB//MMFF94, gas phase, single conformer, calibrated against a 60-molecule benchmark; typical residual ±0.3 D)
Dielectric Constant (εr)	≈ 1.00935 (calculated dilute-gas estimate, Debye equation, 298 K, 1 atm)
Snyder Polarity Index (P′)	Not conventionally assigned
XlogP3-AA	1.58 (Crippen calculated, RDKit) (computed descriptor)

Note: Snyder P′ is a chromatographic solvent scale developed for conventional liquid solvents; the dipole moment is a calculated value (GFN2-xTB single point on an MMFF94 geometry, gas phase, single conformer, calibrated against a 60-molecule benchmark), not a measurement; treat it as good to about ±0.3 D; the relative permittivity is a dilute-gas estimate obtained from the Debye equation at 298 K and 1 atm, not a liquid dielectric constant; XlogP is a calculated partition descriptor, not a direct measure of solvent polarity.

1. Molecular Polarity Analysis of Amphetamine: Geometry & Dipole Vector

To determine whether Amphetamine (C₉H₁₃N) is polar or nonpolar, the decisive question is whether the bond dipoles of the molecule cancel once its three-dimensional shape is taken into account. Amphetamine is a primary amine, built from primary amine (–NH₂). As set out in the C₉H₁₃N Lewis Structure Guide, C₉H₁₃N has 10 heavy atoms, 1 ring system and 2 rotatable bonds. MEDICATION (VET).

The bond polarities follow from electronegativity. The largest differences in the structure are C–N (ΔEN ≈ 0.49), so electron density is pulled toward nitrogen. In three dimensions, the nitrogen centre is trigonal pyramidal, because one non-bonding electron pair occupies the fourth position of a sp3 tetrahedral electron-domain set, slightly compressed relative to the tetrahedral angle. As a result, the calibrated dipole moment is μ ≈ 1.07 D. Treated as a dilute ideal gas at 298 K and 1 atm, the Debye equation converts that dipole into a relative permittivity of about 1.00935 — a number very close to unity, which is exactly what a gas-phase value should look like.

For formulation and process work, the useful consequences are these: the calculated topological polar surface area is 26.0 Ų, 1 hydrogen-bond donor and 1 hydrogen-bond acceptor, the Crippen calculated partition coefficient is logP ≈ 1.58 and the calculated molar refractivity is 43.80 cm³ mol⁻¹. A logP in this range means the molecule is amphiphilic enough to cross between phases, which is often the useful behaviour in extraction and formulation. PubChem’s curated experimental record adds: Amphetamine is Moderate solubility.

2. Amphetamine application: MEDICATION (VET)

PubChem’s use and manufacturing record describes Amphetamine as follows: MEDICATION (VET) These applications are what make the polarity question practical — solvent choice, extraction recovery, cleaning and formulation all turn on how strongly the molecule interacts with polar phases.

The measured physical behaviour recorded for this substance is consistent with that picture. Solubility: Moderate solubility. Physical Description: Colored liquid with an amine odor.. Density: 0.913 at 77 °F (EPA, 1998) - Less dense than water;. Melting Point: -98 ºC. These are database values and should be read with the conditions (temperature, purity, pressure) that the source states.

Treated as a dilute gas, the calculated relative permittivity is about 1.00935 at 298 K and 1 atm. That figure is close to unity because a gas is mostly empty space: it is a useful consistency check on the dipole, but it is not the number to use when sizing a liquid process, where condensed-phase permittivity and specific interactions dominate.

Structurally the reactivity sits in primary amine (–NH₂). That functional inventory, together with the moderate dipole, is what predicts the solubility and adsorption behaviour: polar groups give the molecule a handle on polar solvents and on polar surfaces, while the hydrocarbon portion resists them.

PubChem’s GHS record for this substance lists H226 (95.1%): Flammable liquid and vapor [Warning Flammable liquids] and H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]. Those classifications, not the polarity of the molecule, normally determine packaging, labelling, ventilation and transport requirements.

Recommended Analytical Quality-Control Strategy

• Identity confirmation: FTIR or Raman against a reference spectrum, supported by GC–MS or LC–MS where the compound is amenable; this is the fastest way to catch a mis-labelled lot.
• Assay / purity: GC-FID or GC-MS for volatile material, HPLC with a validated detector for non-volatile or thermally labile material; state the basis (area %, assay on dried substance, or titrimetric) on the certificate of analysis.
• Water content: Karl Fischer titration is the default for a substance whose polarity and hydrogen-bonding capacity make it hygroscopic; moisture is the single most common cause of out-of-specification lots.
• Related substances: a gradient HPLC or GC method capable of resolving the synthesis by-products and the isomeric impurities typical of this structure.
• Acid–base / ionisable content: a validated acid–base titration or potentiometric determination, since the ionisable group controls both the assay and the behaviour in use.

