n-Butyllithium

n-Butyllithium is a colorless to pale yellow, pyrophoric liquid with a pungent odor, typically handled as a solution in hydrocarbon solvents such as hexanes or heptane; it decomposes above 0 °C and has no well-defined boiling point due to thermal instability. It is an organolithium compound and a strong base and nucleophile widely employed as a reagent and initiator in organic synthesis. Its primary industrial use is as a catalyst or stoichiometric reagent in the production of synthetic elastomers—including styrene–butadiene rubber (SBR) and polybutadiene—as well as in the manufacture of pharmaceuticals, agrochemicals, and specialty organic intermediates. Typical application areas include polymerization processes, lithium–halogen exchange reactions, and the synthesis of fine chemicals for pharmaceuticals and crop protection agents.

N-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst.N-Butyllithium is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as:1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances.2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound.3) Nucleophilic addition and substitution reaction.4) Halogen-metal replacement.

This chemical is included in Fine Chemicals. See more about what is n-Butyllithium and n-Butyllithium SDS information.

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