Phosphorus tribromide

Phosphorus tribromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen.Phosphorus tribromide may be used as a reagent:In a novel protocol for synthesizing 7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, a synthetic juvenile hormone mimic of trans,trans,cis-10,11-epoxy-7-ethyl-3,11-dimethyltrideca-2,6-dienoate.To synthesize 1,2,3-diazaphosphinane, 1,2,3-thiazaphosphinine and 1,2-azaphosphole bearing a chromone ring.To synthesize 1-Bromoundec-1-ene from 10-undecen-1-ol.
Phosphorus tribromide is a colourless liquid(possibly hazy) with the formula PBr3. It fumes in air due to hydrolysis and has a penetrating odour. It is widely used in the laboratory for the conversion of alcohols toalkyl bromides.Phosphorus tribromide (PBr3) is commonly used in Hell-Volhard-Zelinsky halogenation for the α-bromination of carboxylic acids to form the corresponding acyl bromide. It is also useful for the conversion of primary and secondary alcohols to alkyl bromides.