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China and the United States are the leading exporters of Ethyl 4,4,4-trifluoroacetoacetate (CAS 372-31-6), collectively accounting for over 60% of global export value in 2023–2024, while Germany, Japan, and South Korea represent the largest importing markets. Import demand has remained relatively stable across key Asian and European markets, with modest growth observed in semiconductor-related end-use sectors influencing Ethyl 4,4,4-trifluoroacetoacetate prices.
Ethyl 4,4,4-trifluoroacetoacetate is a colorless to pale yellow liquid at room temperature, with moderate volatility and a mild, characteristic ester-like odor. It is a β-keto ester bearing a trifluoromethyl group, classified as a fluorinated organic intermediate. Its electron-withdrawing trifluoroacetyl moiety enhances reactivity in condensation and cyclization reactions, making it a valuable building block in fine chemical synthesis. It is primarily employed as a key intermediate in the production of fluorinated pharmaceuticals (e.g., certain antidiabetic and anti-inflammatory agents) and agrochemicals (including herbicides and fungicides). Typical application areas include active pharmaceutical ingredient (API) synthesis and crop protection chemistry.
Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet
Clear liquid
This chemical is included in Fine Chemicals. See more about what is Ethyl 4,4,4-trifluoroacetoacetate and Ethyl 4,4,4-trifluoroacetoacetate SDS information.
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