India and China are the leading global exporters of 5-Fluorouracil, collectively accounting for the majority of international supply, while the United States, Germany, and Japan represent the largest importing markets. Recent years show stable export volumes from India amid modest upward pressure on 5-Fluorouracil prices, while U.S. imports have remained consistently high despite minor fluctuations in sourcing shares among Asian suppliers.
5-Fluorouracil is a white to off-white crystalline powder with no significant odor and low volatility; it has a melting point of approximately 282–283 °C (with decomposition). It is a fluorinated pyrimidine analog and classified as a heterocyclic organic compound. Primarily employed as an active pharmaceutical ingredient (API), it serves as a cytostatic agent in oncology, particularly for the treatment of colorectal, breast, gastric, and head and neck cancers. Its principal commercial use is in the formulation of antineoplastic drugs—both as a standalone injectable or topical preparation and as a key intermediate in the synthesis of prodrugs and related fluoropyrimidine derivatives. Applications are confined exclusively to the pharmaceutical sector, with no significant industrial use in agrochemicals, polymers, dyes, or other chemical manufacturing segments.
1. It is used for biochemical studies and antitumor drugs. 2. It is the anti tumor drug, also used for synthesis of flucytosine. 5-fluorouracil can be used in the study of rice in the biochemical studies, ear differentiation, genetic metabolic measurement, plant growth development research.3. It is used for the digestive system cancer, head and neck cancer, gynecological cancer, lung cancer, liver cancer, treatment of bladder cancer and skin cancer.4. Antimetabolite antitumor drugs.5. Anti tumor drugs. There is a certain effect on a variety of tumors such as digestive tract cancer, breast cancer, ovarian cancer, chorionic epithelial cancer, cervical cancer, hepatocellular carcinoma, bladder cancer, skin cancer (topical), leukoplakia (topical) etc. Adverse reactions mainly are bone marrow transplantation, digestive tract reaction, serious person can have diarrhea, local injection site phlebitis, a few of which have nervous system reactions such as cerebellar degeneration and ataxia. The course of medication should strictly check the blood.
White or almost white, crystalline powder
This chemical is included in Fine Chemicals - Pharmaceutical Intermediates & APIs. See more about what is 5-Fluorouracil and 5-Fluorouracil SDS information.
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