トリフルオロ酢酸

トリフルオロ酢酸は、無色で発煙性の液体であり、刺激的で鋭い臭気を持ち、揮発性が高い。沸点は72 ℃、融点は−15.3 ℃である。これは強力な有機酸であり、フッ素を含むカルボン酸であり、電子吸引性のトリフルオロメチル基によって特徴づけられる。トリフルオロ酢酸は、有機合成における試薬および触媒として広く用いられており、特にペプチドおよび医薬品製造におけるアミノ保護基（例：Boc、t-ブチルエステル）の脱保護に使用される。また、フッ素含有農薬、医薬品および特殊ポリマーの製造における重要な中間体としても機能する。主な応用分野には、医薬品原体（API）の合成、フッ素含有化学中間体、ならびに電気泳動およびクロマトグラフィーにおける溶媒または共溶媒としての利用が含まれる。

Trifluoroacetic acid is mainly for the production of new pesticide, medicine and dyes, and also has great potential of application and development in the fields of materials and solvents. Trifluoroacetic acid is mainly used for the synthesis of various kinds of trifluoromethyl group or heterocyclic containing herbicides. It is currently available for synthesizing various kinds of novel herbicide containing pyridyl and qunoilyl; acting as a strong proton acid, it is widely applied as the catalyst for alkylation, acylation, and olefin polymerization of aromatic compound; as a solvent, trifluoroacetic acid is a kind of excellent solvent for fluorination, nitration and halogenations. In particular, the excellent protective effect of its trifluoroacetyl derivatives on hydroxy and amino group has very important application in the synthesis of amino acid and poly-peptide synthesis, for example, the compound can be used as the protection agent of tert-butoxycarbonyl (t-boc) which is used for removing amino acids during the synthesis of poly-peptide. Trifluoroacetic acid, as the raw material and modifier for the preparation of the ion membrane, can largely improve the current efficiency of soda industry and significantly extend the working life of the membrane; trifluoroacetic acid can also be used for synthesizing trifluoro-ethanol, trifluoroacetic acetaldehyde and trifluoroacetic anhydride. At room temperature, the mercury trifluoroacetic acid can have mercury-fluorophenyl be able to have mercuration reaction (electrophilic substitution), and can also convert hydrazone to diazo compound. The lead salt of this acid can convert arene to phenol. In the experiment of reverse phase chromatography for isolation of peptides and proteins, using trifluoroacetic acid (TFA) as the ion-pairing reagents is a common approach. Trifluoroacetic acid in the mobile phase can improve the peak shape and overcome the problem of the peak broadening and trailing issue through interaction with hydrophobic bonded phase and residual polar surface in a variety of models. Trifluoroacetic acid has an advantage over other ion modifier due to that it is volatile and can be easily removed from the sample preparation. On the other hand, the maximum UV absorption peak of trifluoroacetic acid is less than 200 nm, and thus having very small interference on the detection of polypeptides at low wavelengths.
分析対象物質：トリフルオロ酢酸；マトリックス：化学的純度；手順：水およびアルコールへの溶解、水酸化ナトリウムによる電位差滴定；

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