In short, specify Amphetamine by assay, water content, impurity profile, packaging and transport class, and state the intended application on the enquiry. The polarity analysis above explains behaviour in use; it does not replace a specification.

3. Polarity Comparison: C₉H₁₃N and Related Industrial Fluids

The comparison below places C₉H₁₃N next to structurally related substances from the same catalogue. Dipole moments come from one consistent protocol (GFN2-xTB//MMFF94, gas phase, single conformer) and are quoted only where that protocol has been validated; where it has not, the cell says so instead of giving a number. Permittivities are dilute-gas estimates from the Debye equation, logP values are Crippen calculations, and the solubility column is a qualitative inference from the calculated descriptors rather than a measurement.

The spread across this table is the point: composition alone does not set the polarity verdict. C₉H₁₃N sits where it does because of the balance between its polar functional groups and the asymmetry of its shape, and any of the neighbouring entries can be the better choice once the temperature, the phase and the required polarity window are fixed.

4. Expert R&D Commentary

5. Regulatory, Safety & Sustainability Trends

Regulatory status is specific to the substance and to the jurisdiction, and it changes. For CAS 300-62-9 the authoritative public sources are the ECHA registered-substance database for the EU, and the OSHA and NIOSH tables for occupational exposure in the United States.

PubChem’s GHS record for this substance lists H226 (95.1%): Flammable liquid and vapor [Warning Flammable liquids] and H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]. These statements are the ones that must appear on the label and in section 2 of the safety data sheet; they, rather than the polarity of the molecule, drive classification, packaging group and transport documentation.

No occupational exposure limit for this substance is quoted in this article, because none was present in the database record used here. Publishing a limit that is not on the record would be worse than publishing none: obtain the applicable value from the OSHA Z-table, the NIOSH pocket guide or the equivalent national instrument before designing the ventilation or monitoring programme.

From a compliance and sustainability standpoint, the polarity of C₉H₁₃N is a means rather than an end. It determines which solvent can replace another, how completely the substance can be recovered from a stream, and how much energy the separation will cost — so it belongs in the process justification, while the hazard classification and the exposure limits belong in the safety case.

6. Guidechem's Procurement Tips: What to Specify for Amphetamine

A purchase enquiry for Amphetamine (CAS 300-62-9) should state the grade, assay basis, permitted impurity limits, water content, packaging, and the transport and regulatory status required for the destination market. Where the substance is used as a reagent or intermediate, the impurity profile usually matters more than the nominal percentage.

Because polarity governs phase behaviour, it also governs recovery: a moderate molecule is easier to strip from a non-polar stream and harder to dry than a non-polar one, and vice versa. Confirm the Guidechem supply listing for current availability and compare lots on the certificate of analysis rather than on the label alone.

Frequently Asked Questions (FAQs)

References & Academic Databases

1. PubChem Compound Summary: Amphetamine, CAS RN 300-62-9, CID 3007. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov
2. ECHA Substance Information: Amphetamine, CAS 300-62-9 — REACH registration status, harmonised classification and regulatory context. European Chemicals Agency.
3. NIST Chemistry WebBook / CCCBDB: experimental geometry, vibrational data and dipole-moment compilations for Amphetamine. National Institute of Standards and Technology.
4. CRC Handbook of Chemistry and Physics, 92nd ed. (Haynes, W. M., ed.), CRC Press, 2011 — electronegativity, dielectric constant and dipole-moment tables.
5. Nelson, R. D.; Lide, D. R.; Maryott, A. A.: Selected Values of Electric Dipole Moments for Molecules in the Gas Phase, NSRDS-NBS 10, National Bureau of Standards, 1967.
6. Snyder, L. R.: solvent-polarity classification and the P′ scale for liquid chromatographic solvents. The P′ scale is defined only for conventional liquid solvents and is not assigned to substances outside that scope.
7. Bannwarth, C.; Ehlert, S.; Grimme, S.: GFN2-xTB — an accurate and broadly parametrised self-consistent tight-binding quantum chemical method with multipole electrostatics and density-dependent dispersion contributions. J. Chem. Theory Comput. 2019, 15 (3), 1652–1671.
8. RDKit / Halgren, T. A.: MMFF94 force field for geometry generation (J. Comput. Chem. 1996, 17, 490–519) and the RDKit cheminformatics toolkit used for the Crippen logP, TPSA and hydrogen-bond descriptors quoted here.