트리플루오로아세틱산

트리플루오로아세트산은 무색의 발연성 액체로, 자극적이고 매운 냄새가 나며 휘발성이 높다. 끓는점은 72 °C이며, 녹는점은 −15.3 °C이다. 이는 강한 유기산이자 불소를 함유한 카복실산으로, 전자 흡인성 트리플루오로메틸기를 특징으로 한다. 트리플루오로아세트산은 유기합성에서 시약 및 촉매로 널리 사용되며, 특히 펩타이드 및 제약 제조 공정에서 아미노 보호기(예: Boc, t-Bu 에스터)의 탈보호 반응에 주로 활용된다. 또한 불소 함유 농약, 의약품, 특수 고분자의 제조에 있어서 핵심 중간체로도 기능한다. 주요 응용 분야는 활성 약물 성분(API) 합성, 불소 화학 중간체, 전기영동 및 크로마토그래피에서의 용매 또는 공동 용매 등이다.

Trifluoroacetic acid is mainly for the production of new pesticide, medicine and dyes, and also has great potential of application and development in the fields of materials and solvents. Trifluoroacetic acid is mainly used for the synthesis of various kinds of trifluoromethyl group or heterocyclic containing herbicides. It is currently available for synthesizing various kinds of novel herbicide containing pyridyl and qunoilyl; acting as a strong proton acid, it is widely applied as the catalyst for alkylation, acylation, and olefin polymerization of aromatic compound; as a solvent, trifluoroacetic acid is a kind of excellent solvent for fluorination, nitration and halogenations. In particular, the excellent protective effect of its trifluoroacetyl derivatives on hydroxy and amino group has very important application in the synthesis of amino acid and poly-peptide synthesis, for example, the compound can be used as the protection agent of tert-butoxycarbonyl (t-boc) which is used for removing amino acids during the synthesis of poly-peptide. Trifluoroacetic acid, as the raw material and modifier for the preparation of the ion membrane, can largely improve the current efficiency of soda industry and significantly extend the working life of the membrane; trifluoroacetic acid can also be used for synthesizing trifluoro-ethanol, trifluoroacetic acetaldehyde and trifluoroacetic anhydride. At room temperature, the mercury trifluoroacetic acid can have mercury-fluorophenyl be able to have mercuration reaction (electrophilic substitution), and can also convert hydrazone to diazo compound. The lead salt of this acid can convert arene to phenol. In the experiment of reverse phase chromatography for isolation of peptides and proteins, using trifluoroacetic acid (TFA) as the ion-pairing reagents is a common approach. Trifluoroacetic acid in the mobile phase can improve the peak shape and overcome the problem of the peak broadening and trailing issue through interaction with hydrophobic bonded phase and residual polar surface in a variety of models. Trifluoroacetic acid has an advantage over other ion modifier due to that it is volatile and can be easily removed from the sample preparation. On the other hand, the maximum UV absorption peak of trifluoroacetic acid is less than 200 nm, and thus having very small interference on the detection of polypeptides at low wavelengths.
분석물: 트리플루오로아세트산;; 매트릭스: 화학 순도; 시험법: 물 및 알코올에서 용해; 수산화나트륨을 이용한 전위차 적정법;

이 화학 물질은 정밀 홖학에 포함되어 있습니다. 트리플루오로아세틱산이 무엇인지와 트리플루오로아세틱산의 SDS 정보를 확인해 보세요.

Guidechem에서 트리플루오로아세틱산공급업체 및 트리플루오로아세틱산공급업체 맵을 확인하고, 트리플루오로아세틱산 공급을 찾아 118개의 신뢰할 수 있는 인증된 공급업체로부터 소싱 요구를 충족하세요.